iiinova — where your digital self keeps evolving

Joel Boerckel @jboerckel.bsky.social · 08/10/2026

Excited for #ASBMR2026! Super proud of these amazing scientists from my group: Posters from @gkotsaris90.bsky.social, @cpane94.bsky.social & Tianbai Wang, plus talks from George and Chris (including meet-the-professor). Optogenetics, development, immunobiology @asbmr.bsky.social

032

Reposted by Joel Boerckel

Maitreyi Das @daslabpombe.com · 16/09/2026

The Das lab has 1-2 open postdoctoral positions. Our lab investigates the fundamentals of cell-cycle-dependent cell polarity. Boston College has fantastic resources, including a cutting-edge imaging facility with state-of-the-art microscopes. Please apply here: bc.csod.com/ux/ats/caree...

0813

Joel Boerckel @jboerckel.bsky.social · 13/09/2026

It’s not very day you get to read a beautiful paper. Amazing work @hammofish.bsky.social www.biorxiv.org/content/10.6...

010

Joel Boerckel @jboerckel.bsky.social · 13/09/2026

Would love to hear what you think, Hao!

011

Reposted by Joel Boerckel

Maitreyi Das @daslabpombe.com · 10/09/2026

NIGMS MIRA is officially here! This was one of the longest waits ever, but I'll take it. Also, we have openings for a couple of postdoc positions in cell biology/biochemistry. Details to follow soon.

static.klipy.com

Cookie Monster Dancing

ALT: Cookie Monster Dancing

10599

Reposted by Joel Boerckel

Patrick Oakes @pwoakes.bsky.social · 18/08/2026

@myosincity.bsky.social and I are looking to hire a new postdoc this winter! Open to anyone broadly interested in studying how cells generate and interpret mechanical signals. Interested applicants can reach out to me and Jordan directly.

01313

Joel Boerckel @jboerckel.bsky.social · 10/09/2026

Together, these findings introduce a platform technology for controlling protein signaling activation and termination, generalizable to membrane-acting GTPases, and reveal a mechanistic asymmetry between signaling activation and termination that enables cytoskeletal homeostasis.

010

Joel Boerckel @jboerckel.bsky.social · 10/09/2026

Mechanistically, RhoA signaling termination triggered rapid actin disassembly through Slingshot-mediated cofilin disinhibition.

141

Joel Boerckel @jboerckel.bsky.social · 10/09/2026

We observe asymmetric YAP nuclear influx vs. efflux rates despite inverted activation vs. termination dynamics.

141

Joel Boerckel @jboerckel.bsky.social · 10/09/2026

We show that direct RhoA termination is an order of magnitude faster than passive disactivation, despite comparable signaling amplitude, while RhoA activation features similar kinetics, but greater amplitude than RhoA distermination.

121

Joel Boerckel @jboerckel.bsky.social · 10/09/2026

Here, we engineered a toolbox for bidirectional optogenetic control of RhoA activation and termination on the single-component BcLOV4 platform.

121

Joel Boerckel @jboerckel.bsky.social · 10/09/2026

RhoA inactivation kinetics have been inferred indirectly, by tracking passive recovery after cessation of an activating stimulus. Some favorites on this, from @pwoakes.bsky.social, @squishycell.bsky.social; @olivierpertz.bsky.social: www.nature.com/articles/nco... elifesciences.org/articles/90305

131

Joel Boerckel @jboerckel.bsky.social · 10/09/2026

Optogenetics has taught us a great deal about the biology and dynamics of RhoA activation, but signaling inactivation kinetics have been tricky to study because the field has lacked direct means to control signaling termination.

121

Joel Boerckel @jboerckel.bsky.social · 10/09/2026

Our latest preprint, from Erin Berlew is live: Cytoskeletal disassembly by optogenetic control of RhoA signaling termination. www.biorxiv.org/content/10.6...

