iiinova — where your digital self keeps evolving

Reposted by Bel Esain

Karl Deisseroth @deisseroth.bsky.social · 05/10/2026

Thank you to everyone sharing in this moment! I’m so grateful to all my trainees & collaborators… dlab.stanford.edu/group-members (pic: Peter and I together in 2017) Reading for all those asking: for technical details: dlab.stanford.edu for everyone: deisseroth.org/projections

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Bel Esain @isabelesain.bsky.social · 22/09/2026

Fun being part of this work and seeing the story come out 🐍 Congrats to the whole team!

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Reposted by Bel Esain

Conner Langeberg @clangeberg.bsky.social · 05/09/2026

RNA structure prediction lags behind proteins for lack of data. RNASSTR, our new dataset, offers millions of RNA sequence-secondary structure pairs, split structurally to avoid train/test leakage. 📄 doi.org/10.1261/rna.... 📰 innovativegenomics.org/news/ai-mode...

doi.org

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Bel Esain @isabelesain.bsky.social · 23/07/2026

So excited to see our latest work out!

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Reposted by Bel Esain

Amanda Heidt @scattercushion.bsky.social · 17/07/2026

🧪 Double pub day! I got to catch up with Nobel Prize-winner Jennifer Doudna about her new study crafting synthetic CRISPR proteins that perform gene editing more efficiently than their naturally-occurring counterparts! www.nature.com/articles/d41...

nature.com

CRISPR gets a power boost from AI-designed ‘molecular scissors’

Researchers used artificial intelligence to design functional CRISPR enzymes not seen in nature.

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Bel Esain @isabelesain.bsky.social · 17/07/2026

So excited to see our paper out in Science! Beyond grateful to my co-leads @petrskopintsev.bsky.social @evandeturk.bsky.social, all co-authors & collaborators, everyone in Doudna lab, and @innovativegenomics.bsky.social Being EsAIn in the DouDNA lab, it couldn't have been any other way ✨

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Reposted by Bel Esain

Evan DeTurk @evandeturk.bsky.social · 16/07/2026

It's out! Check out the D-LabSky thread below 👇 Pleasure working with and learning from @petrskopintsev.bsky.social @isabelesain.bsky.social and the whole team on this oen

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Reposted by Bel Esain

Petr Skopintsev @petrskopintsev.bsky.social · 17/07/2026

Proud to present our work, published today in @science.org! My deepest gratitude to @isabelesain.bsky.social, @evandeturk.bsky.social, Jennifer and our collaborators in the Doudna, Cate, Banfield, and Jacobsen labs, and the @innovativegenomics.bsky.social! I hope you enjoy reading it! ✨

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Reposted by Bel Esain

Doudna Lab @doudna-lab.bsky.social · 12/05/2026

New pre-print 📣 “Undruggable” cancer mutations remain very hard to target with current modalities. What if we could instead sense mutant transcripts and convert that recognition into selective cell killing? Check out this work led by postdoc Jingkun Zeng: www.biorxiv.org/content/10.6...

biorxiv.org

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Bel Esain @isabelesain.bsky.social · 30/04/2026

Synthetic microbiomics 🙌 Genome-scale editing with bridge recombinases - Congrats to @jayman1466.bsky.social @sophswartz.bsky.social, Agnes & team!

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Bel Esain @isabelesain.bsky.social · 28/04/2026

An RNA-guided system that recognizes a noncontiguous DNA code? 🤯 Check out the latest work from the Doudna Lab on the discovery of VIPR. Really exciting biology!

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Reposted by Bel Esain

Zehan Zhou @zehanzhou.bsky.social · 15/01/2026

How do the ancestors of CRISPR-Cas unwind DNA and how can this lead to better genome editing? With our collaboration between @doudna-lab.bsky.social x @jacobsenucla.bsky.social x Zev Bryant's lab x @savagecatsonly.bsky.social we've uncovered the secrets behind TnpB's dynamics!

biorxiv.org

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Reposted by Bel Esain

Doudna Lab @doudna-lab.bsky.social · 10/01/2026

New preprint 👉Doudna x Bryant x Jacobsen x Savage collaboration! Work led by @zehanzhou.bsky.social, I. Saffarian-Deemyad, @honglue.bsky.social, T. Weiss We dissect how stepwise DNA unwinding gates TnpB genome editing, revealing how unwound DNA states enhance cleavage www.biorxiv.org/content/10.6...

biorxiv.org

Stepwise DNA unwinding gates TnpB genome-editing activity

TnpB is a compact RNA-guided endonuclease and evolutionary ancestor of CRISPR-Cas12 that offers a promising platform for genome engineering. However, the genome-editing activity of TnpBs remains limit...

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Reposted by Bel Esain

Petr Skopintsev @petrskopintsev.bsky.social · 09/12/2025

Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫

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Reposted by Bel Esain

Evan DeTurk @evandeturk.bsky.social · 09/12/2025

Excited to share our work designing genome editors with machine learning! 🧬💻 Huge thanks to @petrskopintsev.bsky.social @isabelesain.bsky.social @doudna-lab.bsky.social and all co-authors. Check out the thread for a summary of what we found 👇

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Bel Esain @isabelesain.bsky.social · 09/12/2025

First co-led work from the Doudna lab 🤜🤛 We designed minimal RNA-guided nucleases with AI, and even did Cryo-EM during an earthquake (!) Huge honor working with @petrskopintsev.bsky.social, @evandeturk.bsky.social, Jennifer Doudna and co-authors, everyone at D-Lab and @innovativegenomics.bsky.social

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Bel Esain @isabelesain.bsky.social · 06/12/2025

Very looking forward to having you in the lab! 💪🏼🧬✨

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Bel Esain @isabelesain.bsky.social · 26/11/2025

Incredible work by @owentuck.bsky.social, Jason Hu et al 👏🏼 Antiviral systems repeatedly acquire nuclease–protease pairs to fight viruses ⚔️

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Bel Esain @isabelesain.bsky.social · 26/11/2025

Super cool work by @erinedoherty.bsky.social and @jnoms.bsky.social ! 💪🏼 Viruses hack bacterial immunity by breaking down the nucleotide signals that trigger defence 🦠🧬

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Bel Esain @isabelesain.bsky.social · 03/12/2024

So honored to receive the Best Thesis Prize❤️ @cambridgeuni.bsky.social @cruk-ci.bsky.social still feels surreal. Thank you to CRUK, my supervisors for believing in my ideas, and my former lab members, friends and family for always supporting me. So grateful to be part of such an inspiring community!

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Reposted by Bel Esain

Amanda Alker @atp-alker.bsky.social · 30/11/2024

🚨 The Alker Lab is starting at the University of Rhode Island in early 2025 and we will be hiring! 🚨 If you are interested in marine microbiology, bacterial genetics and/or symbiosis, please consider reaching out! Repost to help spread the word 🪸🧪🧬🌊

The Alker lab at the University of Rhode Island is hiring (students, postdocs and lab staff)! We use cutting edge tools in microbiology to investigate marine animal symbioses. Email or DM for further inquiries

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