iiinova — where your digital self keeps evolving

Reposted by Institut Imagine

LabPrudent @prudentlab.bsky.social · 08/10/2026

Delighted to share our lab’s latest paper, published in @science.org , uncovering a new role for Golgi-derived vesicles and phosphoinositides regulating mitochondrial fusion! 👇 www.science.org/doi/10.1126/...

science.org

Golgi-derived vesicles containing PI(3,4)P2 drive mitochondrial fusion

Mitochondria are dynamic organelles that remodel their shape to regulate cell fate. Mitochondrial division involves interactions with the endoplasmic reticulum (ER), lysosomes, and trans-Golgi network...

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Institut Imagine @institutimagine.bsky.social · 05/10/2026

Our international PPU-IMAGINE PhD call is open! 15 funded projects in rare genetic diseases 3-year contract For Master's graduates from outside France Apply by 16 Nov 2026: www.institutimagine.org/en/internati... #PhD #PhDposition #RareDiseases #Genetics #AcademicSky

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Manvendra Singh @manusingh.bsky.social · 28/09/2026

1/8 Proud and super thrilled to share our preprint, “A single-nucleus regulatory atlas links transposons to adult hippocampal neurogenesis.”, led by Umut, Fede, and Souad, the FIRST from our #RETROGEN lab @inem-necker.bsky.social . www.biorxiv.org/content/10.6... shrt thread on what we found 🧵

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Alexandre Benmerah @alexbnmrh.bsky.social · 23/09/2026

Amandine Viau, Joran Martin and I had a very nice meeting @club-cfc.bsky.social in Aussoy where we could present our recent works @institutimagine.bsky.social in the @theracilproject.bsky.social ! Congrats to Joran who won the best talk price! #cilia #ciliopathies #nephronophthisis #kidney

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Institut Imagine @institutimagine.bsky.social · 22/09/2026

🔴 Happening now at Institut Imagine: Prof. @danmucida.bsky.social (Rockefeller University, HHMI) on how immune cells and the gut lining talk to each other, and how the brain senses what's happening in the gut, from infection to inflammation. #Immunology #Neuroimmunology

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Cancer Grand Challenges @cancergrand.bsky.social · 21/09/2026

One bold idea can change everything. Paul Bastard is leading team ATLAS to explore whether autoantibodies also influence cancer risk. Read Paul’s full interview at bit.ly/4A4Og4B 📹 Includes footage from @institutimagine.bsky.social

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Institut Imagine @institutimagine.bsky.social · 14/09/2026

🔴 Happening now at our Monday Seminar: Prof. Xavier Roca (NTU Singapore) on "Diagnostics of mutations affecting splicing in genetic disease." Exploring two decades of splicing biology, from mechanisms to variant interpretation & rare disease therapeutics. 🧬 #InstitutImagine #Genetics

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LabPrudent @prudentlab.bsky.social · 11/09/2026

Come and join us in building an exciting new mitochondrial cell biology lab in Paris! 🚀 📅 Start: Nov–Dec 2026 ⏳ Deadline: 2 Oct 2026 #Mitochondria #Postdoc #CellBiology #mtDNA #Microscopy #Paris

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LabPrudent @prudentlab.bsky.social · 11/09/2026

🔬 Laboratory Manager We’re looking for a scientist with a strong molecular/cell biology background to help run and develop the lab while contributing experimentally to our research. 👉 Apply: www.welcometothejungle.com/fr/companies...

welcometothejungle.com

Lab Manager - Institut Imagine - CDD / Temporaire à Paris

Institut Imagine recrute un(e) Lab Manager à Paris !

