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Eugene Valkov

@eugenevalkov.bsky.social
3.1K followers 2.8K following 766 posts

mRNA regulation & decay | biochemistry | structural biology | molecular biology | cancer All views are personal. Google Scholar: tinyurl.com/EuValScholar ORCID: 0000-0002-3721-1739

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Eugene Valkov @eugenevalkov.bsky.social · 25/09/2026
Nonsense-mediated decay
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Eugene Valkov @eugenevalkov.bsky.social · 25/09/2026
Synthetic lethality
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Eugene Valkov @eugenevalkov.bsky.social · 25/09/2026
Targeted decay
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Eugene Valkov @eugenevalkov.bsky.social · 12/09/2026
Without saying your age, what is your favorite movie that came out when you were 20 years old?
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Gandalf's Iconic 'Fly, You Fools!' Line
ALT: Gandalf's Iconic 'Fly, You Fools!' Line
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Max-Planck-Gesellschaft @maxplanck.de · 09/09/2026
We are hiring! Start at a #MaxPlanckInstitute with your own independent Max Planck Research Group. This position is equivalent to a W2 Professorship at a German university, or Associate Professor internationally. 🔗Apply until October 14th! www.mpg.de/career/max-p... #ScienceCareer #MPRG #TenureTrack
Call for independent Max Planck Research Groups
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Eugene Valkov @eugenevalkov.bsky.social · 08/09/2026
Beautiful work. Congratulations to all involved!
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Sebastian Falk @sebastianfalk.bsky.social · 08/09/2026
Proud to see this preprint from @virginiabusetto.bsky.social out today — she's uncovered how a pseudohelicase-centered complex couples RNA cleavage to poly(UG)ylation. Beautiful mechanistic work from the lab, go check out the thread! 🧵
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Drummond Lab @drummondlab.bsky.social · 08/09/2026
We are hiring! 🌟 Dept of Biochemistry and Molecular Biology at the University of Chicago is searching for a tenure-track assistant professor. It's a broad search: we want great colleagues doing serious biological work at the molecular scale. Join us! apply.interfolio.com/191981 bcmb.uchicago.edu
A picture of the University of Chicago campus, with downtown Chicago in the distance and Lake Michigan on the horizon. The campus's central quad is pictured, a classical collegiate quad with paths and old trees and stone architecture. It's really pretty and I love it.
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The Royal Society @royalsociety.org · 28/08/2026
The Francis Crick Medal and Lecture 2027 is awarded to Dr Thi Hoang Duong (Kelly) Nguyen for her ground-breaking discoveries into the molecular mechanisms of telomere maintenance. #RSMedals royalsociety.org/medals-and-prizes/…
A woman in a blue top with a small colourful pattern smiles at the camera in front of a white background.
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Eugene Valkov @eugenevalkov.bsky.social · 04/09/2026
Sandals. No lab coat. PI-level stuff
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Eugene Valkov @eugenevalkov.bsky.social · 27/08/2026
What would happen if we stopped spending $3.7B on APCs? Where could all that money go instead? 🤔
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Eugene Valkov @eugenevalkov.bsky.social · 27/08/2026
UCSF is recruiting. Top notch science environment in an amazing location
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Eugene Valkov @eugenevalkov.bsky.social · 27/08/2026
I thought initially this was the first evidence of minions in Ancient Greece
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Sebastian Baumgarten @sebbaumgarten.bsky.social · 19/08/2026
The singular job of all known ribosomes: synthesizing protein. Enter the malaria parasite. In our new work, we show that Plasmodium evolved an entire new kind that does just the opposite - inhibit mRNA translation. www.biorxiv.org/content/10.6...
biorxiv.org
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Drew Scanlon @drewscanlon.bsky.social · 24/08/2026
Hi Internet! I'm Drew and THIS IS MY FACE. If this GIF has ever brought you joy in the past, I humbly ask you to consider making a donation to the National MS Society. It would mean a lot to me and to those I know affected by the disease! Donate at blinkingguy.com
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Eugene Valkov @eugenevalkov.bsky.social · 24/08/2026
Make a band bigger: Garbage → Landfill
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Admirable Women @admirablewomen.bsky.social · 23/08/2026
Biochemist Florence Seibert developed the Purified Protein Derivative (PPD) in the 1930s. Before her work, TB skin tests were inconsistent & unreliable. Her PPD formula was adopted as the international standard (1952) & remains in use for TB testing today. Died #OTD in 1991. #WomenInSTEM
Vintage black-and-white studio portrait of American biochemist Florence Barbara Seibert (1897–1991), shown from the shoulders up. The young woman has short, dark, wavy 1920s-style hair parted on the side, wears round wire-rimmed eyeglasses, and offers a gentle smile toward the camera. She is dressed in a light-colored blouse with a ruffled collar. A studio imprint reading “A. F. R. S. Chicago” appears in the lower right corner.
