Suleman Bhana, MD @drbhana.bsky.social · 24/10/2025It’s really too bad Twitter got rid of 3rd party app API’s. It would’ve free to have an app that has feeds from both BlueSky and Twitter/X 000
Suleman Bhana, MD @drbhana.bsky.social · 10/06/2025In honor of attendance at #EULAR2025 I watched “Vicky Christina Barcelona” on my flight. Plot is a mess but the locale is 🧑🍳 😚 Stop me in the hallway if you see me wandering around! 030
Suleman Bhana, MD @drbhana.bsky.social · 06/03/2025www.freethink.com/biotech/evo-.... —new Al in medicine term to learn: “Generative Biology”. Evo 2, an Al trained on DNA of more than 100,000 species is able to spot patterns in genes across species, identify disease-causing mutations , and even write brand new genomes up to 1 million base pairs longfreethink.comArc Institute’s new AI can read and write the code of lifeTraining on the DNA of nearly 130,000 species taught Evo 2 how to generate DNA sequences the same way other AIs do text or images. 120
Reposted by Suleman Bhana, MDStand Up for Science! @standupforscience.net · 06/03/2025"In an unprecedented move, the US National Institutes of Health (NIH) has begun mass terminations of research grants that fund active scientific projects because they no longer meet 'agency priorities'" www.nature.com/articles/d41...nature.comExclusive: NIH to terminate hundreds of active research grantsStudies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature. 23441237
Reposted by Suleman Bhana, MDSaskia Popescu @saskiapopescu.bsky.social · 06/03/2025CDC invites back about 180 fired employees, including some who help fight outbreaks The employees were laid off about two weeks agostatnews.comCDC invites back about 180 fired employees, including some who help fight outbreaksThe CDC is inviting about 180 employees back to work, about two weeks after laying them off. 4195
Reposted by Suleman Bhana, MDNature @nature.com · 04/03/2025Researchers are organizing protests and making their voices heard as Trump officials slash funding and lay off federal scientists go.nature.com/4koFGpqgo.nature.comUS science is under threat ― now scientists are fighting backResearchers are organizing protests and making their voices heard as Trump officials slash funding and lay off federal scientists. 620581
Reposted by Suleman Bhana, MDAli Chou @ali-chou.bsky.social · 15/02/2025I’m encouraged by the so-far-so-good results of #CAR-T cells in human clinical trials for autoimmune diseases! Side note: If you’re interested in a clever twist of CAR-T, called “CAART,” that could reduce global immunosuppression, check out Dr. Aimee Payne’s work @columbiauniversity.bsky.socialcuimc.columbia.eduLiving Drugs for the Skin, and BeyondIn the lab, Aimee Payne, Columbia’s new chair of dermatology, is transforming cells into living drugs for autoimmune diseases of the skin. 131
Reposted by Suleman Bhana, MDanil oza @aniloza.bsky.social · 16/02/2025Sat down with former NIH director Monica Bertagnolli yesterday at #aaasmtg to talk about layoffs set to hit the NIH and other agencies “We’re going to lose the next generation, that is the most difficult loss," she said, adding she got very little sleep Friday 🧪 www.statnews.com/2025/02/16/n...statnews.comTrump administration layoffs set to hit NIH are ‘devastating,’ former director Monica Bertagnolli saysSweeping layoffs are set to hit federal health and science agencies, including at the NIH, and former director Monica Bertagnolli called the situation at the NIH “devastating.” 59450
Reposted by Suleman Bhana, MDMarc Veldhoen @marcveld.bsky.social · 22/02/2025Ferrari cars are often red. A red car is a Ferrari. Wrong? Then why claim this without functional antigen-specif data: Exhausted T cells often express PD-1. A T cell expressing PD-1 is exhausted. It is similarly incorrect. PD'1 and other markers are also expressed on activated and memory T cells. 3416
Reposted by Suleman Bhana, MDLiz Neeley @lizneeley.bsky.social · 18/02/2025If are shocked or outraged by this but you haven’t already found ways to channel that, here’s a small starting place - bsky.app/profile/ucsu... Your first step doesn’t need to be big or perfect, it just has to happen. Take it, and then we can figure out the next one. 03518
