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John MD

@jwbelmon.bsky.social
2.5K followers 2.7K following 1.2K posts

#MD, #PhD | #Pediatrics | #Medical #Genetics | #Human #Genetics | #Cardiovascular | #Congenital | #Genome #Sequencing | #HealthEcon | #Causal #Inference belmontgenetics.org

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Reposted by John MD
Texas Tribune @texastribune.org · 6h
Democratic challenger Vikki Goodwin remains outspent by incumbent Lt. Gov. Dan Patrick and unknown to nearly half the electorate in the campaign’s final stretch. Yet she narrowly led in a poll conducted earlier this month.
texastribune.org
Vikki Goodwin gives Dan Patrick a race for lieutenant governor
The race for Texas’ powerful second-in-command role pits a third-term GOP kingmaker against a state lawmaker who is riding the political tailwind felt by Democrats up and down the ballot.
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Satoshi Yoshiji, MD, PhD @satoshiyoshiji.bsky.social · 4h
Our lab will present at #ASHG2026 and #IGES2026 with 1 symposium, 4 talks, 2 lightning talks, and 5 posters on cardiometabolic genomics and proteomics. We’d love to see you there! ASHG schedule:
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Texas Tribune @texastribune.org · 14/10/2026
Voting rights groups are suing Texas after the state failed to process more than 500,000 voter registration applications submitted through the Texas Department of Public Safety’s web portal.
texastribune.org
Texas sued for failing to process 500,000+ voter registrations
Voting rights groups are asking a judge to enforce a 2021 settlement aimed at providing reliable online registration through DPS.
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Melody Schreiber @melodyschreiber.com · 14/10/2026
BREAKING: Guinea-Bissau did not approve the controversial hepatitis B vaccine trial to move forward, the country's health minister says: www.theguardian.com/world/2026/o...
theguardian.com
Guinea-Bissau denies it has approved controversial vaccine trial in newborns
Health minister says government ‘did not authorize’ Danish-led hepatitis B trial in babies backed by RFK Jr
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Anthony's Spinning Circles here too! @circlesspinning.bsky.social · 14/10/2026
👊🏾❤️💯
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Brendel @brendelbored.bsky.social · 14/10/2026
What’s so striking about this is seeing other reporters get annoyed by his bullshit and say he’s wrong and keep asking questions as opposed to what the national media does for Trump which is go oh ok thank you sir
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Alfonso Martinez Arias @amartinezarias.bsky.social · 10/10/2026
..and have a look at the highly related paper from @arjunraj.bsky.social biorxiv.org/content/10.1... with complementary experiments that reinforce the point and reveal multicellular #memory@arjunraj.bsky.social
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John MD @jwbelmon.bsky.social · 14/10/2026
Perhaps clearer in potential outcomes notation as in Brumback’s text. But she gives only a short description of probabilities of causation - the Causes of Effects of Pearl or Dawid.
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John MD @jwbelmon.bsky.social · 14/10/2026
Have encountered this before. People who couldn’t stand not to win.
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John MD @jwbelmon.bsky.social · 14/10/2026
Entertaining
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Reposted by John MD
Brandi Buchman @brandibuchman.bsky.social · 13/10/2026
Oop Texts show Kimberly Guilfoyle may have raised $3M for Jan. 6 rally - Daily Kos share.google/2EevcRH9a9MF...
share.google
Texts show Kimberly Guilfoyle may have raised $3M for Jan. 6 rally
Alleged messages show Guilfoyle boasting of $3M in Jan. 6 rally funding. Explore the ongoing investigation and new revelations now.
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John MD @jwbelmon.bsky.social · 14/10/2026
dead eyes and rictus of Doug Burgum
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John MD @jwbelmon.bsky.social · 14/10/2026
Poulenc had something important to say about courage in the face of fear www.youtube.com/watch?v=mNkN...
youtube.com
Dialogues des Carmélites, FP 159: Mes chères filles (La nouvelle prieure, Mère Marie,...
YouTube video by Régine Crespin - Topic
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John MD @jwbelmon.bsky.social · 14/10/2026
Spiraling down to skid row
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Reposted by John MD
Texas Tribune @texastribune.org · 14/10/2026
Harris County District Attorney Sean Teare said that his office will investigate why an immigration agent driving an SUV ran over a 48-year-old man during an enforcement operation on Saturday. ICE officers were looking for Jose Mendoza-Cervantes, who had a deportation order.
texastribune.org
Harris County DA considers charges against ICE agent
Harris County District Attorney Sean Teare said his office is investigating why an ICE officer struck Miguel Parra-Hernandez, whose family says suffered two broken legs.
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jamelle @jamellebouie.net · 14/10/2026
that’s right
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Gregg Gonsalves @gregggonsalves.bsky.social · 13/10/2026
This is really terrible news. Helen was one of the best. Helen Branswell, whose reporting on infectious diseases and public health drew acclaim, dies at 69 www.statnews.com/2026/10/13/h... via @statnews.com
statnews.com
Helen Branswell, whose reporting on infectious diseases and public health drew acclaim, dies at 69
Helen Branswell, STAT's infectious disease reporter who earned the respect of experts and public health officials with her accessible, prescient dispatches, has died at age 69.
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Jonathan Howard @joho.bsky.social · 13/10/2026
VInay Prasad said this study was “ethical, feasible, practical and would be quite useful.” I share this not to give him more oxygen. He’s irrelevant. But a lot of people, several here, have said nice things about him. Here’s who they were praising.👇
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Shivam Bhatt @shivambhatt.bsky.social · 13/10/2026
Today is day 2 of Navratri, where we honor the Goddess as Brahmacharini, the young student, the queen of austerities, the icon of tenacity, focus, and determination.
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John MD @jwbelmon.bsky.social · 13/10/2026
Only $15 million? Pocket money for the real players
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Reposted by John MD
Matthew Aguirre @aguirre404.bsky.social · 13/10/2026
Happy to share some new work done in collaboration with my colleagues in Human Genetics at Genentech! In it, we assess five model-based variant pathogenicity labels in the context of rare variant burden testing. [Summary ⬇️]. link.springer.com/article/10.1...
link.springer.com
Markedly divergent performance of variant annotation methods for gene-level association testing - BMC Genomics
Machine learning-based annotation methods are increasingly used to assess the pathogenicity of genetic variants, but their performance at prioritizing variants for gene-level association testing remai...
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Reposted by John MD
Adam Braithwaite @braithwaiteat.bsky.social · 11/10/2026
New paper out now in Genome Medicine! 🎉 Which in vitro model best reflects human inflammatory disease? We profiled >150K PBMCs using #scRNAseq across 11 stimuli to map intra- & intercellular responses across 21 cell subsets. 🧵👇 doi.org/10.1186/s130... 🧪🧬🖥️ #SingleCell #AcademicSky
A multi-panel figure summarizing the experimental workflow and single-cell RNA sequencing results for in vitro stimulated immune cells.
  
