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Eirini Maniou

@emaniou.bsky.social
247 followers 284 following 18 posts

Principal Investigator- Research Ireland Pathway Fellow @DCU working on the biomechanics of neural tube closure 📍Dublin, IE

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Reposted by Eirini Maniou
Journal of Cell Science @jcellsci.bsky.social · 05/10/2026
Elizabeth-Ann Legere, Aimee Ryan @rimuhc.bsky.social and colleagues discover that increased tissue tension caused by depletion of CLDN3 in the non-neural ectoderm causes neural tube defects in chick embryos. journals.biologists.com/jcs/article/...
Figure showing that CLDN3 depletion decreases the rate of neural fold movement during fusion.
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James Briscoe @jamesbriscoe.bsky.social · 27/08/2026
A bluffer's guide to tissue mechanics Everything you wanted to know but were afraid to ask about the physics of morphogenesis Many thanks to @pflenne.bsky.social & colleagues for writing this for @dev-journal.bsky.social journals.biologists.com/dev/article/...
journals.biologists.com
A developmental biologist's guide to mechanics
Summary: A guide to mechanics in development: unlock how forces, material properties and geometry shape the forms of life.
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Melanie D. White @melaniedwhite.bsky.social · 21/08/2026
Happy #FluorescenceFriday! ✨🔬 A peek inside a developing quail embryo, where the brain and heart are already taking shape. A tiny embryo doing some seriously impressive developmental heavy lifting. 💪❤️ 📷 @vanderspuy.bsky.social
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Karen J Liu @karenjliu.bsky.social · 20/08/2026
Postdoc and Tech post! 3-yr BBSRC project studying cell biology of Wnt signaling: advanced imaging, genome editing and embryology. Apply now! work with Matthias Krause and Karen Liu labs. @matthias-krause.bsky.social Tech: www.kcl.ac.uk/jobs/155666-... Postdoc: www.kcl.ac.uk/jobs/155745-...
kcl.ac.uk
Research Assistant | King's College London
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Teresa Rayon @trayon.bsky.social · 15/08/2026
Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation
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Kristina Stapornwongkul @kstapornwongkul.bsky.social · 06/08/2026
First published teamwork of the lab 🎉! We wrote a review about emerging concepts of how metabolism promotes, regulates and changes during gastrulation. We hope it will be useful for anyone interested in the emerging field of developmental metabolism. www.sciencedirect.com/science/arti...
sciencedirect.com
A metabolic view of gastrulation: Coordinating signalling, epigenetics and morphogenesis
Gastrulation is the morphogenetic process by which the single-layered pluripotent epiblast is reorganised into the three germ layers and the basic bod…
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David Brückner @davidbrueckner.bsky.social · 02/08/2026
It was fun writing a perspective about recent work from Fridtjof Brauns, Nikolas Claussen & Boris Shraiman on how tissues can flow without fluidizing: Dynamic control of interfacial tension drives convergent extension, combining instruction & self-organization www.condmatjclub.org/jccm_july_20...
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The Company of Biologists @biologists.bsky.social · 20/07/2026
Our CEO, Claire Moulton, is retiring this week. We will miss Claire’s leadership – her enthusiasm and innovative approach have supported the Company through many major projects – but we wish her all the best for her well-deserved retirement. www.biologists.com/stories/a-bi...
biologists.com
A big thank you to Claire Moulton
We are saying goodbye to Dr O. Claire Moulton this week, who is retiring from her role as CEO of The Company of Biologists. We’d like to take this opportunity to look back at Claire’s career and her i...
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Jesse Veenvliet @jesseveenvliet.bsky.social · 08/07/2026
Just approved an order for standard lab consumables. Prices have nearly doubled since starting the lab. Meanwhile, the bar for publishing keeps rising, requiring ever more costly experiments, while grant budgets barely changed. Hard to see how this is a sustainable trajectory for academic research.
