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Gladstone Institutes

@gladstoneinst.bsky.social
706 followers 167 following 972 posts

To drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and diverse environment.

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Gladstone Institutes @gladstoneinst.bsky.social · 5h
Steve Finkbeiner discusses the remarkable potential of AI to advance science—and the risk of too-stringent government regulations on AI hampering discovery.
cbc.ca
How AI could usher in a 'new scientific golden age' (if it doesn't kill us all first) | CBC News
AI has remarkable potential to exponentially advance scientific discovery, say scientists. But getting out the word of its scientific benefits of can be challenging when forced to compete with headlines about its significant if not existential threat to...
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Gladstone Institutes @gladstoneinst.bsky.social · 19h
Seth Shipman (@seth-shipman.bsky.social) )has been recognized for pioneering molecular technologies that record cellular activity, expand genome editing, and target antibiotic-resistant superbugs. @calacademy.bsky.social
gladstone.org
Gladstone’s Seth Shipman Named Fellow of the California Academy of Sciences | Gladstone Institutes
Shipman is recognized for pioneering molecular technologies that record cellular activity, expand genome editing, and target antibiotic-resistant superbugs.
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Gladstone Institutes @gladstoneinst.bsky.social · 08/10/2026
Researchers from Melanie Ott's lab identify the SARS-CoV-2 protein ORF8 as a driver of lung inflammation, revealing how infected macrophages may worsen severe COVID-19. @theottlab.bsky.social
genengnews.com
SARS-CoV-2 Protein Fuels Lung Inflammation by Hijacking Macrophages
Researchers identify the SARS-CoV-2 protein ORF8 as a driver of lung inflammation, revealing how infected macrophages may worsen severe COVID-19.
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Gladstone Institutes @gladstoneinst.bsky.social · 07/10/2026
Gladstone swept this year's UCSF Postdoc Slam 🏆 🥇 Yolanda Martí-Mateos (Jain Lab) shared how red blood cells at high altitude could unlock new diabetes treatments. 💙 Shoshana Williams (Ott Lab) received the People's Choice Award for a CRISPR test strip that could speed up TB diagnosis.
ucsf.edu
Why This One Small Blood Cell Is Your Secret to Living the High Life
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Gladstone Institutes @gladstoneinst.bsky.social · 06/10/2026
🚨 NEW PUBLICATION 🚨 "Detectrons convert transient RNA sequences into stable DNA barcodes for high-throughput analysis of RNA-dependent processes" @seth-shipman.bsky.social @jihoon-han.bsky.social @natbiotech.nature.com
nature.com
Detectrons convert transient RNA sequences into stable DNA barcodes for high-throughput analysis of RNA-dependent processes - Nature Biotechnology
RNA sequences are detected and converted directly into DNA barcodes.
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Gladstone Institutes @gladstoneinst.bsky.social · 06/10/2026
Gladstone's Jeanne Paz reflects on her early-career years in the lab of 2026 Nobel Prize winner Karl Deisseroth and explains how optogenetics has advanced epilepsy research.
thetransmitter.org
Nobel Prize-winning optogenetics revolutionized neuroscience
The technique enables neuroscientists to target brain circuits with unprecedented specificity, transforming the study of memory, reward and more.
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Gladstone Institutes @gladstoneinst.bsky.social · 05/10/2026
Inspired by bacterial biology, the Gladstone-developed “Detectron” opens up new possibilities for disease research and potentially treatments. New from the lab of @seth-shipman.bsky.social
gladstone.org
Novel Biosensor Uses DNA ‘Barcodes’ to Uncover Disease Signals in Cells | Gladstone Institutes
Inspired by bacterial biology, the Gladstone-developed “Detectron” opens up new possibilities for disease research and potentially treatments.
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Reposted by Gladstone Institutes
Stacie Dodgson, PhD @staciedodgson.bsky.social · 22/09/2026
📣📣 Looking for new faculty @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social Genomic Immunology: aprecruit.ucsf.edu/JPF05958 We are broadly interested in immunotherapy - discovery, design, engineering, and translation, across the full spectrum of modalities and disease indications.
aprecruit.ucsf.edu
In Residence/ Ladder Faculty - Gladstone-UCSF Institute of Genomic Immunology
University of California, San Francisco is hiring. Apply now!
