Reposted by Eleni LoukaMRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 27/02/2026If you would like to learn more about the science and the people behind it, explore our video playlist 👇🧪🧬 #AcademicSky #RareDisease #Science #Researchyoutube.comRare Disease Day 2025 - YouTube 021
Reposted by Eleni LoukaMRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 08/05/2026We are delighted to share that Professor Adam Mead will join Professor Alison Simmons as Deputy Director of the #MRCWIMM from May 2026. Read more 👇 @rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk @adammead.bsky.socialrdm.ox.ac.ukDeputy Directors of the MRC Weatherall Institute of Molecular MedicineProfessor Adam Mead is joining Professor Alison Simmons as a Deputy Director of the WIMM in May 2026. 032
Reposted by Eleni LoukaMRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 21/04/2026#ScientistSpotlight 🧪 This week we’re featuring Antonio Rodríguez Romera, a postdoctoral researcher in Beth Psaila’s lab at the #MRCWIMM. @antoniorromera.bsky.social @bethpsaila.bsky.social @rdm.ox.ac.uk @medsci.ox.ac.uk #AcademicSky #Haematology #CancerResearch #CellBiology #Megakaryocytes 161
Reposted by Eleni LoukaMRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 11/02/2026🧪Celebrating #WomenInScienceDay with just a few of the brilliant women who make research happen at the #MRCWIMM. Science is stronger when talent is recognised, supported and visible. #WomenInScience #WomenInSTEM 1183
Reposted by Eleni LoukaRoman Doll @romanmdoll.bsky.social · 20/12/2025Excited to share that a part of my PhD work is online now on BioRxiv! www.biorxiv.org/content/10.6... We developed a genome editing approach to target the JAK2 V617F mutation and demonstrate its potential to alleviate MPN hallmarks in primary patient cells. Thread 👇 4228
Reposted by Eleni LoukaEric Topol @erictopol.bsky.social · 08/12/2025A big advance, folks, for off-the-shelf, universal, engineered (base-edited) T cells achieving complete response vs incurable leukemia in several patients www.nejm.org/doi/full/10.... 332080
Reposted by Eleni LoukaMark Hartmann @mphartmann.bsky.social · 06/12/2025ONLINE FIRST ALERT! Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia aacrjournals.org/bloodcancerd... @aacrjournals.bsky.social #childhoodcancer #epigenetics #precisiononcology 3216
Reposted by Eleni LoukaMRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 18/11/2025#ScientistSpotlight: This week we’re introducing Verena Körber, one of the newest Group Leaders at the MRC WIMM. @rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk 153
Reposted by Eleni LoukaUniversity of Oxford @ox.ac.uk · 17/11/2025NEW: Oxford scientists have identified how rare populations of abnormal cells drive the formation and persistence of fistulas - painful, tunnel-like tracts that develop in around 30% of people with Crohn’s disease. Crohn’s disease affects around 1 in every 650 people.ox.ac.ukOxford scientists map the cells that drive Crohn’s disease fistulas,Scientists at the University of Oxford, have identified how rare populations of abnormal cells drive the formation and persistence of fistulas - painful, tunnel-like tracts that develop in around 30% 094
Reposted by Eleni LoukaJames Davies @jojdavies.bsky.social · 05/11/2025Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size. 621079
Reposted by Eleni LoukaThe Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · 05/11/2025Not from Tron or a psychedelic wallpaper. This exquisite pic reveals chromatin at base-pair resolution, captured by #ListerFellow James Davies and collaborators🤩 "For the first time, we can see how the genome's control switches are physically arranged inside cells." @jojdavies.bsky.social 1127
Reposted by Eleni LoukaMRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 15/08/2025NEW @cancerresearchuk.org-funded study, led by @bethpsaila.bsky.social & @l-cmurphy.bsky.social, reveals an unexpected and powerful new function for platelets with profound implications for cancer diagnosis and prenatal screening 🧪 @rdm.ox.ac.uk | @medsci.ox.ac.uk | @ox.ac.uk Learn more 👇imm.ox.ac.ukPlatelets Shown to Store DNA in Study that could Transform Cancer ScreeningStudy led by Psaila Group uncovers previously unknown function of platelets as DNA ‘vacuum cleaners’ in the blood, with profound implications for cancer diagnosis and prenatal screening. 1115
Reposted by Eleni LoukaBeth Psaila @bethpsaila.bsky.social · 15/08/2025Huge thanks to @cancerresearchuk.org for funding and sparking the key collabs, co-authors @imm.ox.ac.uk @ox.ac.uk @ludwigcancer.bsky.social @edinburghuni.bsky.social and all who provided feedback along the way @Grc @ash.hematology.org @isehsociety.bsky.social @sarahhross.bsky.socialnews.cancerresearchuk.orgThe "humble" blood cells that could expose cancer's secrets - Cancer Research UK - Cancer NewsOur scientists have discovered that platelets are swelling with information which could help us detect cancers earlier. 282
