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Nature Chemistry - Michelle Francl puts the early women of chemistry, who were ignored at the time, back into the picture.

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Polyunsaturated fatty acid (PUFA) synthase enzymes are best known for their role in membrane lipid biosynthesis in marine psychrophilic bacteria but have also evolved to assemble specialized lipid-con...

Covering literature to September 2025 This review provides a comprehensive account of the 217 natural product inspired antibiotics that have been approved for human use from 1943 through to September…

Covering: up to 2025 Modular polyketide synthases (PKSs) are often described as molecular-scale assembly lines – a moniker that implies a high-degree of coordinated and regulated activity. Belying…

Covering: 2000 to August 2025 The search for new antimicrobial natural products from microorganisms has been limited by the transcriptional silencing of biosynthetic genes when microbes are…

Nature Reviews Microbiology - In this Review, Dinglasan and colleagues explore innovations that facilitate rapid microbial secondary metabolite discovery, focusing on recent techniques for the...

The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

Alessandra Eustaquio, Eriko Takano and Tobias Gulder introduce the Natural Product Reports themed issue on microbial host and metabolic engineering for natural product discovery and production.

After decades, scientists have finally pieced together the 23-step biosynthetic pathway to produce this cancer drug

Covering: 2013 to 2023 In this review, we analyzed the scientific literature of the period 2013–2023 that reported novel specialized metabolites from the Actinomycetes, one of the most prolific…

Microbial synthetic biology might greatly benefit from the application of non-model organisms, which have been evolutionarily optimized for the production of specific proteins and metabolites. This Review discusses the design and application of endogenous production in non-model organisms.

ALT: woody and buzz lightyear from toy story are standing next to each other with the caption smoke everywhere

Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we disc...

Covering: 2014 to 2024 Since the dawn of human history, caves have played an intimate role in our existence. From our earliest ancestors seeking shelter from the elements to more recent generations…

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

Triculamin is a ribosomally synthesized and post-translationally modified peptide (RiPP) lasso peptide with potent antimycobacterial activity, produced by an unusual, non-canonical biosynthetic gene ...

Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately 5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted and cohesive...

“My mom, auntie and grandma have all had cancer, so it makes me happy that something I found could help,” said Camarria Williams.