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Benoit Danilo 🦠

@individualpttrn.bsky.social
214 followers 433 following 122 posts

Molecular biology, directed evolution, recombinant proteins, genome editing and some ghoulish tinkering. Formerly @INRAE_PACA and @Michiganstateu . Now @LRSV_Toulouse

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Reposted by Benoit Danilo 🦠
bioRxiv Plant Bio @biorxiv-plants.bsky.social · 01/10/2026
NO VEIN is an ancestral immunity protein involved in plant-virus interaction www.biorxiv.org/content/10.64898/20…
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Reposted by Benoit Danilo 🦠
Nature Biotechnology @natbiotech.nature.com · 28/09/2026
Lipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing - @pharmacy.utoronto.ca www.nature.com/articles/s41...
nature.com
Lipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing - Nature Biotechnology
Lipid nanoparticles are improved by including RNA cargo size in the design process.
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 28/09/2026
I'm reviewing a paper, the data looks ok but the paper itself seems to be AI written ? I run some tests (on Pangram for example) and it says 100% AI written. I know it is not a perfect tool, but at my first reading it was obvious that it was AI written...In your opinion, what should i do ?
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Reposted by Benoit Danilo 🦠
Carl Zimmer @carlzimmer.com · 27/09/2026
Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc
nyti.ms
Did Anthropic’s A.I. Really Make a Scientific Discovery on Its Own? (Gift Article)
An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.
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Reposted by Benoit Danilo 🦠
Andrew Urquhart @starships-andrew.bsky.social · 24/09/2026
Another step in the #Starship story - they move via a circular intermediate. Helps explain how these elements horizontally transfer and means that we can modify them into transformation vectors (starmids). www.biorxiv.org/content/10.6...
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Reposted by Benoit Danilo 🦠
Jase Gehring @skyjase.bsky.social · 23/09/2026
little bit thirsty to release this on its own. with theminimal wet lab resources at Anthropic, would be hilarious if they get scooped by any of the extremely good nucleic acid biochemistry labs around the world
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Reposted by Benoit Danilo 🦠
Sebastian Samwald (Basti) he/him @samwalds.bsky.social · 23/09/2026
This has originally developed out of a thought along the lines of: "What can you do if you only manage to get weak fluorescence signals?" A short explaining thread 🧵
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Reposted by Benoit Danilo 🦠
Yuan He @yuanhejhu.bsky.social · 22/09/2026
A big week for the lab! Two new papers on how cells repair DNA double-strand breaks: one on getting NHEJ started in chromatin, one on processing the ends before ligation. Years of work by a fantastic team.
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Reposted by Benoit Danilo 🦠
Iva Vukušić @vukusiciva.bsky.social · 21/09/2026
This ridiculous number of applications is, in my view, the result of 2 nightmare developments happening concurrently 1.the precariousness of the job market for young PhD graduates which then fuels further: 2.the AI tools enabling overproduction of proposals. #Research #ERC #ResearchFunding #Academia
Just a screenshot with an EU logo saying that the 2026 call has attracted considerable interest from the research community with 21,627 applications submitted.
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Reposted by Benoit Danilo 🦠
Plant & Cell Physiology @plantcellphysiol.bsky.social · 21/09/2026
🔥Hot off the press: doi.org/10.1093/pcp/... @dekatarousanbs.bsky.social & colleagues @tohoku-life-news-e.bsky.social have developed a #CRISPR/Cas9 system based on ribozyme-gRNA-ribozyme (RGR) technology for loss of function analysis in #ferns (& other plant species) #PlantScience #PlantEvoDevo
doi.org
Generation of KARRIKIN INSENSITIVE2 loss-of-function mutants in Ceratopteris richardii using a CRISPR/Cas9 system based on ribozyme-gRNA-ribozyme (RGR) technology
Ayano Wu, Seto Yoshiya, Junko Kyozuka, Yuki Hata; Generation of KARRIKIN INSENSITIVE2 loss-of-function mutants in Ceratopteris richardii using a CRISPR/Cas
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Reposted by Benoit Danilo 🦠
Plant Physiology @plantphys.bsky.social · 20/09/2026
The ZmBBM2-BBIP1-RCC1-4 module enhances callus growth and genetic transformation efficiency in maize (Qinghui Fu , Qianhan Wei , Chunlai Qi , Anqi Zhao , Xiaojie Yuan , Yuan Yuan , Yunjun Liu) doi.org/10.1093/plph... #PlantScience @aspbofficial
doi.org
The ZmBBM2-BBIP1-RCC1-4 module enhances callus growth and genetic transformation efficiency in maize
Dear Editor,
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 17/09/2026
The Next Gene-Editing Technology May Also Be the Oldest www.nytimes.com/2026/09/17/s...
nytimes.com
The Next Gene-Editing Technology May Also Be the Oldest
Scientists have discovered a powerful gene-targeting system in viruses. Billions of years old, VIPR seems to predate CRISPR and may be even more powerful.
