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Mike Robson

@drmrobson.bsky.social
516 followers 1.1K following 10 posts

Group leader of Chromatin (Dys)function lab @MDC-BIMSB Former Postdoc @Mundlos lab PhD @ Schirmer lab www.mdc-berlin.de/robson

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Reposted by Mike Robson
Karissa Hansen @karissalhansen.bsky.social · 16/06/2026
Looking forward to presenting recent work from my time in @elphegenoralab.bsky.social next week!
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Reposted by Mike Robson
Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · 13/05/2026
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇
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Reposted by Mike Robson
Claudio Cantù @claudiocantu81.bsky.social · 14/04/2026
Register to The PALS Summer School in TranscriptOMICS 👉 Before April 15 And Learn how to perform: Single-cell Multiome data analysis and integration — workflow management and reproducibility from Daniel Mouzo @qmul.bsky.social @scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social
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Reposted by Mike Robson
Claudio Cantù @claudiocantu81.bsky.social · 17/04/2026
The PALS Summer School in Transcriptomics, I promise, will be a unique experience www.trippus.net/summerschool... 23-26 June 2026 in a hidden Swedish paradise 🇸🇪🫎 We have extended the deadline to May 15 or until availability @scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social
event.trippus.net
Summer School 2026
Come to this beautiful Swedish inland scenario to learn the most advanced technologies to study transcriptional regulation.
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Reposted by Mike Robson
Bjørt K.Kragesteen @kragesteen-lab.bsky.social · 23/03/2026
Come and join us at Karolinska Institutet! We are recruiting computational/wet-lab postdocs to the Kragesteen lab to decipher gene regulation of oxygen homeostasis using organoids/hypoxia mouse models coupled with CRISPR and sc/st omic readouts 🏔️🩸🧬🧫 Apply by 7th April: ki.varbi.com/what:job/job...
ki.varbi.com
Two postdoc postions - one computational and one wet lab – in Hypoxia Biology and Genome Regulation
Vill du bidra till medicinsk forskning av toppkvalitet? Kom och bli en del av Kragesteens grupp vid institutionen för Medicinsk Biokemi och Biofysik (MBB) på Karolinska Institutet /Biomedicum och va
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Reposted by Mike Robson
Darío Lupiáñez @dariloops.bsky.social · 24/02/2026
🤩💪 Out now! 3D regulatory hubs in sex determination With @mamartirenom.bsky.social & Capel labs, led by @imotagom.bsky.social & @jrotwitguez.bsky.social 1️⃣ METALoci – explore #3DGenome 🧬 2️⃣ Non-coding region controlling Fgf9 🧩 3️⃣ Meis genes = new key players 🌟 👉 rdcu.be/e5sm2 1/n Bluetorial 👇
rdcu.be
Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs
Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...
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Seychelle Vos @voslab.org · 12/02/2026
Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...
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Reposted by Mike Robson
Michal Gdula @michal-gdula.bsky.social · 05/02/2026
We’re recruiting! Three-year, fully funded #postdoc opportunity: pancreatic cancer #epigenetics & potential new treatments (funded by @ncn.gov.pl & @dfg.de ). Collaboration with @akispapantonis.bsky.social, University of Göttingen (OPUS-LAP). See the ad & contact me! drive.google.com/file/d/1vrFd...
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mathiaseder.bsky.social @mathiaseder.bsky.social · 19/09/2025
✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here: www.science.org/doi/10.1126/...
science.org
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
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Juliane Glaser @julianeg.bsky.social · 04/09/2025
🥳 Very grateful for the support of the ERC Starting Grant for my newly established lab! We will study how transposable elements contribute to mammalian embryonic development. We will have positions available next year. Stay tuned!
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Craig Kaplan @triggerloop.bsky.social · 27/08/2025
Eva Nogales @nogaleslab.bsky.social introducing the 2025 CSH Mechanisms of Eukaryotic Transcription Meeting. Co-organizing with Wendy Bickmore @wbickmor.bsky.social and Joanna Wysocka. Will intermittently try to update as allowed
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Kate Miroshnikova @katemiro.bsky.social · 15/08/2025
Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...