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Reposted by Institut Imagine

LabPrudent @prudentlab.bsky.social · 11/09/2026

🧬 Two postdoc projects: 1️⃣ Inner mitochondrial membrane quality control & mtDNA dynamics 2️⃣ Golgi-derived vesicles, membrane contact sites & mitochondrial dynamics 📅 Start: Nov–Dec 2026 ⏳ Deadline: 2 Oct 2026

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LabPrudent @prudentlab.bsky.social · 11/09/2026

Our lab studies how mitochondrial membrane dynamics, mtDNA biology and inter-organelle contact sites regulate mitochondrial function and cellular homeostasis. We combine cell & molecular biology with cutting-edge live-cell and high-resolution microscopy. 🔬

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LabPrudent @prudentlab.bsky.social · 11/09/2026

🚀 We’re hiring! Join our newly established lab at the @institutimagine.bsky.social in Paris 🇫🇷 We’re recruiting: 🧬 2 Postdoctoral Researchers in Mitochondrial Cell Biology 🔬 1 Laboratory Manager Thread below 👇

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ISDN @isdnsociety.bsky.social · 25/08/2026

The #ISDN2027 symposium on molecular drivers of stability versus #plasticity of neural cell fate and their implication for #brain repair will be completed by @sarabiz86.bsky.social from @institutimagine.bsky.social and Samir Vaid from @tudresden.bsky.social.

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Casanova Lab @casanovalab.bsky.social · 24/08/2026

1/ We are excited to report in @PNASNews that autoantibodies neutralizing type I interferons underlie 35% of cases of Chikungunya virus (CHIKV) encephalitis or myelitis from a multiple cohort study. www.pnas.org/doi/10.1073/...

pnas.org

Autoantibodies neutralizing type I interferons underlie a third of cases of Chikungunya virus encephalitis or myelitis | PNAS

Chikungunya virus (CHIKV) infection is typically not life threatening but may, in rare cases, affect the central nervous system (CNS). In three coh...

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Institut Imagine @institutimagine.bsky.social · 11/08/2026

🔬 Severe pediatric IBD with no genetic cause? Research by Institut Imagine & Uppsala University shows ~2% of cases have autoantibodies neutralizing IL-10, the gut's inflammation brake. Standard tests miss them, but finding them guides targeted care. 🔗 doi.org/10.1136/gutj... #IBD

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Philippe Bastin's Lab @bastinlab.bsky.social · 24/07/2026

There is more than cilia beating in the establishment of left-right symmetry! Proud to have contributed to this beautiful study by Amaia Ochandorena Saa @meilhacsigolene.bsky.social where Thierry Blisnick imaged mouse node by SEM doi/10.1126/sciadv.adx6486 @pasteur.fr @institutimagine.bsky.social

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European Research Council (ERC) @erc.europa.eu · 06/08/2026

"The ERC funding that I was awarded was instrumental for my team to be selected by the scientific board of Institut Imagine." More about Edor Kabashi's research @institutimagine.bsky.social 👉 buff.ly/AXKfPvA More about EU support for researchers who would like to #ChooseEurope 👉 buff.ly/Y62mN2e

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Journal of Human Immunity @jhumimmunity.org · 05/08/2026

#FOXP3 deep intronic variant underlying #IPEX. New report from Pierre Gaufryau, Marie-Claude Stolzenberg, Jérémie Rosain @jrosain.bsky.social et al. @hopitalnecker.bsky.social @institutimagine.bsky.social: rupress.org/jhi/article/... #Atopy #Diagnostics #Autoimmunity #InbornErrorsOfImmunity

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Institut Imagine @institutimagine.bsky.social · 04/08/2026

🩸 Violent immune reactions (HLH) often hide blood cancer. Biopsies are risky, but a new 2-step blood test (cytokine ratio & score) from Hermine's team at Institut Imagine quickly identifies underlying lymphomas—meaning fewer invasive procedures and faster treatment. 🔗 doi.org/10.1002/ajh....

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Institut Imagine @institutimagine.bsky.social · 24/07/2026

🔬 How do ADPKD cysts form? A JCI study by @hkd-l.bsky.social at Institut Imagine & Frank Bienaimé's group @inem-necker.bsky.social shows: without polycystin-1, the tubule sleeve gets softer, not stiffer. This loosening lets the tube expand. A new therapeutic target! 👏 📄 jci.org/articles/vie...

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Cancer Grand Challenges @cancergrand.bsky.social · 23/07/2026

Why do some ‘super avoiders’ never develop cancer? Team ATLAS has launched its global effort to find out, supported by the Breast Cancer Research Foundation, the Susan Wojcicki Foundation, the Torrey Coast Foundation and @cancerresearchuk.org. ➡️ www.cancergrandchallenges.org/news/backing...

