iiinova — where your digital self keeps evolving

Brian Johnston @drbwbri.bsky.social · 06/05/2025

New publication out in Intensive Care Medicine! We review the challenges & advances in managing atrial fibrillation in critical illness, and outline key gaps for future research. Read it here: doi.org/10.1007/s001... #ICU #AFib #CriticalCare

050

Brian Johnston @drbwbri.bsky.social · 07/04/2025

In Lund, Sweden 🇸🇪 for the TARGET meeting — advancing AI-driven virtual twins 🤖 to fight AF ❤️ and stroke 🧠 across Europe 🇪🇺 #TARGETproject #DigitalHealth #AF #EUresearch @nhsuhlg-ri.bsky.social @target-horizoneu.bsky.social @liverpooluni.bsky.social

140

Reposted by Brian Johnston

Shai @shaiuk.bsky.social · 18/03/2025

Prof Xavier Monnet addresses the HD effects of prone positioning. Great take homes about the risk of the waterfall effect and the use of Trendelenburg position in the prone patient to predict fluid responsiveness. Linked paper below #ISICEM25 #EMIMCC ccforum.biomedcentral.com/articles/10....

Opening slide regarding Haemodynamic effects of Prone Positioning by Prof X. Monnet

Infographic describing potential outcomes of prone positioning g on the cardiovascular system

Four keys messages on the impact of prone positioning on patient Haemodynamics

185

Reposted by Brian Johnston

Filippo D’Amico @filippodamico.bsky.social · 20/03/2025

#ISICEM25 | Always fascinating to hear @MichardFrederic discuss the future of bedside screens 🖥️🔍 📊 Evolution to visual decision support tools 🔹 Turning data into knowledge ⚡ Faster & more accurate detection of abnormalities 🧠 Improving situation awareness & reducing cognitive workload

022

Brian Johnston @drbwbri.bsky.social · 21/03/2025

Absolutely thrilled that @liverpooluni.bsky.social 4th year medical student Jessica who undertook her MRes with us at NHS University Hospitals of Liverpool Group has won an award for her poster at #isicem25 #isicem ISICEM. Absolutely bossing it! 👊🏻🤗 well done Jessica! 👊🏻 @nhsuhlg-ri.bsky.social

010

Reposted by Brian Johnston

JAMA @jama.com · 18/03/2025

Among patients with moderate to severe ARDS, inhaled sedation with sevoflurane resulted in fewer ventilator-free days at day 28 and lower 90-day survival than sedation with propofol. ja.ma/4kxDZGm #ISICEM25

Visual Abstract. Inhaled Sedation in Acute Respiratory Distress Syndrome

0178

Reposted by Brian Johnston

Shai @shaiuk.bsky.social · 18/03/2025

The liver IS evil. Is does needs exercise The day ends with a phenomenal talk from one of my favourite hepatologists - Prof Julia Wendon. ACLF… a difficult topic that we all should know more about. Prognosis is everything. #ISICEM25 #EMIMCC

Prof. Julia Wendon finishing her talk on acute on chronic liver failure (ACLF) and encouraging hepatology sustaining behaviours.

074

Reposted by Brian Johnston

Tommaso Scquizzato, MD @tscquizzato.com · 18/03/2025

Now @pirracchior presenting the OVISS Reinforcement Learning Study: Optimal Vasopressin Initiation in Septic Shock @ISICEM.bsky.social #ISICEM25

011

Reposted by Brian Johnston

Tommaso Scquizzato, MD @tscquizzato.com · 18/03/2025

Results of the #SESARtrial: Among patients with moderate/severe ARDS, inhaled sedation with sevoflurane resulted in - fewer ventilator-free days at day 28 - lower 90-day survival than sedation with propofol. Now published in JAMA jamanetwork.com/journals/ja... @isicem.bsky.social #ISICEM25

053

Reposted by Brian Johnston

Shai @shaiuk.bsky.social · 18/03/2025

At #ISICEM Fodder for the evening run is gathering. Not least the OVISS study looking at a reinforcement learning tool for the optimal timing of vasopressin introduction. jamanetwork.com/journals/jam...

jamanetwork.com

Optimal Vasopressin Initiation in Septic Shock

This multicenter study uses reinforcement learning to examine the treatment implications of a vasopressin initiation rule developed to improve short-term and hospital outcomes in critically ill adults...

245

Reposted by Brian Johnston

isicem.bsky.social @isicem.bsky.social · 06/03/2025

@isicem.bsky.social is renowned for its full, high-quality scientific program. Watch now Prof. Fabio Taccone's recommendations & start crafting your personalized learning journey today! More sessions on isicem.org/1/ProgrammeI... #criticalcare #intensivecare #emergencymedicine

033

Reposted by Brian Johnston

JAMA @jama.com · 17/03/2025

"The sparseness of formal regulation contrasts starkly with AI’s potential to cause harm." This Viewpoint examines prospects for populating the regulatory landscape for health and health care AI in the coming years. ja.ma/429LY54

0119

Reposted by Brian Johnston

Rachael Sirianni, PhD @docsirianni.bsky.social · 15/03/2025

This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH

7072655010664

Reposted by Brian Johnston

Science Friday @scifri.bsky.social · 21/02/2025

In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years. Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.

buff.ly

A Vaccine For Pancreatic Cancer Continues To Show Promise

In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine for the disease had no relapse three years later.

