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TTVguideTX

@ttvguidetx.bsky.social
90 followers 530 following 33 posts

Horizon2020 funded EU project on establishing an innovative tool to quantify the activity of the immune system in kidney transplant patients, coordinated by @gregorbond.bsky.social at @meduniwien.ac.at, Austria. Visit us at: www.ttv-guide.eu

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TTVguideTX @ttvguidetx.bsky.social · 14/09/2026
The results of our #TTVguideIT trial were recently presented at the annual meeting of the Upper Austrian Kidney Patients Association. Thanks to Prof. Daniel Cejka at Ordensklinikum Linz for supporting the important dissemination of our findings! Learn more via: www.ttv-guide.eu/results
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Gregor Bond @gregorbond.bsky.social · 09/09/2026
Torque Teno virus 🦠 is safe to guide immunosuppression in kidney transplantation our manuscript is now available as preprint ☺️ ssrn.com/abstract=740... #TTVguide
ssrn.com
Safety of Torque Teno Virus-Guided Immunosuppression in Kidney Transplant Recipients: A Randomised Controlled, Non-Inferiority, Phase 2 Trial
Background: Standardised tacrolimus trough-level targets limit individualisation of immunosuppressive therapy in kidney transplant recipients. Torque teno virus
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TTVguideTX @ttvguidetx.bsky.social · 07/09/2026
Proud that our project was featured by CORDIS Results in Brief - a service of the @ec.europa.eu. #TTVguide
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TTVguideTX @ttvguidetx.bsky.social · 13/08/2026
#TTV is spreading to #Rheumatology. Congratulations to the @squeezeproject.bsky.social team at @meduniwien.ac.at.
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Gregor Bond @gregorbond.bsky.social · 11/06/2026
Join us Friday 7:15 CEST for best of #ERA2026 @markusathome.bsky.social to learn more about TTV-guided immunosuppression in kidney transplantation #TTVguide youtu.be/OxbYH9yOd6w?...
youtu.be
62nd ERA Congress - Profs. Segelmark, Willcocks, Dixon, Fervenza, Bond, Lambers Heerspink, Neuen
YouTube video by MARKUS at HOMe
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TTVguideTX @ttvguidetx.bsky.social · 11/06/2026
Proud and happy to have such a strong partner like @biomerieux.com on board! #TTVguide
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TTVguideTX @ttvguidetx.bsky.social · 08/06/2026
First results out! Our study achieved its primary goal: #TTV guided treatment was shown to be as safe as standard care.Check out the @meduniwien.ac.at press release and our website for more information: www.ttv-guide.eu/results
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Gregor Bond @gregorbond.bsky.social · 05/06/2026
first data of the TTVguideIT RCT presented by @fredhaupenthal.bsky.social at ERA26 in Glasgow Torque Teno 🦠 virus guided immunosuppression 💊 is safe in kidney TX and might help reducing TAC dose #TTVguide
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Gregor Bond @gregorbond.bsky.social · 04/06/2026
First data of the TTVguideIT RCT presented @ERA26 in Glasgow 🏴󠁧󠁢󠁳󠁣󠁴󠁿 Personalized Immunosuppression 💊 by Torque Teno 🦠 virus in kidney TX is safe and might help reducing Tacrolimus #TTVguide @fredhaupenthal.bsky.social 👏
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Gregor Bond @gregorbond.bsky.social · 29/04/2026
the TTVguideTX team @research night for the public @meduniwien.ac.at Vienna - Austria all age groups were welcome to learn about science we presented the principle of TTV-guided immunosuppression #TTVguide
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TTVguideTX @ttvguidetx.bsky.social · 08/05/2026
New paper out! Our project partners in Leiden notified an increased risk of BKPyV DNAemia in recipients of deceased donor kidneys when the contralateral kidney recipient develops BKPyV DNAemia www.mdpi.com/2227-9059/14... #ttvguide
mdpi.com
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TTVguideTX @ttvguidetx.bsky.social · 13/04/2026
New publication: the Vienna group at @meduniwien.ac.at demonstrates the predictive value of #TTV load during months 4 to 12 post-transplant for the incidence of malignancy during years 2 to 5 post-transplant. academic.oup.com/ndt/advance-...
