Physiological homeostasis is traditionally viewed as an individual process optimized through evolution to minimize the energetic costs of regulation. However, it remains unknown whether social proximi...

Perez, Schoenfeldt et al. present an integrated platform and methodology combining automation and machine learning to evaluate thousands of conditions across >400 compounds in yeasts, nematodes, flies...

This study shows that the brain arises from two distinct progenitors: one forms the forebrain and midbrain, whereas the other generates the hindbrain. These insights enable the generation of human hin...

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Interrogating the role of the microbiome in aging, here the authors utilize multi-omics human cohort data to show that the abundance of Bifidobacterium pseudocatenulatum and its metabolite 5-aminovale...

The responsiveness of 16 different epigenetic aging clocks to a broad array of pharmacological and lifestyle interventions in humans was assessed across 51 different longitudinal studies, providing in...

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Glucagon-like peptide-1 receptor agonists engage AMPK–PGC-1α signaling to remodel mitochondrial biogenesis, dynamics, and quality control, but downstream effects are context-dependent and tissue-spec...

The US science-funding agency is withholding $1 billion of its budget so that the money can go to a special White House project.

Because of population aging and morbidity expansion, extending healthspan has become a global challenge and it is required to elucidate molecular mechanisms ...

A study tracking more than 340,000 adults for over a decade found that heavy drinking increased the risk of death regardless of beverage type. At lower levels, however, the picture became more surpris...

Senescent myoblasts exhibit dysregulated Akt/mTORC1 signalling. Antioxidants can alleviate this dysregulation, as well as other downstream senescent phenotypes. Moreover, prolonged antioxidant treatm...

Mitochondrial dysfunction features prominently in tauopathies. The mechanistic link between tau and mitochondria remains uncertain. Li et al. show that tau enters mitochondria and interacts with compl...

There is a positive association between hormone therapy and cognitive performance in postmenopausal women, particularly in age groups with the steeper decline. In addition, there is no significant ass...

Neuronal and glial mitochondria support neuronal circuit function and plasticity through the supply of energetic substrates and the regulation of cellular physiology. Sandi and colleagues describe how...

Translational Psychiatry - Stress-coping phenotypes shape adipose tissue function and plasticity and modulate metabolic resilience

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Introduction: Several human trials have used the mitochondrial antioxidant mitoquinol mesylate (MitoQ). There are no apparent negative consequences on the kidneys following an acute high dose of MitoQ...

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High-dose DHA achieved CNS target engagement in non-demented older adults with low baseline omega-3 intake, independent of APOE ε4. Despite biochemical target engagement, no differences in cognition o...

Mitochondrial decline impairs late-life metabolic plasticity. Using nematodes and human data, this study identifies reduced phosphatidylcholine synthesis as a natural trigger of mitochondrial dysfunct...

Claims about the upper limits to human lifespan are characterized by hype, deficient data and shoddy science, says longevity researcher Saul Newman.

Medium-chain triglycerides (MCT) are emerging as unique dietary supplements that are potentially relevant for the amelioration of brain dysfunctions. …

Classifying ovaries solely as reproductive organs has obscured their role as systemic regulators of female physiology. This Perspective discusses that ovarian aging is a primary determinant of…

A drug combo widely explored for anti-aging may actually damage the brain, according to new mouse research showing severe loss of myelin and changes linked to “chemo brain.” Surprisingly, the damaged ...

Slow-paced breathing (SPB) is commonly used to promote autonomic regulation and emotion regulation, but its effects on emotional memory, and whether t…

A letter from 11 Republican representatives has caught the White House’s attention.

Background: Vascular endothelial dysfunction is a key antecedent to cardiovascular diseases (CVD) in older adults. Reduced nitric oxide (NO) bioavailability secondary to excess mitochondria-related re...

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A multiyear effort to rename polycystic ovary syndrome finally revealed the condition’s new name: polyendocrine metabolic ovarian syndrome

Mice overexpressing Has2 from the naked mole-rat showed an increase in hyaluronan levels in several tissues, and a lower incidence of spontaneous and induced cancer, attenuated inflammation through se...

So many women feel like their body has suddenly turned against them—weight gain, fatigue, brain fog, and rising inflammation—despite doing all the right things. But this isn’t a failure of effort. It’...

How metabolism shapes dendritic cell (DC) immunogenicity is debated—while glycolysis activates, OXPHOS implies tolerance. Heras-Murillo et al. find that ETC electron flow primes cDC1s via redox/metabo...

Exogenous ketone supplementation acutely elevates circulating beta-hydroxybutyrate (R-BHB), but the impact of chronic repeated dosing on exercise performance, cognition, mood, and cardiometabolic h...

We analyzed the association between RDW and skeletal muscle mitochondrial energetics and how skeletal muscle mitochondrial energetics may mediate the associations of RDW with physical and cognitive pe...

Health Secretary Robert F. Kennedy Jr. is launching a new podcast called “The Secretary Kennedy Podcast.” It aims to bring “radical transparency in government.”

Pacing and hair pulling may develop after multiple experiments, years of relative isolation, and more