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Reposted by Benoit Danilo 🦠
Greg Vert @plantubiquitin.bsky.social · 14/09/2026
Latest paper from my lab !! New insight into transporter endocytosis in plants using TurboID. Proud of liza-pellegrin.bsky.social for the great work and @julnev.bsky.social for driving this. doi.org/10.1111/nph.... @lrsv-toulouse.bsky.social @cnrsbiologie.bsky.social
doi.org
<fc>TurboID</fc>‐based proteomic profiling reveals proxitome of the <fc>IRT1</fc> metal transporter and new insight into <fc>IRT1</fc> endocytosis
Identification of new regulators of Arabidopsis IRT1 endocytosis and metal transport using TurboID. TurboID proximity labeling of the Arabidopsis IRT1 root metal transporter identified new IRT1-inter....
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 11/09/2026
Turnip Mosaic Virus-Based gRNA Delivery System for Plant Genome Editing onlinelibrary.wiley.com/share/NPIS2N...
onlinelibrary.wiley.com
Turnip Mosaic Virus‐Based gRNA Delivery System for Plant Genome Editing
Reader environment loaded
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 10/09/2026
I just noticed that we, at the cloning platform, generated more than one thousand individual vectors for plant genome editing in two years.
static.klipy.com
Judges Score 1000 with Number Signs
ALT: Judges Score 1000 with Number Signs
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Reposted by Benoit Danilo 🦠
New Phytologist @newphyt.bsky.social · 09/09/2026
ePE-P3-SpRY expands PAM compatibility for prime editing in rice Chen et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
The ePE-P3-SpRY system enables protospacer adjacent motif-flexible prime editing in rice.
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 07/09/2026
youtu.be/jPWemdn_Ejs?...
youtu.be
Hello Future Us
YouTube video by Peter Gall - Topic
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 07/09/2026
Successful cloning over the weekend
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Reposted by Benoit Danilo 🦠
PlantEvolution 🌱🌾 @plantevolution.bsky.social · 07/09/2026
Please submit comments to the EU Commission’s Call for Evidence on how to implement the new rules for "Plants obtained by new genomic techniques (#NGT)". Submission deadline 28 Sept. Below what I submitted. #plantscience ec.europa.eu/info/law/bet... ec.europa.eu/info/law/bet...
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 06/09/2026
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Reposted by Benoit Danilo 🦠
Alexandra Delbot @alexandradelbot.bsky.social · 02/09/2026
Au cœur des forêts, les arbres ne sont jamais seuls. Ils discutent. Avec leurs congénères, avec eux-mêmes et avec tout un tas d'organismes invisibles. C’est l’un de ces partenariats discrets qui nous intéresse aujourd’hui. Comment les arbres et les champignons communiquent-ils ?
radiofrance.fr
Arbres et champignons : un dialogue fertile
Sous terre, arbres et champignons échangent sucres contre nutriments via les mycorhizes. Dans l'air, l'arbre émet des molécules volatiles surtout pour lui-même, parfois perçues par ses voisins proches...
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Reposted by Benoit Danilo 🦠
Nature Plants @natplants.nature.com · 02/09/2026
New Comment: "Evolution and implementation of EU regulation on new genomic techniques" rdcu.be/FNqnZw7iVk8a Regulation (EU) 2026/1388 on plants obtained by certain new genomic techniques and their products was finally adopted by the European Union on 17 June 2026.
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 31/08/2026
Ligne B qui a réouvert depuis 1 jour. Et déjà la première panne.
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Reposted by Benoit Danilo 🦠
Carl Zimmer @carlzimmer.com · 27/08/2026
The lab is a mysterious place--where some people have "magic hands," and some experiments just won't work. Here's my story about the unspoken knowledge of science, and the struggle to share it. Gift link: nyti.ms/3UccF7Z
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 27/08/2026
A root pathogen drives rhizosphere enrichment of antagonistic Pseudomonas and induces production of an antimicrobial metabolite www.biorxiv.org/content/10.6...
biorxiv.org
A root pathogen drives rhizosphere enrichment of antagonistic Pseudomonas and induces production of an antimicrobial metabolite
In plants, the development of soil-borne diseases has been shown to trigger the recruitment of beneficial microbes, which contribute to defense against pathogens. However, the underlying mechanisms dr...
