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Seth Thomas Scanlon @immunoeditor.bsky.social · 03/07/2026

#Science #Immunology turns 10 years old this month! We celebrate w/ a Special Issue on immune #memory! Check out our 3 outstanding Reviews by Maziar & Kaufmann; @sjturn.bsky.social, Thiele, & @niclag.bsky.social; & @maurogaya.bsky.social & @kimljacobson.bsky.social out this week! scim.ag/448rEkV

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Seth Thomas Scanlon @immunoeditor.bsky.social · 12/06/2026

To celebrate @focisimmunology.bsky.social's annual meeting this week, #Science #Immunology has just released a free sample collection of recent papers with a focus on human & clinical immunology! The collection will be available online to read for the next few weeks! #FOCIS2026 bit.ly/SciImm_free

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Seth Thomas Scanlon @immunoeditor.bsky.social · 25/04/2026

To mark World #Malaria Day, here are 2 recent Science #Immunology papers highlighting cutting-edge malaria research! Nideffer & al. (2025) scim.ag/4izhn63 Gao & al. (2025) scim.ag/4hN5vOY

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Seth Thomas Scanlon @immunoeditor.bsky.social · 09/03/2026

Ghreetings from ghorgeous Ghent, where #Type2Immunity26 co-org by @vibtrainconf.bsky.social & #Science #Immunology is well under way! Check out our free collection of #allergy, #asthma, & #Type2Immunity papers in celebration! Collection: bit.ly/SciImm_free Conference: vibbio.tech/3UwmTNk

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Seth Thomas Scanlon @immunoeditor.bsky.social · 03/03/2026

To celebrate next week's #Type2Immunity26 meeting in Ghent co-org by @vibtrainconf.bsky.social & #Science #Immunology, we've selected 8 recent #allergy, #asthma, & #Type2Immunity papers. Free collection available until end April 2026! Collection: bit.ly/SciImm_free Conference: vibbio.tech/3UwmTNk

General view of the Graslei (Ghent, Belgium) with the Leie river in the foreground. / Photograph by Michiel Hendryckx, distributed under a CC BY-SA 4.0 license.

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Seth Thomas Scanlon @immunoeditor.bsky.social · 27/01/2026

@science.org is looking for a new research editor to handle papers in the field of next-generation #medicine! Spread the word!!! bit.ly/4bWOJfn

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Seth Thomas Scanlon @immunoeditor.bsky.social · 02/01/2026

Happy 2026!!! #Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026! bit.ly/SciImm_free #ScienceImmuno10gy

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Seth Thomas Scanlon @immunoeditor.bsky.social · 07/11/2025

Nov issue of #Science #Immunology out now! This week: exTH17 cells sustain #IL17 –independent rheumatoid #arthritis; CXCR4+ mesodermal progenitors → rostral blood vessels, prodefinitive hematopoiesis, & postnatal tissue #macrophages; & how #Bcells acquire antigens from #parasites! scim.ag/4qQA6Q6

ONLINE COVERB Cell Help Measures Up Against Parasites. How B cells acquire antigens from large pathogens, including single-celled parasites, to support T cell–driven humoral responses is not well understood. Gao et al. used Ighg2A10 B cells specific for the surface Plasmodium falciparum circumsporozoite protein (PfCSP) to examine the interaction between B cells and Plasmodium berghei sporozoites engineered to express PfCSP. Ighg2A10 B cells could internalize and present cognate and bystander surface antigens, which resulted in both intramolecular and intermolecular CD4 T cell help. This help either suppressed or supported protective B cell responses depending on whether the CD4 T cells recognized cytosolic or surface sporozoite antigens. This month’s cover is a pseudocolored and digitally altered scanning electron microscopy (SEM) micrograph of Plasmodium sporozoites (pale purple) attached to Ighg2A10 B cells (bright pink) at one end.
Martin Oeggerli (Micronaut) 2025, with Xin Gao and Ian Cockburn, The John Curtin School of Medicine Research, Australian National University

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Seth Thomas Scanlon @immunoeditor.bsky.social · 24/10/2025

Last week in #Science #Immunology: two papers from Bill Schief, Facundo Batista, @profshanecrotty.bsky.social, & al. provide evidence that simultaneous #immunization with multiple #bnAb #immunogens could be a viable #HIV #vaccine strategy! Xie & al. scim.ag/3W7wfQl Sutton & al. scim.ag/4ofvKQa

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Seth Thomas Scanlon @immunoeditor.bsky.social · 15/10/2025

