Reposted by Trinity Biomedical Sciences Institute
📢Congratulations to CLuB investigator Dr Sharon O'Toole for her award: www.clubcancer.ie/news-events/... #CLuBCancer #STEM igcs.org/2025-dicey-s...
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Club Cancer Research
CLuB’s ambition and focus are on identifying and developing minimally-invasive, cost effective, blood tests to complement or, where possible, replace surgical biopsies for cancer diagnosis and optimal treatment selection. CLuB also uses excised tumours as “avatars” to better understand the specific origin of important components of the liquid biopsy and to test the optimal drug treatment regime for a given patient.
![Bicyclo[1.1.1]pentane is a rigid aliphatic hydrocarbon with a three-dimensional (3D), propeller-like shape and a molecular size which makes it a targeted bioisosteric replacement for phenylene and acetylene groups in medicinal chemistry. For the pharmaceutical application of BCP, simple, efficient, and cost-effective synthetic tools are required to enable the exploration of BCP’s potential as a bioisostere across a broad chemical space. The synthesis of BCP mono- and diketones remains a challenging task, limited by both substrate scope and expensive photocatalysts. Here we present a protocol for Friedel-Crafts acylation of (hetero)aromatic hydrocarbons with BCP acyl chlorides; in particular, the first method to access diaromatic BCP 1,3-diketones. Reaction optimization, substrate scope, and reactivity of the products are discussed. 35 mono- and diketones are reported accompanied by 7 examples of post-synthetic modifications. The synthesis of a BCP analogue of fenofibrate is reported.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:ls54voiihm3bxde2dkgrxbm3/bafkreigzyfnz4ckoa7ifg3rjuuzk7tt3vdih5xlizy6ledhqn5ua3urgie)
