iiinova — where your digital self keeps evolving

Reposted by Gregor Bond

MedUni Wien @meduniwien.ac.at · 09/06/2026

📢 #Bildung ist Zukunft. Darum braucht es starke Universitäten — und keine Kürzungen bei Wissenschaft und Forschung. Mit der Petition #unisretten wird ein klares Zeichen gegen den geplanten Sparkurs gesetzt. ✍️ Jetzt unterstützen! ⬇️

mein.aufstehn.at

Jetzt unterzeichnen: #unisretten

Zur Petition!

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Reposted by Gregor Bond

MedUni Wien @meduniwien.ac.at · 08/06/2026

Successful trial ✅️ An international team coordinated by #MedUniVienna demonstrated in a #clinicaltrial that #TorqueTenovirus-guided dosing of #immunosuppressants in #kidneytransplant recipients is safe. More about the @ttvguidetx.bsky.social study coordinated by @gregorbond.bsky.social! ⬇️

meduniwien.ac.at

Biomarker-guided immunosuppression following kidney transplantation successfully tested

Further details!

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Gregor Bond @gregorbond.bsky.social · 05/06/2026

first data of the TTVguideIT RCT presented by @fredhaupenthal.bsky.social at ERA26 in Glasgow Torque Teno 🦠 virus guided immunosuppression 💊 is safe in kidney TX and might help reducing TAC dose #TTVguide

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Gregor Bond @gregorbond.bsky.social · 04/06/2026

First data of the TTVguideIT RCT presented @ERA26 in Glasgow 🏴󠁧󠁢󠁳󠁣󠁴󠁿 Personalized Immunosuppression 💊 by Torque Teno 🦠 virus in kidney TX is safe and might help reducing Tacrolimus #TTVguide @fredhaupenthal.bsky.social 👏

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Gregor Bond @gregorbond.bsky.social · 29/04/2026

the TTVguideTX team @research night for the public @meduniwien.ac.at Vienna - Austria all age groups were welcome to learn about science we presented the principle of TTV-guided immunosuppression #TTVguide

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Gregor Bond @gregorbond.bsky.social · 22/04/2026

Felix Herkner communicates the potential of TT virus 🦠 guided Immunosuppression to the Austrian 🇦🇹 public #TTVguide

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Gregor Bond @gregorbond.bsky.social · 13/04/2026

Torque Teno virus 🦠 predicts malignancy post kidney transplant #TTVguide

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Reposted by Gregor Bond

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 12/01/2026

Remember the TOPCAT story of what happened in Russia and Georgia? This is worse: www.science.org/content/blog... And in South Florida. From @dereklowe.bsky.social

It seems to be a recurring problem, though. As you can see from the link above, Science's team found that several of these clinical centers have previously fouled up trial data for other companies and other drugs, and that alone should make any responsible CRO avoid them like radioactive waste zones. But the problems are even deeper. It appears that many of these Miami-area centers are cheerfully enrolling "professional patients" who are signing up for as many trials as possible to collect the payments and benefits, and who are likely as not throwing the pills themselves away. By this point in the article, my head was in my hands, and I'm sure that's a common reaction. This sort of idiotic fraud is the exact opposite of medical research.

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Reposted by Gregor Bond

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 09/01/2026

Should we be treating inpatient hypertension? Interesting case with two discussants (Michael Rothberg vs Tara Chang) www.nejm.org/doi/full/10.... I have to confess despite being a nihilist for treating inpatient BP I am tempted to do something in this setting.

A Man with Asymptomatic Hypertension
Sarah Gorey, M.B.
You are the intern on call for the night shift. You are paged to come to the surgical ward to assess a patient. A 63-year-old man with uncomplicated diverticulitis was admitted earlier in the day for antimicrobial and conservative treatment. He rarely visits his family doctor, is not aware of having high blood pressure, and does not take regular medications. You have been called because on a routine check of vital signs, the patient’s blood pressure was 185/115 mm Hg. All other vital signs were within normal limits. The patient has no symptoms; he has no headache, dyspnea, or chest or abdominal pain. He reports feeling slightly stressed at being admitted to the hospital today, which he was not anticipating, but had been sleeping comfortably before the nurse checked his vital signs.
On examination, he appears to be comfortable, and there is no clinical evidence of withdrawal from alcohol or other substances. His abdomen is soft and nontender, and on auscultation, no bruits are heard over the aorta or renal arteries. His pulses are 2+ and symmetric in all anatomical distributions. You note that his blood pressure was also high (166/97 mm Hg) at admission 4 hours earlier and had not been measured again until now. Routine laboratory test results from blood samples obtained at the time of admission show increased levels of leukocytes and inflammatory markers but normal kidney and liver profiles. The nurse manager confirms that the blood-pressure monitors on this ward have been calibrated recently. A repeat blood-pressure measurement obtained after the patient has rested quietly for 10 minutes is still elevated, at 182/103 mm Hg.
You must decide whether the patient’s blood pressure should be monitored over time on an outpatient basis (a “watchful waiting” approach) or whether he should begin receiving antihypertensive medications during this hospitalization.