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Reposted by Benoit Danilo 🦠
Reese Richardson @reeserichardson.bsky.social · 25/08/2026
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 24/08/2026
Adaptive model-guided protein evolution with sparse data optimizes compact eukaryotic genome editors www.nature.com/articles/s41...
nature.com
Adaptive model-guided protein evolution with sparse data optimizes compact eukaryotic genome editors - Nature Biotechnology
Computational protein evolution with sparse data generates efficient small RNA-guided nucleases.
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 22/08/2026
Fume hoods can use as much energy as 3.5 homes per year when left running 24/7 so…
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 20/08/2026
Twenty-two easy ways to power up your lab meetings www.nature.com/articles/d41...
nature.com
Twenty-two easy ways to power up your lab meetings
Scientists share help and advice on how they got their research discussions flowing.
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Reposted by Benoit Danilo 🦠
Nature Biotechnology @natbiotech.nature.com · 19/08/2026
High-throughput synthesis of DNA fragments by molecular self-assembly of overlapping oligonucleotides - @tsinghuauniversity.bsky.social www.nature.com/articles/s41...
nature.com
High-throughput synthesis of DNA fragments by molecular self-assembly of overlapping oligonucleotides - Nature Biotechnology
DNA libraries are synthesized at scale.
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Reposted by Benoit Danilo 🦠
PM Delaux @pierremarcdelaux.bsky.social · 18/08/2026
[⚠️JOB ALERT⚠️] We are looking for a Research assistant (IE for those familiar with the French system) in molecular biology to run DAPseq in the lab. 18 months contract (to start) Start date: October 1st. Exprience in library prep., in vitro transcription/translation system or DAPseq is a must.
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Reposted by Benoit Danilo 🦠
New Phytologist @newphyt.bsky.social · 18/08/2026
The combination of morphogenic regulators BABY BOOM and GRF‐GIF improves maize transformation efficiency and promotes leaf regeneration 📖 nph.onlinelibrary.wiley.com/doi/10.1111/... by Chen et al. @WileyPlantSci #PlantScience
Maize regeneration via somatic embryogenesis by ectopic expression of morphogenic factors TaGRF4-TaGIF1 and ZmBBM.
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Reposted by Benoit Danilo 🦠
Katharina Melkonian @katharinamel1.bsky.social · 17/08/2026
Please check out our latest preprint from the team @lrsv-toulouse.bsky.social with @pierremarcdelaux.bsky.social and many more! Happy to have contributed to this really cool story!
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Reposted by Benoit Danilo 🦠
Nature Biotechnology @natbiotech.nature.com · 12/08/2026
Mechanistic machine learning for prediction of prime editing outcomes - @broadinstitute.org @hhmi-science.bsky.social www.nature.com/articles/s41...
nature.com
Mechanistic machine learning for prediction of prime editing outcomes - Nature Biotechnology
OptiPrime incorporates prime-editing biochemistry to predict prime-editing outcomes.
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Reposted by Benoit Danilo 🦠
bioRxivpreprint @biorxivpreprint.bsky.social · 11/08/2026
SAM-Targeted CRISPR-Cas9 RNP Delivery Combined with Leaf Regeneration Enables DNA-Free, Non-Chimeric Genome Editing in 'Fuji' Apple www.biorxiv.org/content/10.64898/20…
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Reposted by Benoit Danilo 🦠
Michael Hothorn @structplantbio.bsky.social · 05/08/2026
Out in @natplants.nature.com, mapping of brassinosteroid chemical features required for (1) receptor binding, (2) ligand positioning and (3) co-receptor recruitment. Fantastic work by Alberto Caregnato & @hmchen93.bsky.social and our friends in Olomouc. Funding:@snf-fns.ch -> doi.org/10.1038/s414...
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Reposted by Benoit Danilo 🦠
Nature @nature.com · 05/08/2026
Nature research paper: Miniaturizing and modifying natural proteins with Raygun go.nature.com/4w2usM2
go.nature.com
Miniaturizing and modifying natural proteins with Raygun - Nature
Probabilistic sequence encoding from language model embeddings within a generative AI framework enables protein miniaturization, modification and augmentation while maintaining native architecture and functional integrity.
