Understanding the genetic architecture of complex traits in admixed populations remains challenging due to heterogeneous genetic backgrounds and demographic histories. Mischaracterizing admixture can ...

Observational studies are commonly used in psychology and epidemiology to identify risk factors correlated with health outcomes. However, these studies are vulnerable to confounding when shared geneti...

In this Journal Club, Lopez-Hernandez and Ortega-Del Vecchyo discuss a study that mapped the genetic basis of hybrid incompatibility in swordtail fish, revealing melanoma-causing gene interactions that reduce survival in natural hybrid populations.

A combination of mapping approaches identifies interacting genes that lead to incompatibility and melanoma in natural hybrid fish.

We study the gene MUC19, for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants ...

Hacen menos confiables los análisis de características físicas en humanos antiguos, afirma artículo publicado en la revista científica The American Journal of Human Genetics, en el cual participa un g...

Abstract. A key prediction of neutral theory is that the level of genetic diversity in a population should scale with population size. However, as was note

Genomes contain the mutational footprint of an organism's evolutionary history, shaped by diverse forces including ecological factors, selective pressures, and life history traits. The sequentially Ma...

Using polygenic scores, we find that two types of natural selection, stabilizing selection and directional selection, can decrease the prediction accuracy of complex traits in ancient individuals. We ...

Researchers evaluate the accuracy of common statistical methods to identify recent genetic ancestry in GENETICS.

Phantom epistasis arises when, in the course of testing for gene-by-gene interactions, the omission of a causal variant (with a purely additive effect on the phenotype) causes the spurious inference o...

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Abstract. The ancestral recombination graph (ARG) is a structure that represents the history of coalescent and recombination events connecting a set of sequence

The ancestral recombination graph (ARG) is a structure th...

The role of natural selection in shaping biological diver...