In psoriasis and other inflammatory skin diseases, chronic itching or pruritus is a particularly distressing symptom for patients which remains difficult to treat today. Scientists at the Institut Pas...

Nature Reviews Immunology, Published online: 18 March 2026; doi:10.1038/s41577-026-01284-4Past failures of T cell-based vaccines for chronic viral infection may reflect suboptimal induction of quality T cell responses. Here, the authors highlight the need to integrate diverse functional attributes of T cell efficacy with the temporal and contextual demands of different viral infections. They provide mechanistic insights into the induction of CD8⁺ T cell quality to inform rational vaccine design for emerging viruses and chronic diseases such as HIV-1.

Molly Ingersoll has been head of a research team at the Institut Pasteur in Paris since 2012. This unfailingly optimistic microbiologist and immunologist is committed to revolutionizing our approach t...

Natural killer (NK) cells are part of the innate immune system, our first line of defense. We already know that they can develop immune memory after infection with Streptococcus pneumoniae. More recen...

In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship between environmental antigen exposure and subsequent allergy.

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Viruses, bacteria, and other pathogens pose a serious threat to human health, requiring a coordinated response from the innate and adaptive immune systems. Our immune system relies on pathogen recept…

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Postnatal development is a critical period for the maturation of the nervous and immune systems. The choroid plexus (CP) within the brain ventricles guides brain development through the production of ...

Interleukin-27 (IL-27), a member of the IL-12 cytokine family, was long viewed primarily as a regulator of CD4+ T cell immunity. Subsequent studies revealed that IL-27 also directly modulates CD8+ T c...

Nature Communications - NHEJ is the primary repair pathway during class switch recombination. Here the authors show that in absence of NHEJ, Pol θ repairs persistent G1-induced breaks in...

The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...

Institut Pasteur and the CNRS are launching a call for a mid-career group leader position in AI in genomics. We are looking for an experienced researcher (typically with > 8 years of research experien...

Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...

The causes of early-life eczema have been unclear, but evidence indicates that changes to fetal immune cells and sensory neurons during pregnancy play a key part.