Reposted by Suleman Bhana, MDNaomi Harada Thyden, PhD MPH @naomithyden.bsky.social · 18/02/2025Are you interested in analyzing small samples from marginalized communities and aren't sure how? My new commentary in AJE's collection on Methods in Social Epidemiology lays out rec's for researchers, public health practitioners, and data owners. DM your email address if you need access.doi.orgInsufficient sample size or insufficient attention to marginalized populations? A practical guide to moving observational research forwardNaomi Harada Thyden; Insufficient sample size or insufficient attention to marginalized populations? A practical guide to moving observational research for 45828
Reposted by Suleman Bhana, MDJennifer Gulas MD, FACP, FHM @doctorajgu.medsky.social · 18/02/2025Explore this gift article from The New York Times. You can read it for free without a subscription. www.nytimes.com/2025/02/10/h... #medskynytimes.comThe Physicians Really Are Healing Themselves, With Ozempic (Gift Article)At cardiology conferences and diabetes meetings, doctors can’t help noticing that thin seems to be very in. 052
Reposted by Suleman Bhana, MDFrancesca Lake-Dale @francescald.bsky.social · 06/01/2025The January issue of the journal #Rheumatology is now online. This month includes: 1️⃣ The BAD-BSR Behcet's living guideline 1️⃣ Star Trek quote 👀 4️⃣ Systematic reviews on FMF, Still's, MAS & ILD 7️⃣ Graphical abstracts Plus, the brand new 2025 cover 😍 academic.oup.com/rheumatology...academic.oup.comVolume 64 Issue 1 | Rheumatology | Oxford AcademicThe official journal of the British Society for Rheumatology. Publishes high-quality scientific (basic and translational) and clinical-epidemiological papers on a wide range of paediatric and adult rh... 021
Suleman Bhana, MD @drbhana.bsky.social · 14/02/2025Good summary of Lipoprotein(a). The next frontier of ASCVD risk/event reduction. Really interesting to see the intersection of Cardiology, Rheumatology, and Hematology. #CardioMetabolic #RheumSky #CardioSky #HemeSky 031
Reposted by Suleman Bhana, MDImmunotherapy Advances @imtadvances.bsky.social · 04/02/2025⚠️ Cytokine Release Syndrome is a serious side effect of #CAR-T cell therapies. This article examines the pathways driving cytokine production in T cells during #immunotherapy: 🔗 doi.org/10.1093/imma... (6/8)doi.orgRegulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cellsAbstract. CD8+ T cells contribute to immune responses by producing cytokines when their T-cell receptors (TCRs) recognise peptide antigens on major-histoco 121
Reposted by Suleman Bhana, MDMay Kazem MD MHA FRCPC @drmkazem.bsky.social · 12/02/2025#CAR-T cell therapies, a timeline #RWCS2025 Dr. A. Postolova 062
Suleman Bhana, MD @drbhana.bsky.social · 14/02/2025Really promising case series n=6 #SScl pts undergoing CD19 targeting #CAR-T cell therapy.⬇️ mRRS, ⬇️ digital ulcers, ⬇️ Raynaud’s attacks and pain, ⬆️ FVC, ⬇️ Scl70 Ab. Minimal cases of cytokine release syndrome and no reported immune effector cell-associated neurotoxicity syndrome #RheumSky 051
Suleman Bhana, MD @drbhana.bsky.social · 14/02/2025Good review article on the few studies published using #CAR-T cell therapy in SScl. Quick and free read 010
Reposted by Suleman Bhana, MDAsher Rosinger @asherrosinger.bsky.social · 07/02/2025🌊 Proud to share our new paper showing how during a historic 2022 drought in n. Kenya chronic #stress (via nail cortisol) & high levels of #waterinsecurity were assoc. with ⬆️ levels of inflammation. Climate change negatively affects human health & biology. onlinelibrary.wiley.com/doi/10.1002/... 2119
Reposted by Suleman Bhana, MDAmerican Society for Preventive Cardiology @aspcardio.bsky.social · 08/02/2025A: hs-CRP. Covariable-adjusted hazard ratios for the primary end point in comparison of the top with the bottom quintile were 1.70 (95% confidence interval [CI], 1.52 to 1.90) for high-sensitivity CRP, 1.36 (95% CI, 1.23 to 1.52) for LDL cholesterol, & 1.33 (95% CI, 1.21 to 1.47) for lipoprotein(a). 062
Reposted by Suleman Bhana, MDHumaira M RD 🇵🇸 @decoldietitian.bsky.social · 07/02/2025Very pleased to confirm that my research investigating racism and Islamophobia discourses around cardiometabolic disease will be presented at the World Critical Dietetics Conference on the 14th Feb 💞 Tickets can be found at the WCD website: worldcriticaldietetics.org 031
Suleman Bhana, MD @drbhana.bsky.social · 30/01/2025Worth reposting this and highlighting the monumental work of @fackelmeister.bsky.social and colleagues. #CardioMetabolic #GastroSky #RheumSky #microbiome #plantbased 040