academic.oup.com
Torque teno virus is predictive for malignancies after kidney transplantation
AbstractBackground and hypothesis. Malignancy, driven by the effects of immunosuppression, is a major complication following kidney transplantation. The wi
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Gregor Bond @gregorbond.bsky.social · 20/02/2026
clinical trial simulations to optimise analysis strategies for multiple endpoints highlight the trade-off between statistical efficiency and interpretability #ttvguide www.nature.com/articles/s41...
nature.com
Comparison of primary analysis strategies of randomized controlled trials with multiple endpoints with application to kidney transplantation - Scientific Reports
Scientific Reports - Comparison of primary analysis strategies of randomized controlled trials with multiple endpoints with application to kidney transplantation
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TTVguideTX @ttvguidetx.bsky.social · 25/03/2026
If you are a Vienna resident or plan a spring visit to the most liveable city in the World: come join us at our booth at the Researchers Night at @meduniwien.ac.at and learn about the superhero-virus #TTV: langenachtderforschung.at/station/6326
langenachtderforschung.at
Viren können Superheroes sein oder wie kann man das Immunsystem messen? - #LNF26 Lange Nacht der Forschung
Wir erforschen wie man die Stärke des Immunsystems messen kann. Zuerst erklären wir Ihnen, anhand eines Posters und eines Animationsfilms wie das funktioniert und warum uns das TT Virus dabei hilft. D...
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TTVguideTX @ttvguidetx.bsky.social · 20/02/2026
The TTVguideIT trial uses a compound endpoint incl infection, organ rejection & patient- & graft survival. The team around @gregorbond.bsky.social at @meduniwien.ac.at used clinical trial simulations to optimise primary-analysis strategies for such multiple endpoints: www.nature.com/articles/s41...
nature.com
Comparison of primary analysis strategies of randomized controlled trials with multiple endpoints with application to kidney transplantation - Scientific Reports
Scientific Reports - Comparison of primary analysis strategies of randomized controlled trials with multiple endpoints with application to kidney transplantation
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TTVguideTX @ttvguidetx.bsky.social · 19/11/2025
Associations between #TTV and Leukocyte Populations in Solid Organ Transplant Recipients - Partners in The Netherlands provide evidence to support the theory that TTV replicates in immature granulocytes. www.ijidonline.com/article/S120... #TTVguide
ijidonline.com
Torque Teno Virus Loads and Leukocyte Populations in Stable Outpatient Solid Organ Transplant Recipients
Dosing immunosuppressive medication after solid organ transplantation remains a challenge, with no established marker of immune function available for routine clinical use. Torque teno virus (TTV), a ...
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Gregor Bond @gregorbond.bsky.social · 14/11/2025
Immune Monitoring Goes Viral 🦠 Torque Teno Virus for Immunologic Risk Stratification After Kidney Transplantation ⏩️ new review in TI 🔥 doi.org/10.3389/ti.2... #ttvguide
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Gregor Bond @gregorbond.bsky.social · 23/10/2025
can viruses 🦠 be superheroes 🦸‍♂️ ? PhD student Felix Herkner just published the statistical analysis plan of the TTVguideIT trial 💪👏 Torque Teno virus guided immunosuppression #TTVguide data cleaning until Q1/26 analysis Q2/26 trialsjournal.biomedcentral.com/articles/10....
trialsjournal.biomedcentral.com
Statistical analysis plan for TTVguideIT—a multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and Torque Teno virus-guided immuno...
Background Non-interventional studies indicate an association between Torque Teno Virus (TTV) load in peripheral blood and immunosuppression related outcomes in kidney transplant recipients. This make...
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Gregor Bond @gregorbond.bsky.social · 21/09/2025
happy to speak about TT virus 🦠 @Italien 🇮🇹 micro biology congress TTV based immune monotoring #TTVguide
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TTVguideTX @ttvguidetx.bsky.social · 22/07/2025
Last week, our team around @gregorbond.bsky.social from @meduniwien.ac.at took part in the "Kinderuni Wien" - Vienna’s Children’s University - to bring science to life for curious kids aged 7 to 12, where the kids learnt that some viruses like TTV can also be superheroes. #TTVguide
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TTVguideTX @ttvguidetx.bsky.social · 14/07/2025
🗞️ New paper out: Detection of non-intact Torque Teno viral particles. Partners in Italy have analysed the added value of PMAxx™ treatment to detect non-intact Torque Teno viral particles which may overestimate viremia quantified by digital droplet PCR. #TTV #TTVguide www.mdpi.com/1422-0067/26...
mdpi.com
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TTVguideTX @ttvguidetx.bsky.social · 03/07/2025
Interesting insights into running clinical studies in EU projects.