686240355578

Brian Johnston @drbwbri.bsky.social · 17/02/2025

🩺🫀 Exciting news! 🫀🩺 Thank you, Isansys Lifecare, for delivering our next batch of wireless patient monitoring systems for the WARD 24/7 substudy! We’re using AI & wireless monitoring to improve patient care & save lives. #AIinHealthcare #WirelessMonitoring #Research #AI @nhsuhlg-ri.bsky.social

000

Reposted by Brian Johnston

Peter Hampshire @peterunner.bsky.social · 09/02/2025

Disappointing decision whatever the underlying reasons, given that Liverpool's future economic growth is centred on Health and Life Sciences development.

032

Reposted by Brian Johnston

Victoria Derbyshire @vicderbyshire.bsky.social · 04/02/2025

It's World Cancer Day and 10 years ago this year I was diagnosed with breast cancer. I can't believe it was a decade ago This is me in hospital waiting to have a mastectomy. I'm smiling but god I was so anxious, so worried I wouldn't wake up from the anaesthetic 🧵

Me in a hospital bed wearing one of those standard NHS hospital gowns preparing for a mastectomy

1724092254

Reposted by Brian Johnston

TRAstonDrs @castltrastondrs.medsky.network · 04/02/2025

#Medsky🧪 #IDSky #Immunosky #pharmasky #publichealth This Review discusses management of safety issues for #CARTcell therapies : #cytokine release syndrome, as well as druggable targets & cellular engineering strategies to develop safer #CART cells www.nature.com/articles/s41...

Signalling pathways, cytokine axes and possible therapeutic interventions for managing CAR-T cell inflammatory toxicity.

2113

Reposted by Brian Johnston

Pulm PEEPS @pulmpeeps.bsky.social · 04/02/2025

🚨🚨We’re so excited to be back podding today!! Listen now to the first episode in our new Guidelines Series. We’re starting with the Asthma GINA guidelines and today talking about diagnosis, assessment, and phenotyping www.pulmpeeps.com/2025/02/04/9...

095

Reposted by Brian Johnston

Pete Turton @peteturton85.bsky.social · 04/02/2025

And submental muscle recruitment increases during expiratory loading tasks pubmed.ncbi.nlm.nih.gov/17294298/ Although post extubation dysphagia is clearly multi factorial, could training of the submental muscles after extubation improve swallowing?

121

Reposted by Brian Johnston

Pete Turton @peteturton85.bsky.social · 04/02/2025

Expiratory muscle strength training (EMST) has some evidence for improving swallowing in several disease states But what about after extubation in intensive care? Can EMST improve post extubation dysphagia? Our SR protocol, published today #critcare onlinelibrary.wiley.com/doi/full/10....

onlinelibrary.wiley.com

Effects of Expiratory Muscle Strength Training on Swallowing in Survivors of Critical Illness: A Protocol for a Systematic Review and Meta‐Analysis

Background and Aims Post Extubation Dysphagia (PED) is a common consequence of mechanical ventilation. Muscular weakness and atrophy are potential causes. Expiratory Muscle Strength Training (EMST) ...

144

Reposted by Brian Johnston

Eric Topol @erictopol.bsky.social · 04/02/2025

New: The largest medical A.I. randomized controlled trial yet performed, enrolling >100,000 women undergoing mammography screening The use of AI led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared with radiologists w/o AI thelancet.com/journals/lan...

thelancet.com

Screening performance and characteristics of breast cancer detected in the Mammography Screening with Artificial Intelligence trial (MASAI): a randomised, controlled, parallel-group, non-inferiority, ...

The findings suggest that AI contributes to the early detection of clinically relevant breast cancer and reduces screen-reading workload without increasing false positives.

381348346

Reposted by Brian Johnston

Randall Munroe @xkcd.com · 04/02/2025

Stromatolites xkcd.com/3046

7795811241

Brian Johnston @drbwbri.bsky.social · 03/02/2025

🚑 Can AI predict pneumonia severity? A study finds ML models show promise but need better validation. Some outperform CURB-65, but practical barriers remain. Future focus: clinical validation, integration & transparency. AI in healthcare is evolving—will it transform pneumonia care? #AI #Healthcare

journals.sagepub.com

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

121

Reposted by Brian Johnston

Dr Kate Womersley @katewomersley.com · 30/01/2025

The NHS treats research as a hobby rather than a properly remunerated part of a clinician’s work. www.ukri.org/news/report-...