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Eugene Valkov @eugenevalkov.bsky.social · 24/08/2026
Exposure to skilled trades in elementary school is fine. Most adults don’t know how to wire a plug. Germany runs a teacher recommendation at 10yo that steers toward university or away from it. Most German states have since scrapped or merged the bottom track because it sorted by class, not aptitude.
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Eugene Valkov @eugenevalkov.bsky.social · 24/08/2026
He is a Frenchman so will see this is as a quest, no doubt
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Eugene Valkov @eugenevalkov.bsky.social · 24/08/2026
lol, I will inquire with my local proprietor of elixirs!
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Eugene Valkov @eugenevalkov.bsky.social · 24/08/2026
I’d try almost anything, once.
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Eugene Valkov @eugenevalkov.bsky.social · 24/08/2026
What on earth is this?
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Matt Higgins @parasitematt.bsky.social · 20/08/2026
How do African trypanosomes regulate the complement system? Check out our new study from @BiochemCook, in which he identified a new trypanosome receptor which binds to the core C3bBb convertase of the complement system and blocks its activity. Real all about it! doi.org/10.64898/202...
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Eugene Valkov @eugenevalkov.bsky.social · 17/08/2026
NIH Intramural Research Program is hiring via the Stadtman program. Prospective candidates should feel free to reach out to me, and I will be happy to share my experience both as an applicant and a panel member- we are looking for great new colleagues! irp.nih.gov/careers/nih-...
irp.nih.gov
Stadtman Tenure-Track Investigators | NIH Intramural Research Program
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David McQuarrie @davidmcquarrie.bsky.social · 01/08/2026
A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins doi.org/10.1093/nar/...
doi.org
A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins
Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz
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Matthew Cobb @matthewcobb.bsky.social · 29/07/2026
It's my thesis that the Habsburg/Hapsburg lip/jaw was noticed as a family trait only in the mid-C19 (so sez ngram viewer), but I can't find any decent historiography of the issue, despite it being so notorious. There's loads of medical speculation, but that's not what I'm after. Any ideas? Pls RT
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Eugene Valkov @eugenevalkov.bsky.social · 28/07/2026
I found little to disagree with in this assessment of the film. An Uncomplicated Man www.lrb.co.uk/the-paper/v4...
lrb.co.uk
Emily Wilson · An Uncomplicated Man
As they say at the awards shows, I was humbled to learn that Christopher Nolan has read at least the first line of my...
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Deva Woodly @devawo.bsky.social · 25/07/2026
Love it when professors stumble into notoriety by doing nothing but their work.
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@JohnGrossSF @johngrosssf.bsky.social · 24/07/2026
Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins | Science Advances www.science.org/doi/10.1126/... Congratulations on this beautiful work!
science.org
Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins
Unexpected flexibility and evolutionary constraints shape how HIV-1 overcomes a key human antiviral protein.
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Quaid Morris @quaidmorris.bsky.social · 21/07/2026
Can we predict which T cells recognize which peptides? A lot of the signal is hiding in AlphaFold3's (AF3's) hallucinations. enFoldX: instead of one predicted structure, we use the whole noisy ensemble to predict TCR:pMHC binding. www.biorxiv.org/content/10.6... 💻 🧬 github.com/jonlevi/enFoldX
biorxiv.org
Ensembles of in silico structures enable T cell peptide-MHC binding prediction
Adaptive immunity relies on T-cell receptor (TCR) recognition of peptides presented by the major histocompatibility complex (pMHC). Accurate prediction of TCR:pMHC binding pairs from sequence data rem...
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Eugene Valkov @eugenevalkov.bsky.social · 19/07/2026
Football wins! Well done Spain!
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Eugene Valkov @eugenevalkov.bsky.social · 19/07/2026
Whenever I go to a kid 🎭 production and read among all the kid bios “I thank baby J for dying for my sins”, I’m like 😳 for the rest of the performance
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Loukas Theodosiou @bioinformatician.bsky.social · 19/07/2026
After four years, several updates and a handful of CRAN releases, 𝗹𝘁𝗰 𝗰𝗼𝗹𝗼𝗿 𝗽𝗮𝗹𝗲𝘁𝘁𝗲 𝗥-𝗽𝗮𝗰𝗸𝗮𝗴𝗲, reached a version I feel genuinely good about sharing with the community. github.com/loukesio/ltc...
