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Journal of Cell Science @jcellsci.bsky.social · 1h

New JCS snapshot - Outer kinetochore proteins form linear elements to regulate vesicle transport Shane Kowaleski presents the key findings from their JCS paper with Joshua Bembenek and team. journals.biologists.com/jcs/article/...

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Journal of Cell Science @jcellsci.bsky.social · 23h

Also in Issue 18: - Research Highlights on lamin assembly, organelle dynamics in plant cells, prions & mitochondria function and stress granules - The pyrenoid at a glance - Review on the mechanisms and mechanics of aging journals.biologists.com/jcs/issue/13...

Journal of Cell Science poster
The pyrenoid at a glance
Philippe Van der Stappen, Benjamin D. Engel, Manon Demulder

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Journal of Cell Science @jcellsci.bsky.social · 23h

Issue 18 is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image is an osteosarcoma cell visualised by structured illumination microscopy showing actin (magenta), paxillin (green) & myosin-X (cyan). See research by Popović et al. journals.biologists.com/jcs/article/...

JCS cover: An osteosarcoma cell visualised by structured illumination microscopy. The actin cytoskeleton is shown in magenta, paxillin in green and myosin-X in cyan. See article by A. Popović et al. (jcs265278).

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Journal of Cell Science @jcellsci.bsky.social · 06/10/2026

Ana Popović @anagracanin.bsky.social, Guillaume Jacquemet @guijacquemet.bsky.social and colleagues discover that CCT8 associates with the MYO10 motor domain and regulates #filopodia and breast cancer cell invasion. journals.biologists.com/jcs/article/...

Figure showing that CCT8 modulates filopodia formation independently of the TRiC.

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Journal of Cell Science @jcellsci.bsky.social · 05/10/2026

Read more about this research in our ‘First person’ interview with Elizabeth-Ann Legere. In this interview, Elizabeth-Ann shares that part of this research was supported by a @biologists.bsky.social Travelling Fellowship to visit @glgalea.bsky.social’s lab. journals.biologists.com/jcs/article/...

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Journal of Cell Science @jcellsci.bsky.social · 05/10/2026

Elizabeth-Ann Legere, Aimee Ryan @rimuhc.bsky.social and colleagues discover that increased tissue tension caused by depletion of CLDN3 in the non-neural ectoderm causes neural tube defects in chick embryos. journals.biologists.com/jcs/article/...

Figure showing that CLDN3 depletion decreases the rate of neural fold movement during fusion.

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Journal of Cell Science @jcellsci.bsky.social · 02/10/2026

Infectious prions strain mitochondrial function Daniel Shoup, Suzette Priola & team find that exposure of cells to prions induces changes in #mitochondrial redox state & respiration. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

Figure showing that mitochondria take on a more oxidizing environment after exposure to 22L PrPSc BH.

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Journal of Cell Science @jcellsci.bsky.social · 01/10/2026

This article is associated with a silver birch tree, planted in The Forest of Biologists. forest.biologists.com/landscape/

Tree no. 19249
Silver birch (Betula pendula)

Medium-sized deciduous tree, native to the British Isles. Known for its white bark, which sheds in strips. It has small, light-green, triangular leaves. Male and female catkins are found in the same tree (monoecy), with wind pollination and wind dispersal of seeds.

With fast early growth, birch is a useful pioneer species. Birch trees can also improve soil quality by recycling nutrients. Birch is frost resistant and windfirm but planted trees can be vulnerable to birch dieback (caused by fungal pathogens). Naturally regenerated birch – grown from seeds that have fallen from a tree – appear less prone to disease but climatic variables also play a part. Birch woods have a light canopy, encouraging the growth of other plants on the forest floor, and are valuable to wild life.

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Journal of Cell Science @jcellsci.bsky.social · 01/10/2026

A new lamin assembly assay using Xenopus egg extracts Ross Pedersen, Yixian Zheng and colleagues reconstitute lamin assembly on nuclear pore complex-containing membranes. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

Figure showing that lamin-B3 assembly occurs on annulate lamellae in the absence of nuclei.

