geddescc.bsky.social @geddescc.bsky.social · 05/06/2026Auditorium holds 3000 and not a spare seat! Impressive. 000
geddescc.bsky.social @geddescc.bsky.social · 04/06/2026#ERA26 Late breaking trials session. All 5 presenters and 2 chairs all men. Were there really no women in the huge number of investigators who could have presented? 011
Reposted by @geddescc.bsky.socialSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 04/06/2026Unlike COMPASS, TRACK demonstrates rivaroxaban doesn’t have the same CV benefit in CKD jamanetwork.com/journals/jam... Simultaneous pubs from #ERA26jamanetwork.comLow-Dose Rivaroxaban and Cardiovascular Events in Advanced Kidney DiseaseThis randomized clinical trial examines the safety and efficacy of low-dose rivaroxaban in the treatment of patients with advanced chronic kidney disease at high risk for cardiovascular events. 1158
Reposted by @geddescc.bsky.socialNEJM.org @nejm.org · 03/06/2026This letter reports the clinical course of a broadly HLA-sensitized patient in whom anti-CD19 CAR T-cell therapy enabled successful kidney transplantation. Read the full letter: nej.md/4e1Gn5E 071
Reposted by @geddescc.bsky.socialBrian Rifkin @brianrifkin.bsky.social · 03/06/2026First time at #ERA26 and I’ve already found the best idea…kidney art by school children #NephSky Check out more here: forms.office.com/Pages/Respon... 041
geddescc.bsky.social @geddescc.bsky.social · 04/06/2026#ERA26 Katherine Tuttle. Phase 3 trials of aldosterone synthase inhibitors to slow CKD progression underway. 000
geddescc.bsky.social @geddescc.bsky.social · 04/06/2026#ERA26 Katherine Tuttle. additional of SGLT2i to aldosterone synthase inhibitor in subjects with CKD enhances albuminuria effect and protects from oedema and hyperkalaemia. 000
Reposted by @geddescc.bsky.socialFriends of Glasgow Royal Infirmary @friendsofgri.bsky.social · 25/03/2026Cannot wait for you to see what we have been doing Rottenrow: the Birth of a City Opening in April. We think it is our best exhibition yet.... Foyer glow up and some serious garden improvements coming at the same time @whatsonglasgow.bsky.social 042
Reposted by @geddescc.bsky.socialJD Foster @kidneyvet.bsky.social · 19/03/2026Yes- horses can get membranous nephropathy! Really nice spikes and holes on the silver stain and subepithelial complexes confirmed on EM. This horse had nephrotic edema and hypoalbuminemia. UPC was 5.8. #vetneph 143
Reposted by @geddescc.bsky.socialAmerican Journal of Kidney Diseases @ajkd.bsky.social · 17/03/2026Effectiveness and Safety of Apixaban Initiation Following Newly-Diagnosed Atrial Fibrillation in Patients With Kidney Failure on Hemodialysis bit.ly/44IMgkk 012
Reposted by @geddescc.bsky.socialSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 15/03/2026The Armanni-Ebstein (not Epstein😅) lesion in a nondiabetic patient The glycosuria from flozination can cause these, very interesting phenomenon www.kidney-international.org/article/S008... in Kidney International #RenalPath 083
Reposted by @geddescc.bsky.socialSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 27/02/2026Interesting POV on new therapies in glomerular diseases in NDT #Free academic.oup.com/ndt/article/... What Jon Barratt calls palliative, others call supportive, these call ‘foundational’. RASi and Flozins ✅evidence for BP is opinion I think? But cost issues are huge, as shown here. 463
Reposted by @geddescc.bsky.socialSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 20/02/2026Remembering Claudio Ponticelli www.kidney-international.org/article/S008... In Kidney International 1156
geddescc.bsky.social @geddescc.bsky.social · 19/02/2026Is there evidence to support diastolic targets though? Why not keep it simple with only systolic targets? My understanding is isolated diastolic hypertension not a risk factor. But would be keen to know if there is evidence to the contrary especially in CKD 130
geddescc.bsky.social @geddescc.bsky.social · 18/02/2026I think the lesson is to do the research before mandating this type of thing even if it seems like a really good idea 011
geddescc.bsky.social @geddescc.bsky.social · 03/07/2025Great paper from UK RaDaR dataset on outcomes in adult and childhood nephrotic syndrome journals.lww.com/jasn/fulltex...journals.lww.comLong-Term Outcomes in Nephrotic Syndrome by Kidney Biopsy... : Journal of the American Society of Nephrologysociated with good kidney outcomes at 10 years.Monogenic nephrotic syndrome cases had very high proteinuria and rapid progression to kidney failure with little response to current treatments. Backgro... 010
