iiinova — where your digital self keeps evolving

Reposted by Dominique Guerrot

PKD International @pkdinternational.bsky.social · 05/09/2026

🧵💙 A day of connection, knowledge and shared commitment in Leuven 👉 Yesterday, 4 September, marked the beginning of the first PKD International Global Members Meeting, bringing together representatives and patient organisations from around the world in Leuven.

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Stéphane Burtey @sburtey.bsky.social · 26/08/2026

Immigration et crime, pas de lien. C'est marrant aucun politique ne s'est emparé de ce papier. Je comprends pas pourquoi. Vous pouvez le garder pour les supers débats qui s'annoncent pour les élections présidentielles. www.nature.com/articles/d41...

nature.com

Undocumented migration does not raise crime rates, huge study finds

Analysis of neighbourhoods in more than 100 US cities finds no evidence that rising numbers of undocumented immigrants are linked with violent crime.

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Reposted by Dominique Guerrot

PKD International @pkdinternational.bsky.social · 19/08/2026

🧵 Following developments in PKD research and clinical trials can be challenging, particularly for patients who are unfamiliar with—or find it difficult to navigate—the information available on ClinicalTrials.gov

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Kidney International @kidneyint.bsky.social · 28/07/2026

A three-year randomized, double-blind, placebo-controlled study of lanreotide in stage 2/3 autosomal dominant polycystic kidney disease doi.org/10.1016/j.kint.2026.05.018 #NephSky #MedSky #OpenAccess #ADPKD #genetickidneydisease

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ISNkidneycare @theisn.org · 17/07/2026

📖 Don't miss our @kidneyint.bsky.social #ISNFridaySelection: Individual participant-level analysis of four RCT examined therapeutic effects of BP lowering on hierarchical kidney outcome using win statistics www.kidney-international.org/articl…

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 03/06/2026

Perfect timing for @kireports.bsky.social to publish the IgG4 review as the @nejm.org publishes this RCT of Obexelimab www.nejm.org/doi/full/10....

First Adjudicated Flare of IgG4-Related Disease for Which Rescue Therapy Was Required (Intention-to-Treat Population).

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Antoine Lanot @antoinelanot.bsky.social · 03/06/2026

💊 How do you taper corticosteroids in patients with ANCA-associated vasculitis? Try CorTapANCA, free interactive tool to prescribe steroid tapering protocols in AAV: 🔗 CorTapANCA App Please repost to help us reach more colleagues. #Nephrology #Vasculitis #AAV #ANCA #Glucocorticoids #KidneyDisease

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 01/06/2026

Safety of kidney biopsies during pregnancy - 1/2nd trimesters academic.oup.com/ndt/advance-... Selection bias as ~ 43% turned out to be lupus? Biopsies were safe, but lot of IUGR and 9% fetal death - likely related to underlying dz and meds and not the biopsy itself

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Dominique Guerrot @dguerrot.bsky.social · 31/05/2026

Important metaanalysis presented at #ESH2026 & in The Lancet: In patients with CKD, each 5 mmHg reduction in systolic BP reduced major cardiovascular events by ~9%, with similar relative benefits across CKD stages, proteinuria status and baseline BP levels. linkinghub.elsevier.com/retrieve/pii...

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Stéphane Burtey @sburtey.bsky.social · 28/05/2026

Pour ceux qui rêve d'un système à l'américaine pour maitriser les dépenses de santé. Je mets ça là et puis pour la cour des comptes un des problèmes du déficit c'est peut être aussi les recettes. Choix politique bien évidement.

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Joel Topf @kidneyboy.bsky.social · 28/04/2026

You ever read a title and feel it reach through your consciousness, tap you on the shoulder, and whisper, "It's all been worth it. Expertise matters."

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Reposted by Dominique Guerrot

American Journal of Kidney Diseases @ajkd.bsky.social · 14/04/2026

Monoallelic IFT140 Variants Causing Childhood-Onset Autosomal Dominant Polycystic Kidney Disease bit.ly/3J9ZIWT

Radiology imaging of pediatric ADPKD-IFT140 cases. (A, B) Case IFT1-IV-2: MRI at 17 years of age showing 12 cysts on the right kidney and 16 on the left. The largest measures 26 mm on the lower pole of the right and 4 cm on the upper pole of the left. The majority are <5 mm in length. A: Coronal T2 image (MRI) with the arrow pointing to the 4 cm cyst with internal septation located at the upper pole of the left kidney. B: Coronal T2 MRI with the arrow pointing at the 26 mm simple cyst on the lower pole of the right kidney. (C, D) Case IFT1-IV-4: Ultrasound imaging at 4 years of age showing 3 cysts on the right kidney and none on the left. All cysts measured 2-5 mm. Longitudinal ultrasound pictures of the right kidney with the arrow pointing at the cysts. (E, F) Case IFT2-III-5: Ultrasound imaging at 9 months old showing multiple cysts on the right kidney with a 3 cm cyst on the upper pole and a 0.7 cm cyst on the left kidney.

