Eugene Valkov @eugenevalkov.bsky.social · 12/09/2026Without saying your age, what is your favorite movie that came out when you were 20 years old?static.klipy.comGandalf's Iconic 'Fly, You Fools!' LineALT: Gandalf's Iconic 'Fly, You Fools!' Line 131
Reposted by Eugene ValkovMax-Planck-Gesellschaft @maxplanck.de · 09/09/2026We are hiring! Start at a #MaxPlanckInstitute with your own independent Max Planck Research Group. This position is equivalent to a W2 Professorship at a German university, or Associate Professor internationally. 🔗Apply until October 14th! www.mpg.de/career/max-p... #ScienceCareer #MPRG #TenureTrack 0112136
Eugene Valkov @eugenevalkov.bsky.social · 08/09/2026Beautiful work. Congratulations to all involved! 011
Reposted by Eugene ValkovSebastian Falk @sebastianfalk.bsky.social · 08/09/2026Proud to see this preprint from @virginiabusetto.bsky.social out today — she's uncovered how a pseudohelicase-centered complex couples RNA cleavage to poly(UG)ylation. Beautiful mechanistic work from the lab, go check out the thread! 🧵 1205
Reposted by Eugene ValkovDrummond Lab @drummondlab.bsky.social · 08/09/2026We are hiring! 🌟 Dept of Biochemistry and Molecular Biology at the University of Chicago is searching for a tenure-track assistant professor. It's a broad search: we want great colleagues doing serious biological work at the molecular scale. Join us! apply.interfolio.com/191981 bcmb.uchicago.edu 190108
Reposted by Eugene ValkovThe Royal Society @royalsociety.org · 28/08/2026The Francis Crick Medal and Lecture 2027 is awarded to Dr Thi Hoang Duong (Kelly) Nguyen for her ground-breaking discoveries into the molecular mechanisms of telomere maintenance. #RSMedals royalsociety.org/medals-and-prizes/… 3529
Eugene Valkov @eugenevalkov.bsky.social · 27/08/2026What would happen if we stopped spending $3.7B on APCs? Where could all that money go instead? 🤔 042
Eugene Valkov @eugenevalkov.bsky.social · 27/08/2026UCSF is recruiting. Top notch science environment in an amazing location 021
Eugene Valkov @eugenevalkov.bsky.social · 27/08/2026I thought initially this was the first evidence of minions in Ancient Greece 020
Reposted by Eugene ValkovSebastian Baumgarten @sebbaumgarten.bsky.social · 19/08/2026The singular job of all known ribosomes: synthesizing protein. Enter the malaria parasite. In our new work, we show that Plasmodium evolved an entire new kind that does just the opposite - inhibit mRNA translation. www.biorxiv.org/content/10.6...biorxiv.org 18439
Reposted by Eugene ValkovDrew Scanlon @drewscanlon.bsky.social · 24/08/2026Hi Internet! I'm Drew and THIS IS MY FACE. If this GIF has ever brought you joy in the past, I humbly ask you to consider making a donation to the National MS Society. It would mean a lot to me and to those I know affected by the disease! Donate at blinkingguy.com 156200218538
Reposted by Eugene ValkovAdmirable Women @admirablewomen.bsky.social · 23/08/2026Biochemist Florence Seibert developed the Purified Protein Derivative (PPD) in the 1930s. Before her work, TB skin tests were inconsistent & unreliable. Her PPD formula was adopted as the international standard (1952) & remains in use for TB testing today. Died #OTD in 1991. #WomenInSTEM 2306103
Eugene Valkov @eugenevalkov.bsky.social · 24/08/2026Exposure to skilled trades in elementary school is fine. Most adults don’t know how to wire a plug. Germany runs a teacher recommendation at 10yo that steers toward university or away from it. Most German states have since scrapped or merged the bottom track because it sorted by class, not aptitude. 010
Eugene Valkov @eugenevalkov.bsky.social · 24/08/2026He is a Frenchman so will see this is as a quest, no doubt 110
Eugene Valkov @eugenevalkov.bsky.social · 24/08/2026lol, I will inquire with my local proprietor of elixirs! 110