182

Reposted by Brian Johnston

Selvaseelan Selvarajah @drselvarajah.bsky.social · 30/01/2025

One of my kitchen utensils seems to be playing classical music. I think it’s the Chopin board. #dadjokes

4307

Brian Johnston @drbwbri.bsky.social · 16/01/2025

🚨 Thrilled to announce that we have kicked off 2025 by meeting another milestone in the NOTE-AF study at @nhsuhlg-ri.bsky.social - we've opened the cardiology study arm and recruited our first participant. 🚨 Introducing virtual twin-driven AI models for atrial fibrillation (AF) 👇 target-horizon.eu

target-horizon.eu

Target

010

Reposted by Brian Johnston

Richard Branson @richardbranson.bsky.social · 13/01/2025

Fantastic to see the UK’s first drug consumption room finally open its doors in Glasgow. Congratulations to all those who made this happen. As the experience from more than 200 drug consumption rooms around the world shows, The Thistle will save many lives: www.theguardian.com/society/2025...

theguardian.com

‘All eyes are on Glasgow’: UK’s first legal drug consumption room ready to open

The Thistle will be available 365 days a year and provide a supervised space where drugs can be injected safely

1854113566

Brian Johnston @drbwbri.bsky.social · 12/01/2025

Beautiful frosty day in Neston

030

Brian Johnston @drbwbri.bsky.social · 11/01/2025

🚨Thrilled to share output from the first project the TRIC Network undertook🚨 Conceived at the height of the first wave of the COVID pandemic, the PIM-COVID project assessed the psychological impact of COVID in ICU survivors. Important findings —> journals.sagepub.com/doi/10.1177/...

journals.sagepub.com

Psychological impact of an intensive care admission for COVID-19 on patients in the United Kingdom - Alicia AC Waite, Mary Gemma Cherry, Stephen L Brown, Karen Williams, Andrew J Boyle, Brian W Johnst...

Background: The psychological impact of surviving an admission to an intensive care unit (ICU) with COVID-19 is uncertain. The objective of the study was to ass...

285

Reposted by Brian Johnston

Alicia Waite @aliciawaite.bsky.social · 11/01/2025

📣PIM-COVID study results are finally here!📣 ✋1620 COVID-19 ICU survivors consented 🏥 52 sites across the UK 6 months post-ICU: 🚨44% survivors had probable PTSD 30% anxiety 26% depression. 12 months post-ICU: 🚨43% survivors had probable PTSD 29% anxiety 24% depression. tinyurl.com/PIM-COVID 1/5

doi.org

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

124

Reposted by Brian Johnston

Critical Care Reviews @criticalcarereviews.com · 04/01/2025

Sepsis-induced cardiogenic shock: controversies and evidence gaps in diagnosis and management CCR Journal Watch criticalcarereviews.com/latest-evide... CCR Newsletter - subscribe at criticalcarereviews.com/newsletters/...

084

Brian Johnston @drbwbri.bsky.social · 03/01/2025

I was considering buying the SeeStar S50 - this image makes it more likely 😮😮

040

Reposted by Brian Johnston

Critical Care Reviews @criticalcarereviews.com · 01/01/2025

It's Jan 1st, so we reset the Paper of the Day record Every day we'll review one topic & cover the entire spectrum of critical care across 2025 The papers are open access & available on the website or via email Interested? Join in! criticalcarereviews.com/latest-evide...

1238

Reposted by Brian Johnston

Critical Care Reviews @criticalcarereviews.com · 28/12/2024

Oral blood pressure augmenting agents for intravenous vasopressor weaning CCR Journal Watch criticalcarereviews.com/latest-evide... Get the latest critical care literature every weekend via the CCR Newsletter - subscribe criticalcarereviews.com/newsletters/...

053

Reposted by Brian Johnston

George The Station Cat @george-station-cat.bsky.social · 25/12/2024

Christmas isn’t joyful for everyone. Some are missing loved ones, some are fighting silent battles and others are just trying to make it through the day Be gentle with those around you & yourownself A little kindness can be someone’s greatest gift this season ❤️

955750650

Reposted by Brian Johnston

Altmetric @altmetric.com · 25/12/2024

Merry Xmas Skywalkers! On the first day of Altmetric Christmas Highest scoring article containing A Partridge in a Pear Tree thanks to this literary flourish within a letter next to the article by Richard Lawson of Wollstonecraft www.altmetric.com/de... Fulltext search via Dimensions Analytics

Text: A few weeks later the morning ward round isdrawing to a close. Twenty-five patients have beenseen, and seven consultations, two MRIs, a bone scanand a partridge in a pear tree have been generated for the unfortunate but uncomplaining intern.
From: https://onlinelibrary.wiley.com/doi/full/10.5694/j.1326-5377.2002.tb05004.x

0326

Reposted by Brian Johnston

Fox Daily @foxdailys.bsky.social · 23/12/2024

A mother's love knows no bounds. ❤️🦊 This image perfectly captures the beautiful bond between a fox and her kits.

504048297

Reposted by Brian Johnston

Dr Farbod @emergencybod.medsky.social · 24/12/2024

On the 21st of December, in the Northern Hemisphere, the Sunrise reaches the most northerly point on the horizon and we have the shortest day. For 3 mornings the Sun rises at the same spot. On the morning of the 25th it shifts southwards 1 degree and thus the Sun, light of the world, is reborn.

A missionary telling Indians that without them they'd still be worshipping the Sun. The Indians tell him the sun is real.

3244