While monogenic disorders of immunity typically involve rare alleles, some arise from alleles common in specific populations. Examples include IFNAR1/2 null alleles in the Arctic/Pacific and PTCRA hyp...

Type III interferons are essential immune mediators playing pleiotropic roles during health and disease. In this review, we highlight the molecular and cellular pathways that lead to the production of...

Romans living in ancient Britain were plagued by intestinal parasites, all of which are spread by fecal contamination

Time: 8:00 - 11:30 AM Chairs: Chrysothemis C. Brown, Memorial Sloan Kettering Cancer Ctr., USA Petter Brodin, Imperial Col. London and Karolinska Inst., GBR, SWE

Background The ABO blood group system is associated with differential susceptibility to thrombotic vascular diseases. ABO is also known to be a strong trans-protein quantitative trait locus for plas...

Chen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.

Loss-of-function MDA5 variants increase the risk of chronic inflammation but protect against autoimmune disease. Singh et al. show that autoimmune-protective variants impair MDA5 signaling via differe...

A large-scale ten-year study conducted by the Institut Pasteur on a thousand individuals has shed new light on steroid hormones. Levels of these molecules, which play a crucial role in our health, var...

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Mammary intraepithelial lymphocytes enhance mammary gland differentiation during pregnancy, thereby promoting offspring fitness.

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