Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...

Rapid learning, memory, and generalization are often attributed to circuits of the neocortex and hippocampus, but their specific role remains unclear. To examine these cognitive abilities together in ...

Mice spontaneously form leader and follower roles during cooperation, and the medial prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position.

Weber's law is a rare quantitative regularity in psychology, yet its origins remain debated. Here we provide causal evidence that it arises from the more fundamental principle of efficient coding. Thi...

Neurons in the brain are often many synapses away from motoneurons, yet if a movement results in error, each distant neuron needs a teacher that considers its specific contribution to production of th...

Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.

Humans handle numbers nimbly, suggesting a richer neural manifold structure than the prevalent mental number line model. In populations of medial temporal lobe (MTL) neurons in humans performing two s...

Food intake is governed by two interacting drives. The homeostatic hunger drive regulates food intake to fulfill caloric needs while the hedonic drive promotes intake of palatable foods outside of cal...

Zimnik et al. provide a new, interpretable, unsupervised dimensionality approach for neural population activity. Their approach, sparse component analysis (SCA), reveals the latent factors correspondi...

Artificial intelligence may soon enable researchers to generate high-quality science at a previously unimaginable speed.

Some units at the US funding giant are so understaffed, they are focusing on mandated grant renewals rather than new awards.

Zipple et al. show that transferring laboratory mice to naturalistic outdoor enclosures prevents and even reverses a canonical anxiety phenotype in rodents. The findings underscore the value of studyi...

The Computational Psychiatry Pre-Conference is a one-day workshop and symposium (approximately 10:00 AM–6:30 PM) designed to prepare early-career researchers for the main conference while fostering collaboration and skill-building.

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Nature Neuroscience - Jang et al. measured dopamine and acetylcholine release in the striatum of rats performing a decision-making task and found that the relative timing of cholinergic and...

Tracking the intellectual DNA of Computational and Systems Neuroscience through its flagship meeting

Simple math suggests that small groups of scientists can significantly bias peer review.

Mice learning a neurofeedback brain–computer interface task show neuron-specific teaching signals in cortical dendrites, consistent with a vectorized solution for credit assignment in the brain.