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Mike Lee

@theleelab.bsky.social
1.1K followers 1.3K following 30 posts

A laboratory of Systems Pharmacology at UMass Medical School. We study cancer therapies, and aim to understand how they activate cell death and how to make this work better. www.umassmed.edu/Lee-Lab

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Reposted by Mike Lee
Jeremy Berg @jeremymberg.bsky.social · 24/07/2026
My quote of the day The light obtained by setting straw men on fire is not what we mean by illumination. Adam Gopnik
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Cosimo Commisso @cosimocommisso.bsky.social · 28/05/2026
Still time to send an abstract and register for the FASEB Cell Signaling in Cancer meeting. There are many speaking slots available for proffered abstracts, along with a fantastic lineup of speakers. Join us in Kentucky! events.faseb.org/event/Cell-S...
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Mike Lee @theleelab.bsky.social · 19/05/2026
The 2026 FASEB Meeting on Cell Signaling in Cancer will be held in Louisville, KY July 13-15. It's not too late to join us! The abstract submission deadline is June 1. To view the speaker lineup, submit your abstract, and register, check out our conference website: events.faseb.org/event/Cell-S...
Information for the 2026 FASEB Conference on Cell Signaling in Cancer. Keynote speakers: Celeste Simon and Ann Marie Pendergast. Session topics are also listed: Targeted Therapies, Cancer Metabolism, Oncogenic Signaling, Epigenetic Regulation, Systems Pharmacology, Tumor Microenvironment, and Lipid Signaling
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Reposted by Mike Lee
Denis Wirtz @deniswirtz.bsky.social · 27/02/2026
NIH is not issuing awards. You may think that it's because they it is coming up with new directions of research...The apposite is true. Here is a graph showing how many fewer new funding opportunities that NIH has posted over time. -91%, a trend that started on Jan 2025.
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Mike Lee @theleelab.bsky.social · 19/11/2025
Life Science Editors wrote a really great "Snippet" about our recent paper describing PDAR. @lifescienceeditors.bsky.social @cp-cell.bsky.social Why cells die without Pol II www.lifescienceeditors.com/2025/11/15/w...
lifescienceeditors.com
Why cells die without Pol II - Scientific editing and writing experts - Life Science Editors
Scientific editing and writing experts for manuscripts and grants
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Reposted by Mike Lee
Carl T. Bergstrom @carlbergstrom.com · 24/10/2025
The dark truth behind FormatMyPaper.com
ubadah.substack.com
Beware giving this site your unpublished data
Users noticed the website had fake testimonials and a domain name registered seemingly overnight.
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Stand Up for Science! @standupforscience.net · 09/10/2025
RFK Jr. has a less-than-zero understanding of how science works. "Make the proof" should be disturbing for anybody who cares about health, truth, or democracy. Join our fight to impeach RFK Jr. here 👉 www.standupforscience.net/quack-o-gram... #impeachrfk #impeachthequack
standupforscience.net
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MeidasTouch @meidastouch.com · 26/09/2025
🚨 BREAKING: James Comey posts a video statement following his indictment "My family and I have known for years that there are costs to standing up to Donald Trump...But I'm not afraid. And I hope you're not either...And I'm innocent. So let's have a trial and keep the faith."
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Nature @nature.com · 25/09/2025
We used machine-learning tools in an attempt to recreate the method for cutting funding, and then applied it to past US NIH grants to reveal the broad-reaching consequences go.nature.com/4pBArFH
go.nature.com
What research might be lost after the NIH’s cuts? Nature trained a bot to find out
We used machine-learning tools in an attempt to recreate the method for cutting funding, and then applied it to past US National Institutes of Health grants to reveal the broad-reaching consequences of such action.
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Max Kozlov @maxkozlov.bsky.social · 25/09/2025
NEW: Nature trained AI to predict which NIH grants from 2014 would have been cut if the Trump admin had its way back then — and what science would have been lost to history. "The results show the damage that cuts in funding can do to research, and the unpredictable nature of the research process."
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Mike Lee @theleelab.bsky.social · 22/08/2025
A nice Q&A with Nick Harper about the discovery of PDAR, and his road to becoming a scientist @umasschan.bsky.social www.umassmed.edu/dsb/dsb-comm...
