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Reposted by Sofi Quinodoz

Albert and Mary Lasker Foundation @laskerfdn.bsky.social · 14/07/2025

Combining sequencing and imaging, @brangwynnelab.bsky.social maps the spatiotemporal dynamics of rRNA processing, demonstrating how rRNA serves as both a scaffold and a substrate for the nucleolus—a multiphase, liquid-like structure. 🧪 🧬

nature.com

Mapping and engineering RNA-driven architecture of the multiphase nucleolus - Nature

Spatially segregated rRNA processing dictates nucleolar morphology and drives outward progression of pre-ribosomal RNA through nucleolar phases.

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