Telomerase is a ribonucleoprotein complex that elongates telomeric DNA, ensuring germline immortality. In this study, we identified the Caenorhabditis elegans telomerase RNA component 1 (terc-1), as t...

Frejacques, Saglio, et al. demonstrate variation among C. elegans wild isolates in the multigenerational memory of an initial RNA interference trigger. Genetic polymorphisms and environmental variable...

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The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways sig...

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By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal

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Specialized ribosomes help determine which proteins are synthesized, however, the influence of age on ribosome heterogeneity and whether dysregulation of this process drives organismal aging is unknow...

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Abstract. This book chapter will focus on modifications to chromatin itself, how chromatin modifications are regulated, and how these modifications are dec