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TTVguideTX @ttvguidetx.bsky.social · 02/07/2025
Our team around @gregorbond.bsky.social recently participated at #ESOT2025 - here's our most important learnings: 🔸 More & more groups worldwide pick up the idea of TTV-guided immunosuppression. 🔸 First data on the association between TTV load & the development of malignomes is available. #ttvguide
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Gregor Bond @gregorbond.bsky.social · 30/06/2025
#ESOTCongress 2025 London 🇬🇧 action at the eposters Torque Teno virus 🦠 for the prediction of Infection post kidney TX first long term data #TTVguide
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Gregor Bond @gregorbond.bsky.social · 29/06/2025
freddi at #ESOTcongress 🇬🇧 depression is a major factor for reduced HRQOL post kidney TX @fredhaupenthal.bsky.social
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Gregor Bond @gregorbond.bsky.social · 28/06/2025
happy 😊 meeting you @ #ESOTcongress this Monday 1.7. in London 🇬🇧 talks 🗣️ on Torque Teno virus 🦠 guided immunosuppression 💊 09:30 and 11:00 room S1 13:15 room S5, 16:15 room S4 #ttvguide
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Gregor Bond @gregorbond.bsky.social · 17/06/2025
meet me at #ESOTcongress in London 🇬🇧 🗓️ July 1, 13:00-14:00, ROOM s5 to discuss Torque Teno virus 🦠 based immunologic monotoring viruses 🦠 can be superheroes 🦸 #ESOT2025 #TTVguide #ESOT
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pstudenic.bsky.social @pstudenic.bsky.social · 12/06/2025
Very happy to see #TTV having the opportunity to be presented and discussed in the realm of #rheumatology Great work of Daniel Mrak and interdisciplinary collaboration😊 POS0914 @squeezeproject.bsky.social #EULAR2025
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TTVguideTX @ttvguidetx.bsky.social · 12/06/2025
#TTV spreading to #Rheumatology. Currently happening at #EULAR2025. @pstudenic.bsky.social #TTVguide
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TTVguideTX @ttvguidetx.bsky.social · 10/06/2025
Are you based in Vienna & have a 7-12 yr old? 🧒🏻👧🏼 Registration opens today for the Vienna Kids University in July where @gregorbond.bsky.social will give a lecture on how some viruses can be true superheroes. 🦠 Kids will learn about the Torque Teno virus & experience being a student. Join & share! 👩🏻‍🏫
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Gregor Bond @gregorbond.bsky.social · 07/06/2025
congrets to Katharina Mayer receiving the young investigator award @ #ERA25 👏 how do TX baseline and fup data influence TT virus 🦠 load? #TTVguide
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Gregor Bond @gregorbond.bsky.social · 06/06/2025
torque teno virus 🦠 load predicts malignoma post kidney TX 💪 👏 carsten herz at #era25 viruses 🦠 can be 🦸 superheros TTVbased immune monitoring #TTVguide
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Gregor Bond @gregorbond.bsky.social · 05/06/2025
Sebastian Kapps presents first data on Torque Teno virus 🦠 in long-term kidney TX patients at #ERA25 #TTVguide
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TTVguideTX @ttvguidetx.bsky.social · 05/06/2025
Yesterday our team around @gregorbond.bsky.social came together for our Year 4 meeting at @meduniwien.ac.at to celebrate a major milestone: 🩺 The last patient visit has officially been completed in late May. Now we move to data cleaning & analysis. Follow us for insights into the potential of #TTV .
