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Arwen Gao @arwengao.bsky.social · 10/11/2025

More than 100 participants, it’s happening NOW! #DuSRA2025

Arwen Gao @arwengao.bsky.social · 08/09/2025

Check out our newly published paper at IScience! We showed that knocking down a fat-processing enzyme gene, plag-15, can switch on lysosome programs and extend lifespan in worms! cell.com/iscience/ful... #Healthyaging #lysosome #Celegans

cell.com

Targeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes

Molecular physiology; Lipidomics; Transcriptomics

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Reposted by Arwen Gao

auwerx-lab.bsky.social @auwerx-lab.bsky.social · 03/07/2025

Congrats to the Terytty, @arwengao.bsky.social and colleagues for identifying the importance of Lysosomal Surveillance Response (LysR) in fighting age-related protein accumulation. news.epfl.ch/news/a-recyc... www.nature.com/articles/s41...

news.epfl.ch

A recycling mechanism that helps cells fight aging

An international team led by EPFL has discovered a powerful anti-aging pathway in roundworms, revealing how boosting the cell’s lysosomes can help clear waste and promote healthy aging. The findings o...

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Arwen Gao @arwengao.bsky.social · 26/06/2025

Thrilled to share our new study: “A lysosomal surveillance response to stress extends healthspan” Knockdown of vha-6 in C. elegans activates LySR—a protective program that boosts lysosomal activity, clears aggregates, and extends lifespan. www.nature.com/articles/s41... #lysosomes #LySR #aging

nature.com

A lysosomal surveillance response to stress extends healthspan - Nature Cell Biology

Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional programme that boosts lysosomal activity and improves protein aggregate clearance...

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Reposted by Arwen Gao

Riekelt Houtkooper @rhhoutkooper.bsky.social · 03/12/2024

Save the date! DTMC 2025 is promising to be super exciting! Watch this space for updates, or sign up for the newsletter!

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Arwen Gao @arwengao.bsky.social · 28/05/2025

Team members from our group are presenting at #DTMC2025😊😊

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