Abstract. Complement inhibitors are increasingly used in kidney diseases, ranging from complement-mediated thrombotic microangiopathies to glomerulonephrit

The force-sensing ion channel PIEZO2 is an essential regulator of the renin-angiotensin-aldosterone system (RAAS), a pathway that controls blood volume. Loss of PIEZO2 in the kidney cells that produce...

Abstract. Monoclonal gammopathy of renal significance (MGRS) is a heterogeneous group of clonal B-cell or plasma cell proliferative disorders that cause ki

YouTube video by MARKUS at HOMe

Nature Reviews Nephrology - In this Review, the authors focus on the role of collagen IV in Gould syndrome and Alport syndrome. They discuss the molecular and phenotypic similarities and...

When a low-income patient receiving home dialysis misses the bus to the clinic, his nephrologist makes a decision that launches a long-term relationship and brings unexpected meaning into his own life...

Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this mult...

Analysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combinat...

IgG4-Related Kidney Disease

Scientists are using machine learning to find new treatments among thousands of old medicines.

Pauci-immune crescentic glomerulonephritis (GN) is nearly synonymous with anti-neutrophil cytoplasmic antibody (ANCA) associated disease. Cases with immune complex deposition create a diagnostic conun...

In recent years, the strategy of using laser microdissection and mass spectrometry (LCM/MS) has expanded the landscape of antigens associated with membranous nephropathy (MN). Specific associations wi...

Listen now | Finding the Mechanisms and the Basis for Potential Cures

In recent years, the strategy of using laser microdissection and mass spectrometry (LCM/MS) has expanded the landscape of antigens associated with membranous nephropathy (MN). Specific associations with phenotypes, diseases and sometimes reversible triggers led to an antigen-based classification of MN, informing precision medicine and highlighting for the potential value of routine use of proteomics in classifying MN. This study aimed at reproducing and further improving the original LCM/MS for antigen detection in MN.