Reposted by @geddescc.bsky.socialEdgar V. Lerma 🇵🇭 @edgarvlermamd.medsky.network · 08/06/2025A stylized representation of the unmet need in a typical adult patient with IgA Nephropathy #IgAN ca. 2024 #ERA25 🇦🇹 #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/39211339/ 121
Reposted by @geddescc.bsky.socialJayana Devathasan @jyndvthsn.bsky.social · 05/06/202510 years of SGLT2i trials shared by Dr Kaitlyn Mayne at #era25! 043
Reposted by @geddescc.bsky.socialKate Stevens @kateisabelle24.bsky.social · 03/06/2025Disease-modifying anti-nephropathic drugs ‘DMANDs’ in NDT this month @ndt-era.bsky.social The right drug for the right patient…that’s how we keep changing the story for patients with kidney disease academic.oup.com/ndt/article/...academic.oup.comDisease-modifying anti-nephropathic drugs (DMANDs)—a definition proposed by the Immunonephrology Working Group (IWG) of the European Renal Association (ERA)ABSTRACT. A definition of ‘disease modification’ for kidney disease is long overdue. Here, we propose three key criteria for disease modification in immune 042
Reposted by @geddescc.bsky.socialSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 02/06/2025Foundational therapies in ESRD for heart failure Dr Matt Graham-Brown from Leicester presents at #NephGR www.youtube.com/watch?v=Ar11... (Rounds from Feb, late share!)youtube.comFoundation therapies for heart failure in end stage kidney disease with Dr Matt Graham-BrownYouTube video by Ottawa Nephrology 092
geddescc.bsky.social @geddescc.bsky.social · 29/05/2025KFRE underestimates risk in people with CKD and frailty journals.lww.com/cjasn/abstra...journals.lww.comFrailty in Adults with Chronic Kidney Disease and... : Clinical Journal of the American Society of Nephrologyaim was to validate KFRE by frailty status and assess whether model performance could be improved by using cystatin based estimated glomerular filtration rate (eGFR) equations and to assess the impact... 042
geddescc.bsky.social @geddescc.bsky.social · 28/05/2025The remaining challenge is measuring BP by standardized method. Very few clinics can do it in Scotland. Is the same true in Canada? pubmed.ncbi.nlm.nih.gov/39638870/pubmed.ncbi.nlm.nih.govBlood pressure measurement technique in clinical practice in the NHS Greater Glasgow and Clyde - PubMedBlood pressure (BP) measurement is a common procedure conducted in various disciplines and is widely available on clinical reports. The diagnosis and management of hypertension require reliable measur... 010
Reposted by @geddescc.bsky.socialRémi Goupil @goupilremi.bsky.social · 28/05/2025That’s what we just did in Canada! Target is SBP < 130 mmHg for all www.cmaj.ca/content/197/... 021
geddescc.bsky.social @geddescc.bsky.social · 27/05/2025So we should remove diastolic targets from guidelines no? @hswapnil.medsky.social 112
Reposted by @geddescc.bsky.socialKidney International @kidneyint.bsky.social · 27/05/2025A randomized controlled trial of intravenous immunoglobulin vs standard of care for the treatment of chronic active antibody-mediated rejection in kidney transplant recipients doi.org/10.1016/j.kint.2025.04.023 #NephSky #MedSky @dialysisbloke.bsky.social #kidneytransplant #KTx 053
geddescc.bsky.social @geddescc.bsky.social · 15/05/2025It is not lack of capacity driving this in Scotland. It is patient choice. 020
Reposted by @geddescc.bsky.socialSTITCHES Medicine - the Best of Medical Research @medicine.stitches.today · 06/05/2025Discontinuing aspirin during surgery for chronic subdural hematoma did not lower recurrence rates compared to continuous treatment. by Kamenova M, Pacan L (...) Soleman J et 9 al. in JAMA Neurol #MedSky 👉 get more here 📖 read the article: jamanetwork.comAspirin Continuation or Discontinuation in Surgically Treated Chronic Subdural HematomaThe SECA randomized clinical trial assesses the risk of recurrence of chronic subdural hematoma (cSDH) and cardiovascular events in patients undergoing surgical treatment for cSDH with continuous vs discontinuous low-dose acetylsalicylic acid treatment. 031
geddescc.bsky.social @geddescc.bsky.social · 24/04/2025Come to #ERA2026 in Glasgow @hswapnil.medsky.social . It will be a great meeting and we will make you very welcome. 021
Reposted by @geddescc.bsky.socialFriends of Glasgow Royal Infirmary @friendsofgri.bsky.social · 24/04/2025#archive30 #day24 It's very hard to choose 😵💫 But this is a pretty #popularitem - an original X ray tube Plus the man who set up the world's very first X ray department in 1896 at #glasgowroyalinfirmary our medical electrician Dr John McIntyre ❤️ @arascot.bsky.social 061