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Tatiana Moiseeva @tat1anamoiseeva.bsky.social · 15/07/2026
Our lab at Pitt is looking to hire a technician. Ideal candidate would be a recent graduate with some cell biology skills, looking to expand their experience before applying to a PhD program in a couple of years. If you are this person, interested in DNA replication, please email me. moiseevalab.com
moiseevalab.com
Tatiana Moiseeva Lab
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Eugene Valkov @eugenevalkov.bsky.social · 18/07/2026
Agincourt 2.0 🏴󠁧󠁢󠁥󠁮󠁧󠁿 vs 🇫🇷
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Eugene Valkov @eugenevalkov.bsky.social · 18/07/2026
Google keeps the current internals as a trade secret, so this is the commonly understood outline.
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Eugene Valkov @eugenevalkov.bsky.social · 18/07/2026
The table is maintained continuously, not rebuilt on a schedule. Each page gets re-visited at a rate matched to how fast it changes- a news front page within minutes, a static lab page every few weeks. Steady state with constant turnover rather than periodic overhaul.
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Eugene Valkov @eugenevalkov.bsky.social · 18/07/2026
Think of it as a lookup table built in advance. Rather than storing each page with its words, the engine stores each word with the list of pages it appears in. query pulls two of those lists and takes intersection, which is quick because both are sorted. Relevance and authority scores are computed.
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Eugene Valkov @eugenevalkov.bsky.social · 18/07/2026
An LLM however has no index. It composes the answer token by token, and every token pushes your whole prompt through hundreds of billions of parameters. A few hundred words means a few hundred full passes. Put simply,librarian pointing at a shelf vs. writer drafting a fresh essay, every single time.
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Eugene Valkov @eugenevalkov.bsky.social · 18/07/2026
Google search is basically a lookup. Crawlers indexed billions of pages months ago and pre-computed most of the ranking. Your query just reads that index and returns links. Reading a sorted list is computationally ‘cheap’.
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Alex Cope, PhD (he/him) @alexcope241.bsky.social · 08/07/2026
If anyone is looking for a postdoc/staff scientist with experience in evolutionary genetics, computational biology/bioinformatics, and/or various omics methods (RNA-seq, Ribo-seq, LC-MS/MS), I'm still looking! (1) doi.org/10.1126/scie... (2) doi.org/10.1073/pnas... (3) doi.org/10.1371/jour...
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Eugene Valkov @eugenevalkov.bsky.social · 09/07/2026
Looks like a genuine breakthrough for small(ish) particles
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Sebastian S. Cocioba @atinygreencell.bsky.social · 08/07/2026
@breakliquid.bsky.social and I are delighted to say our OpenEVO preprint is finally live! An open source hand-made turbidostat that's modular, affordable, and made to be customized. Designed with love for the research community. Enjoy!!!💚 www.biorxiv.org/content/10.6...
biorxiv.org
OpenEvo: An Open-Source Platform for Automated Evolution and Analysis
Here we introduce OpenEvo, a fully open-source, low-cost turbidostat platform for automated continuous culture and directed evolution experiments. Existing tools are expensive, complex, or lack open-s...
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Eugene Valkov @eugenevalkov.bsky.social · 06/07/2026
Best team won
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England Fans Cheer: Come On England!
ALT: England Fans Cheer: Come On England!
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Eugene Valkov @eugenevalkov.bsky.social · 04/07/2026
Applied! Thank you for this!
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Eugene Valkov @eugenevalkov.bsky.social · 04/07/2026
Ugh. I asked it to build a disk usage analysis app for my Mac, as a pure test case. It reverted to opus on that too
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Eugene Valkov @eugenevalkov.bsky.social · 04/07/2026
Has anyone been able to use Anthropic’s Fable for any coding task or analysis? It balked and reverted to Opus on literally everything for me
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Eugene Valkov @eugenevalkov.bsky.social · 01/07/2026
I intend to claim back pay if Nature Springer and Elsevier take this up
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Breaking Bad: This Is What We'Ve Been Working For
ALT: Breaking Bad: This Is What We'Ve Been Working For
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De-Sheng Ker @kerds.bsky.social · 30/06/2026
We solved a high resolution structure of the nucleosome core particle directly from nuclear extract from a single T25 flask (3 mL culture). No affinity purification. No sucrose gradients. Just lysate on grids. Raw data available now for anyone who wants to reprocess. www.biorxiv.org/content/10.6...
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Eugene Valkov @eugenevalkov.bsky.social · 27/06/2026
🤣 open.substack.com/pub/inprepar...
open.substack.com
Springer Nature CEO Opens Special Bottle Of Wine Upon News of Open Science Self-Cannibalization
LONDON—Springer Nature CEO Willem Klaassen-Hooft opened a 2016 Châteauneuf-du-Pape he had been saving for the right occasion Tuesday evening after reading that an open science advocate had used AI to ...
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