Background and ObjectivesNeighborhood disadvantage is a recognized risk factor for Alzheimer disease and Alzheimer disease–related dementias (AD/ADRD) and is linked to AD/ADRD pathology at autopsy. Ho...

AbstractObjectives. Early-life rural-urban residence has been linked to differences in later-life cognitive functioning and dementia risk. However, the con

Neighborhood disadvantage in later life is associated with poorer cognition and increased vulnerability to dementia. Cognitive reserve (CR), an indivi…

Lifespan Health Neuroscience Laboratory

INTRODUCTION An earlier age of menopause (AOM) is hypothesized to increase vulnerability to the neuropathological processes of dementia, which begin in midlife. METHODS We tested this hypothesis i.....

In a large cross-national study, education was linked to better memory and larger brain volumes but not to slower cognitive or brain decline with age, suggesting that the association reflects early-li...

We characterized motion during diffusion MRI scans across 16,995 image sessions and find that (1) modern preprocessing pipelines effectively mitigate motion to the point where biases are not detectab....

A cohort study of over 15,000 US adults found that the lifetime risk of developing dementia from ages 55 to 95 is 42%, with the highest risk in APOE ε4 carriers, women and Black adults, and projected ...