I'm so excited to be in stunning Stockholm for the 50th annual meeting of the #Scandinavian Society for #Immunology! swimm.se/ssi-2025/ @finnsocimm.bsky.social @swimm-immuno.bsky.social @yssi-immunology.bsky.social @ki.se

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Seth Thomas Scanlon @immunoeditor.bsky.social · 09/10/2025

To celebrate this year’s #NobelPrize in #Medicine, awarded for the discovery of regulatory #TCells, we have selected 8 papers recently published in #Science #Immunology that highlight recent advances in #Treg biology! The collection will be online until the end of Oct 2025! bit.ly/SciImm_free

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Seth Thomas Scanlon @immunoeditor.bsky.social · 03/10/2025

The October issue of #Science #Immunology is out now! This week: how #TCR avidity shapes #CD8 #TCell responses to #mRNA #vaccines and the latest research on the immunology of #brain #tumors reviewed! New content added every week! scim.ag/46TGooP

Decoding the Brain Tumor Immune Microenvironment. Brain tumors originate either from within the brain or as metastases from other tissues and pose major clinical challenges because of their heterogenous and aggressive nature. Bunse et al. review the cellular and molecular determinants of brain tumor antigenicity and factors that contribute to the immunosuppressive brain tumor microenvironment (TME). This month’s cover illustration depicts distinct malignant glioma (upper left) and metastatic (bottom right) TMEs as collages of aperiodic penrose tiles overlaid on a stylized positron emission tomography (PET) scan of the brain.
Credit: Rioka Hayama

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Seth Thomas Scanlon @immunoeditor.bsky.social · 05/09/2025

The September issue of #Science #Immunology is out! This week: METTL1 m⁷G RNA modification of NAD+ #metabolism → #macrophage -mediated #inflammation; proenkaphalin+ #Tregs restrain skin inflamm via control of #nociception; #RNA helicase DDX55 is regulator of naïve #TCell homeostasis scim.ag/3HKC5DP

Shining a Light on Naïve T Cell Homeostasis:

Homeostatic maintenance of naïve T cells is critical to maintain a large and diverse T cell pool. However, the underlying mechanisms regulating this process are not well understood. Wu et al. report that the RNA helicase DDX55 regulates the homeostatic maintenance of naïve T cells by preventing MYC from binding to enhancer- and promoter-like transposable elements (TEs) near T cell activation genes. In naïve T cells, DDX55 prevents the inappropriate activation of TEs and ensures their genomic stability by preventing R-loop formation. This month’s cover features a light bulb with its filament stylized as a DNA double helix. Its left half glows with an intact filament, symbolizing TEs as regulators, and its right side is dimmed and features a broken filament, representing TEs’ disruptive potential.
Credit: Bingyu Yang and Jianling Zhu/Sichuan University

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Seth Thomas Scanlon @immunoeditor.bsky.social · 12/08/2025

The cover was illustrated by Rioka Hayama, who also designed #Science #Immunology 's wicked JAN 2025 cover! riokahayama.com

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Seth Thomas Scanlon @immunoeditor.bsky.social · 12/08/2025

This week's @science.org #IMMUNOLOGY-themed SPECIAL ISSUE features Reviews by {Kassiotis & Stoye}, {Nahrendorf, Ginhoux, & Swirski}, {Sharma, Gibbons, & Saphire}, & {@jessmetcalf.bsky.social, @grahammunology.bsky.social, Yates, & Cummings} + an absolutely wild & wonderful cover! scim.ag/3UqRrA6

COVER This illustration depicts the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age. The infant silhouette contains DNA, and the figures are enveloped by the nuclear and plasma membranes. These components reference the evolution of immunity over millennia, as viruses integrated into the genome and as life progressed from single-celled to multicellular organisms. See the special section beginning on page 586.

Illustration: Rioka Hayama

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Seth Thomas Scanlon @immunoeditor.bsky.social · 01/08/2025

The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice! wwwscience.org/toc/sciimmun...

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Seth Thomas Scanlon @immunoeditor.bsky.social · 04/07/2025

The July issue of #Science #Immunology is out now! This week: • Additional levels of #IL13RA1 gene regulation help explain susceptibility to #allergy! • Spi-B is a #checkpoint of #type2 immunity by restraining #TuftCell activation in gut! New content each week! www.science.org/toc/sciimmun...

