Aske Merrild @amerrild.bsky.social · 16/05/2026Our new paper is out: In this paper, we continue our work on gelatinamin, a lasso peptide that we previously discovered due to its sequence similarity and peculiar evolutionary relationship to triculamin. doi.org/10.1002/cbic... 110
Reposted by Aske MerrildbioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/12/2025Biosynthesis, Structure, and Antibiotic Properties of Gelatinamin A, a Triculamin-like Lasso Peptide www.biorxiv.org/content/10.64898/20… 011
Aske Merrild @amerrild.bsky.social · 02/02/2025>80 grams of engineered lasso peptide from 20 L E. Coli fermentation broth. This and more amazing results from Lassogen in preprint. 010
Reposted by Aske MerrildChekan Lab @chekanlab.bsky.social · 16/01/2025We are excited to see our review published! In it, we explore the diversity of enzymatic strategies for installing aromatic side chain cross-links in RiPPs. If you like interesting chemistry and new enzyme reactions, be sure to check it out! 0185
Reposted by Aske MerrildDr Katherine Duncan @kateduncan.bsky.social · 19/10/2024I’m not entirely sure how these starter packs work… but I’ve created one for microbial natural products - hopefully it helps us connect! go.bsky.app/72NeGsT 2118
Reposted by Aske MerrildThomas Tørring @thomastorring.bsky.social · 22/12/2024A Christmas present to all of the lasso peptide connoisseurs out there. The next chapter in our work is on triculamin is ready on bioRxiv. Great work by two incredibly talented graduate students @amerrild.bsky.social and @tizianasvenningsen.bsky.social. www.biorxiv.org/content/10.1...biorxiv.orgConvergent Evolution of the Antimycobacterial Lasso Peptide TriculaminTriculamin is a ribosomally synthesized and post-translationally modified peptide (RiPP) lasso peptide with potent antimycobacterial activity, produced by an unusual, non-canonical biosynthetic gene c... 22011