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Abby Buchwalter @abbybuch.bsky.social · 22/07/2025
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
nature.com
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
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Reposted by Mike Robson
Johannes Stein @jmstein.bsky.social · 13/08/2025
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen! Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org! doi.org/10.1073/pnas... 👇🧵
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Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 29/03/2025
Celebrating 10 years of our lab with a new preprint: www.biorxiv.org/content/10.1... How does enhancer location within a TAD control transcriptional bursts from a cognate promoter? Experiments by Jana Tünnermann and modelling by Gregory Roth
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Juliane Glaser @julianeg.bsky.social · 09/07/2025
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
nature.com
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
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Mike Robson @drmrobson.bsky.social · 08/07/2025
Calling all aspiring Postdocs! One extra week to apply to join our exciting HFSP-funded project to uncover how chromatin moves to function. Deadline July 15th. www.mdc-berlin.de/career/jobs/...
mdc-berlin.de
Wissenschaftliche*r Mitarbeiter*in/ Postdoc (m/f/d)
Chromatin ist nicht unbeweglich. Es handelt sich um ein hochdynamisches Material, dessen 3D-Struktur zentrale genomische Prozesse – von der Transkription bis zur DNA-Reparatur – steuert. Doch wie verh...
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Mike Robson @drmrobson.bsky.social · 08/07/2025
Calling all aspiring Postdocs! One extra week to apply to join our exciting HFSP-funded project to uncover how chromatin moves to function. Deadline July 15th. www.mdc-berlin.de/career/jobs/...
mdc-berlin.de
Wissenschaftliche*r Mitarbeiter*in/ Postdoc (m/f/d)
Chromatin ist nicht unbeweglich. Es handelt sich um ein hochdynamisches Material, dessen 3D-Struktur zentrale genomische Prozesse – von der Transkription bis zur DNA-Reparatur – steuert. Doch wie verh...
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Reposted by Mike Robson
Mike Robson @drmrobson.bsky.social · 20/06/2025
Postdoc🚨! Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro
mdc-berlin.de
Wissenschaftliche*r Mitarbeiter*in/ Postdoc (m/f/d)
Chromatin ist nicht unbeweglich. Es handelt sich um ein hochdynamisches Material, dessen 3D-Struktur zentrale genomische Prozesse – von der Transkription bis zur DNA-Reparatur – steuert. Doch wie verhält sich Chromatin als Material – als Flüssigkeit, Feststoff oder viskoelastisches Gel –, um diese Funktionen in lebenden Zellen auszuführen? Ohne eine Antwort auf diese Frage können wir nicht vollständig verstehen, wie Chromatin bei Krankheiten gestört wird.
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Reposted by Mike Robson
Evgeny Kvon @evgenykvon.bsky.social · 02/07/2025
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
nature.com
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
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Mike Robson @drmrobson.bsky.social · 20/06/2025
Postdoc🚨! Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro
mdc-berlin.de
Wissenschaftliche*r Mitarbeiter*in/ Postdoc (m/f/d)
Chromatin ist nicht unbeweglich. Es handelt sich um ein hochdynamisches Material, dessen 3D-Struktur zentrale genomische Prozesse – von der Transkription bis zur DNA-Reparatur – steuert. Doch wie verhält sich Chromatin als Material – als Flüssigkeit, Feststoff oder viskoelastisches Gel –, um diese Funktionen in lebenden Zellen auszuführen? Ohne eine Antwort auf diese Frage können wir nicht vollständig verstehen, wie Chromatin bei Krankheiten gestört wird.
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Mike Robson @drmrobson.bsky.social · 31/05/2025
We're thrilled to continue our deep dive into how chromatin mechanics govern how our genomes function with our A-team @andersshansen.bsky.social @Davide Michieletto, and @Sandra Tenreiro. A huge thanks to the @dfg.de and @hfspo.bsky.social for supporting us. Stay tuned! PhDs/Postdocs coming soon!