Checkpoint on Type 2 Immunity. Tuft cells play key roles in the initiation and propagation of type 2 immune responses in the gut, but whether they have regulatory machinery for constraining these responses is not known. Wang et al. found that the transcription factor Spi-B prevents excessive type 2 immune responses against helminth infection and food allergens by limiting tuft cell activation and proliferation in the small intestine. Spi-B represses c-Kit signaling in tuft cells, which limits their production of the cytokine TSLP and the subsequent activation of T helper 2 (TH2) cells. This month’s cover image features a tuft cell (dark red) within the epithelial lining of the small intestine in which Spi-B has been inactivated, leading to increased production of TSLP by tuft cells and the cytokine interleukin-13 (IL-13) by TH2 cells (white).

Credit: A. Fisher/Science Immunology

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Seth Thomas Scanlon @immunoeditor.bsky.social · 27/06/2025

I am so delighted to be in #Japan for this year's RIKEN IMS–JSI International Symposium on #Immunology! 🇯🇵 温かく迎えてくれた主催者に感謝する！

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Seth Thomas Scanlon @immunoeditor.bsky.social · 25/06/2025

To celebrate @focisimmunology.bsky.social 's annual meeting this week, #Science #Immunology has just released a new free sample collection of recent papers with a focus on human immunology! The collection will be available online to read until the end of July 2025! #FOCIS2025 bit.ly/SciImm_free

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Seth Thomas Scanlon @immunoeditor.bsky.social · 18/06/2025

This month in #Science #Immunology, Shivangi Dave & André Ballesteros Tato at the #NIH review the noncanonical contributions of #TFollicularHelper ( #TFH ) cells cells to immune regulation beyond their traditional roles in #BCell help! science.org/doi/10.1126/sciimmunol.adr1052

Conventional and nonconventional functions of TFH cells: In addition to their conventional role as GC facilitators—providing survival and proliferation signals to GC B cells—TFH cells also perform noncanonical functions. They can support CD8+ T cell responses, produce effector-like cytokines that critically influence B cell fate decisions beyond GC maintenance, and exhibit TSCM properties that allow them to serve as reservoirs for pathogenic Teff cell subsets across various anatomical niches

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Seth Thomas Scanlon @immunoeditor.bsky.social · 06/06/2025

The June issue of #Science #Immunology has launched! This week: inducible #FoxP3 degradation in #Tregs; the immune landscape of human #psoriatic #arthritis; & #IL12 gives #mRNA #vaccines a boost! New content every week! Check it out! www.science.org/toc/sciimmun...

ONLINE COVERLNP mRNA Vaccines Get a Boost. Lipid nanoparticle (LNP) mRNA vaccines induce robust immune responses and provide protection against infectious diseases, but this immunity can be short-lived, necessitating frequent booster vaccinations. Aunins et al. investigated how adjuvanting LNP-mRNA vaccines with mRNA encoding the cytokine interleukin-12 (IL-12) influences CD8 T cell responses in mice. Il12 mRNA-LNPs (LNP–IL-12) enhanced antigen-specific CD8 T cell responses and CD8 T cell memory, providing greater protection against bacterial infection and in a mouse model of melanoma. Cytokine-adjuvanted mRNA-LNPs may help future vaccine platforms better tailor the magnitude and nature of the immune response. This month’s cover image features a stylized mRNA-LNP with various lipid (red, coral, and pink) and cholesterol molecules (maroon) encapsulating Il12 mRNA (yellow).

Credit: A. Mastin/Science Immunology

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Seth Thomas Scanlon @immunoeditor.bsky.social · 30/05/2025

Austin is so talented! Here's his illustration for the Science Immunology Feb 2024 cover, drawn in a markedly different style!

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Seth Thomas Scanlon @immunoeditor.bsky.social · 02/05/2025

The May issue of #Science #Immunology is out now! This week: #interferon regulates #thymic epithelial cell differentiation; #efferocytosis determines #alveolar #macrophage functional plasticity: & mapping the #stromal cell landscape of human #LymphNodes! science.org/toc/sciimmunol/10/107

ONLINE COVER: Lymph Nodes Get a Remodel. Fibroblastic reticular cells (FRCs) are stromal cells that coordinate structural remodeling and adaptive immune responses in the lymph node. Using single-cell transcriptomics and high-resolution microscopy, Lütge et al. comprehensively characterized the stromal cell landscape of human lymph nodes during quiescence and inflammation. Inflammation drove lymph node remodeling including the expansion of peptidase inhibitor 16 (PI16)+ FRCs in macrophage-rich perivascular niches. This month’s cover image shows an inflamed human lymph node that has undergone expansion of podoplanin+ FRCs (purple) near alpha smooth muscle actin (ACTA2)+ vascular smooth muscle cells (green) to support immune cell infiltration and BCL6+ germinal center B cell (orange) activity.