The top left panel illustrates the experimental workflow, showing healthy donor PBMCs treated with immunomodulators for 48 hours, followed by cell fixation, SPLiT-Seq single-cell barcoding, RNA sequencing, and downstream comparative analysis.  

The bottom left panel displays a UMAP plot showing the distinct clustering of various immune cell types across myeloid and lymphoid lineages, including monocytes, B cells, T cells, and NK cells.  

The right panel features a grid plot comparing the responses of these specific immune cell types across 11 different stimulations. This plot highlights the mean fold change (represented by color) and the number of differentially expressed genes (represented by the size of the squares) per cell type and stimulation condition.
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David Simon @audacityofdespair.bsky.social · 11/10/2026
No doubt this has occurred to other bystanders as well, but it would seem that a handful of billionaires dropping $150 million into a single state's election in an attempt to defeat a wealth-tax initiative just about makes the entire case for a wealth-tax initiative.
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clyde bruckman's skeleton's final repost @ultralaser.bsky.social · 11/10/2026
reminder that the MINIMUM WAGE was originally intended to be enough for any single worker to support a family
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NIH Vigils @nihvigils.bsky.social · 11/10/2026
Ahem. impeachvought.com
impeachvought.com
Impeach Vought
We are current and former federal workers from across the government. We have witnessed first-hand the harm Russell Vought has inflicted on American communities. We are urging Congress to act now to p...
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John MD @jwbelmon.bsky.social · 10/10/2026
Untestable exchangeability assumptions [oops, sorry, that’s rcts with external transportability problems]
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Jonathan Howard @joho.bsky.social · 09/10/2026
As a reminder...
sciencebasedmedicine.org
Doctors Who Glorified Trump Have Permanently Tied Themselves to Everything He Does
The purges, censorship, and politicization in the worlds of medicine and science are not distinct from the corruption and vandalism of the country writ large. We Want Them Infected doctors are part o
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Pablo Navarro @pablonavarrolab.bsky.social · 09/10/2026
An absolutely incredible paper I had the chance to watch develop and support.
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John MD @jwbelmon.bsky.social · 09/10/2026
“It was ChatGPT that had convinced Deb to order the TruAge test in the first place.”
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John Greally @greally.bsky.social · 09/10/2026
Profoundly disturbing. When DNA methylation tests meet the garbage wellness industry. Zoltar’s advice outside the old Gem Spa in the East Village was about as valuable, and cost a lot less www.nytimes.com/2026/10/08/s...
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Jacqueline Antonovich @jackiantonovich.bsky.social · 09/10/2026
Academia distilled.
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Brandon Friedman @brandonfriedman.bsky.social · 09/10/2026
This is Nazi rhetoric, full stop. It's not only a call to instigate a race war in the United States, but it's reminiscent of historic European justifications used to incite pogroms against Jews. People who say things like this are incredibly dangerous, as there is nothing they won't eventually do.
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Patrick Cosmos @veryimportant.lawyer · 09/10/2026
There should be a political party that wants to stop this and punish the people doing this
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Sanho Tree @sanho.bsky.social · 09/10/2026
Remember when Senator Foghorn Leghorn posed as a Democrat?
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Burton’s Sleepy Hollow is a great rated R horror movie for kids @jdvdub.bsky.social · 09/10/2026
Importantly, everyone knows he’s right. You can tell that they know it. He’s learning that you can say things like this when they are true.
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jamelle @jamellebouie.net · 09/10/2026
jesus christ i have never heard a democratic talk this bluntly about an opponent
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John MD @jwbelmon.bsky.social · 08/10/2026