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LabPrudent @prudentlab.bsky.social · 20/07/2026

After 10 fantastic years at the @mrc-mbu.bsky.social, @cam.ac.uk, it is time for our lab to move to France!! I am delighted to announce that we will begin a new adventure at the @institutimagine.bsky.social in Paris in September 2026!!

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Institut Imagine @institutimagine.bsky.social · 20/07/2026

🧠 What if Alzheimer's isn't just about neurons? A new Nature Neuroscience study from Michela Deleidi's team at Imagine shows stressed mitochondria cause microglia (brain immune cells) to age prematurely, disrupting neural connections. 📄 lnkd.in/gCg5qdRb

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Journal of Experimental Medicine @jem.org · 16/07/2026

ADAR1 loss-of-function variants altering RNA editing define a new #interferon-dependent #psoriasis subtype. New study from Florence Assan, Hervé Bachelez @institutimagine.bsky.social and colleagues: rupress.org/jem/article/... #HumanDiseaseGenetics

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Institut Imagine @institutimagine.bsky.social · 09/07/2026

Closing out today's MAGIC session: Caroline Parada (Institut Pasteur) presents "Building digits: mechanochemical control of phalanx-joint development." How do our fingers actually form? A beautiful look at the precise balance of mechanics and chemistry. 🖐️🧪 #Morphogenesis #DevelopmentalBiology

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Institut Imagine @institutimagine.bsky.social · 09/07/2026

Next up: Karine Guevorkian (Institut Curie) explores spreading dynamics & mechanical domains in the presomitic mesoderm of chicken embryos. Incredible insights into the physical forces driving early development! 🐣🔬

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Institut Imagine @institutimagine.bsky.social · 09/07/2026

Kicking off today's MAGIC meeting on "Development & Mechanics"! 🧬 First up: Audrey Desgrange (Institut Imagine) on the "Biomechanics of heart development." We're exploring how physical forces actively shape our most vital organ. ❤️🔬 🧵👇 #DevBio #Biomechanics #HeartResearch

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Institut Imagine @institutimagine.bsky.social · 06/07/2026

📢 Happening Now: Weekly Monday Seminar! We are thrilled to welcome Prof. Aleixo Muise (University of Toronto & @sickkids.bsky.social sky.social) to Institut Imagine today. He is currently presenting: "Novel insights into Monogenic Intestinal Disease." #Genetics #Immunology #Research

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Institut Imagine @institutimagine.bsky.social · 02/07/2026

🏅 Notre directrice générale, la Pr Bana Jabri, figure dans le palmarès 2026 du TIME France Health, parmi « Les 20 personnalités françaises qui font la santé » !

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Dr Ino Agrafioti @inoagrafioti.bsky.social · 01/07/2026

Congratulations to LS1 grantees @hecklab.bsky.social and Annarita Miccio at @institutimagine.bsky.social , for being awarded ERC POC grants! :)

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Institut Imagine @institutimagine.bsky.social · 22/06/2026

Roundtable 1 is live, moderated by Pr. Marina Cavazzana. Pr. David Liu, Dr. Winston Yan, Dr. Anne Galy & Dr. Giuseppe Ronzitti discuss bringing genome editing from the bench to first-in-human trials. 🚀

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Institut Imagine @institutimagine.bsky.social · 22/06/2026

We're live from the Future of Genetic Medicine Symposium today at Institut Imagine! 🧬 We are incredibly delighted to partner with @genethonfr.bsky.social & the Broad Institute's Center of Genetic Surgery for this event.

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Institut Imagine @institutimagine.bsky.social · 18/06/2026

🏥 To close out, Isabelle Melki (Hôpital Armand-Trousseau / Institut Imagine) highlights Type I interferons, exploring their critical role as both biomarkers and key drivers in juvenile neuropsychiatric lupus. 🧠💡 #Lupus #TranslationalMedicine

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Institut Imagine @institutimagine.bsky.social · 18/06/2026

🧬 Now speaking: @jamiesugrue.bsky.social (@pasteur.fr) explores how Ikaros negatively regulates TLR-induced type I interferon responses. Fascinating insights into its pleiotropic associations in infection & autoimmunity! 🛡️ #Immunology #Infection

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Institut Imagine @institutimagine.bsky.social · 18/06/2026