Credit: Lisa Kurz/Kantonsspital St. Gallen

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Seth Thomas Scanlon @immunoeditor.bsky.social · 10/04/2025

In sunny Freiburg for the International Symposium on #Perinatal and #EarlyLife #Immunity! www.perinatal-immunity.de/en/symposium...

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Seth Thomas Scanlon @immunoeditor.bsky.social · 07/03/2025

The March issue is out! This week: TOX-inducible-KO 🐁show how #TOX maintains #exhausted CD8 #Tcell epigenetic fate; visualizing temporal & spatial #STING expression; & UVB-driven #mitochondrial Z-🧬complexed w ZBP1 fuels #autoimmune #photosensitivity via cGAS-STING! science.org/toc/sciimmunol/10/105

This month’s cover features a keratinocyte mitochondrion damaged by UVB radiation, which then releases reactive oxygen species (red spheres) and Z-DNA complexed with ZBP1 into the cytoplasm. (Credit: A. Fisher/Science Immunology)

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Seth Thomas Scanlon @immunoeditor.bsky.social · 05/03/2025

To celebrate with the @keystonesymposia.bsky.social #myeloid cell meeting happening now in Hannover, we have released a free collection of 6 recent #Science #Immunology papers focused on myeloid cells! Check 'em out! They will be available until the end of April! bit.ly/SciImm_free #KSmyeloid25

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Seth Thomas Scanlon @immunoeditor.bsky.social · 28/02/2025

To commemorate #RareDiseaseDay, here are some recent #Science #Immunology research papers that elucidate the immune mechanisms underlying certain rare human diseases and/or report new strategies to treat them! @science.org

The February 2024 cover of Science Immunology depicts CRISPR–Cas9–mediated repair of a dysfunctional cytotoxic T cell (red) from an individual with familial hemophagocytic lymphohistiocytosis (FHL), which allows it to secrete normal cytotoxic granules (pink) and effectively kill virally infected B cells (blue). (Credit: A. Fisher/Science Immunology)

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Seth Thomas Scanlon @immunoeditor.bsky.social · 10/02/2025

Ha ha! The Vince Lombardi is ours! Phellow Philadelphians: rejoice!

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Seth Thomas Scanlon @immunoeditor.bsky.social · 07/02/2025

Our February issue is now live! This week: CD22 restrains #IL4 -driven #TVMcell expansion during #helminth infection; molecular determinants of #TCR x-reactivity against #influenza variants; & #MultipleMyeloma breakout lesions are tumor–immune interaction hotspots! science.org/toc/sciimmunol/10/104

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Seth Thomas Scanlon @immunoeditor.bsky.social · 04/02/2025

#Paris lab visits day 2: @pasteur.fr! Un grand merci to all the researchers who shared their exciting data with me today! Formidable!

Bust of Ilya Mechnikov, Pasteur Institute, Paris, France

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Seth Thomas Scanlon @immunoeditor.bsky.social · 03/02/2025

I would like to send a great big thank you to the many researchers who made my visit to @institutcurie.bsky.social today so wonderful!

Mural of scientist Marie Curie (Paris, France)

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Seth Thomas Scanlon @immunoeditor.bsky.social · 08/01/2025

At AAAS headquarters & just caught a terrific gallery show curated by @science.org Visuals team. "The invisible, novel, and complex: A decade of visualizing science" highlights a selection of eye-popping covers, photos, and custom illustrations from the past 10 years. In DC? Be sure to check it out!

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Seth Thomas Scanlon @immunoeditor.bsky.social · 03/01/2025

The January issue of #Science #Immunology is now live! This week: new insights into #NLRP3 #inflammasome activation; key distinctions btw rodent & human #PD1 orthologs uncovered; & targeting thrombospondin-1 (Thbs1) to suppress #HSC #inflammaging! www.science.org/toc/sciimmun...

Reversing the Hands of Time.

Inflammaging is the age-associated increase in systemic inflammation, which can have negative effects on blood cell production and the immune system. Using a mouse model of premature hematopoietic aging, Ramalingam et al. identified thrombospondin-1 (Thbs1) as a driver of age-associated changes to hematopoietic stem cells (HSCs). Deletion of Thbs1 prevented HSC myeloid bias, loss of HSC self-renewal, and systemic signs of inflammaging in aged mice. This month’s cover illustration depicts the process of HSC inflammaging as a pocket watch. Thbs1 gene deletion causes the watch hands to move backwards, which reverses aging-associated HSC defects and turns back the clock on inflammaging.