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Nicoletta Petridou @nicolettapetridou.bsky.social · 23/06/2026
Double preprint! 👇 Check out our latest studies on timing, heterogeneity and collective behaviour (with a fun tiny bonus on evolution!) 1. www.biorxiv.org/content/10.6... 2. arxiv.org/abs/2605.13234
biorxiv.org
Cellular timing heterogeneity regulates phase transitions in living matter
Rigidity transitions govern tissue organization in ways reminiscent of inert materials. Yet, living tissues are composed of active units with autonomous timing mechanisms, raising the question whether...
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Elena Scarpa & The Squeezable Cells Lab @squeezycellslab.bsky.social · 10/06/2026
We are thrilled to announce our new preprint from the wonderful @sorayavillaseca.bsky.social Ever wondered how cells squeeze through tiny spaces in embryos? Neural crest cells use Dynein to transport their nucleus along microtubules. Check out the preprint!! www.biorxiv.org/content/10.6...
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Eirini Maniou @emaniou.bsky.social · 30/04/2026
It was a pleasure to host @glgalea.bsky.social for a seminar today @dcu-lsi.bsky.social. Gabe gave a very enganging talk linking neural tube closure with stochastic asymmetries in embryo geometry and developmental robustness. Thank you all for joining!
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Development @dev-journal.bsky.social · 23/04/2026
We are pleased to welcome 8 new fellows to our Pathway to Independence programme. Welcome Maëlle Bellec, @iamzico.bsky.social, @evhealy.bsky.social, @josepmercadal.bsky.social, @nikhil-mishra.bsky.social, Jessica Perochon, Yamini Ravichandran & Margherita Zamboni. Read more⤵️ tinyurl.com/4bk4wrk7
Maëlle Bellec, Swarnabh Bhattacharya, Evan Healy, Josep Mercadal, Nikhil Mishra, Jessica Perochon, Yamini Ravichandran and Margherita Zamboni.
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Melanie D. White @melaniedwhite.bsky.social · 01/04/2026
I'm so pleased to see this work on neural crest development out in Nature today! This was a truly fantastic collaboration with @gleesonlab.bsky.social, Keng loi (Harry) Vong and @xiaoxuyang.bsky.social. Huge thanks to everyone involved 👏 🧪🐣 #devbio www.nature.com/articles/s41...
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Eirini Maniou @emaniou.bsky.social · 27/03/2026
Congrats, Giulia! 👏👏
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Eirini Maniou @emaniou.bsky.social · 26/03/2026
Excited to share our new publication on the mechanics of cranial neural tube closure. A really enjoyable and fruitful collaboration bridging Developmental Biology and biophysical modelling. Take a look here! www.cell.com/current-biol...
cell.com
Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis
Pérez-Verdugo et al. show that hindbrain neuropore closure is driven by surface ectoderm actomyosin purse-string tension and active migration. These forces create reproducible patterns of cell elongat...
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Kristina Stapornwongkul @kstapornwongkul.bsky.social · 17/02/2026
We‘re looking for a motivated Master student to join our team! Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬 Then please apply! #optogenetics #metabolism #devbio #hESCs Please RT. Thank you!🙏
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Rita Mateus @ritamateus.bsky.social · 05/02/2026
New paper alert!🤩Super proud that our story led by superstar postdocs @liujinghui.bsky.social and @nerlielisa.bsky.social is finally out! We found how electrical signals are key for promoting organ regenerative growth!!! A thread 🧵https://www.science.org/doi/10.1126/sciadv.aec0687
science.org
Injury-induced electrochemical coupling triggers organ growth
Organ repair and growth rely on coupling tissue-wide membrane depolarization with intracellular proliferative signaling.
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Toby Andrews @tobyandrews.bsky.social · 02/02/2026
Job alert! 📣 I’m looking for a research assistant to join my new team @idrm.ox.ac.uk Were using #zebrafish to understand gene-environment interactions that shape the heart 🫀generate natural diversity 🐸🐭 and contribute to congenital defects ❤️‍🩹 Full info below, and please share! 🫶🏻 bit.ly/467TO0M
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hpscenthusiast.bsky.social @hpscenthusiast.bsky.social · 22/01/2026
It was our pleasure to have @emaniou.bsky.social at @universitypress.cambridge.org talking about her recent ongoing work as a group leader in @dublincityuni.bsky.social.