Reposted by Eleni LoukaOxford Cancer @oxfordcancer.bsky.social · 18/08/2025'[...]analysis of platelets can potentially improve screening tests, including for cancer.' @bethpsaila.bsky.social comments on newly published research findings that could transform approaches to the early detection and prevention of #Cancer. www.oxcode.ox.ac.uk/news/platele...oxcode.ox.ac.ukPlatelets shown to store DNA in study that could transform cancer screeningOxford-led study uncovers previously unknown function of platelets as DNA ‘vacuum cleaners’ in the blood, with profound implications for cancer diagnosis and prenatal screening. 042
Reposted by Eleni LoukaBeth Psaila @bethpsaila.bsky.social · 15/08/2025Thrilled that our paper is in print @science.org!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelightscience.orgBy sucking up DNA, clot-producing platelets could help diagnose cancerThe cells could be a new source of tumor DNA for liquid biopsies 47322
Reposted by Eleni LoukaJeanne Inchauspé @jeanneinchauspe.bsky.social · 15/08/2025Check out our latest publication in @science.org, showing that platelets are a source of tumour DNA! 031
Reposted by Eleni LoukaLauren Murphy @l-cmurphy.bsky.social · 14/08/2025🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @science.org! 🎉 🧽 📖 Read our paper here: doi.org/10.1126/sci... 🎬 Watch a summary: youtu.be/MttCA3GGWEM 🧵 Or keep reading for the key points! 🔑 1/19 24311
Reposted by Eleni LoukaMRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 03/07/2025NEW: Researchers at the MRC WIMM and @dkfz.bsky.social have developed a new method to analyse how our tissues evolve as we age, called SCIFER 🧬 🧪 Read more 👇 @rdm.ox.ac.uk | @medsci.ox.ac.uk | @ox.ac.ukimm.ox.ac.ukNew tool allows researchers to track how mutations arise in tissuesResearchers at the MRC Weatherall Institute of Molecular Medicine and the German Cancer Research Center (DKFZ) have developed a new method to analyse how our tissues evolve as we age. 053
Reposted by Eleni LoukaMRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 01/07/2025WIMM Day 2025 brought our researchers together to share discoveries, swap ideas & celebrate success — from gene editing to immunotherapy to public engagement. Catch the recap + award winners here:imm.ox.ac.ukCelebrating science, collaboration and excellence at WIMM Day 2025The MRC WIMM community gathered for its flagship annual event, WIMM Day, on Tuesday 24th June. Held at the Saïd Business School, the day showcased the breadth and impact of research across the institu... 043
Reposted by Eleni Loukaadammead.bsky.social @adammead.bsky.social · 26/05/2025We're hiring at Oxford! Join our team working on cutting-edge research in haematology & myeloproliferative neoplasms (MPNs). 🔬 Apply here: my.corehr.com/pls/uoxrecru... 🔍 Learn about our research: imm.ox.ac.uk/research/res... #AcademicJobs #Haematology #MPN #Oxfordmy.corehr.comJob Details 072
Reposted by Eleni LoukaMRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 10/06/2025NEW: Researchers at the MRC Molecular Haematology Unit, led by @ckbrierley.bsky.social & @adammead.bsky.social, have uncovered a potential new therapeutic target in BP-MPN - a particularly aggressive type of leukaemia. 🧪🧬 Read more: @oxfordbrc.bsky.social | @rdm.ox.ac.uk | @medsci.ox.ac.ukimm.ox.ac.ukNew research reveals druggable target arising from chromosomal rearrangement in aggressive leukaemiaResearchers at the University of Oxford have uncovered a potential new therapeutic target in a particularly aggressive and hard-to-treat form of leukaemia. 0259
Reposted by Eleni LoukaBeth Psaila @bethpsaila.bsky.social · 27/03/2025We are recruiting!! Ads now live for a Data Coordinator and 2 Research Assistants/biobankers to join a new @ludwigcancer.bsky.social - @imm.ox.ac.uk joint initiative to prevent progression from early- to advanced blood cancer. Joint posts with Adam Mead+others in Oxford Ludwig. Links below 11611
Reposted by Eleni LoukaMRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 07/03/2025For International Women's Day tomorrow, we asked some of our female scientists, including @agoriely.bsky.social & @sumanasharma.bsky.social, to reflect on why this day is so important, the barriers and biases women can face in their careers, and which women have inspired them. #IWD2025youtu.beInternational Women's Day at the MRC WIMMYouTube video by MRC Weatherall Institute of Molecular Medicine 0105
Reposted by Eleni LoukaMRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 28/02/2025To conclude our #RareDiseaseDay series, we spoke with @ellouka.bsky.social, a clinician scientist researching Paediatric Myelodysplastic Syndromes (MDS) and Juvenile Myelomonocytic Leukaemia (JMML). These are incredibly rare childhood cancers, with no current treatment options available. 🧪youtu.beRare Disease Day 2025: Paediatric LeukaemiasYouTube video by MRC Weatherall Institute of Molecular Medicine 0198