Credit: Rioka Hayama

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Seth Thomas Scanlon @immunoeditor.bsky.social · 19/12/2024

Our Editors’ Choice of articles published in #Science #Immunology this year is out now! This free sample collection will be available online to read until the end of February 2025! bit.ly/SciImm_free

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Seth Thomas Scanlon @immunoeditor.bsky.social · 18/12/2024

‪ When I pitched a cover featuring #helminths illustrated with #Jugendstil / #ArtNouveau styling to @science.org's amazing Visuals team, never in my wildest dreams did I imagine the finished product would be so exquisite! Scientific illustrator Ashley Mastin really hit it out of the park!

The December 2024 cover of Science Immunology features an adult female Heligmosomoides polygyrus bakeri (Hpb) in the center, flanked by adult Hpb males with their characteristic caudal bursae on the left and right sides, crescent-shaped Hpb larvae from various stages surrounding the adults, and Hpb eggs in the four corners of the image.
(Credit: A. Mastin/Science Immunology)

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Seth Thomas Scanlon @immunoeditor.bsky.social · 17/12/2024

I'm in #Amsterdam today to meet researchers at #Sanquin and @nkinl.bsky.social! Thanks, @brendaraud.bsky.social for organizing my visit!

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Seth Thomas Scanlon @immunoeditor.bsky.social · 11/12/2024

Yesterday's wonderful visit to @imperialcollegeldn.bsky.social is now followed by an exciting trip to my old stomping grounds, the MRC-LMB in Cambridge, UK!

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Seth Thomas Scanlon @immunoeditor.bsky.social · 06/12/2024

The December issue of #Science #Immunology is out now! This week: #MAITcell plasticity in #antibacterial immunity; how #inflammatory status of #lung before #COVID19 infection impacts #viral control; & #helminths utilize glutamate dehydrogenase to prevent #AAMs & #TH2 activation! bit.ly/SI_DEC_24

This month’s cover features an adult female Hpb in the center, flanked by adult Hpb males with their characteristic caudal bursae on the left and right sides, crescent-shaped Hpb larvae from various stages surrounding the adults, and Hpb eggs in the four corners of the image.

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Seth Thomas Scanlon @immunoeditor.bsky.social · 19/11/2024

#ScienceImmunology recently released a free sample collection of papers highlighting the immunology of #cytokines! Articles are free online to read for another few weeks! Check 'em out! bit.ly/SciImm_free

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Seth Thomas Scanlon @immunoeditor.bsky.social · 18/11/2024

This week in #ScienceImmunology: Olivier Demaria, Eric Vivier, & al. use tetraspecific #NKCell engager (comprising an anti- #NKp46 Ab fragment + #IgG1 #Fc fragment + #IL2 variant + anti- #CD20 Ab) to target #BCell -specific #NonHodgkin #lymphoma (B-NHL) in mouse & NHP models! bit.ly/SI_adp3720

Representative CD20 staining of spleen and mandibular lymph node sections from animals treated with vehicle or CD20-NKCE-IL2v (0.5 mg/kg). Scale bars: 3 mm

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Seth Thomas Scanlon @immunoeditor.bsky.social · 17/11/2024

Germinal centers from Confetti mice?

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Seth Thomas Scanlon @immunoeditor.bsky.social · 14/11/2024

At #ScienceImmunology, I lead a fantastic team of #research #editors comprising Chris Fogg (@cnfogg.bsky.social), Claire Olingy (@claireolingy.bsky.social), and Hannah Isles (@hannah-isles.bsky.social)! Be sure to give them a follow! www.science.org/journal/scii...

The Science Immunology editors in front of AAAS Headquarters in Washington DC. (L to R): Chris Fogg, Claire Olingy, Seth Thomas Scanlon, & Hannah Isles

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Seth Thomas Scanlon @immunoeditor.bsky.social · 14/11/2024

#Intro Born & raised in #Philadelphia, undergrad at @upenn.bsky.social & PhD at @uchicago.bsky.social. Postdocs @ #MRC-LMB & #UManchester. After 10 yrs in #UK, I moved to the #Netherlands in 2022. Since September 2023, I have been the #Editor of #ScienceImmunology, where I lead an amazing team!

Picture of Seth Thomas Scanlon at a conference.

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