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Gregor Bond @gregorbond.bsky.social · 28/11/2025

no screening in Austria 🇦🇹 😥

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Gregor Bond @gregorbond.bsky.social · 14/11/2025

thanks 🙏 BTS for the invitation! what a warm welcome to london 🇬🇧 I guess DSA, GEP, ddcfDNA and TTV will nicely come together as comprehensive immune monitoring post SOT bts.org.uk/bts-autumn-s... #TTVguide

bts.org.uk

BTS Autumn Symposium - British Transplantation Society

The Fundamentals of Transplantation: A Joint Educational Event by The Herrick Society of Trainees in Transplant Surgery & The British Transplant Physician Trainees

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Gregor Bond @gregorbond.bsky.social · 14/11/2025

Immune Monitoring Goes Viral 🦠 Torque Teno Virus for Immunologic Risk Stratification After Kidney Transplantation ⏩️ new review in TI 🔥 doi.org/10.3389/ti.2... #ttvguide

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Reposted by Gregor Bond

NEJM.org @nejm.org · 06/11/2025

ORIGIN phase 3 trial: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria. nej.md/3JEq8QL @asnkidney.bsky.social | #KidneyWk

American Society of Nephrology Kidney Week 2025
Original Article | Nov. 6, 2025 | NEJM.org
A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy

Figure 2A. Change from Baseline in 24-Hr Urinary Protein-to-Creatinine Ratio through Week 36.

The NEJM identity sits at the bottom.

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Reposted by Gregor Bond

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 06/11/2025

Eli Lilly continuing to hit it out the park Selective amylin agonist as an alternative to GLP1RAs? #eloralintide www.thelancet.com/journals/lan... in @thelancet.com (Yeah I know it’s #KidneyWk but what do we do till Houston wakes up!) cc @rnflex.bsky.social

Figure 2. Change in bodyweight
(A) Mean percent change in bodyweight from baseline to week 48, shown as observed means and bars indicating SEs. The model-based estimates of the mean percent change in bodyweight and differences among treatment groups at week 48 with the corresponding p values (efficacy estimand only) and 95% CIs are shown in (B) (efficacy estimand) and (D) (treatment-regimen estimand); bars indicate SEs. Multiplicity adjustment was not performed, and p values should be interpreted as exploratory. (C) shows the percentage of participants with bodyweight reductions of at least 5%, 10%, 15%, 20%, 25%, and 30% from baseline to week 48. The percentage of participants is annotated above each bar, calculated with the use of Rubin's rules by combining the percentages of participants who met the thresholds in imputed datasets. *The model-based estimates and 95% CIs from a mixed model repeated measures analysis for the efficacy estimand are shown on the right, denoted by 48.

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Reposted by Gregor Bond

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 07/11/2025

a conservative dialysis strategy in possibly recovering AKI helps people recover faster! jamanetwork.com/journals/jam... in @jama.com from #KidneyWk Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?

jamanetwork.com

A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury

This trial examines whether a conservative dialysis strategy can improve recovery of kidney function for patients with acute kidney injury who require dialysis.

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Reposted by Gregor Bond

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 07/11/2025

low dose Tac + Everolimus is not superior to Tac + MMF in older transplant recipients in @asnpublications.bsky.social another LBCT from #KidneyWk published journals.lww.com/jasn/fulltex...

journals.lww.com

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Reposted by Gregor Bond

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 04/11/2025

Natural history of RRT from the ERA registry The visual abstract in this case tells a lot academic.oup.com/ndt/advance-... @ndt-era.bsky.social #NephSky

Visual abstract
Sad story reflecting that most people start with HD and most of them die

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Reposted by Gregor Bond

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 16/10/2025

As expected, Iptacopan phase 3 in IgA nephropathy slows GFR decline APPLAUSE-IgA Adding another new medication we won’t be able to access or afford to our IgA armamentarium #NephSky www.novartis.com/news/media-r...

novartis.com

Novartis Fabhalta® (iptacopan) meets Phase III primary endpoint, slows kidney function decline in patients with IgA nephropathy (IgAN)