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 04/08/2026
Grande découverte dans la bibliothèque familiale
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Reposted by Benoit Danilo 🦠
marialukarska.bsky.social @marialukarska.bsky.social · 30/07/2026
Our ProteinGuide paper is finally out! Thanks to all the co-authors @junhaobearxiong.bsky.social, @ishangaur.bsky.social, @hnisonoff.bsky.social, @loltrogge.bsky.social, @jlistgarten.bsky.social, @savagecatsonly.bsky.social! @innovativegenomics.bsky.social www.nature.com/articles/s41...
nature.com
Property guidance for protein sequence generative models with ProteinGuide - Nature Biotechnology
On-the-fly conditioning of pretrained protein generative models guides protein generation toward specific properties.
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Reposted by Benoit Danilo 🦠
Plant Physiology @plantphys.bsky.social · 31/07/2026
14-3-3 λ suppresses ethylene-mediated root growth inhibition through EIN3/EIL1 in Aratbidopsis (Zhi-Xin Xiang , Yong-Lun Lv , Ying-Rui Li , Yi-Feng Zhou , Yan-Ke Lu , Meng Xu , Feng Ding) doi.org/10.1093/plph... #PlantScience @aspbofficial
doi.org
14-3-3 λ suppresses ethylene-mediated root growth inhibition through EIN3/EIL1 in Aratbidopsis
Binding of a plant protein to key transcription factors dampens the ethylene signal, preventing roots from halting their growth.
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Reposted by Benoit Danilo 🦠
Nature Biotechnology @natbiotech.nature.com · 31/07/2026
The new laws break away from 20-year-old restrictive GMO directives to give an official nod to plants made with new genomic techniques www.nature.com/articles/s41...
nature.com
EU relaxes rules for gene-edited crops - Nature Biotechnology
The new laws break away from 20-year-old restrictive GMO directives to give an official nod to plants made with new genomic techniques.
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Reposted by Benoit Danilo 🦠
Darius Kosmützky @dariuskos.bsky.social · 31/07/2026
Ever had issues with contamination in #Marchantia or #liverwort tissue culture? We've developed a protocol that is simple and low-effort (albeit slow) to get rid of fungi and bacteria: dx.doi.org/10.17504/pro.... Work led by Isaac Coven and supported by Chetan Pandey, myself & @dromius.bsky.social.
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 30/07/2026
The forbidden candy
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Reposted by Benoit Danilo 🦠
Physghoul 👻 🎃 @physgal.bsky.social · 28/07/2026
Fascinating paper on the progression of women in academia. 👩🏻‍🔬 ⚛️ 🧪 #AcademicSky docs.iza.org/dp18477.pdf?... Here's an excerpt from the conclusion:
When women do obtain tenure, the effects extend well beyond their own careers. Beyond the direct promotion of the qualifying candidate, departments experience on average one additional female promotion over the subsequent fifteen years, a substantial expansion of the female PhD pipeline, and improved retention and career progression among female doctoral graduates. These effects are concentrated in departments where women are underrepresented, but not entirely absent, suggesting that a minimal female presence is a precondition for trickle-down effects to materialize, whether through mutual support, departmental influence, or other channels that require women not to be entirely isolated.
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Reposted by Benoit Danilo 🦠
New Phytologist @newphyt.bsky.social · 28/07/2026
Precise manipulation of large genomic fragments through TJ-PE in rice Liu et al. nph.onlinelibrary.wiley.com/share/SEXRUQ...
Proposed models of template-jumping prime editing-mediated homologous and nonhomologous replacements in rice.
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 28/07/2026
youtube.com/watch?v=QkF_...
youtube.com
IDLES - DANNY NEDELKO (Official Video)
YouTube video by IDLES
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 27/07/2026
The whale and the pebbles.
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Reposted by Benoit Danilo 🦠
GeminiTeamLab @geminiteamlab.bsky.social · 25/07/2026
How does a geminivirus replicate its genome using a pick&mix strategy with host proteins? 🦠🦠🌱🧬 Our new preprint identifies plant proteins repurposed by geminiviruses to carry out rolling-circle replication. Congrats @chaonan123.bsky.social , who spearheaded this work! www.biorxiv.org/content/10.6...
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Benoit Danilo 🦠 @individualpttrn.bsky.social · 25/07/2026
Smokes from the Girondes Fire. And I’m at least 250km from them…Terrifying.
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Ian Henderson @hendersi.bsky.social · 25/07/2026
CRISPR-mediated centromere fission generates neochromosomes with distorted meiotic inheritance in Arabidopsis biorxiv.org/content/10.6... new preprint from us - includes changing the Arabidopsis karyotype from 5 -> 6 chromosomes using Cas9 & outcomes of 5/6 chromosome hybrid meiosis
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