2144

Reposted by Joel Boerckel

bmeunite.bsky.social @bmeunite.bsky.social · 24/08/2026

We are excited to announce our 2026 cohort of BME UNITE Future Faculty Fellows! The BME UNITE seminar series is designed to showcase future faculty candidates from diverse and underrepresented backgrounds in BME. Register here: tinyurl.com/bmeunite2026

Names, photos, and institutions of 2026 BME UNITE Future Faculty Fellows. Text seminar details with link to presentation schedule.

154

Joel Boerckel @jboerckel.bsky.social · 13/08/2026

Is the new KT1 restricted to US citizens like K22 or still open like K99?

000

Joel Boerckel @jboerckel.bsky.social · 27/07/2026

“Amdahl’s law: the speedup achievable by optimizing one component of a system is limited by the fraction of total time that component represents.”

041

Reposted by Joel Boerckel

Stephan Huveneers @huveneerslab.bsky.social · 24/06/2026

We are hiring! Are you an ambitious postdoc with a background in vascular bioengineering and cell biology? Then please join our team at Amsterdam UMC and help unravel the mechanisms that govern vascular integrity. #embobuildnetworks #vascularbiology #EVBO werkenbij.amsterdamumc.org/en/vacatures...

werkenbij.amsterdamumc.org

Vacatures - Postdoc Vascular Biology - Amsterdam UMC

Are you an ambitious scientist with a background in vascular bioengineering and cell biology? Join our team at Amsterdam UMC and help unravel the mechanisms that govern vascular integrity.

058

Joel Boerckel @jboerckel.bsky.social · 28/05/2026

Your budget quantifies your values.

040

Joel Boerckel @jboerckel.bsky.social · 28/05/2026

Whenever I give department seminars, I try to make time to visit the uni library. The library is the heart of the university. The books and our monuments to them will outlast both us and the internet - if we preserve them. I haven’t visited MIT, but this feels like a death.

Suzzallo and Allen Libraries, University of Washington

Harvey Cushing/John Hay Whitney Medical Library, Yale University

Beinecke Rare Book and Manuscript Library, Yale University

3328

Joel Boerckel @jboerckel.bsky.social · 27/05/2026

This is amazing. Huge congrats friend!!

120

Reposted by Joel Boerckel

Katherine Aird @airdlab.bsky.social · 27/05/2026

It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum.bsky.social demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats Apoorva Uboveja! www.nature.com/articles/s41...

nature.com

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - Nature

The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...

34817

Reposted by Joel Boerckel

Carl T. Bergstrom @carlbergstrom.com · 25/05/2026

He warned us we'd have to remind you. "Particularly in times of international conflict, when the dominant definition of the situation is such as to emphasize national loyalties, the man of science is subjected to conflicting imperatives of scientific universalism and ethnocentric particularism."

325241

Joel Boerckel @jboerckel.bsky.social · 23/05/2026

“then it’s nothing for you to do but enjoy the few minutes you got left the best way you can-by killing somebody or burning down his house or doing some other meanness to him. No pleasure but meanness.” -Flannery www.nytimes.com/2026/05/22/u...

nytimes.com

Green Card Seekers Must Leave U.S. to Apply, Trump Administration Says

191

Joel Boerckel @jboerckel.bsky.social · 21/05/2026

Same boat. ✊🏼 You got this, friend!

120

Reposted by Joel Boerckel

Jenna Norton @jenna-m-norton.bsky.social · 02/05/2026

This was fitting news to receive on May 1, international workers day. I will be returning to work on Monday after being kept on retaliatory administrative leave for 5 months and 3 weeks. I return along with the brave Katrina Declaration signers from FEMA, also reinstated this week. 🧵1/?

301424377

Joel Boerckel @jboerckel.bsky.social · 21/04/2026

just got knocked over by this new paper from the Andrei Chagin lab: www.science.org/doi/epdf/10.... physically dropped the paper in delighted surprise when I got to the second half of Fig 5:

062

Reposted by Joel Boerckel

Wayne Orr @a-wayne-orr.bsky.social · 15/04/2026

We’re hiring! Tenure-track faculty position in cancer research at LSU Health Shreveport (Pathology & Translational Pathobiology). Looking for investigators building programs at the interface of cancer, metabolism, inflammation, and vascular biology. www.lsuhsc.edu/shv/CareerOp...

lsuhsc.edu

LSUHSC Career Opportunities - Assistant/Associate/Full Professor (Tenure-Track) – Cancer Research

022

Joel Boerckel @jboerckel.bsky.social · 15/04/2026

I have wanted someone to do exactly this ever since I first read Murray! Tried to work some on the vascular problem a dozen years ago, but it was beyond me. Truly wonderful, Denis. From a morphogenesis perspective, which network leads and which follows?

