Post-traumatic stress disorder (PTSD) is traditionally viewed as a brain-centered disorder characterized by impaired fear extinction and dysregulated emotional processing. Despite advances in pharmaco...

Molecular Psychiatry - Network adaptability governs resilience and susceptibility to social defeat

Adaptive behavior requires animals to estimate threat, update these estimates following new aversive outcome experiences, and align fear responding to up-to-date estimates. The periaqueductal gray is ...

BackgroundTreatment-resistant depression (TRD) is a major clinical challenge, with many patients failing to respond to conventional antidepressants. Psychede...

Translational Psychiatry - Rapid-acting and neuromodulatory interventions for treatment-resistant OCD: clinical implications in stress reduction

Rationale Psychedelics exhibit rapid, durable therapeutic effects across diverse psychiatric conditions, yet their broad-spectrum psychoactivity poses challenges for clinical translation. Objectives A...

Microglial synapse removal has been heavily studied. Here, the authors reveal roles for microglia in synapse formation by showing that absence of nucleus accumbens microglia during development reduces...

Translational Psychiatry - Modulation of vicarious fear extinction with oxytocin in social anxiety disorder

Translational Psychiatry - Resolving temporal threat uncertainty by observational learning involves the amygdala, hippocampus and anterior insula

Working memory (WM) is a key element of cognition that depends on accurate internal representation of stimuli and often impaired in psychiatric disorders, including schizophrenia. Prior human neuropha...

Comrie et al. show that the hippocampus flexibly represents different alternative possibilities—including paths ahead, behind, and far away—to meet distinct cognitive demands related to decision-makin...

Viral infections during critical periods of pregnancy trigger inflammatory responses that alter offspring brain development and behavior, resulting in psychiatric disorder-associated phenotypes. This...

Human brain activity under psilocybin contains latent temporal structure that improves alignment with ongoing context and covaries with the subjective quality of the psychedelic experience.

In the years since the pandemic and the political turmoil surrounding the American scientific establishment, much time has been spent discussing why science has lost influence on public policy in the ...

A population-scale single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex provides a perspective of the transcriptomic landscape in neurodegenerative and neuropsychiatric disorde...

The dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development, relative stability in midlife and selec...

Neurobiology of spatial memory is not fully understood. Using two behavioral tasks, authors demonstrate that the precision of spatial representations is lower in rats using egocentric coordinates, and...

Click on the article title to read more.

The use of ketamine as a treatment for mood disorders continues to grow in popularity. However, the differences between individuals consuming ketamine within clinical settings and those self-medica...

Depressive and anxiety disorders impose a substantial public health burden, yet current serotonergic therapies are limited by delayed onset, modest remission rates, and adverse side effects. Here w...

Adolescents have impaired fear regulation, especially after chronic stressor exposure. Treatments that typically improve the retention of fear extinct…

The ventral regions of the hippocampus play a crucial role in emotional responses through projections to the hypothalamus. In this context, the ventral hippocampus sends extensive projections to comp...

Neuropsychopharmacology - Modulation of GABA and glutamate by ketamine in depression: A systematic review and meta-analysis of magnetic resonance spectroscopy studies

Advances in areas including genomics, automation and data science, as well as the diversification of therapeutic modalities, have led to a substantial expansion of the drug target landscape in the pas...

Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...

Molecular Psychiatry - Reconciling the neurogenic hypothesis of depression with recent advances in adult hippocampal neurogenesis research in humans

Biomedical artificial intelligence is advancing from tools that answer human-posed questions to agents that ask their own. Guo et al. assess this transition, including scaling logic, autonomous-labora...

Obesity and anxiety often co-occur, but their neural link is unclear. Here, authors show that an Arc-PVN-LHA hypothalamic circuit coordinates HFD-associated anxiety-like behavior and feeding in a stat...

The authors show that reciprocal interactions between cortical areas generate slow dynamics that gradually build consensus across distributed cortical networks, revealing a potential general principle...

During Pavlovian fear conditioning, presentation of a conditioned stimulus, such as a tone, together with an unconditioned stimulus, such as an electrical shock, excites neurons in the lateral amygdal...

Peer-reviewed scientific journal publishing basic neuroscience research in the areas of neuronal plasticity, learning and memory