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Journal of Cell Science @jcellsci.bsky.social · 30/09/2026

Jin-Mo Gu, Andreas Nebenführ and colleagues discover that accelerated organelle movements can indirectly affect the motility of other organelles in plant cells. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

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Journal of Cell Science @jcellsci.bsky.social · 29/09/2026

In their Review, Ishani Sharma and Partha Roy examine the cell-intrinsic, niche-specific and #immune controls that govern #cancer dormancy transitions, and the strategies aimed at blocking relapse. journals.biologists.com/jcs/article/...

Figure showing regulation of dormancy emergence of DTCs in the lung microenvironment. On arrival in the lung, DTCs lodge in the alveolar and perivascular niches. Dormancy is enforced by several converging cues. These include contact with AT1 lung epithelium (which promotes survival and restrains growth), anti-proliferative action of vascular endothelium-derived TSP-1, sequestration of tumor-derived ECM remodeling enzymes (e.g. LOXL2) by endothelial PEAR1, and activation of a NAS1-driven NR2F1-based dormancy transcriptional program by stromal cell-derived BMP. NR2F1 mediates suppression of ΔNp63, the pro-proliferative isoform of p63 (TP63). Reactivation (indicated by the proliferation marker Ki67) occurs when tumor cells interact with AT2 epithelium (which provides pro-proliferative signals). Additional reactivation cues include tumor-derived factors tenascin-C and Coco (which antagonizes BMP to release the dormancy brake via integrin-dependent FAK signaling; phosphorylated FAK is indicated as pFAK), sprouting angiogenesis (which supplies TGF-β1 and periostin), and activation of integrin-dependent ERK–MLCK signaling triggered by alterations in the ECM (e.g. fibrotic ECM and/or remodeling of laminin by NET-derived proteases like MMP9). Together, these opposing endothelial, epithelial, stromal and matrix inputs determine whether DTCs remain dormant or undergo metastatic outgrowth in the lung. Created in BioRender by Sharma, I., 2026. https://BioRender.com/j23rlwk. This figure was sublicensed under CC-BY 4.0 terms.

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Journal of Cell Science @jcellsci.bsky.social · 28/09/2026

Our second special issue for 2027 will focus on the topic of membrane dynamics and repair. We invite you to submit your latest research to this issue, which will be coordinated by our Guest Editors @jezcarlton.bsky.social and @pihanson.bsky.social. journals.biologists.com/jcs/pages/me...

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Journal of Cell Science @jcellsci.bsky.social · 28/09/2026

Read more about this research in our ‘First person’ interview with Stephanie Martinez @stephanieemartinez.bsky.social: journals.biologists.com/jcs/article/...

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Journal of Cell Science @jcellsci.bsky.social · 28/09/2026

Cutting corn-ers: @stephanieemartinez.bsky.social and @carolynplants.bsky.social discover that KATANIN p60 guides asymmetric division plane positioning in maize. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

Figure showing that PPBs are incompletely formed in p60 mutants.

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Journal of Cell Science @jcellsci.bsky.social · 25/09/2026

Read more about this research in our ‘First person’ interview with Rui-Jie Ma: journals.biologists.com/jcs/article/...

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Journal of Cell Science @jcellsci.bsky.social · 25/09/2026

Rui-Jie Ma, Shao-Chen Sun and colleagues discover that TRIM28 regulates the G2/M transition via histone modification and DNA damage repair during mouse oocyte meiosis. journals.biologists.com/jcs/article/...

Figure showing that TRIM28 regulate histone modifications in NSN-type mouse GV oocytes.

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Journal of Cell Science @jcellsci.bsky.social · 24/09/2026

Anne Ashford, Simon Cook @drsimoncook.bsky.social @babrahaminst.bsky.social and colleagues use phosphoproteomics to identify novel DYRK1B targets and establish DYRK1B as a regulator of processing body abundance. journals.biologists.com/jcs/article/... #OpenAccess #ReadandPublish

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Journal of Cell Science @jcellsci.bsky.social · 22/09/2026

Also in Issue 17: - Research Highlights on asymmetric cell division and clathrin-mediated endocytosis - Review on the cell biology of cancer dormancy - Plus, four ‘First person’ interviews journals.biologists.com/jcs/issue/13...