Reposted by Suleman Bhana, MDAddictionNews.com @addictionnews.bsky.social · 29/01/2025A dialogue between Chris Hayes and Nicholas Reville on using GLP1-RA drugs to treat addiction. Another exclusive from @addictionnews.bsky.social.addictionnews.comA Clockwork Ozempic? > AddictionNewsA dialogue between MSNBC anchor Chris Hayes and Nicholas Reville on using GLP1-RA drugs to treat addiction. 011
Suleman Bhana, MD @drbhana.bsky.social · 30/01/2025Great illustration from this paper on the tissue distribution of #GLP1 and #GIP receptors and biologic actions. You have my permission to roll your eyes or bang your head on the desk every time a financial analyst refers to these as “obesity meds”. #CardioMetabolic pubmed.ncbi.nlm.nih.gov/37195250/ 040
Suleman Bhana, MD @drbhana.bsky.social · 30/01/2025FLOW study in @nejm.org. MOA for renal protection with SEM likely multi factorial but independent of weight/glycemic control. #GLP1 RA’s reduce glomerular inflammation (⬇️ IL6), reduce fibrosis (⬇️ TGFb), & reduce vascular oxidative stress (⬆️NO, ⬇️ RAS). #RheumSky #NephSky #CardioMetabolic 041
Reposted by Suleman Bhana, MDJennifer Gulas MD, FACP, FHM @doctorajgu.medsky.social · 30/01/2025www.medscape.com/viewarticle/...medscape.comOzempic Receives New Indications in Chronic Kidney DiseaseSemaglutide is now approved for reducing the risk for worsening kidney disease and cardiovascular death in adults with chronic kidney disease. 063
Suleman Bhana, MD @drbhana.bsky.social · 30/01/2025For any other rheumatologists digging through all the #CAR-T papers, AAV in this case is for Adeno-Associated Viral/Virus. Not to be confused with ANCA-Associated Vasculitis. #RheumSky 000
Reposted by Suleman Bhana, MDbenmgreenberg.bsky.social @benmgreenberg.bsky.social · 27/12/2024One of the biggest scientific breakthroughs of 2024. #CAR-T therapy for autoimmune disease. Imagine a world where patients can receive 1 treatment and be cured! Looking forward to trials in #multiplesclerosis, #neuromyelitisoptica and #anti-MOGassociateddisorder! www.nejm.org/doi/full/10....nejm.orgCD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up | NEJMTreatment for autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and systemic sclerosis often involves long-term immune suppression. Resetting aberran... 001
Reposted by Suleman Bhana, MDDiscovery Immunology @discovimmunol.bsky.social · 23/01/2025As part of our article exchange with @immunolcellbiol.bsky.social, this month we're highlighting the article 'Identification of clonally expanded γδ T-cell populations during CAR-T cell therapy' Read the article exploring immune response after anti-CD19 #CAR-T therapy here: doi.org/10.1111/imcb...doi.org<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online LibraryIn this study, we investigated the longitudinal dynamics and clonal expansion of circulating γδ T cells in four patients receiving anti-CD19 CAR-T cell therapy. Using single cell multi-omics analysis.... 082
Reposted by Suleman Bhana, MDErica Saint Clair, PhD @esaintclair.bsky.social · 08/12/2024Dr. Shan Liu just called out the Western diet as the "Fast Food" diet and she ain't wrong 😂 And look, the Western diet upped tumor volume... I have a good friend who came back from stage 4 lung cancer after a *massive* diet change, so I find this talk on #keto boosting #Car-T interesting #ASH24 🧪 9343
Reposted by Suleman Bhana, MDChris Wincup @chriswincup.bsky.social · 22/01/2025In November we hosted our first Autoimmune CAR T Symposium at @kingscollegelondon.bsky.social 🏥 It was a pleasure to be joined by an international group of speakers & 170+ attendees 💡 Very happy to share our brief Q&A video from the event here #CARTcell #SLE 🎦 youtu.be/fZnuYHugMjA?... 053
Reposted by Suleman Bhana, MDOmer Dushek @tcell.bsky.social · 08/01/2025Our new work on optimising CAR-T cell sensitivity is now on bioRxiv! Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes biorxiv.org/cgi/content/... 1287
Suleman Bhana, MD @drbhana.bsky.social · 24/01/2025Anyone know how to extrapolate this data in heme malig’s to autoimmune diseases where there are already auto-reactive T and B cells? #RheumSky #OncSky #CAR-T 041
Reposted by Suleman Bhana, MDKatherine Bridge @bridgekatherine.bsky.social · 14/01/2025Any #academics in my network working in or near the field of #CAR-T therapy? Asking for an industry friend organising a conference, looking for speakers. UK or Europe based preferable. 012