Reposted by @geddescc.bsky.socialSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 16/04/2025This seems like a - let us write more guidelines that will get heavily cited and boost my h-index - piece I will argue we need less guidelines They should be like wars - waged only when absolutely necessary (stealing from @cardiobrief.bsky.social Larry Husten www.forbes.com/sites/larryh...)forbes.comWhy Health Guidelines Should Be Waged Like WarUpdated Here's a modest proposal: we need fewer and shorter guidelines. In fact, I'd like to propose that guidelines, like war, should be waged only when there is absolute consensus and overwhelming e... 282
Reposted by @geddescc.bsky.socialScience Magazine @science.org · 11/04/2025Exclusive: Towana Looney, a 53-year-old woman who received a kidney from a gene-edited pig on 25 November 2024, had it removed last week after the organ suddenly stopped functioning, Science has learned. scim.ag/3EiaJmMscim.agLongest human transplant of pig kidney failsIn latest xenotransplant test, Towana Looney’s body rejects gene-edited organ after more than 4 months 06727
Reposted by @geddescc.bsky.socialSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 10/04/2025Overall they sleep poorly Median ~ 6.5 hours - and look at the spread 2/ 141
Reposted by @geddescc.bsky.socialSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 10/04/2025Very interesting pilot trial from @bhanu24.bsky.social and colleagues in @ajkd.bsky.social Renal Denervation in .....loin pain hematuria syndrome! www.ajkd.org/article/S027... #NephSkyajkd.orgRenal Denervation in Loin Pain Hematuria Syndrome: A Pilot Randomized Controlled TrialLoin pain hematuria syndrome (LPHS) is a rare disease characterized by severe, unrelenting unilateral or bilateral loin pain localized to the kidney but not caused by any identifiable urinary tract di... 222
Reposted by @geddescc.bsky.socialHeather Badenoch 🇨🇦 @heatherbadenoch.bsky.social · 08/04/2025Nearly all patient representatives on the Organ Procurement and Transplantation Network board have resigned. #MedSky 022
Reposted by @geddescc.bsky.social😱 Spooky SpectreKILLoquy 🔪 🩸 @caulimovirus.bsky.social · 05/04/2025hyponatremia: serum sodium tells us where you are and urine osm/lytes tell us how you got there 3465
geddescc.bsky.social @geddescc.bsky.social · 03/04/2025Contrary to other studies we observed highest incidence of thrombotic events in min change but we analysed events per month of NS. So maybe nothing special about membranous other than NS is sustained for longer than other causes? pubmed.ncbi.nlm.nih.gov/27669572/pubmed.ncbi.nlm.nih.govVenous Thromboembolism in Primary Nephrotic Syndrome - Is the Risk High Enough to Justify Prophylactic Anticoagulation? - PubMedPatients with primary NS are at an increased risk of VTE. The timing of VTE means that only half of episodes would be targeted by prophylactic anticoagulation. Given the low frequency of events, a wel... 011
geddescc.bsky.social @geddescc.bsky.social · 03/04/2025Could it be that higher incidence of thrombotic events in the first 6m is because some NS scenarios involve imbalance of protein loss in favour of thrombosis and some don’t? So what remains after a few months is latter (who by implication will be harmed by anticoag because they never needed it) 000
geddescc.bsky.social @geddescc.bsky.social · 03/04/2025We’re no further forward after 30 years of debate. Producing detailed treatment algorithms based on flawed observational evidence makes the RCTs the authors cry out for less likely to happen. Recommending a “Highly personalised” approach is code for “we don’t know”. 000
Reposted by @geddescc.bsky.socialFriends of Glasgow Royal Infirmary @friendsofgri.bsky.social · 03/04/2025#archive30 #day3 #soundandvision #musicinthegri our concert series, a wonderful project instigated & led by Arthur Doyle, a man who definitely has vision & makes some wonderful sounds on his violin. The last concert in GRI was in1883; recitals were a common means of raising £ in the days pre #nhs 172
Reposted by @geddescc.bsky.socialKidney International @kidneyint.bsky.social · 27/03/2025Anti-Nephrin Antibodies in Adult Chinese Patients with Minimal Change Disease and Primary Focal Segmental Glomerulosclerosis doi.org/10.1016/j.kint.2025.02.028 #NephSky #MedSky #minimalchangedisease #FSGS #IgG #IgM #focalsegmentalglomeruloscelrosis 061
geddescc.bsky.social @geddescc.bsky.social · 27/03/2025Delivering a trial with adequate power to answer the question of anticoagulation and AF should now be a priority for the nephrology community. journals.lww.com/jasn/abstrac...journals.lww.comAnticoagulation for Patients with Atrial Fibrillation... : Journal of the American Society of Nephrologyagulation (n=48).Despite coronavirus disease–related pauses, recruitment was completed in 30 months, with 83% of participants completing follow-up in their assigned treatment arm. Background Atrial... 020
