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Simone Immler

@immler.bsky.social
836 followers 1.1K following 10 posts

Professor of Genetics & Reproduction, University of East Anglia Founder and Scientific Director, Virilitas Labs

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Reposted by Simone Immler
Alice Godden @alicegodden.bsky.social · 13/12/2025
Delighted to see our work picked up by @theguardian.com this is a real window of opportunity for us to reduce carbon emissions to give the bears a hope at survival before it really is too late.
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Reposted by Simone Immler
Alice Godden @alicegodden.bsky.social · 13/12/2025
🐻‍❄️❄️ New paper alert! From me Ben & @immler.bsky.social “Diverging transposon activity among polar bear sub-populations inhabiting different climate zones” (Godden, Rix & Immler, 2025). 👉 link.springer.com/article/10.1... A thread 🧵. #climate #transposons #TESky #polarbear #ursus @biouea.bsky.social
link.springer.com
Diverging transposon activity among polar bear sub-populations inhabiting different climate zones - Mobile DNA
Mobile DNA - A new subpopulation of polar bears (Ursus maritimus) was recently discovered in the South-East of Greenland. This isolated colony inhabits a warmer climate zone, akin to the predicted...
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UEA Biological Sciences @biouea.bsky.social · 15/12/2025
The future of polar bears? Amazing work, @alicegodden.bsky.social, Ben Rix and @immler.bsky.social. #UEAScience 🐻‍❄️
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Alexei Maklakov @alexeimaklakov.bsky.social · 11/12/2025
1/6 New preprint! Do changes to insulin/IGF-1 signalling (IIS) that extend lifespan also protect the germline, or do they come with a mutational cost? led by @eduxbury.bsky.social with @alicegodden.bsky.social @immler.bsky.social Johnny de Coriolis Hanne Carlsson www.biorxiv.org/content/10.6...
biorxiv.org
Lifespan-extending downregulation of insulin signalling reduces germline mutation load
Reduced insulin/IGF-1 signalling (IIS) robustly extends lifespan and enhances somatic stress resistance across taxa, yet its consequences for germline genome integrity remain unclear. Here we combine ...
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Reposted by Simone Immler
Elizabeth Duxbury @eduxbury.bsky.social · 11/12/2025
Very happy to share this large-scale study from my postdoc with @alexeimaklakov.bsky.social. Lifespan-extending downregulation of insulin signalling reduces germline mutation load. Many thanks to our collaborators @alicegodden.bsky.social @immler.bsky.social Johnny de Coriolis and Hanne Carlsson.
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Reposted by Simone Immler
Alice Godden @alicegodden.bsky.social · 02/10/2025
🧬 Our latest paper out in Scientific Reports! We explored how Gum Arabic (a dietary fibre) affects the microbiota–gut–brain axis and whole-organism fitness in zebrafish. 🔗 www.nature.com/articles/s41... @immler.bsky.social @biouea.bsky.social What we found ⬇️
nature.com
Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish - Scientific Reports
Scientific Reports - Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish
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Simone Immler @immler.bsky.social · 26/06/2025
This is a simple parsimonious model to explain the evolution of lifespan extension by dietary restriction and other forms of stress that suppress fertility. Happy to be part of this exciting study!
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Healthcare-Global @healthcare-global.bsky.social · 06/04/2025
www.sciencealert.com/hormone-free...
sciencealert.com
Hormone-Free Male Birth Control Pill Enters Clinical Trials For The First Time
A hormone-free male birth control pill is undergoing clinical testing for the first time ever.
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Reposted by Simone Immler
Christoph Kaleta @kaletalab.bsky.social · 04/04/2025
1/7: Proud to present our next study on aging microbiome - a massive experimental effort led by the Rosenstiel and Sommer labs and contributions by @sci-witch.bsky.social. @uni-kiel.de @crc1182.bsky.social microbiomejournal.biomedcentral.com/articles/10....
microbiomejournal.biomedcentral.com
Life-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice - Microbiome
Background Alterations in the composition and function of the intestinal microbiota have been observed in organismal aging across a broad spectrum of animal phyla. Recent findings, which have been der...
