A 14-protein plasma signature identifies individuals benefiting from anti-IL-1β-based lung cancer risk reduction and demonstrates how diverse tumor-promoting factors converge on the induction of an al...

Microplastics (MPs), microparticles from plastic degradation, pose a substantial threat to human health. Macrophages, the body’s immune sentinels, are…

AbstractThe risks and health consequences of cancers increase dramatically at older ages. To develop interventions to limit the impact of cancers, from preventative to therapeutic, we must seek both e...

The high-plasticity cell state (HPCS) is a critical hub that enables reciprocal transitions between cancer cell states, and targeting the HPCS may suppress cancer progression and eradicate treatment r...

While progress has been made in treating advanced non-small-cell lung cancer, patients would further benefit from methods that detect progressive premalignant lesions and strategies that effectively i...

Lung cancer remains the deadliest cancer in the United States, with lung adenocarcinoma (LUAD) as its most prevalent subtype. While computed tomography (CT)-based screening has improved early detectio...

Former Guardian science editor, letters editor, arts editor and literary editor Tim Radford has condensed his journalistic experience into a handy set of rules for aspiring hacks

Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and dif...

PIK3CA mutation is frequently concurrent with known oncogenic drivers such as EGFR mutation in lung cancer, raising an interesting question about its real function. Cachexia is a systemic disease invo...

Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.

This Review addresses the roles of type 2 immunity in cancer and the potential for cancer immunotherapies targeting this pathway.

Hemalatha et al. track the endogenous redox ratio (NAD(P)H/FAD) with live imaging in the mouse skin to study the interface of wild-type stem cells with oncogenic mutant cells. They find that maintaini...

Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.

Tumor progression is an evolutionary process during which cells acquire distinct genetic alterations. Several cancer evolutionary studies reconstruct this evolutionary process by applying bulk DNA seq...

Severe lung injury causes airway basal stem cells to migrate and outcompete alveolar stem cells, resulting in dysplastic repair. We found that this “stem cell collision” generates an injury-induced ti...

Join us to explore how stem cell competition can lead to premalignancy and cancer in this interactive event!

Subtyping of non-small cell lung cancer can be challenging based on pathology. Here, the authors utilise multi-omics analysis of 229 patients to identify further subtypes, and altered immune compositi...