El hallazgo abre nuevas vías para tratar alteraciones inmunitarias relacionadas con la edad mediante terapias ya disponibles

Un estudio liderado por el grupo de María Mittelbrunn en el Centro de Biología Molecular Severo Ochoa (CBM-CSIC-UAM) ha identificado uno de los mecanismos que alteran la producción de células […]

Gabandé-Rodríguez, Soto-Heredero and colleagues identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. CCR5 blockade ...

Gabandé-Rodríguez, Soto-Heredero and colleagues identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. CCR5 blockade ...

Una molécula de la microbiota intestinal prolonga la supervivencia de ratones con enfermedades mitocondriales

Here, the authors show that strategies to restore host–microbiota symbiosis by preserving butyrate levels delay multimorbidity and extend lifespan in mice with mitochondrial dysfunction, in associatio...

Learned risk-taking behaviours can persist for years after leaving the lab — and even after taking on a new research topic.

Job Description We are seeking a highly motivated postdoctoral researcher to join our laboratory to study the early steps of development of childhood B-cell Acute Lymphoblastic Leukemia (B-ALL). The p...

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

YouTube video by Centro de Biología Molecular Severo Ochoa

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources such as environmental amino acids, providing a potential therapeutic target.

¿Qué significa tener un buen amigo? ¿Cuál es el verdadero valor de la amistad? ¿Y cómo deberíamos cultivar nuestras relaciones de amistad para hacerlas verdaderamente significativas? El filósofo José ...

AbstractBackground and Aims. Thoracic aortic aneurysms and dissections (TAADs) are depicted by aortic medial degeneration characterized by glycan-rich matr

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

Una investigación liderada por el Hospital público 12 de Octubre de la Comunidad de Madrid en colaboración con el Centro de Biología Molecular Severo Ochoa (CBM-CSIC-UAM), ha descubierto el motivo […]

T cells undergo age-related changes that impair their organismal functions. Here Soto-Heredero et al. show that regulatory T cells characterized by the expression of KLRG1 accumulate with age in both ...

Un equipo del Centro de Biología Molecular Severo Ochoa (CBM-CSIC-UAM) ha hallado un mecanismo celular que podría potenciar la respuesta inmune del organismo frente al cáncer. La investigación, que ap...

The scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines.

Key Points. CD4 CTLs are significantly increased and clonally expanded in the bone marrow of patients with multiple myeloma.CD4 CTLs directly kill myeloma