Apolipoprotein E (APOE) is the strongest genetic influence in Alzheimer’s disease (AD). Compared to the most frequent allele, ε3, the ε4 allele increases AD risk, and the ε2 allele is protective. Here...

The symptom profiles of different neurodegenerative diseases often overlap, and diagnosing age-related cognitive symptoms is complex. A patient may have multiple overlapping disease processes in the brain at the same time.

Molecular Psychiatry - Neuroanatomy reflects individual variability in impulsivity in youth

We introduced a simplified variant of FROG, the winning algorithm of the TADPOLE challenge, for predicting dementia progression using multimodal longitudinal data. Combining the longitudinal-to-cross...

Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathologi...

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative...

A pervasive dilemma in brain-wide association studies (BWAS) is whether to prioritize functional MRI (fMRI) scan time or sample size. We derive a theoretical model showing that individual-level phenot...

There is a growing imperative to understand the neurophysiological impact of our rapidly changing and diverse technological, social, chemical, and physical environments. To untangle the multidimension...

“Naturalistic imaging” paradigms, where participants watch movies during fMRI, have gained popularity over the past two decades. Many movie-watching studies measure inter-subject correlation (ISC), wh...