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Journal of Cell Science @jcellsci.bsky.social · 22/09/2026

Issue 17 is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows a pupal Drosophila abdomen 14 h after pupariation labelled with E-Cadherin (green) with nuclei of pannier-GAL4 expressing cells in magenta. See Lyon et al. journals.biologists.com/jcs/article/...

JCS Cover: Dorsolateral view of a pupal Drosophila abdomen at 14 h after pupariation. Apical junctions are marked with E-Cadherin–GFP (green) whereas the nuclei of cells expressing pannier-GAL4 are labelled with His2A–RFP (red). At this time point, the abdomen is predominantly composed of large polyploid larval epidermal cells (LECs), which are destined to undergo apoptosis as development progresses. The small diploid histoblasts that eventually form the adult epithelium are visible in small nests along the lateral (right-hand) side of the abdomen, having just begun to proliferate at this early developmental stage. See article by K. Lyon et al. (jcs264798).

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Journal of Cell Science @jcellsci.bsky.social · 18/09/2026

Did you know… JCS encourages the involvement of postdocs & other ECRs in the peer review process. Find out more in our reviewer guide: journals.biologists.com/jcs/pages/re... #PRW2026 #PeerReviewWeek We'd like to take this opportunity to thank all the researchers that have reviewed for us.

JCS Cover: Fluorescence micrograph of the female reproductive tract of Drosophila melanogaster. The image highlights the oviduct, spermathecae, seminal receptacle and associated reproductive organs involved in fertilisation and egg deposition, together with mature eggs poised for laying. Cell nuclei are shown in turquoise (DAPI), while enhanced fluorescence displayed in violet provides contrast for visualisation of additional structural features of the reproductive tract. See article by C. A. M. Costa et al. (jcs264328).

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Journal of Cell Science @jcellsci.bsky.social · 17/09/2026

We're now accepting submissions for our next special issue, which will focus on 'Proteostasis' and will be coordinated by two of our Academic Editors, Pedro Carvalho and Tamotsu Yoshimori. Submission deadline: 2 November Find out more: journals.biologists.com/jcs/pages/pr... #proteostasis

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Journal of Cell Science @jcellsci.bsky.social · 17/09/2026

Kyle Lyon, Samuel Manning and Richard Burke find that the Hippo signalling pathway regulates the timing of epithelial cell replacement during #Drosophila abdominal #morphogenesis. journals.biologists.com/jcs/article/...

Figure showing that downregulating Hippo pathway-dependent transcription in LECs promotes their premature removal from the epithelium.

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Journal of Cell Science @jcellsci.bsky.social · 16/09/2026

Did you know… Through our publisher @biologists.bsky.social, we fund the restoration & preservation of ancient woodlands. These trees are dedicated to our peer reviewers. The trees are also represented in our virtual forest: forest.biologists.com/landscape/ #PRW2026 #PeerReviewWeek

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Journal of Cell Science @jcellsci.bsky.social · 16/09/2026

Goutham Kodakandla, Ying Fan, Darren Boehning and colleagues discover that the protein acyltransferase DHHC21 S-acylates STIM1 in vitro and in vivo to regulate Ca2+ homeostasis and immune cell function. journals.biologists.com/jcs/article/... #OpenAccess #ReadandPublish

Figure showing that DHHC21 KO cells have impaired SOCE.

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Journal of Cell Science @jcellsci.bsky.social · 15/09/2026

Did you know… JCS is one of the affiliate journals of @reviewcommons.org, a platform for high-quality, journal-independent peer review of manuscripts from the life sciences before submission to a journal. #PRW2026 #PeerReviewWeek Our collection: journals.biologists.com/collection/1...

JCS cover: Deconvolved confocal images showing a lateral view of the tail of the nematode Caenorhabditis elegans, highlighting the localisation of epidermal AGEF-1 (an orthologue of BIG2; gold, cyan and orange puncta in the top, middle and bottom images, respectively) and RAB-35 (cyan, green and yellow blobs and striated patterns in the top, middle and bottom images, respectively). AGEF-1 interacts with RAB-35 in the nematode epidermis to modulate the integrity of touch-sensing nerves embedded within the skin. See article by I. Bonacossa-Pereira et al. (jcs264565), a Review Commons transfer.

