Journal of Translational Medicine -

Background Current barriers to achieving radical life extension include the inability to use syngeneic, youthful mesenchymal stem cells (MSCs) and the anti-regenerative effects of senescence-associate...

A new letter in the Journal of Translational Medicine argues that a senolytic vaccine study showed real therapeutic benefit in mice but failed to prove selective senescent-cell clearance or genuine

AMP-activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis, which is implicated in metabolic health and disease, as well as in ageing. Here, we show that direc....

Scientists have successfully prolonged the lifespan of animals.

As research into longevity advances, scientists are finding new ways to test a once-speculative idea: that aging itself could become a target of medicine.

New research shows how hard it can be to stop medications once they become routine, even after medical advice shifts.

Exclusive: Prof Jim Al-Khalili says he will offer solution to ‘arrow of time’ problem in Royal Institution lectures

According to a new study, creatine supplementation might help maintain and increase lean mass even without diet or exercise.

Excess sugar consumption is implicated in multiple cancers through insulin resistance, chronic inflammation, and metabolic reprogramming, yet wheth...

Britain’s postwar sugar rationing was an accidental experiment. Decades on, it’s revealing how early diet shapes cancer risk, ageing and eating habits for life.

Researchers are investigating whether food compounds can imitate calorie restriction. The strongest evidence still comes from cells and animals.

Using a genome-wide CRISPR screen, the authors demonstrate that excess cysteine drives mitochondrial iron accumulation and iron–sulfur cluster failure, triggering a distinct iron-dependent cell death ...

The findings explain why the cell prefers glutathione, and may lead to new therapies for certain types of neurodegeneration and cancers.

Existing aging theories describe what changes with age but do not prescribe how to intervene. We propose a control-theoretic framework that is not merely descriptive but prescriptive: it specifies wh

Apple today announced its most advanced health and fitness experience yet, deepening the capabilities of Apple Watch and iPhone as intelligent, science-based tools for personal health.

Nut consumption and the risk of hypertension: a systematic review and dose response meta-analysis of prospective studies

Consuming between 30-35g of nuts daily was linked with a 26% lower risk of hypertension.

WASHINGTON, DC — A new peer-reviewed review published in the journal Biology argues that much of the debate over whether plant-based diets deliver enough iron, protein, creatine, and other nutrients r...

: Although complementary and alternative medicine (CAM) practices are widely used across the US population, population-level associations with mortality remain understudied. This study examined explor...

Anti-aging advice is everywhere. After all, who doesn’t want to live a longer, healthier life?But according to Arizona State University researcher Connor Sheehan, not every wellness practice promoted ...

This study identifies oligodendrocytes as active contributors to cognitive decline in aging, by leveraging a unique human brain bank with more than 70 years of associated cognitive data combined with ...

Brain cells that produce the protective coating around nerve fibres can become dysfunctional with age and may actively contribute to cognitive decline, according to new research.