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Max Delbrück Center @mdc-berlin.bsky.social · 30/05/2025
@drmrobson.bsky.social has won two grants from @dfg.de & @hfspo.bsky.social totaling over €2 million. He and his lab now work to decode the mechanics of #chromatin, hoping to finally define its physical state and better understand how it governs gene regulation www.mdc-berlin.de/news/news/mi...
portrait of a man
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Reposted by Mike Robson
Daniel Ibrahim @danielibrahim.bsky.social · 27/05/2025
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...
rdcu.be
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
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@tim_stasevich @tim-stasevich.bsky.social · 12/02/2025
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...
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Mike Robson @drmrobson.bsky.social · 08/05/2025
The Robson lab's second paper! A truly fun collaboration with an unexpected and important finding - progenitors reconfigure 3D genomes organisation to commission loci for future cell fates. A heroic amount of work from a rockstar team.
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Jop Kind @jopkind.bsky.social · 08/05/2025
Very excited to share our latest work revealing a prominent role for LADs in commisioning cell fates in mouse organ & tissue development, particularly of the limb. Amazing work by Isabel and Samy together with @stemundi.bsky.social & @drmrobson.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates
Diverse forms of heterochromatin block inappropriate transcription and safeguard differentiation and cell identity. Yet, how and when heterochromatin is reconfigured to facilitate changes in cell-fate...
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Jop Kind @jopkind.bsky.social · 28/04/2025
This year I am climbing the alpe d’Huez by bike 6 times to raise money for cancer research. 100% of the funds are directly invested into cancer research. Please click on the link below if you wish to fund this cause and help me reach my goals. Thanks! www.opgevenisgeenoptie.nl/fundraisers/...
opgevenisgeenoptie.nl
Jop Kind
Ik doe mee aan Alpe d’HuZes omdat ik geloof dat wij samen kunnen werken aan een wereld waarin je niet meer doodgaat aan kanker, wil jij mij steunen?
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Konrad Chudzik @konrad-chudzik.bsky.social · 08/05/2025
🚨 Preprint 🚨 Ever wondered how cells prepare their genomes to enable new cell-fates? In this team up with the Kind lab, we show that genes are repositioned in the nucleus to get ready for future activation and tissue formation. Read 🧵👇 to find out how and when this happens! doi.org/10.1101/2025...
biorxiv.org
Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates
Diverse forms of heterochromatin block inappropriate transcription and safeguard differentiation and cell identity. Yet, how and when heterochromatin is reconfigured to facilitate changes in cell-fate...
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Mike Robson @drmrobson.bsky.social · 23/04/2025
And modelling extraordinaire @gfudenberg.bsky.social who somehow got missed!
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Konrad Chudzik @konrad-chudzik.bsky.social · 14/04/2025
Grateful to my wonderful collaborators worldwide: Yuko Sato, Xingchi Yan, Simon Ulrich, @watanyatra.bsky.social, Lothar Schermelleh, Hiroshi Kimura, IrinaSolovei & my supervisor @drmrobson.bsky.social. Thank you for your hard work & support throughout! 🌍🙏
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Jesse Veenvliet @jesseveenvliet.bsky.social · 19/04/2025
😱 A very hungry #PacManoid ate the original post 🍬🍬🍬 Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again! Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st... Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
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Mike Robson @drmrobson.bsky.social · 14/04/2025
The first paper from the Robson lab and a wonderful team effort with our international collaborators. Through a lot of detective work, we unravel an important artifact, Ab-trapping, that leads to profoundly misleading signal in both microscopy and genomics. Absolutely worth a read!
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Juliane Glaser @julianeg.bsky.social · 16/01/2025
It’s official 🎉 I am excited to share that I will start my lab this spring at the Max Planck Institute for Immunobiology and Epigenetics @mpi-ie.bsky.social in beautiful Freiburg 🤩🗻☀️ I am looking forward to new collaborations and working with the fantastic community in Freiburg & its surroundings!
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