Picture of Nick Harper, a graduate student in the Lee Lab at UMass Chan Medical School
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Mike Lee @theleelab.bsky.social · 15/08/2025
I’m excited to highlight our latest paper, just published in Cell 🎉 We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression. 1/n 🧪 www.cell.com/cell/fulltex...
cell.com
RNA Pol II inhibition activates cell death independently from the loss of transcription
When RNA polymerase II (RNA Pol II) is inhibited, the inhibition is sensed and signaled to mitochondria, leading to programmed cell death independently of the loss of RNA Pol II transcription activity...
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Abby Dernburg @adernburg.bsky.social · 31/07/2025
For who still thinks this can’t happen here… it’s already happening. www.theatlantic.com/science/arch...
theatlantic.com
Every Scientific Empire Comes to an End
America’s run as the premiere techno-superpower may be over.
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Joshua Weitz @joshuasweitz.bsky.social · 25/06/2025
"[A] sleeper issue is the proposed 40 percent cut to the National Institutes of Health, in the White House’s proposed budget for the next fiscal year." Perhaps injecting some economic impact data may help awaken what should not be a sleeper issue... @prospect.org scienceimpacts.org/fy26
Economic loss due to NIH budget cuts by Congressional district, scienceimpacts.org/fy26
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Mike Lee @theleelab.bsky.social · 23/06/2025
Things have been challenging over these last few months, but we also had a lot to celebrate... Tiana and Mika joining the lab 🎉, Kelly passing her QE 🎉, Gavin publishing a paper and submitting another 🎉, Megan publishing a paper 🎉, Nick getting excellent reviews 🎉 ...so we did a paint nite.
The Lee Lab at Paint Nite at Nu Kitchen in Worcester, MA
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Reposted by Mike Lee
Michael E. Mann @michaelemann.bsky.social · 29/05/2025
Trump’s new ‘gold standard’ rule will destroy American science as we know it" by Colette Delawalla (@cdelawalla.bsky.social), Victor Ambros, Carl Bergstrom, Carol Greider, Michael Mann and Brian Nosek for @theguardian.com: www.theguardian.com/commentisfre...
theguardian.com
Trump’s new ‘gold standard’ rule will destroy American science as we know it | Colette Delawalla
The new executive order allows political appointees to undermine research they oppose, paving the way to state-controlled science
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Vijay G. Sankaran @bloodgenes.bsky.social · 20/05/2025
www.forbes.com/sites/johndr...
forbes.com
Trump’s NIH And NSF Cuts Estimated To Cost The U.S. Economy $10 Billion Annually
Economists find public R&D drives U.S. productivity growth — and pays for itself
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Reposted by Mike Lee
Neil deGrasse Tyson @neildegrassetyson.com · 20/05/2025
Not that anyone asked, but during my tenure on the Pentagon’s Defense Innovation Board, under part of Obama-2 and all of Trump-1, we visited Military Bases domestically & abroad. At no time did any member of the Armed Forces I met say to me: “America needs less science funding.”
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Ben Allen @evodynamics.bsky.social · 15/05/2025
Grants on antibiotic resistance (and many other things) cancelled "due to unsafe antisemitic actions that suggest the institution lacks concern for the safety and wellbeing of Jewish students." Every single Jewish org needs to stand up and speak clearly against this weaponization of antisemitism
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Health Nerd @gidmk.bsky.social · 15/05/2025
"People should not take medical advice from me" ~ the man directly in charge of medical advice for the United States
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boehninglab @boehninglab.com · 09/05/2025
www.thenation.com/article/poli...
thenation.com
Inside the Bloodbath at the NIH
Sources say that a climate of fear has spread throughout the agency as the Trump administration takes a hatchet to its core functions.
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Reposted by Mike Lee
Don Moynihan @donmoyn.bsky.social · 19/04/2025
Set aside the headline, this is a good primer on the how the federal govt wanted higher Ed to take on a bigger research role, and funded the infrastructure to make that possible via merit-based peer reviewed processes. The research funding is not entitlements and cutting it comes w real costs
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Talia Hatkevich @taliahatkevichphd.bsky.social · 19/04/2025
Yyyyyyeeeeessssssa!!!! We are finally standing up!!!!!!!!!!!!