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American Journal of Kidney Diseases @ajkd.bsky.social · 26/03/2026

EDITORIAL: Guidance on Care for Autosomal Dominant Polycystic Kidney Disease: A Patient Perspective bit.ly/4bIyDEt (FREE)

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CJNephro @cjnephro.bsky.social · 21/03/2026

Le #CJN en mode running c'est le #NEPHRORUN 🦵 l'occasion de visiter #STRASBOURG en brûlant des calories🥨 @dguerrot.bsky.social @mickaelbob.bsky.social @lobbedezt.bsky.social

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 16/03/2026

FIND CKD meets primary outcome (GFR slope) in n ~ 1500 with proteinuric non-diabetic CKD Bayer press release: www.bayer.com/media/en-us/... BL data + design paper pubmed.ncbi.nlm.nih.gov/38858818/ in NDT H/T Brendon Neuen on LinkedIn (!)

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NDT @ndt-era.bsky.social · 16/03/2026

Urinary dipstick findings and UTI risk with SGLT2 inhibitors: a post hoc analysis of the CANVAS and CREDENCE trials doi.org/10.1093/ndt/...

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Joel Topf @kidneyboy.bsky.social · 09/03/2026

Saline Doesn’t Ruin Hyponatremia Labs (and it might help) How many times have you been evaluating a patient in the ED and bemoaned the sneaky liter of saline they got before anyone sent some urine for analysis. Turns out it doesn't ruin the labs at all. pbfluids.com/2026/03/sali...

pbfluids.com

Saline Doesn’t Ruin Hyponatremia Labs (It Might Help)

A study by Dr. Chienwichai highlights challenges in diagnosing hyponatremia due to undisclosed intravenous saline administration. While saline infusion does not obscure urine biochemical tests, it …

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Dominique Guerrot @dguerrot.bsky.social · 08/03/2026

Great to see the fantastic nephrology podcast community highlighted by #NephMadness 👍 French-speaking listeners may also enjoy #NephrOdio, a nephrology education podcast with 630K downloads to date !

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Reposted by Dominique Guerrot

NEJM.org @nejm.org · 06/03/2026

Finerenone improves kidney and cardiovascular outcomes in patients with chronic kidney disease and type 2 diabetes, but its efficacy in type 1 diabetes is unknown. The FINE-ONE trial involving patients with CKD and type 1 diabetes is summarized in a new Quick Take video. nej.md/3PcIJWt

A visual representation of the FINE-ONE trial, which assessed the efficacy and safety of finerenone among patients with CKD and type 1 diabetes.

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Reposted by Dominique Guerrot

ASN Publications @asnpublications.bsky.social · 22/02/2026

This prospective study in #ASNJASN of 976 adults measured the association between subclinical primary aldosteronism and kidney outcomes. Read more: kidney.pub/JASN1039 Rémi Goupil

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Dominique Guerrot @dguerrot.bsky.social · 11/02/2026

🙋‍♀️🙋‍♂️ Help shape practice on hypertension in ADPKD! 🔎 An ERKNet survey for adult & pediatric nephrologists, based on a PKD France initiative with support by ERA Kidney & Genes WG and ESPN 🇪🇺 Many thanks for your input ! Dominique Guerrot & Djalila Mekahli

surveymonkey.com

ERKNet Survey | Blood Pressure Management in ADPKD - A European Survey of Clinical Practice

Take this survey powered by surveymonkey.com. Create your own surveys for free.

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Dominique Guerrot @dguerrot.bsky.social · 11/02/2026

surveymonkey.com

ERKNet Survey | Blood Pressure Management in ADPKD - A European Survey of Clinical Practice

Take this survey powered by surveymonkey.com. Create your own surveys for free.

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Reposted by Dominique Guerrot

JAMA @jama.com · 20/01/2026

Meta-analysis: #SGLT2 inhibitors slow kidney decline consistently across CKD severity and albuminuria range, supporting their routine use for kidney health. ja.ma/4pNzTve

Four graphs display events prevented or caused per 1000 patients treated with a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor for 1 Year by Diabetes Status and Level of Albuminuria. The graphs show variance for diabetes vs. no diabetes.

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Mo. Elrggal @kidneyman.bsky.social · 20/12/2025

CKD prevalence in elderly and the eGFR inflation effect, a very important paper in the @ndt-era.bsky.social . Not just for elderly but also for the young CKD population academic.oup.com/ndt/article/... #nephinp #nephrology_in_practice

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 10/12/2025

#NephGR tomorrow at @ottawahospital.on.ca Tristan De Nattes from Rouen on treating ABMR #NephSky

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Reposted by Dominique Guerrot

Inserm @inserm.fr · 12/12/2025

Dans une nouvelle étude des scientifiques de l'Inserm ont analysé comment le système lymphatique se dérègle dans l’insuffisance cardiaque. Ils ont, pour la première fois, identifié les mécanismes responsables de ce dysfonctionnement. Lire le communiqué : presse.inserm.fr/decouverte-d...

presse.inserm.fr

Découverte de valves au cœur du système lymphatique cardiaque et de leur rôle dans l’insuffisance cardiaque - Salle de presse de l'Inserm

Dans une nouvelle étude, des chercheurs de l’Inserm et de l’Université de Rouen Normandie, en collaboration avec une équipe de l’Université de Wurtzbourg (Allemagne), ont analysé comment le système ly...