Reposted by Eugene ValkovMatt Higgins @parasitematt.bsky.social · 20/08/2026How do African trypanosomes regulate the complement system? Check out our new study from @BiochemCook, in which he identified a new trypanosome receptor which binds to the core C3bBb convertase of the complement system and blocks its activity. Real all about it! doi.org/10.64898/202... 03913
Eugene Valkov @eugenevalkov.bsky.social · 17/08/2026NIH Intramural Research Program is hiring via the Stadtman program. Prospective candidates should feel free to reach out to me, and I will be happy to share my experience both as an applicant and a panel member- we are looking for great new colleagues! irp.nih.gov/careers/nih-...irp.nih.govStadtman Tenure-Track Investigators | NIH Intramural Research Program 1915
Reposted by Eugene ValkovDavid McQuarrie @davidmcquarrie.bsky.social · 01/08/2026A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins doi.org/10.1093/nar/...doi.orgA multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteinsAbstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz 05722
Reposted by Eugene ValkovMatthew Cobb @matthewcobb.bsky.social · 29/07/2026It's my thesis that the Habsburg/Hapsburg lip/jaw was noticed as a family trait only in the mid-C19 (so sez ngram viewer), but I can't find any decent historiography of the issue, despite it being so notorious. There's loads of medical speculation, but that's not what I'm after. Any ideas? Pls RT 31621
Eugene Valkov @eugenevalkov.bsky.social · 28/07/2026I found little to disagree with in this assessment of the film. An Uncomplicated Man www.lrb.co.uk/the-paper/v4...lrb.co.ukEmily Wilson · An Uncomplicated ManAs they say at the awards shows, I was humbled to learn that Christopher Nolan has read at least the first line of my... 000
Reposted by Eugene ValkovDeva Woodly @devawo.bsky.social · 25/07/2026Love it when professors stumble into notoriety by doing nothing but their work. 011523
Reposted by Eugene Valkov@JohnGrossSF @johngrosssf.bsky.social · 24/07/2026Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins | Science Advances www.science.org/doi/10.1126/... Congratulations on this beautiful work!science.orgStrain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteinsUnexpected flexibility and evolutionary constraints shape how HIV-1 overcomes a key human antiviral protein. 074
Reposted by Eugene ValkovQuaid Morris @quaidmorris.bsky.social · 21/07/2026Can we predict which T cells recognize which peptides? A lot of the signal is hiding in AlphaFold3's (AF3's) hallucinations. enFoldX: instead of one predicted structure, we use the whole noisy ensemble to predict TCR:pMHC binding. www.biorxiv.org/content/10.6... 💻 🧬 github.com/jonlevi/enFoldXbiorxiv.orgEnsembles of in silico structures enable T cell peptide-MHC binding predictionAdaptive immunity relies on T-cell receptor (TCR) recognition of peptides presented by the major histocompatibility complex (pMHC). Accurate prediction of TCR:pMHC binding pairs from sequence data rem... 13114
Eugene Valkov @eugenevalkov.bsky.social · 19/07/2026Whenever I go to a kid 🎭 production and read among all the kid bios “I thank baby J for dying for my sins”, I’m like 😳 for the rest of the performance 010
Reposted by Eugene ValkovLoukas Theodosiou @bioinformatician.bsky.social · 19/07/2026After four years, several updates and a handful of CRAN releases, 𝗹𝘁𝗰 𝗰𝗼𝗹𝗼𝗿 𝗽𝗮𝗹𝗲𝘁𝘁𝗲 𝗥-𝗽𝗮𝗰𝗸𝗮𝗴𝗲, reached a version I feel genuinely good about sharing with the community. github.com/loukesio/ltc... 216940
Reposted by Eugene ValkovTatiana Moiseeva @tat1anamoiseeva.bsky.social · 15/07/2026Our lab at Pitt is looking to hire a technician. Ideal candidate would be a recent graduate with some cell biology skills, looking to expand their experience before applying to a PhD program in a couple of years. If you are this person, interested in DNA replication, please email me. moiseevalab.commoiseevalab.comTatiana Moiseeva Lab 12744
Eugene Valkov @eugenevalkov.bsky.social · 18/07/2026Google keeps the current internals as a trade secret, so this is the commonly understood outline. 130