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Teresa Rayon @trayon.bsky.social · 13/01/2026
Looking forward to this meeting. Early bird registration encouraged!!
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James Briscoe @jamesbriscoe.bsky.social · 13/01/2026
There's still time to apply to be a 2026 @dev-journal.bsky.social Pathway to Independence fellow For those about to apply for their first independent academic position, the programme offers - mentoring - leadership training - profile rising - networking journals.biologists.com/dev/pages/pi...
journals.biologists.com
Pathway to Independence programme | Development | The Company of Biologists
Pathway to Independence programme | Development | The Company of Biologists Development's Pathway to Independence programme Launched in 2022, Development’s Pathway Independence programm...
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Ale Mongera @mongeralab.bsky.social · 12/12/2025
Super cool work spearheaded by the amazing @agrigas.bsky.social! Excited for this collaboration with @manningresearch.bsky.social and for everything still to come! 🎉 Also thank you to @emaniou.bsky.social and @glgalea.bsky.social for your help!
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Alex Grigas @agrigas.bsky.social · 12/12/2025
How do sparse mesenchymal cells, with unique stellate arms spanning large gaps between cells, maintain their network while still flowing during development? In our new preprint we describe the avian PSM as a fluid under tension and develop new theory to explain it: www.biorxiv.org/content/10.6...
biorxiv.org
Sparse mesenchymal cell networks as a fluid under tension
Sparse mesenchymal cellular networks are ubiquitous across animals, shaping both embryonic and adult structures through dynamic interactions with epithelia. Yet, the physical principles underlying the...
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Developmental Biology @devbiol.bsky.social · 04/12/2025
#DBfeature 🐣 Fate mapping approaches and scRNA-seq uncover how the avascular mesenchyme is critical to the normal outgrowth and patterning of digits By C Batho-Samblas, J Smith, L Keavey, N Clancy, L McTeir, and MG Davey tinyurl.com/2t6dau56 #SpecialIssue in #Avian Model Systems
Schematic of a developing avian hindlimb, highlighting the interdigital area (orange), digital ray (green), and avascular mesenchyme (AVM, white). 
Zoom in 1: "In communication to distal and proximal elements", show the tip of the digital ray (PFR)sending unknown signals to the apical ectodermal ridge (AER, yellow), which in turn communicated back with Fgf8 signal. These signals accumulate in the AVM.
Zoom in 2: "Progenitor to the digits", the signals from the AER pass through the AVM into the PFR.
Zoom in 3: "Joint patterning/specification", the signals induce a new phalanx segment.
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Alex Eve @amjeve.uk · 02/12/2025
Please consider applying, @dev-journal.bsky.social provides: - Profile raising - Mentor sessions - Leadership training and a growing network of supportive peers.
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James Briscoe @jamesbriscoe.bsky.social · 03/12/2025
Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions: Mentoring Profile raising Leadership training Network building Spread the word... www.biologists.com/grants/devel...
biologists.com
Development's Pathway to Independence Programme
Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...
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Eirini Maniou @emaniou.bsky.social · 04/11/2025
Our review on microfluidic strategies for engineering organoid culture systems is out now www.sciencedirect.com/science/arti...
sciencedirect.com
Microfluidic Platforms for Organ-on-a-Chip Models: Creating dynamic microenvironments for organoid and multi-organ systems
Organoids have revolutionized in vitro modeling of human development and disease, yet their full potential remains constrained by the limited spatial …
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epithelial mechanics fan club @epimechfc.bsky.social · 23/10/2025
🎉🎉 We finally have a website! 🎉🎉 Did you miss a thread? Want to know who our delegates are? Do you want to join our big club? Check it out: epithelialmechanics.github.io Huge thanks to all thread-contributors and to you for following us!
epithelialmechanics.github.io
Epithelial Mechanics Fan Club
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Jonathan Harris @jonathanaharris.bsky.social · 16/09/2025
"Killing members of a group, causing them serious bodily and mental harm, deliberately inflicting conditions calculated to destroy the group, and preventing births" This is the daily horror being inflicted on Palestinians through this war, and arguably long before it. www.bbc.co.uk/news/article...
bbc.co.uk
Israel has committed genocide in Gaza, UN commission of inquiry says
The panel finds that four of the five genocidal acts defined under international law have been carried out against Palestinians during the war.