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Reposted by Dominique Guerrot

JAMA @jama.com · 10/12/2025

For critically ill patients who had both severe metabolic acidemia and moderate to severe acute kidney injury, sodium bicarbonate therapy did not significantly decrease day 90 all-cause mortality. ja.ma/4pFsAWU

Infographic from JAMA. Question: Does sodium bicarbonate decrease mortality at 90 days for patients with acidosis & acute kidney injury? Conclusion: No improvement. Findings: Sodium bicarbonate 62.1%, Control 61.7%.

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Dominique Guerrot @dguerrot.bsky.social · 11/12/2025

Well actually you wrote “renal” instead of “kidney” in a Twitter post in 2022… Access denied, sorry

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Ardem Patapoutian @ardemp.bskyverified.social · 04/12/2025

A long delay between pre print and publication means this paper only got better and better. Congrats @rose-hill.bsky.social and all collaborators, including many in renal physiology. A role for PIEZO2 in sensing pressure in the kidney and regulating the renin pathway. www.cell.com/cell/fulltex...

cell.com

Renal PIEZO2 is an essential regulator of renin

The force-sensing ion channel PIEZO2 is an essential regulator of the renin-angiotensin-aldosterone system (RAAS), a pathway that controls blood volume. Loss of PIEZO2 in the kidney cells that produce...

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Reposted by Dominique Guerrot

American Journal of Kidney Diseases @ajkd.bsky.social · 30/11/2025

Stopping Versus Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study bit.ly/3ZdrYxb #OpenAccess #VisualAbstract #CKD

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F. Perry Wilson, MD @fperrywilson.bsky.social · 24/11/2025

I’ve called GLP-1 agents like Ozempic and Mounjaro "miracle drugs." But a new study forces me to re-evaluate that moniker. The miracle has a problem: It ends when the prescription runs out. Let's look at the data on the "Rebound Effect." 🧵

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NEJM.org @nejm.org · 22/11/2025

Among older adults with frailty, evidence on the benefits and risks of discontinuing antihypertensive drugs is limited. Research findings from the RETREAT-FRAIL trial are summarized in a new Quick Take video. nej.md/482WnBv #MedSky #CardioSky

Visual representation of the RETREAT-FRAIL trial, which evaluated the effect of a progressive reduction in antihypertensive medications, as compared with usual care, on all-cause mortality among older adults with clinically significant frailty.

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Stéphane Burtey @sburtey.bsky.social · 22/11/2025

Suivez le conseil du Pr Guerrot, signez et faites tourner cette pétition. On s'en fout que ce ne soit pas un outil parfait, c'est mieux que rien.

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Robert Reich @rbreich.bsky.social · 18/11/2025

Medicare for All would save $450B a year. Every dollar spent on food stamps generates $1.50-$1.80 in economic activity. Each dollar going to low-wage workers adds $1.20 to the economy overall. It’s not about what this country can or can’t afford. It’s about priorities.

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Reposted by Dominique Guerrot

Juan Carlos Q Vélez, MD @juancarlosqvelez.bsky.social · 08/11/2025

I met a clever renal fellow at #KidneyWk who named his pets Ace and Arb. I’m inspired. I’ll name my next puppies Muddy and Waxy #UrinarySediment

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NEJM.org @nejm.org · 07/11/2025

In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results: nej.md/49zWuqo @asnkidney.bsky.social | #KidneyWk

American Society of Nephrology Kidney Week 2025
Original Article | Nov. 7, 2025 | NEJM.org
Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis

Fig. 1A. A Serious Cardiovascular Events

The NEJM identity sits at the bottom.

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Michelle Rheault, MD @rheaultm.bsky.social · 06/11/2025

Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself) Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 05/11/2025

Machine perfusion is better than just cold storage for kidneys 10 year follow up of the original 2009 trial in the @nejm.org www.nejm.org/doi/full/10.... #NephSky #KidneyWk

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Alexander Woywodt @pwoywodt.bsky.social · 01/11/2025

Interesting paper in @ckj-era.bsky.social - In my own practice I offer genetic testing to all my ADPKD patients now Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...

academic.oup.com

Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025

Abstract. ADPKD is the most common monogenic cause of kidney failure globally and a significant cause of morbidity and mortality. It is now recognized that

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NEJM.org @nejm.org · 18/10/2025

Among participants with advanced pheochromocytoma or paraganglioma, belzutifan showed durable antitumor activity and a reduced need for antihypertensives, although most participants had treatment-related adverse events. Full LITESPARK-015 phase 2 trial results: nej.md/475bfP9 #ESMO25

European Society for Medical Oncology
Original Article | October 18, 2025 | NEJM.org
Belzutifan for Advanced Pheochromocytoma or Paraganglioma

Figure 2C. Overall Survival.

The NEJM identity sits at the bottom.

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Dominique Guerrot @dguerrot.bsky.social · 06/08/2025

🫀 #Hypertension in autosomal dominant polycystic kidney disease: unique pathways, common consequences. In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease. Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵

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