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Reposted by Gladstone Institutes
Benoit Bruneau @benoitbruneau.bsky.social · 24/09/2026
@gladstoneinst.bsky.social gang ready for the @americanheart.bsky.social Heart Walk!
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Reposted by Gladstone Institutes
Nature Reviews Genetics @natrevgenet.nature.com · 28/09/2026
Machine learning and statistical methods for molecular quantitative trait loci go.nature.com/4d9DTTi New #Review by @barbaraengelhardt.bsky.social @gladstoneinst.bsky.social, Joshua S. Weinstock @emoryuniversity.bsky.social, Sarah K. Nyquist & @alexisbattle.bsky.social @jhu.edu out now!
go.nature.com
Machine learning and statistical methods for molecular quantitative trait loci - Nature Reviews Genetics
Molecular quantitative trait loci (molQTLs) provide key insights into how non-coding variants shape complex traits and disease. In this Review, the authors outline statistical and machine learning app...
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Reposted by Gladstone Institutes
Nature Biotechnology @natbiotech.nature.com · 05/10/2026
Detectrons convert transient RNA sequences into stable DNA barcodes for high-throughput analysis of RNA-dependent processes - @seth-shipman.bsky.social @gladstoneinst.bsky.social www.nature.com/articles/s41...
nature.com
Detectrons convert transient RNA sequences into stable DNA barcodes for high-throughput analysis of RNA-dependent processes - Nature Biotechnology
RNA sequences are detected and converted directly into DNA barcodes.
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Gladstone Institutes @gladstoneinst.bsky.social · 05/10/2026
It's Down Syndrome Awareness Month. Nearly 50% of babies with Down syndrome are born with heart defects. Our scientists used stem cells + gene editing + AI to find the gene behind it.
gladstone.org
Science in Seconds | Researchers Pinpoint Key Gene Behind Heart Defects in Down Syndrome | Gladstone Institutes
In this video, Gladstone scientists share how they used stem cells, gene editing, and AI to identify a gene driving heart defects in Down syndrome--and how reducing its levels in mice restored normal heart development, offering hope for future treatments
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Gladstone Institutes @gladstoneinst.bsky.social · 04/10/2026
Gilbert Herrera, grad student at the Gladstone-UCSF Institute of Genomic Immunology, has been named the Ellen & Bernard Marson Fellow. The award provides 3 years of support for a promising trainee pursuing innovative immunotherapy research. Read more: bit.ly/4hGCrJy
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Gladstone Institutes @gladstoneinst.bsky.social · 04/10/2026
Gladstone is among the early users of Anthropic’s Claude Science platform, which is being used to support new approaches to biological research.
webpronews.com
Anthropic Builds Bay Area Wet Lab to Test AI's Real-World Biology Ambitions
Anthropic has opened a wet lab in the San Francisco Bay Area for physical biology experiments, confirmed by its head of life sciences. The facility supports Claude AI's push into protein design and au...
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Gladstone Institutes @gladstoneinst.bsky.social · 03/10/2026
Gladstone Associate Investigator Seth Shipman shares his thoughts on Anthropic's claim that its scientists used AI to discover new enzymes with promise for biotechnology.
nytimes.com
Did Anthropic’s A.I. Really Make a Scientific Discovery on Its Own?
An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.
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Gladstone Institutes @gladstoneinst.bsky.social · 02/10/2026
A team of scientists at Gladstone and UCSF discovered how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread, pointing to a new strategy for therapeutic intervention. Read more: bit.ly/4hk8sad
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Gladstone Institutes @gladstoneinst.bsky.social · 01/10/2026
Our Gladstone community came out in force for the San Francisco Heart Walk! We had 91 walkers across 11 teams, and raised $1,766.40 for cardiovascular research. So much gratitude for everyone who walked, donated, and cheered us on. ❤️
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Gladstone Institutes @gladstoneinst.bsky.social · 29/09/2026
It's World Heart Day. Heart failure affects approximately 64 million people worldwide. At Gladstone, Michael Alexanian is asking: what if we could just switch it off? He's found two genes, BRD4 & MEOX1, that may hold the answer.
gladstone.org
Ask a Scientist: Can We Turn Off the Molecular Switches That Cause Heart Failure?
Michael Alexanian is studying two promising genetic avenues for addressing heart failure, a massive global health burden in need of innovative treatments.