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Gregor Bond @gregorbond.bsky.social · 21/05/2025
Sebastian Kapps taking science 🧬 to the public 👨🏽‍🦱👩🏾👨🏼‍🦲👵🏼 can we use a virus 🦠 to quantify the immune system? #ttvguide
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TTVguideTX @ttvguidetx.bsky.social · 09/05/2025
📢 Partners from @chugrenoblealpes.bsky.social showed that TTV DNA load was slightly higher in whole blood (WB) than in plasma. Overall TTV detection was similar and distribution of TTV DNA loads did not differ. Read the full paper here: www.kireports.org/article/S246... #TTVguide
kireports.org
Comparison of Torque Teno Virus DNA Load in Plasma and Whole Blood
The main challenge of immunosuppressive therapy after solid organ transplantation is creating an immunological balance that prevents organ rejection without promoting opportunistic infections. Torque ...
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TTVguideTX @ttvguidetx.bsky.social · 06/05/2025
📢 First results from the AdTorque trial: a prospective study to define the optimal strategy for the detection of non-adherence towards immunosuppressive drugs after #kidneytransplantation. academic.oup.com/ndt/advance-...
academic.oup.com
Self-reported Non-adherence to Immunosuppressive Medication Detected by the BAASIS Predicts Allograft Rejections in Kidney Transplant Recipients
AbstractBackground. After kidney transplantation adherence to immunosuppressive medication is crucial for graft survival and its assessment requires valid
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TTVguideTX @ttvguidetx.bsky.social · 16/04/2025
Watch @fredhaupenthal.bsky.social - #TTVguide investigator from @meduniwien.ac.at presenting first data from the AdTorque trial: self-reported non-adherence by the BAASIS predicts graft rejection oup.cloud.panopto.eu/Panopto/Page...
oup.cloud.panopto.eu
Self-reported Non-adherence to Immunosuppressive Medication Detected by the BAASIS Predicts Allograft Rejections in Kidney Transplant Recipients
Presented by Gregor Bond Article DOI:
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TTVguideTX @ttvguidetx.bsky.social · 09/04/2025
Our coordinator @gregorbond.bsky.social today, presenting results of TTV-guided monitoring at the @squeezeproject.bsky.social General Assembly meeting, supporting SQUEEZE leader of Functional Drug Monitoring, @pstudenic.bsky.social, with spreading the Torque Teno virus to #Rheumatology. #TTVguide
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TTVguideTX @ttvguidetx.bsky.social · 03/04/2025
It's time to meet another one of the 13 recruiting centres involved in our #clinicaltrial - for one last time we are in Austria. 🇦🇹 Today, meet the #nephrology and #virology team at Ordensklinikum Linz around Daniel Cejka and learn about their roles and contributions to our common cause. #TTVguide
Graphic introducing Ordensklinikum Linz (OKL) as a TTV GUIDE TX trial center, featuring hospital and project logos on a light blue background with an orange gradientPhoto of the main entrance of Ordensklinikum Linz, a large modern hospital building with signage and a tree in front, accompanied by text describing the hospital's nephrology expertise and transplant servicesPortrait of Dr. Daniel Cejka, lead nephrologist at OKL, with a description of his role, team members, and nearly two decades of experience in transplant medicinePortraits of four team members at OKL involved in kidney transplant research, clinical studies, nephrology, virology, and immunologic research, with text highlighting their specific roles and expertise.
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Gregor Bond @gregorbond.bsky.social · 28/03/2025
very important study for clinical trial design!!
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TTVguideTX @ttvguidetx.bsky.social · 15/03/2025
Our scientific coordinator, @gregorbond.bsky.social recently gave a talk on #TTV for immunologic monitoring for @eurofinsviracor.bsky.social. Here's the recording: youtu.be/iGmCIdbXZCY #TTVguide
youtu.be
Torque Teno Virus for Immunologic Monitoring Gregor Bond TTV Webinar
YouTube video by Eurofins Viracor
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Gregor Bond @gregorbond.bsky.social · 11/03/2025
big news on torque teno virus 🦠 guided immunosuppression this summer in London 🏴󠁧󠁢󠁥󠁮󠁧󠁿 at the EU Transplant Congress #TTVguide #ESOTcongress
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TTVguideTX @ttvguidetx.bsky.social · 13/03/2025
The recordings of our recent webinars on TTV-guided immunosuppression and Ethical Dimensions of Clinical Trials hosted by the European Kidney Patient Federation (EKPF) are now available in six languages on our website under results (scroll down to videos & recordings!) www.ttv-guide.eu/results #ttv
ttv-guide.eu
RESULTS
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TTVguideTX @ttvguidetx.bsky.social · 07/03/2025
Today we continue introducing our partners with the team at @i-med.ac.at, another one of our key trial centres. With expertise in nephrology and transplant medicine, the group contributes to advancing TTV-guided immunosuppression in kidney transplantation. 👩🏻‍⚕️🏥 Happy to have them on board!
