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Tobi Alegbe

@tobioinformatics.bsky.social
127 followers 173 following 31 posts

I look at small things on a big scale Single-cell data scientist at Open Targets, EMBL-EBI. Previously StatGen PhD student at Sanger Institute

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Reposted by Tobi Alegbe
Open Targets @opentargets.org · 04/08/2026
6 years 646 patients 1193 samples 100 endoscopists 9 lab scientists 3 postdocs 2 PhD students 502 courier runs from Addenbrooke’s Hospital to @sangerinstitute.bsky.social IBDverse is the largest single-cell dataset of Inflammatory Bowel Disease (IBD)—and generating the data for it was no mean feat
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Open Targets @opentargets.org · 15/06/2026
Out now in Nature Genetics! The largest single-cell RNA sequencing dataset of terminal ileal biopsies profiles 1.1 million cells from over 100 Crohn’s disease patients and over 200 healthy controls. Crohn’s disease is a type of inflammatory bowel disease (IBD) www.nature.com/articles/s41...
nature.com
Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn’s disease pathogenesis - Nature Genetics
IBDverse is a single-cell RNA atlas of terminal ileal biopsies comprising 1.1 million cells from 111 patients with Crohn’s disease and 232 healthy participants. Analysis of the data identifies genes, ...
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Tobi Alegbe @tobioinformatics.bsky.social · 12/06/2026
Gothenburg airport currently flaunting the longest line of geneticists in the world. @pacbio.bsky.social can you beat this on Sunday? #ESHG2026
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Tobi Alegbe @tobioinformatics.bsky.social · 07/06/2026
Delighted to see this out, check out my pinned post for a run through of the findings from when it was a preprint!
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Reposted by Tobi Alegbe
Chris Wallace @chr1sw.bsky.social · 07/06/2026
Very privileged to have played a small part in this single cell eqtl study of intestinal and blood cells. Led by the fabulous @carlanderson.bsky.social @tobioinformatics.bsky.social @bradleyomics.bsky.social.
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Open Targets @opentargets.org · 08/12/2025
#OnThisDay 10 years ago, we launched the Open Targets Platform! 🎂 🧬🖥️
Graphic with a 10 surrounded by fireworks and the Open Targets Platform logo
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Matthew Neville @mattneville.bsky.social · 08/10/2025
Now published! Our paper on: (1) Accurate sequencing of sperm at scale (2) Positive selection of spermatogenesis driver mutations across the exome (3) Offspring disease risks from male reproductive aging [1/n] www.nature.com/articles/s41...
nature.com
Sperm sequencing reveals extensive positive selection in the male germline - Nature
A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.
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Kaur Alasoo @kauralasoo.bsky.social · 02/10/2025
Happy to share that this work together with @opentargets.org is now out at Nature Communications.
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Tobi Alegbe @tobioinformatics.bsky.social · 12/09/2025
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Reposted by Tobi Alegbe
Wellcome Sanger Institute @sangerinstitute.bsky.social · 27/08/2025
Scientists have uncovered hidden genetic drivers of conditions like IBD by stimulating immune cells. 🔬 The findings have resulted in a dataset called MacroMap, which offers insight into why some people are vulnerable to certain conditions. sanger.ac.uk/news_item/ac...
sanger.ac.uk
Activated immune cells reveal hidden drivers of autoimmune diseases
A new resource, MacroMap, provides a rich dataset that researchers can use to explore genetic mechanisms behind complex diseases.
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Tobi Alegbe @tobioinformatics.bsky.social · 27/07/2025
KELLYGOAT
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Tobi Alegbe @tobioinformatics.bsky.social · 08/07/2025
🚨New preprint just dropped 🚨 medrxiv.org/content/10.1101/2025.06.24.25330216 The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!
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Tobi Alegbe @tobioinformatics.bsky.social · 05/06/2025
An awesome preprint by a superstar PhD student looking at the utility of blood vs tissue in the context of disease!
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Reposted by Tobi Alegbe
Lucia Ramirez-Navarro @luciaramirez.bsky.social · 04/06/2025
🚨 SUPER EXCITED to share our new preprint on the mucosal and circulatory immune landscape of Crohn’s disease! 🩸 Blood is commonly used in biomarker discovery and drug development, but how well does it reflect what's actually happening in the gut? 👀 🧵 1/10 🔗 www.medrxiv.org/content/10.1...
medrxiv.org
Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn's disease
Crohn's disease (CD) is a heterogeneous disease characterized by chronic inflammation of the gastrointestinal tract driven by an aberrant immune response. To understand the immune mechanisms underlyin...
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Reposted by Tobi Alegbe
Gareth-Rhys Jones @gastrogrj.bsky.social · 27/11/2024
Heading to #EMDS24 in 🇦🇹 this week? Come hear about our work on the "inflammatory handbrake" exerted by intestinal monocytes in human IBD and murine colitis through ACOD1. Wednesday, Session 4 1640-55; See you there! www.biorxiv.org/content/10.1...
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