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Journal of Cell Science @jcellsci.bsky.social · 15/09/2026

Read more about this research in our ‘First person’ interview with Aleksandra Tempes: journals.biologists.com/jcs/article/...

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Journal of Cell Science @jcellsci.bsky.social · 15/09/2026

Aleksandra Tempes, Agnieszka Brzozowska, Jacek Jaworski, Anna Malik and colleagues find that phosphorylation of adaptor protein AP2 coordinates clathrin-mediated endocytosis. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

Figure showing that lack of S45 phosphorylation of AP2 μ2 mimics the effects of p70S6K inhibition on transferrin internalization.

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Journal of Cell Science @jcellsci.bsky.social · 14/09/2026

Did you know… If you have a paper that's been reviewed elsewhere, we can consider your manuscript for a fast-track decision. Send us the paper, reviewer reports and decision letters, and we’ll use these to make a decision. #PRW2026 #PeerReviewWeek journals.biologists.com/jcs/pages/re...

JCS cover: Our cover image shows muscle fibre basement membranes and intramuscular nerves labelled for laminin (cyan), SV2 & neurofilament M (yellow) and nuclei (magenta).

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Journal of Cell Science @jcellsci.bsky.social · 14/09/2026

Read more about this research in our ‘First person’ interview with Sakshi Jain: journals.biologists.com/jcs/article/...

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Journal of Cell Science @jcellsci.bsky.social · 14/09/2026

Sakshi Jain, Upendra Nongthomba and colleagues find that Beadex modulates haematopoiesis and innate immune defence against microbial infection in Drosophila melanogaster. journals.biologists.com/jcs/article/...

Figure showing that Beadex regulates phagocytosis and actin cytoskeleton dynamics in larval haemocytes. Confocal images and quantitative analysis of haemocytes isolated from wandering third instar larvae.

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Journal of Cell Science @jcellsci.bsky.social · 11/09/2026

Apocalypse? Nah! Part II – two roads diverge Mole considers how AI can/will/has changed how we interact with scientific literature journals.biologists.com/jcs/article/...

Original artwork by Pete Jeffs. Sketch of ‘Mole’ wearing a pointed hat looking at a crystal ball. Mole is saying “I look, I look, I see, I see...” The teapot, which is also wearing a pointed hat and sitting on a table responds, “…me thinks, me thinks, Mole has had too much tea!”

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Journal of Cell Science @jcellsci.bsky.social · 10/09/2026

Our latest interview is with Stephen Tait @mitosrus.bsky.social, winner of the 2026 @bscb-official.bsky.social Hooke Medal. We caught up with Stephen to discuss this award, his research and his career path. journals.biologists.com/jcs/article/...

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Journal of Cell Science @jcellsci.bsky.social · 09/09/2026

This article is associated with a wild cherry tree, planted in The Forest of Biologists. forest.biologists.com/landscape/

Tree no. 17191
Wild cherry (Prunus avium)
Wild cherry
Medium-sized, fast-growing deciduous tree, native to the UK and Europe. It has a deep-reddish brown bark and cream-coloured lenticels. The oval, toothed leaves have pointed tips and two red glands on the stalk. A hermaphrodite species, it blossoms early in spring and produces white, cup-shaped flowers, pollinated by insects to develop deep-red cherries. The fruit is eaten by several birds and mammals that then disperse the seed in their droppings.

A pioneer light-demanding species, wild cherry quickly colonizes glades and clearings. However, it is often outcompeted by other hardwoods later, and is thus extensively used for afforestation of agricultural land. The trees favour full sunlight and moist to well-drained fertile soil, including slightly acidic or calcareous conditions. Wild cherry is susceptible to bacterial cankers, and pruning wounds can allow fungal infection leading to silver leaf disease.