geddescc.bsky.social @geddescc.bsky.social · 26/03/2025Haven’t entered for #nephmadness for couple of years as Twitter toxic. Really enjoyed entering for 2025. Excellent CME. Great work as ever from all involved. mild dismay at infiltration of “… up to x%” instead of “approximately x%” from general journalism in to nephrologist prose. up to x = 0 to x 🫣 011
Reposted by @geddescc.bsky.socialAmerican Journal of Hypertension @amjhypertension.bsky.social · 25/03/20255 minute resting + 60 seconds between measurements is the current standard for Blood Pressure Could 3 minutes resting + 30 seconds between measurements also work? from @spjuraschek.bsky.social et al 🔗 academic.oup.com/ajh/article/... 🔓 #OpenAccess #Free 086
Reposted by @geddescc.bsky.socialSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 19/03/2025So @danfuster.bsky.social and colleagues seem to find HCTZ doesn’t work for anything! In a post hoc analysis of NOSTONE (where CT scans were done in all & repurposed for calculating bone density) HCTZ doesn’t increase it vs placebo journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social 165
Reposted by @geddescc.bsky.socialZaven Sargsyan @sargsyanz.bsky.social · 18/03/2025ACEi and ARBs are not “nephrotoxic.” We all know about their long term renal protective benefits… But even in the short term, they improve renal blood flow! They do reduce GFR and impair K+ excretion, which is why we might hold them for a bit in AKI. But bad for kidneys? No 173
geddescc.bsky.social @geddescc.bsky.social · 12/03/2025More evidence that DDAVP is not useful to reduce the risk of kidney biopsy bleeding journals.lww.com/kidney360/ab...journals.lww.comEffect of Desmopressin in Post Kidney Biopsy Bleeding... : Kidney360 010
Reposted by @geddescc.bsky.socialZaven Sargsyan @sargsyanz.bsky.social · 11/03/2025I've never been to an M&M about kidney injury attributable to iodinated contrast. I've been to several M&Ms for adverse outcomes from missed/delayed diagnoses because people hesitated to use IV contrast for fear of what we now know to be a ghost 4287
Reposted by @geddescc.bsky.socialFriends of Glasgow Royal Infirmary @friendsofgri.bsky.social · 08/03/2025Did you catch our smallpox exhibition yet? Still plenty of time and it is well worth a view -even if we do say so ourselves 😜 We include several old newspaper clippings from the last outbreak in Glasgow in March 1950. The parallels with the covid pandemic make for interesting reading.... 0209
![Figure 1:The four established pillars supporting the diagnosis and management of CKD in glomerulonephritis: kidney histology, optimal blood pressure control, RAS blockade, and SGLT2 inhibition. These form the foundation of current best practice, highlighting the challenge for emerging therapies to integrate into this already optimized framework while still demonstrating additional benefit. The new treatment options for IgA nephropathy include targeting APRIL, BAFF, complement, and CD38, as well as combined AT1 and endothelin receptor inhibitors, and extended-release intestinal budesonide. Illustration created with BioRender and adapted from Li et al., 2025 [49].](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:33h4q6nw674jdcwfxaq2m2nl/bafkreibe6r5nknp6zjzmgwf3t2dgrazhkfvoycuzobvwtczkkz5jubl5uy)
![annual treatment costs of new therapies vary by region, with sparsentan ranging from €56 640 in Germany to $118 800 in the USA [43, 44], slow-release budesonide from €126 655 to $174,00 0 [45], and Iptacopan from €460 510 to $550 377 [45]. Anti-APRIL and anti-BAFF therapies are expected to be in the range of €100 000–150 000 or $100 000–150 000 per patient per year [46]. It is estimated that ~400 000 patients with IgA nephropathy live in the EU and the USA combined, and up to 50% of them may be eligible to receive these new therapies [47, 48].
Given these expenses, the revenue generated by the new specific therapies should be sufficient to support outcome studies conducted on a background of up-to-date therapies, particularly SGLT2 inhibition, as outlined before. At the same time, this is also a call to action for all nephrologists managing patients with glomerular diseases: novel and expensive therapies should not be prescribed uncritically before ensuring that the four fundamental pillars of supportive care are fully in place for at least several months, as demonstrated in the STOP-IgA trial [39].](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:33h4q6nw674jdcwfxaq2m2nl/bafkreiba5o4li72zhbaaipuqlkikslqikj6xmr5pe3dpdxvejfrmcwmzc4)