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Reposted by Simone Immler
Alice Godden @alicegodden.bsky.social · 22/03/2025
🔬 My latest work w/ @immler.bsky.social et al: Env. stress alters sperm sRNAs, linking gene expr. + transposons in #zebrafish offspring. @heredityjournal.bsky.social 🧬 Social stress shapes RNA/TE activity across generations #Sperm #miRNA #piRNA #Transposons #TEsky @biouea.bsky.social rdcu.be/eeAwB
rdcu.be
Environmentally induced variation in sperm sRNAs is linked to gene expression and transposable elements in zebrafish offspring
Heredity - Environmentally induced variation in sperm sRNAs is linked to gene expression and transposable elements in zebrafish offspring
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Reposted by Simone Immler
Nature Portfolio @natureportfolio.nature.com · 01/03/2025
A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪
go.nature.com
Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine
Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range of age-related diseases were compared, highlighting the potential beneficial effects of environment-focused interventions.
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Simone Immler @immler.bsky.social · 11/02/2025
Happy International Women in Science day! I owe a lot to all of you that I met along the way, as my supervisors, mentors, friends, colleagues, PhD students, postdocs, research assistants, daughters, mothers and… and.. and…
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Reposted by Simone Immler
Zebrafish Rock! @zebrafishrock.bsky.social · 11/02/2025
Celebrate 'International Day of Women and Girls in Science Day' by strengthening your timeline with these outstanding Scientists! *Now in two volumes below* 🧪 #WomenInScience (Volume 1): go.bsky.app/4BegEjv #WomenInScience (Volume 2): go.bsky.app/VoebYrt
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Physalia-courses@ONLINE @physaliacourses.bsky.social · 11/02/2025
🚀 Join us to learn about genome assembly, and annotation, exploring cutting-edge sequencing tech like Illumina @pacbio.bsky.social , @nanoporetech.com 🧬🔬 Don't miss out—join us: www.physalia-courses.org/courses-work... #Genomics #Bioinformatics #GenomeAssembly
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Oded Rechavi @odedrechavi.bsky.social · 07/02/2025
IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science @nightsciencepod.bsky.social 10-13 of June in Prague & the Woods of Bohemia... Be there or be REJECTED. #theconferencetoendallconferences
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Miguel Godinho Ferreira @miguelgf.bsky.social · 03/02/2025
New model of premature #aging in #zebrafish 👏 "Loss of wrn leads to a short lifespan and age-related characteristics in the intestine of zebrafish embryos, such as cellular senescence, genomic instability, and epigenetic alteration." Go Fish! 🐟 www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Physalia-courses@ONLINE @physaliacourses.bsky.social · 04/02/2025
Join our online course on Genome-Wide Prediction of Complex Traits with @oscargenomics.bsky.social & Evangelina (March 24-28). You will learn the essential steps to implement genome-wide prediction analyses in animals, plants and humans Limited spots! 👉 www.physalia-courses.org/courses-work...
physalia-courses.org
GENOME-WIDE PREDICTION OF COMPLEX TRAITS
Dates 24-28 March 2025 To foster international participation, this course will be held online
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Zebrafish Rock! @zebrafishrock.bsky.social · 02/02/2025
Hand-drawn images of larval and juvenile zebrafish. Credit to @stednitz.bsky.social. #ZebrafishZunday 🧪
Hand-drawn images of zebrafish from 21 days post fertlization (dpf)(top), 36dpf and 7dpf. Anterior to left. You can see the eye and tails of the fish with the distinct stripes.
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Reposted by Simone Immler
Casey Dunn @caseywdunn.bsky.social · 29/01/2025
Try our new in silico PCR (sPCR) tool sharkmer- github.com/caseywdunn/s.... You give it primers and fastq reads, it gives you sequences that would be amplified by PCR. Works in minutes on a laptop for high copy regions like rRNA, great for species id etc. Feedback welcome. #bioinformatics #ngs
github.com
GitHub - caseywdunn/sharkmer
Contribute to caseywdunn/sharkmer development by creating an account on GitHub.