000

Reposted by Joel Boerckel

Denis Wirtz @deniswirtz.bsky.social · 14/04/2026

Whole organism 3D mapping reveals universal branching topology and biophysical optimization governs vascular and nervous system development Read about our work here: www.biorxiv.org/content/10.6...

1438

Joel Boerckel @jboerckel.bsky.social · 14/04/2026

Glad you’re ok Mathis!! Hope you heal up soon!

010

Reposted by Joel Boerckel

Joachim Goedhart @joachimgoedhart.bsky.social · 13/04/2026

📣 New preprint alert! Co-authored by @spalaciosm.bsky.social and @andreacaldarola.bsky.social : Quantitative imaging of calcium dynamics with a green fluorescent biosensor and fluorescence lifetime imaging www.biorxiv.org/content/10.6...

Image of a calcium calibration curve, calcium concentration traces of individual cells and lifetime images of cells

14317

Joel Boerckel @jboerckel.bsky.social · 13/04/2026

Thanks Joel! We should grab a coffee some time soon!

110

Reposted by Joel Boerckel

ASBMR @asbmr.bsky.social · 02/04/2026

JBMR® Plus is accepting applications for editor‑in‑chief. Current EIC Deborah Veis, MD, PhD, calls the role one of the most impactful of her career. This paid position's term begins October 2026. Apply by April 3. www.surveymonkey.com/r/8FM2GFJ?ut... Learn More: www.asbmr.org/publications...

012

Joel Boerckel @jboerckel.bsky.social · 29/03/2026

Amazing opportunity to work with Kim, who is the most creative scientist and an amazing mentor

031

Joel Boerckel @jboerckel.bsky.social · 25/03/2026

Impossible to overstate how timely the @orssociety.bsky.social meeting feels, again, this year. Cannot wait to see dear friends and hear exciting science. Keep an eye out for these amazing scientists at #ORS2026 this week: @cpane94.bsky.social @gkotsaris90.bsky.social @eseidlscience.bsky.social

0164

Reposted by Joel Boerckel

Orthopaedic Research Society @orssociety.bsky.social · 19/12/2025

Introducing the #ORS2026 Spotlight Speakers! We are excited to welcome thesee internationally recognized experts, March 27–31, in Charlotte, NC, sharing insights across mechanobiology, regeneration, data-driven #orthopaedics, and more. 🔎 Learn more: www.ors.org/2026spotlightspeakers

032

Reposted by Joel Boerckel

ORS ISFR @isfrfractures.bsky.social · 25/03/2026

Congratulations to ISFR members @gkotsaris90.bsky.social and @amitsc.bsky.social for their nominations for the New Investigator Recognition Award! Be sure to add their talks to your schedule at #ORS2026 and catch their exciting work in bone fracture repair! 🦴🩻🔬

053

Reposted by Joel Boerckel

Orthopaedic Research Society @orssociety.bsky.social · 16/01/2026

🎉 Congrats to our finalists for the ORS Business Innovation Competition at #ORS2026! BIC serves as a springboard for #msk innovation, supporting early-stage ideas as they move from the lab to the marketplace. Learn more about each finalist 👉 www.ors.org/2026bic .

061

Joel Boerckel @jboerckel.bsky.social · 24/03/2026

Oh Becky, I’m so sorry for your loss.

020

Joel Boerckel @jboerckel.bsky.social · 24/03/2026

Beautiful paper! Congrats Christa!

110

Joel Boerckel @jboerckel.bsky.social · 11/03/2026

No, thank you! We should zoom some time - I’d love to show you some cool data

120