Suleman Bhana, MD @drbhana.bsky.social · 24/01/2025Anti CD-19 Allogenic CAR-T Cell therapy from #CaribouBioscience. GALLOP phase 1 study in SLE. #RheumSky 010
Reposted by Suleman Bhana, MDMay Kazem MD MHA FRCPC @drmkazem.bsky.social · 16/01/2025Phase I of novel CAR-T therapy for SLE nephritis #SLE #CAR-T #rheumskylupus.orgUPDATE: Phase 1 Trial Begins for Investigational CAR-T Therapy, CB-010, for Lupus Nephritis TreatmentThe Phase 1 GALLOP study evaluating the investigational CAR-T therapy, CB-010, for treatment of lupus nephritis has launched. 061
Reposted by Suleman Bhana, MDWaggoner Lab @labwaggoner.bsky.social · 23/01/2025Mitochondrial injury and complement dysregulation are drivers of pathological inflammation in viral myocarditis journals.asm.org/doi/10.1128/... 022
Suleman Bhana, MD @drbhana.bsky.social · 24/01/2025From the paper “it is not a competition between LDLc and inflammation, but instead that they are partners in crime.” IL-1 beta and IL-6 ravage the vasculature. Holistic lowering of the burden of these cytokines should be a primary target in ASCVD prevention #CardioRheumatology 100
Reposted by Suleman Bhana, MDRohit Vashisht @rohitv.bsky.social · 23/01/2025Well said, and very nice! It’s Time to Bench the Medical Exam Benchmark @roxanadaneshjou.bsky.social @emilyalsentzer.bsky.social ai.nejm.org/doi/full/10....ai.nejm.orgIt’s Time to Bench the Medical Exam BenchmarkMedical licensing examinations, such as the United States Medical Licensing Examination, have become the default benchmarks for evaluating large language models (LLMs) in health care. Performance o... 063
Reposted by Suleman Bhana, MDScott Gottlieb, MD @scottgottliebmd.bsky.social · 23/01/2025My segment on @cnbc.com on the ensuing cough and cold season, and vaccine policy in the U.S.m.youtube.comDr. Scott Gottlieb on navigating covid, the flu and RSVYouTube video by CNBC Television 14810
Suleman Bhana, MD @drbhana.bsky.social · 24/01/2025Dismantling the #NIH will be incredibly destructive to medical research and discovery to prevent and treat 1000’s of illness. There is just not enough funding in the private sector to meet the needs of patients. #MedSky 021
Suleman Bhana, MD @drbhana.bsky.social · 24/01/2025If anyone knows how SLE contributes to ferroptosis (outside of APS induced thrombosis) in preeclampsia, please let me know. Very curious about this. 🙏 #RheumSky 062
Reposted by Suleman Bhana, MDSteven Mathern @stevenmathern.bsky.social · 24/01/2025free ebook 'Section 1: Introduction to Cardiogenic Shock and Therapies Section 2: Basics of Mechanical Circulatory Support Section 3: In-Depth Review of Devices Section 4: Selecting Devices and Device Combinations Based on Clinical Need' #impella #cardiosky scaipro.scai.org/Listing/Shor...scaipro.scai.org Short-Term Mechanical Circulatory Support for Cardiogenic Shock eBook 011
Reposted by Suleman Bhana, MDStacey L. Clardy @staceylclardy.bsky.social · 24/01/2025🧠 Neurology Podcast: Dr. Derek Stitt and Dr. Miranda M. Wan discuss improving training and public awareness to optimize #PalliativeCare for patients with neurologic conditions. Hint: We can do better - listen to find out how! Listen now: hubs.la/Q033py7j0hubs.laAttitudes and Perceptions on Palliative CareDr. Derek Stitt talks with Dr. Miranda M. Wan about improving training and public awareness to optimize palliative care for patients with neurologic conditions. Read the related article in . Disclosur... 122
Suleman Bhana, MD @drbhana.bsky.social · 24/01/2025Several takeaways but this stood out: “Regions like Latin America and Sub-Saharan Africa had the highest proportions of unidentified taxa, linked to reference database biases, suggesting undersampling and the potential for unobserved microbial diversity.” Microbial Diversity = a new fronteir 000
Reposted by Suleman Bhana, MDJAMA @jama.com · 15/01/2025The USPSTF latest guidelines on screening for #osteoporosis recommends that women 65 years or older and postmenopausal women under 65 who are at increased risk for osteoporotic fractures undergo screening. 🔗 ja.ma/3DZMpWb #MedSky 186
Reposted by Suleman Bhana, MDJAMA @jama.com · 15/01/2025Most viewed in the last 7 days from JAMA: USPSTF recommends all women undergo routine #breastcancer screening every other year beginning at age 40, an update from the 2016 recommendation to start at age 50. ja.ma/4jdQciA 095