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Gladstone Institutes @gladstoneinst.bsky.social · 25/09/2026
Happy Research Administrator Day! Today we’re celebrating the people that make discovery possible at Gladstone. Your work creates the support our scientists need to pursue new ideas and advance their research. Thank you for everything you do behind the scenes to support our our science.
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Gladstone Institutes @gladstoneinst.bsky.social · 23/09/2026
🎉 It's Postdoc Appreciation Week, and we're celebrating the talented scientists who bring so much to our research and community. Postdocs are helping shape the future of science, and we're proud to support them as they grow into the next generation of scientific leaders.
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Gladstone Institutes @gladstoneinst.bsky.social · 22/09/2026
Ayush Midha, a graduate student in the Jain Lab, is uncovering how the body adapts when oxygen runs low—work that has surprising ties to cancer and fertility.
gladstone.org
Meet Gladstone: Ayush Midha
Ayush Midha, a graduate student in the Jain Lab, studies how the body's metabolism adapts to low oxygen—work that's uncovered backup energy pathways, potential fertility treatments, and a link between...
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Gladstone Institutes @gladstoneinst.bsky.social · 20/09/2026
Science is hard — failure is part of the process. Gladstone's Lexi Schneider explains why a strong support system (and hobbies outside the lab!) are just as essential to good science as the experiments themselves
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Gladstone Institutes @gladstoneinst.bsky.social · 20/09/2026
🚨 🚨 NEW PUBLICATION 🚨 🚨 "Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells" @theottlab.bsky.social @ucsanfrancisco.bsky.social
science.org
Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets the respiratory epithelium, yet severe disease features diffuse lung injury and hyperinflammatory syndromes driven by dys...
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Gladstone Institutes @gladstoneinst.bsky.social · 18/09/2026
A new discovery reveals how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread—and points to a new strategy for therapeutic intervention.
gladstone.org
How a Single Viral Protein Hijacks Immune Cells to Supercharge COVID-19 Infection
A new discovery reveals how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread--and points to a new strategy for therapeutic intervention.
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Gladstone Institutes @gladstoneinst.bsky.social · 17/09/2026
Congrats to Gilbert Herrera who was named the inaugural Ellen & Bernard Marson Fellow! Herrera is making key discoveries about how immune cells can fight cancer more effectively.
gladstone.org
Rethinking ‘Exhausted' T Cells: Gilbert Herrera Named Inaugural Ellen & Bernard Marson Fellow
The fellowship provides three years of funding for graduate students pursuing groundbreaking immunology research.
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Gladstone Institutes @gladstoneinst.bsky.social · 17/09/2026
Gladstone researcher Nevan Krogan says the new autism research provides an important roadmap for understanding autism and identifying potential treatments.
cnn.it
Largest ever ‘map' of autism may hold clues for new targeted therapies | CNN
Scientists are getting a step closer to understanding exactly how autism develops in the brain – and what might work to treat it.
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Gladstone Institutes @gladstoneinst.bsky.social · 14/09/2026
Jun Takahashi was selected for pioneering the translation of induced pluripotent stem (iPS) cell biology into regenerative therapies for Parkinson’s disease, culminating in the world’s first clinical approval for iPS cell-derived cell transplantation. Read more: bit.ly/3VdWRlo
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Gladstone Institutes @gladstoneinst.bsky.social · 11/09/2026
Nevan Krogan discusses how researchers are connecting hundreds of autism-linked genes to the proteins they affect, helping identify common biological pathways that could lead to new treatments.
n.pr
Scientists map the interactions of key proteins linked with profound autism
After more than a decade, UCSF scientists have mapped around 100 varied genes associated with profound autism to a smaller set of biological pathways, offering a promising path for developing drugs.
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Gladstone Institutes @gladstoneinst.bsky.social · 10/09/2026
🎧 Listen to this story 🎧 An unprecedented map of 22 million immune cells provides the functional rulebook for virtual biology and next-generation immunotherapies.
open.spotify.com
Scientists Decode Gene Circuits of Human Immunity, Fueling New Era of Disease Research
Gladstone Audio News · Episode
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Gladstone Institutes @gladstoneinst.bsky.social · 09/09/2026
AI didn't just join biomedical research at Gladstone—it's being built here. From Geneformer to the "thinking microscope," our scientists are using AI to find cures faster.
gladstone.org
How AI Is Accelerating Life-Saving Discovery
Gladstone scientists are developing new AI tools that promise to revolutionize how science is done and lead to new treatments for the most devastating diseases.