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Reposted by Mike Lee
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 14/04/2025
Harvard steps up www.harvard.edu/research-fun...
harvard.edu
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Adam Serwer @adamserwer.bsky.social · 14/04/2025
What we saw today was two jumped up thugs and their bootlicking sychophants laughing at the US Constitution, the supreme court, and the idea that anyone can stop them from doing anything they want www.theatlantic.com/politics/arc...
theatlantic.com
The Constitutional Crisis Is Here
The Supreme Court told the Trump administration to “facilitate” the return of Kilmar Abrego Garcia from El Salvador’s infamous CECOT prison. So far, the administration is pretending to comply while re...
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Aaron Rupar @atrupar.com · 01/04/2025
🔥 @ninajankowicz.com: "Mr Taibbi said when he was first searching through the so-called Twitter files he didn't know what he was looking at. Well, he still doesn't. Everything looks like a conspiracy when you don't know how anything works."
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Rachael Sirianni, PhD @docsirianni.bsky.social · 31/03/2025
Here, with breakdown by type of F award. These kinds of training grants are essential to support the academic workforce pipeline. These grants are paying the salaries of the ppl who do the work
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Solomon @solomonrmissouri.com · 28/03/2025
Explore this gift article from The New York Times. You can read it for free without a subscription. www.nytimes.com/2025/03/28/o...
nytimes.com
Opinion | Hillary Clinton: This Is Just Dumb (Gift Article)
The Signal group chat is only the latest in a string of self-inflicted wounds by the new administration.
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David Burbach 🇺🇸 @dburbach.bsky.social · 26/03/2025
JFC, Fulbright scholar not accused of any crime, no immigration violation, no reason to expect any violence -- just Marco Rubio's whim -- and instead of summoning her first step is no-uniform / no-ID guys in masks and hoodies grabbing her off a public street.
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Sean Ryder @seanryderphd.bsky.social · 26/03/2025
Six masked agents in street clothes disappearing a Tufts Ph.D. student in broad daylight on the streets of Somerville. There is video footage out there every person should watch.
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Cosimo Commisso @cosimocommisso.bsky.social · 26/03/2025
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Evan Hill @evanhill.bsky.social · 13/03/2025
Some pretty stunning answers here from DHS Deputy Secretary Troy Edgar in today's interview with NPR's Michel Martin, in which Edgar equates pro-Palestinian protests with terrorist activity and can't point to any crime committed by Mahmoud Khalil: npr.org/2025/03/13/n...
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Sherry Pagoto, PhD @drsherrypagoto.bsky.social · 12/03/2025
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...
forbes.com
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
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John Wallingford @jbwallingford.bsky.social · 24/02/2025
Data for every State can be found here: 3/3 www.unitedformedicalresearch.org/nih-in-your-...
unitedformedicalresearch.org
NIH In Your State - United For Medical Research
Select a state on the map to see the impact of NIH funding across America.
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Reposted by Mike Lee
Senator Patty Murray @murray.senate.gov · 24/02/2025
By crushing cancer research, what are Elon & Trump making more efficient? Their NIH funding cuts are illegal—so instead, they're suffocating the grant approval process for cancer researchers with so much red tape that labs & clinical trials will be forced to shut down.
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Blossom Damania @damania.bsky.social · 24/02/2025
NIH funding creates medicines, jobs and economic growth
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Mike Lee @theleelab.bsky.social · 13/12/2024
We just posted a preprint about a death mechanism that we find truly surprising. When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?! preprint here and a thread (1/n): www.biorxiv.org/content/10.1... 🧪
biorxiv.org
Pol II degradation activates cell death independently from the loss of transcription
Pol II-mediated transcription is essential for eukaryotic life. While loss of transcription is thought to be universally lethal, the associated mechanisms promoting cell death are not yet known. Here,...
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Ivano Amelio @ivanoamelio.bsky.social · 16/11/2024
Let's bring the #CellDeath community together here on 🦋 Just get in touch to join this Starter Pack go.bsky.app/R6mGrKU
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