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Journal of Cell Science @jcellsci.bsky.social · 09/09/2026

Susanne Steigleder, Julian Nüchel @jnuechel.bsky.social, Marius Lemberg @marius-lemberg.bsky.social and colleagues identify a Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65. journals.biologists.com/jcs/article/...

Proposed mechanism of TMED9- and GRASP65-induced unconventional proTGFα secretion.

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Journal of Cell Science @jcellsci.bsky.social · 08/09/2026

Read more about this research in our ‘First person’ interview with Leanna Leverton: journals.biologists.com/jcs/article/...

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Journal of Cell Science @jcellsci.bsky.social · 08/09/2026

In these two studies, Leanna Leverton, Dharma Pally, Alexandra Naba nabalabuic.bsky.social & team dissect the role of SNED1 in ECM construction and remodelling. Highlight: journals.biologists.com/jcs/article/... 1: journals.biologists.com/jcs/article/... 2: journals.biologists.com/jcs/article/...

Figure showing that SNED1 colocalises with fibronectin and collagen I during ECM assembly.

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Journal of Cell Science @jcellsci.bsky.social · 07/09/2026

This article is associated with a sessile oak tree, planted in The Forest of Biologists. forest.biologists.com/landscape/

Tree no. 17179
Sessile oak (Quercus petraea)
Sessile oak
Tall deciduous broadleaf tree, native to much of Europe and commonly found in hilly areas. Its leaves are dark green and shallow lobed, with a long stalk. Male flowers are green catkins and female flowers resemble red buds, found in the same tree (monoecy). After pollination by wind, female flowers develop into acorns.

Sessile oak is windfirm, cold hardy and tolerant to drought, and grows well on soils with low nutrients. It can suffer from acute oak decline, resulting in rapid dieback. Oak trees support more wildlife than any other tree – various birds and animals eat the acorns; caterpillars eat the flowers and leaves; and mosses, lichens and liverworts grow on the bark. Fallen leaves form a rich leaf mould in autumn, supporting the forest floor ecosystem.

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Journal of Cell Science @jcellsci.bsky.social · 07/09/2026

In this Review, James Conway @jrwconway.bsky.social discusses how integrin function is dynamically shaped by post-translational modifications. journals.biologists.com/jcs/article/...

Schematic of several PTMs investigated for their roles in regulating integrin functions. PTMs occurring on integrin β-subunits, including some of their known regulators and adaptors are shown. Integrins span the plasma membrane, with large extracellular domains that bind extracellular matrix (ECM) ligands, and short cytoplasmic tails that serve as platforms for intracellular signalling and mediate binding to the cell cytoskeleton. Glycosylation adds sugars to the extracellular domains via glycosyltransferases and glycosidases. Phosphorylation of conserved tyrosine (Y) or serine (S) and threonine (T) residues in the cytoplasmic tails can regulate the binding of different adaptor proteins and supports the dynamic roles of integrins during cell migration. Some of the known kinases and phosphatases that add or remove these modifications, respectively, are shown. Further PTMs can be made to other cytoplasmic residues, including ubiquitylation (i) or acetylation (ii) of lysine residues (K).

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Journal of Cell Science @jcellsci.bsky.social · 07/09/2026

Also in Issue 16: - Research Highlights on vesicle trafficking and the ECM - Apocalypse? Nah! Part II – two roads diverge from Mole - Interview with 2026 Hooke Medal winner Stephen Tait @mitosrus.bsky.social - Review on PTMs of integrins journals.biologists.com/jcs/issue/13...

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Journal of Cell Science @jcellsci.bsky.social · 07/09/2026

Issue 16 is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows muscle fibre basement membranes and intramuscular nerves. The image was acquired by @beccasimkin.bsky.social and was the winner of the @focalplane.bsky.social -ELMI2026 image competition.

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Journal of Cell Science @jcellsci.bsky.social · 04/09/2026

Mario Pinar, Miguel Peñalva @miguelpenalva.bsky.social and team find that a subcomplex comprising TRAPPC11, TRAPPC12, TRAPPC13 and the fungal TRAPPC2L homolog, Tca17, targets Aspergillus TRAPPIII to autophagy. journals.biologists.com/jcs/article/... #OpenAccess #ReadandPublish

Figure showing that the localisation of Trs85 to PASs is impaired in cells lacking Trs33 or the Tca17 and TRAPPC11/12/13 subcomplex.

