The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...

Recent clinical trials show that serotonergic psychedelics, including the prototypical hallucinogen lysergic acid diethylamide (LSD), possess a great …

Low frequency brain waves convey information between regions. Here, the authors demonstrate that for patients with major depression, mood becomes more negative as low frequency waves increase intensit...

Stress is a critical risk factor for the development of psychological disorders, including anxiety and post-traumatic stress disorder (PTSD). Key brain regions, including the basolateral amygdala (BLA...

Psychedelic Medicine Podcast with Dr. Lynn Marie Morski · Episode

Chronic stress activates Rap1 in vHPC PNs to promote anxiety-like behaviors by increasing their intrinsic excitability.

Studies of psychedelic use in naturalistic and clinical settings have suggested safety and mental health benefits for adults with histories of childho…

Major depressive disorder (MDD) remains a leading cause of disability worldwide, with current treatments limited by delayed onset and low efficacy. The serotonergic psychedelic N,N-dimethyltryptamine ...

The appropriate and rapid encoding of stimuli bearing a negative valence enables behaviors that are essential for survival. Recent advances in neuroscience using rodents as a model system highlight th...

Pain and welfare monitoring is essential for ethical animal testing, but current cage-side assessments are qualitative and subjective. Here we present the GrimACE, the first fully standardised and aut...

The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

Molecular Psychiatry - Coding principles and mechanisms of serotonergic transmission modes

The neural basis of affect sharing is not fully understood. Here, the authors show that the anterior cingulate cortex (ACC) stably recruits neural ensembles encoding observational fear, specifically r...

We propose six actionable steps of allyship that researchers, faculty members and educators can engage in to foster a diverse, equitable and inclusive academia: listening to marginalized voices, challenging one's own biases, speaking up to include disadvantaged groups, speaking out to confront bias, advocating for inclusive policies and dismantling institutional biases.

The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous variety of projection neurons a...

Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range...

Through circuit dissection in juvenile, adolescent and adult mice, Klune, Goodpaster and colleagues reveal multiple developmental switches in mPFC–NAc and mPFC–BLA pathways that underlie developmental...

Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain path...

Background and Objectives Whereas adverse early life experiences (ACEs) correlate with cognitive, emotional and physical health at the population level, existing ACEs screens are only weakly predictiv...

Pyramidal cells are classically thought to comprise the excitatory output of the subiculum. Here, the authors show the existence of “ovoid cells”, excitatory subiculum neurons with specialized gene ex...

Rationale Alcohol is one of the most frequently used drugs of abuse and has a major impact on human health worldwide. People assigned female at birth and those with adverse childhood experiences are s...

Munguba et al. use behavioral pharmacology, viral tracing, optogenetics-guided electrophysiology, and projection-targeted photopharmacology to pinpoint distinct anxiolytic effects on spatial versus so...

The default mode network (DMN) is implicated in cognition and behavior. Here, the authors show that the DMN is cytoarchitecturally heterogeneous, it contains regions receptive to input from the sensor...

Psilocybin is a serotonergic psychedelic with therapeutic potential for several neuropsychiatric disorders, including depression and anxiety disorders…

Author will highlight the ‘enormous disadvantage’ handed to children without access to books, and call on government to improve early-years literacy

Although combat-deployed soldiers are at a high risk for developing trauma-related psychopathology, most will remain resilient for the duration and af…

This study models early life stress (ELS) to observe sex-specific effects on fear memory formation using innovative unsupervised classification together with cellular metabolism alterations in key str...

Job Title: Associate or Senior Editor, Nature Neuroscience Location: New York, Jersey City, Philadelphia or Berlin Application Deadline: January 6, 2025 About Springer Nature Group Springer Nature ope...

Although the basolateral amygdala (BLA) and corticotropin releasing hormone receptor type I (CRHR1) signaling are both central to the stress response,…

Depression is a stress-associated disorder, and it represents a major global health issue. Its pathophysiology is complex and remains insufficiently understood, with current medications often showing ...

Nature Reviews Molecular Cell Biology - This Roadmap article discusses recent advances in the production and use of brain organoids to understand brain development and associated disorders. The...