Background and ObjectivesNeighborhood disadvantage is a recognized risk factor for Alzheimer disease and Alzheimer disease–related dementias (AD/ADRD) and is linked to AD/ADRD pathology at autopsy. Ho...

AbstractObjectives. Early-life rural-urban residence has been linked to differences in later-life cognitive functioning and dementia risk. However, the con

Neighborhood disadvantage in later life is associated with poorer cognition and increased vulnerability to dementia. Cognitive reserve (CR), an indivi…

Bell et al. report that multisite chronic pain in older adults is linked to faster cognitive decline and increased Alzheimer’s disease pathology, particula

The amyloid cascade hypothesis predicts that amyloid-beta (Aβ) aggregation drives tau tangle accumulation. We tested competing causal and non-causal h…

Traumatic brain injury (TBI) is associated with increased risk of dementia, but it is unclear how earlier life TBI is related to brain health in older…

Objective Some individuals demonstrate greater cognitive resilience—the ability to maintain cognitive performance despite adverse brain-related changes—through as yet unknown mechanisms. We examined.....

AbstractObjectives. Childhood disadvantage is associated with lower general cognitive ability (GCA) and brain structural differences in midlife and older a