Background and ObjectivesNeighborhood disadvantage is a recognized risk factor for Alzheimer disease and Alzheimer disease–related dementias (AD/ADRD) and is linked to AD/ADRD pathology at autopsy. Ho...

AbstractObjectives. Early-life rural-urban residence has been linked to differences in later-life cognitive functioning and dementia risk. However, the con

The locus coeruleus (LC) is a small noradrenergic nucleus in the dorsal pons that sends projections across the brain regulating sleep, arousal, attention, stress responses, and some forms of cognition...

INTRODUCTION An earlier age of menopause (AOM) is hypothesized to increase vulnerability to the neuropathological processes of dementia, which begin in midlife. METHODS We tested this hypothesis i.....

Bell et al. report that multisite chronic pain in older adults is linked to faster cognitive decline and increased Alzheimer’s disease pathology, particula

The amyloid cascade hypothesis predicts that amyloid-beta (Aβ) aggregation drives tau tangle accumulation. We tested competing causal and non-causal h…

Traumatic brain injury (TBI) is associated with increased risk of dementia, but it is unclear how earlier life TBI is related to brain health in older…

Although strong evidence exists for blood–brain barrier (BBB) disruption in Alzheimer’s disease (AD), substantial uncertainty remains regarding its ro…

Former National Institutes of Health Director Dr. Francis Collins, who abruptly left his NIH research lab in February, fears aggressive downsizing could impact Americans’ health.

The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

Objective Some individuals demonstrate greater cognitive resilience—the ability to maintain cognitive performance despite adverse brain-related changes—through as yet unknown mechanisms. We examined.....

The Trump Administration claims it is allowing "lifesaving" foreign aid to continue, but in reality, DOGE is preventing vital work on HIV and AIDS from saving lives.

Background Bipolar Disorder (BD) is a complex disease. It is heterogeneous, both at the phenotypic and genetic level, although the extent and impact of this heterogeneity is not fully understood. One ...

Aides to Elon Musk charged with running the U.S. government human resources agency have locked career civil servants out of computer systems that contain the personal data of millions of federal employees, according to two agency officials.

The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.

Many traditional methods for analyzing gene-gene relationships focus on positive and negative correlations, both of which are a kind of ‘symmetric’ relationship. Biclustering is one such technique tha...