The first comprehensive, multi-task, multi-omic benchmark for LLMs in aging biology. Five compact Longevity-LLMs from Insilico Medicine beat frontier models on aging tasks.

Introduction and Objective: Diabetic foot ulcers (DFUs) are chronic, slow-healing wounds characterized by unresolved inflammation affecting a significant p

Profiling the aging nonhuman primate small intestine at single-nucleus resolution, Li et al. identify barrier dysfunction, inflammation, stem cell fate bias and a decline in NCoR1 levels. Metformin tr...

PKMYT1, a member of the WEE family of kinases that regulates mitotic entry by phosphorylating CDK1 at Thr14, has recently gained prominence as a promising synthetic lethal target for oncology. Sinc...

Background DNA methylation plays a key role in mediating the anti-aging effects of glucose-lowering drugs. This study aims to systematically explore the potential anti-aging effects of target genes of...

A hybrid model combines quantum and classical approaches to generate compounds targeting the KRAS protein.

Pharmaceutical firms are turning to AI to find new molecules that might be able to tackle disease.

Since the deep learning revolution of the early 2010s, significant efforts and billions of dollars have been invested in applying artificial intelligence (AI) to drug discovery and development (AIDD)....

Background Recent advancements in artificial intelligence have revolutionized dermatological diagnostics. These technologies, particularly machine learning (ML), including deep learning (DL), have s.....

Generative artificial intelligence is used to design an effective treatment for inflammatory bowel disease in preclinical models.