Too cold
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Jack-o-Rutabaga @streamlass.bsky.social · 08/10/2026
It beeth persimmon season. Rejoice yherefore!
A ripe orange persimmon on a dessert plate with a green border
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James O'Malley @jamesomalley.co.uk · 07/10/2026
Holy shit. Someone has decompiled the Adobe suite, rebuilt it in Rust and released it as open source. Either all software is dead or the US copyright laws are about to receive an update. getartcraft.com/apps
getartcraft.com
Crafting Apps: open-source creative tools
Image editing, vector illustration, video, photography, PDFs, motion graphics and page layout: seven native, open-source apps from the ArtCraft team, built in Rust and free to use.
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John MD @jwbelmon.bsky.social · 08/10/2026
Remains unethical
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Joyce White Vance @joycewhitevance.bsky.social · 07/10/2026
Will the 11th Circuit see through Trump’s new delay tactic as he tries to keep the public from seeing the Mar-a-Lago volume of Jack Smith’s report? joycevance.substack.com/p/pat-robert...
joycevance.substack.com
Pat Robertson Tried It While Campaigning. Will Trump Fare Any Better?
But he shouldn’t.
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Gillian Brockell @gillianbrockell.com · 06/10/2026
I LOVE how @propublica.org dealt with official comment here, editorially and stylistically.
The Trump administration says none of this is happening. 

"DHS is NOT arresting U.S. citizens by mistake." "There are no 'indiscriminate' stops." Allegations of "racial profiling are disgusting, reckless and categorically FALSE." "The pattern is NOT of law enforcement using force." "ICE does not zip tie or restrain children." 

But that is precisely what is happening, and at a far larger scale than previously reported.
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The Associated Press @apnews.com · 06/10/2026
Eva Marie Saint, star of "On the Waterfront" and "North by Northwest," has died. She was 102. bit.ly/4zm8kOP Photo by Richard Shotwell/Invision/AP
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Texas Observer @texasobserver.org · 06/10/2026
"It is not one troubled marriage. It is a political culture that asks women to set aside character, accountability, and even their own interests whenever party power is at stake."
texasobserver.org
Angela Paxton's Message: Elect the Elephant at All Costs
Her appeal to put party loyalty above character and accountability ignores the price women will pay if Ken Paxton becomes a U.S. senator.
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Paul Hünermund @p-hunermund.com · 06/10/2026
If the robots can do science better than us, then it's time to move on.
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Musicology Duck @musicologyduck.bsky.social · 06/10/2026
so incredibly massively fucking tired of this
Three National guard soldiers walking through a metro station
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Betty C. Jung @bettycjung.bsky.social · 05/10/2026
Unpasteurized milk was linked to 22X more outbreaks than pasteurized milk.
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Impact of Genomic Variation on Function @igvfconsortium.bsky.social · 05/10/2026
IGVF researchers developed a scalable approach to interpret uncertain genetic variants. Using experimental and predictive evidence, the team reclassified 75% of 16,115 VUS and preclassified 62% of >90,000 unobserved variants. www.biorxiv.org/content/10.6...
biorxiv.org
A scalable approach to resolving variants of uncertain significance
Over 90% of missense variants across ∼4,000 disease-associated genes are variants of uncertain significance (VUS). Experimental variant effect measurements provide critical evidence about pathogenicit...
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Richard Sever @richardsever.bsky.social · 03/10/2026
Any sane academic evaluation policy would forbid mention of Impact Factor
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Gautam Kamath @gautamkamath.com · 16/09/2026
Nihar Shah did a heroic experiment for TMLR: he spent 20-25 hours over two weeks interviewing authors of seemingly low-quality submissions about their own papers. He confirmed what we all suspected: people submitting these papers have *no idea* what is going on in them.
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