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Journal of Cell Science @jcellsci.bsky.social · 03/09/2026

Sibylle Schleich and Aurelio Teleman @telemanlab.bsky.social identify that stress- and mitosis-induced phosphorylation of NIFK at Ser247 by p38–MSK1 and Aurora B, respectively, primes mitotic hyperphosphorylation and promotes timely mitotic entry. journals.biologists.com/jcs/article/...

NIFK is phosphorylated on Ser247 by Aurora B during mitosis.

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Journal of Cell Science @jcellsci.bsky.social · 02/09/2026

Daniel Rioux, Samreen Manj and Derek Prosser find that Avl9 links recycling and secretion during vesicle trafficking. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

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Journal of Cell Science @jcellsci.bsky.social · 01/09/2026

Vitaly Zimyanin, Magdalena Magaj, Stefanie Redemann and team discover that KLP-19 regulates microtubule overlap and dynamics during anaphase in C. elegans. journals.biologists.com/jcs/article/...

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Journal of Cell Science @jcellsci.bsky.social · 28/08/2026

Apocalypse? Nah! Part I – future tense Mole considers how AI can/will/has changed how we interact with scientific literature journals.biologists.com/jcs/article/...

Cartoon of an anthropomorphised mole sticking its head out of ‘Mole lab’ to talk to two headphone-wearing molelets. Mole says, “Ah-Gen-M!!! Listening to paper on their AI players…. They reply, “No way, Mole!” “…We’re mini-prepping to Kanda Bongo Man”
Original artwork by Pete Jeffs

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Journal of Cell Science @jcellsci.bsky.social · 27/08/2026

We invite you to submit your latest research to our upcoming special issue: Proteostasis. This issue will be coordinated by two of our Academic Editors: Pedro Carvalho and Tamotsu Yoshimori. journals.biologists.com/jcs/pages/pr...

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Journal of Cell Science @jcellsci.bsky.social · 27/08/2026

Read more about this research in our ‘First person’ interview with Iker Benavides-Puy: journals.biologists.com/jcs/article/...

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Journal of Cell Science @jcellsci.bsky.social · 27/08/2026

Iker Benavides-Puy, Jakob Nilsson and colleagues discover that regulation of the PP2A-B55 by the FAM122A depends on a bipartite binding mechanism and is regulated by phosphorylation of FAM122A. journals.biologists.com/jcs/article/...

Figure showing that FAM122A Ser158 is required for PP2A-B55 inhibition and efficient mitotic entry.

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Journal of Cell Science @jcellsci.bsky.social · 26/08/2026

Md Mydul Islam, Vignesharavind Subramanianbalachandar and Robert Steward, Jr interrogate endothelial cell biomechanical adaptation to altered connexin 43 expression under fluid shear stress. #OpenAccess #ReadandPublish journals.biologists.com/jcs/article/...

Figure showing impact of chalcone on tractions and intercellular stress.

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Journal of Cell Science @jcellsci.bsky.social · 25/08/2026

This article is associated with a field maple tree, planted in The Forest of Biologists. forest.biologists.com/landscape/

Tree no. 17135
Field maple (Acer campestre)

Sturdy broad-leaved deciduous tree, with a wide ecological range and natural distribution over most of Europe. Field maple has a light brown and flaky bark, with brown slender twigs that develop corky ridges with age. Its small, dark-green leaves have five lobes with rounded teeth, and fade to a rich golden-yellow or red before falling in autumn. A hermaphroditic species – its small, yellow-green, clustered flowers are pollinated by insects and develop into large, winged crimson fruits (samaras) that are dispersed by wind.

Field maple has a compact habit and grows in woods, scrub and hedgerows. While extremely tolerant to shade during the first decade, its light requirements are higher in seed-bearing years. It prefers warmer climates, but can also tolerate hard winters. Highly resistant to air pollution, the trees are widely planted in gardens and parks.

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