As the use of population descriptors such as race, ethnicity, and ancestry have become increasingly common in modern genetics research, there have been growing calls to critically examine their use. M...

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Cell-type-specific eQTL mapping from single-cell pseudobulk expression.

Flexible, scalable, QTL analyses using generalized linear models implemented in JAX - mancusolab/jaxqtl

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Abstract. The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model pred

PhD-level thinking, LLM bias, alignment, AGI, data centers, and AI politics

Nature Genetics - Multi-ancestry GWAS meta-analysis identifies risk loci for severe nausea and vomiting of pregnancy. Downstream analyses explore maternal and fetal contributions of these loci and...

Grammar-first generalized linear modeling in JAX.

More about what it does (maybe more than one line). Continuation lines should be indented.

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Most current GWAS-eQTL approaches prioritize genes whose mediating effects on complex traits act through cis-regulation, while trans-acting genes remain largely underexplored. Recent perturbational sc...

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Ancestral recombination graphs (ARGs) are an attractive means for quantitative genetic analysis of complex traits because they encode the realized genetic relatedness between a sample of individuals i...

Genome-wide association studies and rare-variant burden tests reveal complementary aspects of trait biology.

Genetic association tests prioritize candidate genes based on different criteria.

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Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely. This study shows that differences in architectures of highly polygenic traits arise mainly f...

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