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Ale Mongera @mongeralab.bsky.social · 11/09/2025
📣Our project, “Mechanometabolic Control of Vertebrate Limb Elongation,” has been funded by Wellcome! Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
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Eirini Maniou @emaniou.bsky.social · 11/09/2025
Congrats Ale!! 👏👏
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Julia Eckert @juliaeckert.bsky.social · 15/08/2025
Now published in @natcomms.nature.com! 🥳 👉 rdcu.be/eATn3 We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
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Giulia Paci @giuliapaci.bsky.social · 11/08/2025
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
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Society for Developmental Biology @socdevbio.bsky.social · 11/08/2025
🐣Chick embryo (Gallus gallus domesticus): a window into vertebrate development. From heart and limb formation to neural crest migration and axis patterning, this model has been cracking the developmental code for over a century. Image by Vincent Pasque #ModelMonday #DevBio
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Biozentrum, University of Basel @biozentrum.unibas.ch · 04/08/2025
Apply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until October 12, 2025. bit.ly/4caiqqX @biozentrum.unibas.ch @unibas.ch #fellowship #PhD#Switzerland
bit.ly
Biozentrum PhD Fellowships
Share your passion for life sciences. If you are talented and highly motivated, want to broaden your horizons and are interested in a wide range of research topics, apply for one of the sought after B...
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gserranonajera.bsky.social @gserranonajera.bsky.social · 07/08/2025
Hi bsky! Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity! w/ A. Delahaye & ‪@bensteventon.bsky.social‬ shorturl.at/v01DO
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Eirini Maniou @emaniou.bsky.social · 07/07/2025
PhD position available in our team @dublincityuni.bsky.social from September. Please share/ contact me for informal enquiries.
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Kristina Stapornwongkul @kstapornwongkul.bsky.social · 07/07/2025
Thank you for speaking with me about my research @iamshef.bsky.social! #newPI #metabodev #MetabolismMondays Please check out Shefali’s weekly interviews with different ECRs about metabolism and development @the-node.bsky.social! What a great initiative 👏 thenode.biologists.com/author/shefa...
thenode.biologists.com
Shefali Shefali, Author at the Node
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Eirini Maniou @emaniou.bsky.social · 02/07/2025
Thanks for the support Katherine!
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Eirini Maniou @emaniou.bsky.social · 30/06/2025
Thank you so much Bertrand! It means a lot.
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Eirini Maniou @emaniou.bsky.social · 29/06/2025
Thank you Louis!
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Eirini Maniou @emaniou.bsky.social · 29/06/2025
Thanks so much Kristina!! Lets join forces! :)
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Eirini Maniou @emaniou.bsky.social · 27/06/2025
Could I please be added too? 🙏
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Eirini Maniou @emaniou.bsky.social · 26/06/2025
Thank you Maki! Counting on you for iPSC troubleshooting!
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Eirini Maniou @emaniou.bsky.social · 26/06/2025
Thank you!!
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Eirini Maniou @emaniou.bsky.social · 26/06/2025
Thank you Baptiste, you are next! 😀
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Eirini Maniou @emaniou.bsky.social · 26/06/2025
Excited to share I’m starting my group in Dublin this September, supported by a Research Ireland Pathway award. We will work on neurulation mechanics using chicken embryos and human iPSCs. Looking forward to this new adventure! #newPI #womeninSTEM
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Yasin Dagdas @plantophagy.bsky.social · 02/06/2025
Important changes on @erc.europa.eu grants‼️Grant structure & most importantly eligibility timeframes (10 years for starting, 15 years for consolidator post PhD-but you can have them only once) changes: erc.europa.eu/news-events/...
erc.europa.eu
Changes to the 2026 and 2027 Work Programmes
With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...
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Julia Eckert @juliaeckert.bsky.social · 25/05/2025
Our new review paper from @yap-lab.bsky.social is online - together with Virgile Viasnoff! 👉 'New directions in epithelial mechanoadaptation' www.sciencedirect.com/science/arti...
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