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Reposted by Simone Immler
Simone Immler @immler.bsky.social · 28/01/2025
If you are interested in the biological function of piRNAs and how they interact with TEs, this is the tool for you (for any organism with relevant info available) - full credit to @alicegodden.bsky.social who came up with this brilliant idea! And enjoy the fish 🐟 eating the Pi(e) 🥧
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Reposted by Simone Immler
Zebrafish Rock! @zebrafishrock.bsky.social · 28/01/2025
FishPi software is freely available here: github.com/alicegodden/...
github.com
GitHub - alicegodden/fishpi: piRNA TE analysis tool
piRNA TE analysis tool. Contribute to alicegodden/fishpi development by creating an account on GitHub.
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Simone Immler @immler.bsky.social · 28/01/2025
If you are interested in the biological function of piRNAs and how they interact with TEs, this is the tool for you (for any organism with relevant info available) - full credit to @alicegodden.bsky.social who came up with this brilliant idea! And enjoy the fish 🐟 eating the Pi(e) 🥧
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Reposted by Simone Immler
Itai Yanai @itaiyanai.bsky.social · 27/01/2025
Apple: podcasts.apple.com/us/podcast/n... Spotify: open.spotify.com/episode/5vDS...
podcasts.apple.com
69 | Keith Yamamoto and the freedom to fail
Podcast Episode · Night Science · 01/27/2025 · 41m
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Reposted by Simone Immler
Evolution Letters @evolletters.bsky.social · 23/01/2025
The maintenance of genetic polymorphism underlying sexually antagonistic traits doi.org/10.1093/evle... Now in @evolletters.bsky.social by Ewan Flintham et al.
doi.org
The maintenance of genetic polymorphism underlying sexually antagonistic traits
Abstract. Selection often favors different trait values in males and females, leading to genetic conflicts between the sexes when traits have a shared gene
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Reposted by Simone Immler
Eric Topol @erictopol.bsky.social · 22/01/2025
Reversing Type 2 diabetes A randomized trial of an SGLT-2 drug and moderate caloric restriction (vs placebo drug) led to remission in 44% vs 28% in the control group
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Cedric Feschotte @cedricfeschotte.bsky.social · 20/01/2025
Tour de force! @metorrespadilla.bsky.social & team develop Smart-seq+5′ to map TSS in single embryos with unprecedented res revealing plethora of TE-driven transcripts in 5 mammal species. Some surprisingly old & conserved. Treasure trove of new biology for yrs to come! www.cell.com/cell/fulltex...
cell.com
An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development
Mapping transcription start sites across five mammalian species before, during, and after embryonic genome activation unveils widespread transposable element-driven transcription and co-option of evol...
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Simone Immler @immler.bsky.social · 18/01/2025
I still enjoy looking at zebrafish embryos even after many years. New lab members and students seeing them for the first time never fail to express their amazement
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Reposted by Simone Immler
Simone Immler @immler.bsky.social · 08/01/2025
A great end to 2024: The Zebrafish Sperm Proteome analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/... We described >5400 sperm proteins! Spearheaded by PhD student Jayme Cohen in collaboration with many people at @uniofeastanglia.bsky.social @johninnescentre.bsky.social
analyticalsciencejournals.onlinelibrary.wiley.com
The Zebrafish Sperm Proteome
One of the key processes that forms the basis of fertilisation is the tight interaction between sperm and egg. Both sperm and egg proteomes are known to evolve and diverge rapidly even between closel...
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Simone Immler @immler.bsky.social · 08/01/2025
A great end to 2024: The Zebrafish Sperm Proteome analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/... We described >5400 sperm proteins! Spearheaded by PhD student Jayme Cohen in collaboration with many people at @uniofeastanglia.bsky.social @johninnescentre.bsky.social
analyticalsciencejournals.onlinelibrary.wiley.com
The Zebrafish Sperm Proteome
One of the key processes that forms the basis of fertilisation is the tight interaction between sperm and egg. Both sperm and egg proteomes are known to evolve and diverge rapidly even between closel...