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Gregor Bond @gregorbond.bsky.social · 16/10/2025

viruses 🦠 can be superheroes 🦸‍♀️ Felix Herkner present the statistical analysis plan of the TTVguideIT trial at the Austrian Transplant Congress Torque Teni Virus guided immunosuppression #TTVguide

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Gregor Bond @gregorbond.bsky.social · 21/09/2025

happy to speak about TT virus 🦠 @Italien 🇮🇹 micro biology congress TTV based immune monotoring #TTVguide

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Gregor Bond @gregorbond.bsky.social · 02/09/2025

mhm that makes me curiouse to have a look at the calculations of the DSMB that led to the termination of the trial; must have been a tought decision

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Gregor Bond @gregorbond.bsky.social · 31/08/2025

well written; as a kidney doc I would just not agree that protein is bad for your kidneys

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Reposted by Gregor Bond

Joel Topf @kidneyboy.bsky.social · 25/07/2025

I use a cool programmable calculator called Soulver that works on and syncs across my iPhone, iPad, and Mac. I just created a formula to calculate the sodium after any combination of IV fluids and urine output based on Edelman.

sNa = 105 = 105
tbw = 50 = 50
=
D5W_In = 0 = 0
NS_In = 1000 = 1,000
LR_In = 0 = 0
Hypertonic_In = 200 = 200
tK_In = 40 = 40
Kwater_In = 400 = 400
urine_Na = 10 = 10
urine_K = 10 = 10
urine_Vol = 6000 = 6,000
=
final_Na = (eK_x_eNa + tNaIn + tK_In - urine_lytes)/(tbw + tWaterIn - urine_L) = 119.00438596
=
eK_x_eNa =sNa × tbw = 5,250
tNaIn = (NS_In × .154) + ( Hypertonic_In × 0.513) + (LR_In × 0.13) = 256.6
tWaterIn = (D5W_In + NS_In + Hypertonic_In + Kwater_In)/1000 = 1.6
urine_lytes = (urine_Na + urine_K) × urine_L = 120
urine_L = urine_Vol/1000 = 6
=
=
=
=
Total: 13568.2043859649

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Reposted by Gregor Bond

TTVguideTX @ttvguidetx.bsky.social · 22/07/2025

Last week, our team around @gregorbond.bsky.social from @meduniwien.ac.at took part in the "Kinderuni Wien" - Vienna’s Children’s University - to bring science to life for curious kids aged 7 to 12, where the kids learnt that some viruses like TTV can also be superheroes. #TTVguide

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Gregor Bond @gregorbond.bsky.social · 17/07/2025

I had great fun at kids university @meduniwien.ac.at today 😁 viruses 🦠 can be superheroes 🦸‍♀️ 🙏 @sebastiankaps.bsky.social and @fredhaupenthal.bsky.social for your support #ttvguide

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Reposted by Gregor Bond

TTVguideTX @ttvguidetx.bsky.social · 02/07/2025

Our team around @gregorbond.bsky.social recently participated at #ESOT2025 - here's our most important learnings: 🔸 More & more groups worldwide pick up the idea of TTV-guided immunosuppression. 🔸 First data on the association between TTV load & the development of malignomes is available. #ttvguide

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Gregor Bond @gregorbond.bsky.social · 01/07/2025

the highly prevalent and apathogenic TorqueTeno virus 🦠 is associated with immunosuppression 💊 Carsten Herz presents first data on the predicive value of malignancy post kidney transplant #TTVguide

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Gregor Bond @gregorbond.bsky.social · 30/06/2025

#ESOTCongress London 🇬🇧 Action at the eposters a multicenter observational study to validate the value of proteinuria for assessment of kidney graft quality

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Gregor Bond @gregorbond.bsky.social · 30/06/2025

#ESOTCongress 2025 London 🇬🇧 action at the eposters Torque Teno virus 🦠 for the prediction of Infection post kidney TX first long term data #TTVguide

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Gregor Bond @gregorbond.bsky.social · 30/06/2025

#ESOTCongress London 🇬🇧 presidents dinner ☺️

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Gregor Bond @gregorbond.bsky.social · 29/06/2025

freddi at #ESOTcongress 🇬🇧 depression is a major factor for reduced HRQOL post kidney TX @fredhaupenthal.bsky.social

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Gregor Bond @gregorbond.bsky.social · 28/06/2025

happy 😊 meeting you @ #ESOTcongress this Monday 1.7. in London 🇬🇧 talks 🗣️ on Torque Teno virus 🦠 guided immunosuppression 💊 09:30 and 11:00 room S1 13:15 room S5, 16:15 room S4 #ttvguide

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