Alport syndrome is a genetically heterogeneous disorder of the glomerular basement membrane (GBM) caused by pathogenic variants in the COL4A3, COL4A4, and COL4A5 genes. The disease may follow X-linked...

Background: Standardised tacrolimus trough-level targets limit individualisation of immunosuppressive therapy in kidney transplant recipients. Torque teno virus

A clinical trial shows that using the torque teno virus to guide the use of immunosuppressive drugs is safe, potentially reducing the...

The optimal treatment of hyponatremia has been debated for >50 years. It is now widely accepted that in severe hyponatremia (<120 mmol/L), the rate of correction should not exceed 8 mmol/L per 24 hour...

Introduction Blood gas analysis is routinely performed in hemodialysis patients to monitor acid–base status and serum potassium. Despite frequent testing, longitudinal analyses of acid–base paramete...

Nature Reviews Nephrology, Published online: 14 July 2026; doi:10.1038/s41581-026-01099-5This Review focuses on the potassium switch signalling pathway and its regulation of urinary sodium excretion according to plasma potassium levels. Welling and colleagues examine how this pathway affects the interplay between potassium intake, salt handling in the kidney and blood pressure, and its implications for dietary interventions for blood pressure control.

Switching from intravenous antibiotics to oral fosfomycin was noninferior to continuing intravenous therapy for complicated urinary tract infections caused

AbstractBackground. Medullary sponge kidney (MSK) is characterized by precalyceal dilatation of the renal tubules. This entity is associated with recurrent

Nature Reviews Nephrology, Published online: 02 June 2026; doi:10.1038/s41581-026-01091-zHNF1B as a central gatekeeper of tubular homeostasis

Kidney stones are common, affecting 10%-15% of the population.1 The foundation for the current therapy to prevent kidney stones is based on the principle that supersaturation of solutes in the urine p...

HLA sensitization poses a major challenge to kidney transplantation for patients with end-stage kidney disease, especially for highly sensitized candidates. Attempts at antibody elimination (desens...

Objective To assess the effect of calcium, vitamin D, or combined supplementation on fractures and falls in adults. Design Systematic review and meta-analysis. Data sources Trials included in system...

Can polymyxin B hemadsorption truly shift the fate of septic shock, or is the outcome already written?

The calcium-sensing receptor (CaSR) is a central regulator of renal mineral homeostasis and tubular function. Since the discovery of its expression in the kidney, numerous studies have demonstrated th...

AbstractBackground and hypothesis. Malignancy, driven by the effects of immunosuppression, is a major complication following kidney transplantation. The wi

Water, water everywhere. Can a wink, a nudge and a push increase water intake to decrease kidney stone formation?

Wir erforschen wie man die Stärke des Immunsystems messen kann. Zuerst erklären wir Ihnen, anhand eines Posters und eines Animationsfilms wie das funktioniert und warum uns das TT Virus dabei hilft. D...

A study by Dr. Chienwichai highlights challenges in diagnosing hyponatremia due to undisclosed intravenous saline administration. While saline infusion does not obscure urine biochemical tests, it …

Chronic hyponatremia is associated with adverse outcomes, including falls, neurocognitive disorders, and mortality, but whether hyponatremia itself increases morbidity and mortality, or is simply a...

Download Venous to Arterial Blood Gas by Daniel Batlle on the App Store. See screenshots, ratings and reviews, user tips, and more apps like Venous to Arterial…

Podcast Episode · Freely Filtered, a NephJC Podcast · 2025-12-27 · 1h 25m

Abstract. Patients with advanced cardiovascular kidney metabolic syndrome generally face a high risk of cardiovascular complications. Guideline-directed me