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Gladstone Institutes @gladstoneinst.bsky.social · 08/09/2026
Scientists just stress-tested genes across 22 million human immune cells—using real cells from real donors, not lab models. Gladstone's Emma Dann & Ronghui Zhu break down why this massive new dataset could reshape cancer immunotherapy and autoimmune treatment.
gladstone.org
Science in Seconds | An Unprecedented Map of Human Immune Cells
In this video, Gladstone scientists Emma Dann and Ronghui Zhu explain how their new study offers a powerful framework for designing cancer immunotherapies and treating autoimmune conditions.
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Gladstone Institutes @gladstoneinst.bsky.social · 07/09/2026
The AI model behind this heart disease breakthrough? Geneformer — developed at Gladstone by Christina Theodoris' lab. Researchers used it to predict that patients with MYH7 and TTN mutations could benefit from a gene therapy that already reversed cardiomyopathy in mice.
insideprecisionmedicine.com
Gene Therapy Could Reverse Genetic Heart Disease, Spare Children from Transplants
A gene therapy could restore heart function in over 25% of children born with mutations that cause cardiomyopathy.
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Gladstone Institutes @gladstoneinst.bsky.social · 04/09/2026
Published in Cell, an unprecedented map of 22 million immune cells provides the functional rulebook for virtual biology and next-generation immunotherapies. The massive dataset stands as the largest contribution yet to Biohub Billion Cells Project. Read more: bit.ly/3SQzaPc
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Gladstone Institutes @gladstoneinst.bsky.social · 04/09/2026
Meet Lexi Schneider from the Yang Lab! She's developing a groundbreaking tool called TORCH to help scientists understand how the brain and body talk to each other—something that's been notoriously hard to study.
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Reposted by Gladstone Institutes
Biohub @biohub.org · 28/08/2026
This is the largest dataset contributed to the Billion Cells Project to date. It is an important step toward the scale and coordination needed to build the Virtual Biology Initiative.
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Reposted by Gladstone Institutes
Benoit Bruneau @benoitbruneau.bsky.social · 03/09/2026
fantastic and tremendously insightful review on fibrosis by my @gladstoneinst.bsky.social colleagues Michael Alexanian and Deepak Srivastava www.cell.com/action/showP...
cell.com
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Gladstone Institutes @gladstoneinst.bsky.social · 01/09/2026
A microscope that never sleeps, runs thousands of experiments at once, and learns from every result in real time. Steven Finkbeiner breaks down the AI-powered "thinking microscope" racing to crack Alzheimer's and ALS.
commonwealthclub.org
Giving Scientists Superpowers: How an AI-Powered “Thinking Microscope” Is Fast-Tracking Medical Breakthroughs
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Gladstone Institutes @gladstoneinst.bsky.social · 31/08/2026
Scientists just stress-tested genes across 22 million human immune cells — using real cells from real blood donors, not lab models. Gladstone's Emma Dann & Ronghui Zhu break down why this massive new dataset could reshape cancer immunotherapy and autoimmune treatment.
youtube.com
Science in Seconds | An Unprecedented Map of Human Immune Cells
YouTube video by Gladstone Institutes
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Gladstone Institutes @gladstoneinst.bsky.social · 29/08/2026
Could vaccines help keep treat cancer? In August, a late-stage clinical trial of a personalized mRNA vaccine for melanoma showed promising results. At Gladstone, researchers are working toward a future where therapeutic cancer vaccines are effective, accessible, and available to more patients.
youtube.com
The Promise of Cancer Vaccines: Can Vaccines Help Treat Cancer?
YouTube video by Gladstone Institutes
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Gladstone Institutes @gladstoneinst.bsky.social · 28/08/2026
An unprecedented map of 22 million immune cells provides the functional rulebook for virtual biology and next-generation immunotherapies. @ucsanfrancisco.bsky.social @marsonlab.bsky.social @stanford.edu @biohub.org @cp-cell.bsky.social @10xgenomics.bsky.social
gladstone.org
Scientists Decode Gene Circuits of Human Immunity, Fueling New Era of Disease Research
An unprecedented map of 22 million immune cells provides the functional rulebook for virtual biology and next-generation immunotherapies.