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Reposted by Simone Immler
Alice Godden @alicegodden.bsky.social · 31/12/2024
🚨New paper from @immler.bsky.social lab Led by Jayme Cohen doi.org/10.1002/pmic... On the #Zebrafish #sperm proteome out now! 🐠
doi.org
The Zebrafish Sperm Proteome
One of the key processes that forms the basis of fertilisation is the tight interaction between sperm and egg. Both sperm and egg proteomes are known to evolve and diverge rapidly even between closel...
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Reposted by Simone Immler
Nicolas Galtier @nicolasgaltier.bsky.social · 22/12/2024
Sorry, better quality picture:
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BrunetLab @brunetlab.bsky.social · 18/12/2024
Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵
rdcu.be
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
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Asher Cutter @asherdcutter.bsky.social · 16/12/2024
Just accepted #EcologyLetters! Exciting work by recent grad Rebecca Schalkowski with @katjakasimatis.bsky.social and Megan Greischar linking 2 species community coexistence to sperm cell mediated reproductive interference! Preprint here www.authorea.com/users/804447...
authorea.com
Reproductive interference alters species coexistence in nematodes due to asymmetric sperm-induced harm
Species coexistence is shaped by a range of biotic and abiotic factors. Beyond predation, parasitism, and competition, one species may interfere with another's reproduction to induce sexual exclusion ...
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Alex Gunderson @agunderson.bsky.social · 16/12/2024
New paper in J Exp Bio on the heat tolerance of sperm in the brown anole lizard. PhD student Wayne Wang developed a way to measure sperm cell LT50, found that sperm heat tolerance is repeatable across males, and that episodic male heat stress reduces sperm motility 🦎 #anolis doi.org/10.1242/jeb....
A male brown anole lizard perched on a bushA microscope image of hundreds of lizard sperm cells
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Zebrafish Rock! @zebrafishrock.bsky.social · 14/12/2024
A few newbies (to Bluesky) added 💪 Welcome to: @uribelab.bsky.social @acoffin.bsky.social @dagansegal.bsky.social @immler.bsky.social #WomenInScience
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Matthew Hahn @3rdreviewer.bsky.social · 10/12/2024
New paper led by @yadirapga.bsky.social! Even though opossums have kids at 0.5 years, they still have typical male-biased mutation (though not quite as high as humans). "Low mutation rate but high male-bias in the germline of a short-lived opossum" www.biorxiv.org/content/10.1...
biorxiv.org
Low mutation rate but high male-bias in the germline of a short-lived opossum
Age and sex have been found to be important determinants of the mutation rate per generation in mammals, but the mechanisms underlying these factors are still unclear. One approach to distinguishing b...
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Aaron Vogan @fungage-lab.bsky.social · 09/12/2024
The final version of our latest Starship manuscript is out!🚀We study the evolution of a gene cluster for formaldehyde resistance to show that #HGT mediated by giant Starship #transposons is a recurrent force in #fungal adaptation. www.science.org/doi/full/10....
Summary slide showing how the giant transposon "Chrysaor" (Centre) confers resistance to high concentrations of formalin in both Paecilomyces variotii (bottom right) and Aspergillus fumigatus (Bottom left). Phylogenies (Top left) and whole genome comparisons (Top right) indicate that Chrysaor has been horizontally transferred between these species.
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Alice Godden @alicegodden.bsky.social · 08/12/2024
We have just updated FishPi with more functionality- check it out! #TESky
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Alice Godden @alicegodden.bsky.social · 08/12/2024
🚨Pleased to share our latest preprint on #zebrafish #geneexpression and #transposons in #sperm & #embryos exposed to social stress
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Alice Godden @alicegodden.bsky.social · 08/12/2024
🚨 Happy to share my latest preprint on #polarbear #transposon activity in response to diverging climates in #Greenland #TEsky 🐻‍❄🌞❄️🧬👩‍💻
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