🎙️ Next up, we welcome Mathieu Rodero (Faculté des Saints-Pères, @upcite.bsky.social). He is breaking down dysregulated dsRNA sensor signaling and viral infection during the onset of juvenile dermatomyositis. 🦠🔬 #Dermatomyositis #Autoimmunity

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Institut Imagine @institutimagine.bsky.social · 18/06/2026

🔬 Kicking off our weekly MAGIC meeting! Our own Alice Lepelley is on stage sharing novel insights into type I IFN neuroinflammation driven by PTPN1 mutations in humans. 🧠🧬 #Neuroinflammation #Genetics #Interferon

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Institut Imagine @institutimagine.bsky.social · 08/06/2026

🧬 Happening now: Prof. Yenan Bryceson (Karolinska Institutet) is presenting today's Monday Seminar at Imagine. He's discussing the "Regulation of flexibility in T cell signaling," exploring the biology of cytotoxic T cells to better understand primary immunodeficiencies & develop cancer therapies.

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Cancer Grand Challenges @cancergrand.bsky.social · 05/06/2026

Studying cancer avoidance isn’t straightforward. It means finding individuals who don’t develop cancer, and analysing them at scale. That level of research needs global collaboration, and Cancer Grand Challenges makes it possible. Read about this work ➡️ www.technologynetworks.com/cancer-resea...

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Institut Imagine @institutimagine.bsky.social · 04/06/2026

Juliette Leon (INEM) closes the seminar with anti-HLA desensitization strategies in organ transplantation. These approaches are essential to lower the risk of rejection and improve graft survival. 🫀🏥 #Transplant #Immunology

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Institut Imagine @institutimagine.bsky.social · 04/06/2026

Lucienne Chatenoud (INEM) presents the use of non-mitogenic anti-CD3 antibodies in type 1 diabetes. The goal? Modulating the immune response to protect the pancreas and slow disease progression. 🩸 #Diabetes #Immunotherapy

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Institut Imagine @institutimagine.bsky.social · 04/06/2026

Brigitte Bader-Meunier (Hôpital Necker) discusses anti-interferon therapeutic antibodies in pediatric dermatomyositis. A crucial step forward to better treat this rare autoimmune disease in children! 🧒💊 #RareDiseases #Immunology

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Institut Imagine @institutimagine.bsky.social · 04/06/2026

Sandrine Moutel (@institutcurie.bsky.social) opens the session on the role of antibodies in oncology. These targeted therapies have become essential for specifically identifying and attacking tumor cells to better fight cancer. 🔬 #Oncology

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Institut Imagine @institutimagine.bsky.social · 04/06/2026

Live from Institut Imagine for the MAGIC seminar! 🧬 Today, we're exploring major advances in therapeutic antibodies and immunology with 4 experts. Follow this thread for key takeaways from the presentations. ⬇️

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Journal of Human Immunity @jhumimmunity.org · 03/06/2026

STAT2 R148 variant: A 16th-century founder mutation and clinical response to high-dose JAK inhibitor therapy. New study from Nima Parvaneh (Tehran University of Medical Sciences), Jacinta Bustamante @institutimagine.bsky.social and colleagues: rupress.org/jhi/article/... #Autoinflammation #IEIs

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Institut Imagine @institutimagine.bsky.social · 01/06/2026

Wrapping up Monday with some fantastic science! 👏 Earlier today, we had the pleasure of hosting Dr. Enzo Poirier (Institut Curie) for our #MondaySeminar. Huge thanks to him for sharing his work on engineering immunotherapies by harnessing the conservation of immunity. 🧬

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Institut Imagine @institutimagine.bsky.social · 29/05/2026

🧠 What makes the human brain uniquely... human? That's the question at the heart of a study just published in @nature.com by Denis Jabaudon, Esther Klingler, and their teams. 📄 Javed, Gómez et al., Nature (2026) — DOI: lnkd.in/eF_mH72U

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Institut Imagine @institutimagine.bsky.social · 28/05/2026

Wrapping up today's presentations, Nicolas Garcelon is unveiling our own infrastructure: a dedicated collaborative platform for federated learning right here at Institut Imagine. This will empower our teams to leverage massive datasets safely and accelerate discoveries! 🚀🌐

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