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Gladstone Institutes @gladstoneinst.bsky.social · 28/08/2026
A group of scientists, led by Gladstone Investigator Nevan Krogan, studied 100 autism risk genes and found that many patient-derived mutations disrupt core biological processes—a discovery that opens new avenues for future interventions. @qbi-ucsf.bsky.social
qbi.ucsf.edu
QBI - The Molecular Map of Autism: A Road to Potential Drug Targets
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Reposted by Gladstone Institutes
Benoit Bruneau @benoitbruneau.bsky.social · 27/08/2026
Phenomenal paper from our @gladstoneinst.bsky.social and @ucsanfrancisco.bsky.social colleagues on protein-protein interactions of autism-related proteins. www.science.org/doi/10.1126/...
science.org
Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology
Systematic mapping of protein-protein interaction (PPI) networks and determining how causal mutations rewire them in autism spectrum disorder (ASD) provide a powerful framework for uncovering disease ...
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Gladstone Institutes @gladstoneinst.bsky.social · 26/08/2026
Michael Alexanian (@michaelalexanian.bsky.social ) is studying two promising genetic avenues for addressing heart failure, a massive global health burden in need of innovative treatments.
gladstone.org
Ask a Scientist: Can We Turn Off the Molecular Switches That Cause Heart Failure?
Michael Alexanian is studying two promising genetic avenues for addressing heart failure, a massive global health burden in need of innovative treatments.
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Gladstone Institutes @gladstoneinst.bsky.social · 26/08/2026
Shinya Yamanaka is ranked number 2 in Unfiltered's list of the most credible scientific voices in longevity.
unfilteredonline.com
Who are the most credible voices in longevity?
The most credible voices in longevity are mostly not the most visible ones. Of the 100 people ranked in the Unfiltered Longevity 100 for 2026, 38 are working scientists whose standing rests on peer-reviewed output, institutional position and replication...
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Gladstone Institutes @gladstoneinst.bsky.social · 25/08/2026
It's been 20 years since Shinya Yamanaka first discovered induced pluripotent stem cells (iPS) cells. Watch this animated short to learn more about how iPS cells work and how scientists use them in the lab.
youtube.com
Celebrating 20 Years of iPS Cells │What Are iPS Cells?
YouTube video by Gladstone Institutes
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Gladstone Institutes @gladstoneinst.bsky.social · 25/08/2026
Shinya Yamanaka is featured on the cover of TIME, reflecting on the 20-year journey of his groundbreaking iPS cell discovery and its potential to transform human health.
time.com
Shinya Yamanaka Made Cells Young Again. Can That Reverse Aging?
Twenty years after his Nobel-winning discovery, doctors are using Yamanaka's cell-reprogramming breakthrough to treat real patients—and address aging itself.
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Gladstone Institutes @gladstoneinst.bsky.social · 24/08/2026
Meet Lexi Schneider, a PhD student who develops new technologies to help better understand the blood brain barrier.
gladstone.org
Meet Gladstone: Lexi Schneider
Meet Lexi Schneider, a PhD student using innovative technology to uncover how the blood-brain barrier communicates.
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Gladstone Institutes @gladstoneinst.bsky.social · 24/08/2026
Scientists in the labs of Benoit Bruneau, Katie Pollard, and Deepak Srivastava uncovered a mechanism showing how small reductions in protein levels can disrupt DNA’s three-dimensional structure and lead to disease.
scitechdaily.com
A Single Faulty Gene Copy Can Unravel the Heart's DNA
By studying a gene associated with congenital heart defects, scientists uncovered a mechanism showing how small reductions in protein levels can disrupt DNA's three-dimensional structure and lead to disease.
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Gladstone Institutes @gladstoneinst.bsky.social · 23/08/2026
Using a new screening platform they developed, scientists at Gladstone and UCSF uncovered gene edits that enhance CAR-T cells’ ability to infiltrate and eliminate solid tumors. Learn more: bit.ly/4qtsjrw
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Gladstone Institutes @gladstoneinst.bsky.social · 23/08/2026
Congratst to Gladstone postdoc Stephanie Gaglione, who was named a Timmerman Traverse Fellow. Stephanie uses technologies to comprehensively profile the antigens displayed by virally-driven cancers, with a focus on targets that provoke an immune system response.
damonrunyon.org
Damon Runyon Cancer Research Foundation awards $4.2 million to exceptional early-career scientists | New Discoveries
The Damon Runyon Cancer Research Foundation has named 14 new Damon Runyon Fellows, brilliant postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading s...
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