Graphic slide introducing the Medical University of Innsbruck (MUI) as a TTV GUIDE TX trial center, featuring the MUI and TTV GUIDE logos on a light blue background with an orange gradient shapeA person in blue gloves and a white coat holding a medical model of a kidney, using a metal pointer to highlight anatomical details. Accompanying text provides an overview of the Medical University of Innsbruck, its research focus, and contributions to nephrology and transplantationBlack and white portrait of Prof. Hannes Neuwirt, the principal investigator of the TTV GUIDE TX study at MUI, with text detailing his responsibilities in patient recruitment, study coordination, and stakeholder communicationPortraits of key team members from MUI involved in the TTV GUIDE TX project, including sub-investigators, transplant laboratory experts, and nephrology specialists, with text explaining their roles in patient engagement, sample processing, and data management
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TTVguideTX @ttvguidetx.bsky.social · 03/03/2025
Partners from Italy summarize what we know and do not know about the enigmatic virus #TTV. This comprehensive review looks at origin, detection and clinical value of TTV and its interaction with the immune system. #TTVguide www.mdpi.com/1999-4915/17...
mdpi.com
Torque Teno Virus: Lights and Shades
Torque Teno Virus (TTV) is a highly prevalent non-pathogenic DNA virus whose plasma levels may be related to the host’s immune status. TTV gained attention about 25 years ago, but its replication is n...
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Gregor Bond @gregorbond.bsky.social · 02/03/2025
we are proud to be part of the OEAD science ambassador team visiting school kids in vienna 🇦🇹 bringing science closer to young minds 🧬 ➡️ 🏫 🧒 👦 @oeadcitizenscience.bsky.social #ttvguide youngscience.oead.at/de/wissensch...
youngscience.oead.at
Botschafter/innen-Profile
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Gregor Bond @gregorbond.bsky.social · 28/02/2025
#ttvguide @ttvguidetx.bsky.social
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TTVguideTX @ttvguidetx.bsky.social · 26/02/2025
Meet the team at @medunigraz.at, one of our key trial centres. With expertise in nephrology and transplant medicine, the group around @kathrineller.bsky.social contributes to advancing TTV-guided immunosuppression in kidney transplantation. 👩🏻‍⚕️🏥 Happy to have them on board in our #Horizon2020 project!
Graphic slide introducing the Medical University of Graz (MUG) as a TTVguideTX trial centre, featuring the MUG and TTV GUIDE logos on a light blue background with an orange gradient shape.Exterior view of the Medical University of Graz, a modern, glass-fronted building with greenery and banners displaying the university’s name and logo. Some general information of the MedUni GrazPortraits of Prof. Kathrin Eller and Dr. Andreas Deak, the principal investigators at MedUni Graz, with text describing their roles in the TTV GUIDE TX clinical trial and patient recruitmentPortraits of MedUni Graz team members, including nephrologists, study nurses, and virologists, with a brief description of their contributions to the TTV GUIDE TX project
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TTVguideTX @ttvguidetx.bsky.social · 19/02/2025
🗞️ New paper out on Torquetenominivirus and Torquetenomidivirus as Complementary Biomarkers to Torquetenovirus (#TTV). Partners in Italy have described associations with Torquetenominivirus (TTMV) and Torquetenomidivirus (TTMDV) with SARS-CoV-2 Vaccination response. www.mdpi.com/1422-0067/26...
mdpi.com
Assessment of Torquetenominivirus (TTMV) and Torquetenomidivirus (TTMDV) as Complementary Biomarkers to Torquetenovirus (TTV)
Recent studies have identified Torquetenovirus (TTV) as a promising biomarker of immune competence, particularly in assessing the vaccine response of solid organ transplant (SOT) recipients. However, ...
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