Eugene Valkov @eugenevalkov.bsky.social · 18/07/2026The table is maintained continuously, not rebuilt on a schedule. Each page gets re-visited at a rate matched to how fast it changes- a news front page within minutes, a static lab page every few weeks. Steady state with constant turnover rather than periodic overhaul. 140
Eugene Valkov @eugenevalkov.bsky.social · 18/07/2026Think of it as a lookup table built in advance. Rather than storing each page with its words, the engine stores each word with the list of pages it appears in. query pulls two of those lists and takes intersection, which is quick because both are sorted. Relevance and authority scores are computed. 150
Eugene Valkov @eugenevalkov.bsky.social · 18/07/2026An LLM however has no index. It composes the answer token by token, and every token pushes your whole prompt through hundreds of billions of parameters. A few hundred words means a few hundred full passes. Put simply,librarian pointing at a shelf vs. writer drafting a fresh essay, every single time. 5233
Eugene Valkov @eugenevalkov.bsky.social · 18/07/2026Google search is basically a lookup. Crawlers indexed billions of pages months ago and pre-computed most of the ranking. Your query just reads that index and returns links. Reading a sorted list is computationally ‘cheap’. 1130
Reposted by Eugene ValkovAlex Cope, PhD (he/him) @alexcope241.bsky.social · 08/07/2026If anyone is looking for a postdoc/staff scientist with experience in evolutionary genetics, computational biology/bioinformatics, and/or various omics methods (RNA-seq, Ribo-seq, LC-MS/MS), I'm still looking! (1) doi.org/10.1126/scie... (2) doi.org/10.1073/pnas... (3) doi.org/10.1371/jour... 01619
Eugene Valkov @eugenevalkov.bsky.social · 09/07/2026Looks like a genuine breakthrough for small(ish) particles 021
Reposted by Eugene ValkovSebastian S. Cocioba @atinygreencell.bsky.social · 08/07/2026@breakliquid.bsky.social and I are delighted to say our OpenEVO preprint is finally live! An open source hand-made turbidostat that's modular, affordable, and made to be customized. Designed with love for the research community. Enjoy!!!💚 www.biorxiv.org/content/10.6...biorxiv.orgOpenEvo: An Open-Source Platform for Automated Evolution and AnalysisHere we introduce OpenEvo, a fully open-source, low-cost turbidostat platform for automated continuous culture and directed evolution experiments. Existing tools are expensive, complex, or lack open-s... 211535
Eugene Valkov @eugenevalkov.bsky.social · 06/07/2026Best team wonstatic.klipy.comEngland Fans Cheer: Come On England!ALT: England Fans Cheer: Come On England! 010
Eugene Valkov @eugenevalkov.bsky.social · 04/07/2026Ugh. I asked it to build a disk usage analysis app for my Mac, as a pure test case. It reverted to opus on that too 100
Eugene Valkov @eugenevalkov.bsky.social · 04/07/2026Has anyone been able to use Anthropic’s Fable for any coding task or analysis? It balked and reverted to Opus on literally everything for me 110
Eugene Valkov @eugenevalkov.bsky.social · 01/07/2026I intend to claim back pay if Nature Springer and Elsevier take this upstatic.klipy.comBreaking Bad: This Is What We'Ve Been Working ForALT: Breaking Bad: This Is What We'Ve Been Working For 120
Reposted by Eugene ValkovDe-Sheng Ker @kerds.bsky.social · 30/06/2026We solved a high resolution structure of the nucleosome core particle directly from nuclear extract from a single T25 flask (3 mL culture). No affinity purification. No sucrose gradients. Just lysate on grids. Raw data available now for anyone who wants to reprocess. www.biorxiv.org/content/10.6... 13615
Eugene Valkov @eugenevalkov.bsky.social · 27/06/2026🤣 open.substack.com/pub/inprepar...open.substack.comSpringer Nature CEO Opens Special Bottle Of Wine Upon News of Open Science Self-CannibalizationLONDON—Springer Nature CEO Willem Klaassen-Hooft opened a 2016 Châteauneuf-du-Pape he had been saving for the right occasion Tuesday evening after reading that an open science advocate had used AI to ... 020