Reposted by Eleni LoukaAndi Roy @roylab-oxford.bsky.social · 25/01/2025Preprint alert: this was a wonderful collaborative project with Prof Karadimitris @imperialcollegeldn.bsky.social and many others. Thanks to all and especially @cancerresearchuk.org for the CAYP innovation award funding. All feedback welcome!biorxiv.orgBi-specific CAR-iNKT cell immunotherapy for high-risk KMT2A-rearranged leukemia outperforms CAR-T in an NKG2D-dependent manner and eradicates leptomeningeal diseaseCurrent therapies, including autologous CAR-T immunotherapy, fail to cure half of infants with KMT2A-rearranged acute lymphoblastic leukemia (KMT2Ar-ALL). Here we deploy allogeneic iNKT cells, innatel... 093
Reposted by Eleni LoukaUniversity of Oxford @ox.ac.uk · 17/01/2025NEW: @ineosoxford.bsky.social has been awarded a £5 million Wellcome Discovery Award to develop vaccines against pathogens that cause diarrhoea - the third most common cause of death for children under five years of age. More info ⬇️ox.ac.ukWellcome Discovery Award of £5m to fund pioneering research to combatThe Ineos Oxford Institute has been awarded a £5 million Wellcome Discovery Award to develop vaccines against pathogens that cause diarrhoea - the third most common cause of death for children under 0269
Reposted by Eleni LoukaOxford Medical Sciences Division @medsci.ox.ac.uk · 20/12/2024Celebrating Excellence in Medical Sciences Division 2024 Massive congratulations to our elected Academy of Medical Sciences fellows #ExcellenceInOxfordMedSci2024 medsci.ox.ac.uk/news/academy... 041
Reposted by Eleni LoukaRoss Chapman @rosschapmanlab.bsky.social · 12/12/2024In our first skeet, check out a very cool postdoc opportunity, in the very cool @susanagodinho.bsky.social lab 👇 262
Reposted by Eleni LoukaChristina Simoglou Karali @christinask.bsky.social · 10/12/2024Had the best time at #ASH24 presenting with Simone Riva our work at the @imm.ox.ac.uk with Prof. Adam Mead and Prof. Jim Hughes on the construction of a novel multi-omic resource atlas for human granulopoiesis and the identification of molecular machinery underlying IMiD-induced neutropenia. 0121
Reposted by Eleni LoukaDaniel Lipka @dblipka.bsky.social · 10/12/2024Absolutely outstanding presentation by @ellouka.bsky.social at #ASH24 about the role of dendritic cells secreting GAS6 in maintaining LSCs in juvenile myelomonocytic leukemia #jmml #HemeSky 183
Reposted by Eleni LoukaJosh Moore @josh-moore.bsky.social · 09/12/2024 We’re thrilled to introduce MuSpAn! For researchers in biological imaging, MuSpAn provides tools for Multiscale Spatial Analysis with advanced mathematical methods. 🌟 For more information: www.muspan.co.uk 📝 Preprint: doi.org/10.1101/2024... We hope you find it as useful as we do! (Poster below) 2228
Reposted by Eleni LoukaJoshua Bull @joshuabull.bsky.social · 09/12/2024MuSpAn is a starting point, not the end stage! We've been working hard to finalise the behind the scenes infrastructure, but now the array of available methods will just keep expanding. In particular, our group works on method development for spatial data - new methods will keep appearing here! 141
Reposted by Eleni LoukaJoshua Bull @joshuabull.bsky.social · 09/12/2024Very pleased to announce that our package for Multiscale Spatial Analysis - MuSpAn - has landed! The preprint is on biorxiv now, but you can find a lot more details at www.muspan.co.uk, including documentation, worked tutorials (an ever-expanding list), install guides, and how to get the code!muspan.co.ukMuSpAn: a Multiscale Spatial Analysis toolbox for biologists | MuSpAn: a Multiscale Spatial Analysis toolboxMuspan is a powerful software package designed for biologists to perform spatial analysis on imaging data. Our multiscale toolbox simplifies the analysis of spatial transcriptomics and histology, enab... 44315
Reposted by Eleni LoukabioRxivpreprint @biorxivpreprint.bsky.social · 08/12/2024MuSpAn: A Toolbox for Multiscale Spatial Analysis www.biorxiv.org/content/10.1101/202… 023
Reposted by Eleni LoukaAmerican Society of Hematology @ash.hematology.org · 29/11/20248 days ago, ASH decided to join Bluesky. 🌤️ So far, we're enjoying fewer distractions & more meaningful connections. 💬 Engaging with our amazing #hematology and #hemeonc communities has never been easier. We created an #ASH24 feed for you & we have more feeds coming soon: bit.ly/ASH24feed #Hemesky 112126
Reposted by Eleni LoukaMarieke Oudelaar @mariekeoudelaar.bsky.social · 22/11/2024📣 Preprint alert! We have studied the formation of pair-wise and multi-way enhancer-promoter interactions in the #3Dgenome in a lymphoid-to-myeloid transdifferentiation system and learned interesting new things about their function in #GeneRegulation. 1/10 www.biorxiv.org/content/10.1...biorxiv.org 26222
