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Erica Saint Clair, PhD

@esaintclair.bsky.social
176 followers 95 following 191 posts

Senior Scientific Analyst - Stansberry Research PhD Molecular Biophysics from Boston University

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Erica Saint Clair, PhD @esaintclair.bsky.social · 22/07/2025
I'm excited to be going to #ObesityWeek for the first time! I'd love to connect with anyone else going or hear what you're most excited to see there! obesityweek.org
obesityweek.org
INNOVATIVE SCIENCE TO TRANSFORMATIONAL CARE
The preeminent international conference for obesity researchers and clinicians, ObesityWeek® is home to the latest developments in evidence-based obesity science: cutting-edge basic and clinical resea...
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Erica Saint Clair, PhD @esaintclair.bsky.social · 17/03/2025
Excited to be at #GDC for the first time! #GDC2025
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Erica Saint Clair, PhD @esaintclair.bsky.social · 29/01/2025
Is anyone able to grab this for me? #icanhazpdf journals.physiology.org/doi/abs/10.1...
journals.physiology.org
Hindlimb immobilization induces insulin resistance and elevates mitochondrial ROS production in the hippocampus of female rats | Journal of Applied Physiology
Alzheimer’s disease (AD) is the fifth leading cause of death in older adults, and treatment options are severely lacking. Recent findings demonstrate a strong relationship between skeletal muscle and ...
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Erica Saint Clair, PhD @esaintclair.bsky.social · 22/01/2025
I just donated to Wikipedia for the first time... I use it a ton. It almost always has good information. And I want to see it succeed against Musk.
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Erica Saint Clair, PhD @esaintclair.bsky.social · 13/01/2025
I just dug up some info on BioArctic's BrainTransporter tech - almost 10x increase in drug in the brain! That's quite the image 🧪
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Erica Saint Clair, PhD @esaintclair.bsky.social · 20/12/2024
The participants were all Latino - which feels like a first in a study. I need to dig up the underlying paper to figure out how much of a change was really detected 🧪 #sleepapnea #neurology
scitechdaily.com
Is Sleep Apnea Silently Reshaping Your Brain?
Sleep breathing problems, like sleep apnea, may lead to changes in the hippocampus and white matter, impacting brain health and increasing dementia risk. A study on Latino adults revealed that those w...
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Erica Saint Clair, PhD @esaintclair.bsky.social · 19/12/2024
Hoping to try out Boltz-1...we'll see how well it installs 🤞 #proteinfolding #boltz #alphafold
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Erica Saint Clair, PhD @esaintclair.bsky.social · 17/12/2024
Our #gingerbread is coming along. This year Jeff the #lochness monster is looking for a security job in the local town. Love that my little added a briefcase 😂
A gingerbread creation showing a bridge leading to what will be a town. A lockness monster weaves in and out of the water surrounding the town with a name tag of Jeff and a briefcase
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Erica Saint Clair, PhD @esaintclair.bsky.social · 13/12/2024
We've entered the time of year where I gain five pounds just by mixing up gingerbread...
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Erica Saint Clair, PhD @esaintclair.bsky.social · 12/12/2024
A nice handy slide from the FDA sessions at #ASH24 of CAR-T therapy approvals to date!
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Erica Saint Clair, PhD @esaintclair.bsky.social · 10/12/2024
And so begins the last session at #ASH24
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Erica Saint Clair, PhD @esaintclair.bsky.social · 09/12/2024
Gonna throw it out there - if you're at #ASH24 and haven't visited headshot alley you're missing out on an incredible offer!
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Erica Saint Clair, PhD @esaintclair.bsky.social · 09/12/2024
Guys! #ASH24 had a #puppy pen!! Look at this little guy! Apparently 4 or 5 puppies have been adopted so far, which is nuts. I can't imagine going to a conference and coming home with a puppy (despite deep desire and begging from my littles)
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Erica Saint Clair, PhD @esaintclair.bsky.social · 09/12/2024
Slide deck from the #Keto and #Car-T talk at ASH today - for those interested. Going to try and post in a reasonable order, but failry new to bluesky...a thread... 1/x @donadickinson.bsky.social @bigmoke.bsky.social @tmask.bsky.social
Slide - Keto diet enhances CART cell antitumor function via beta hydroxybutyrateShows patient with an IV drip bag full of CART product, and a tumor inside the cartoon bodyShows macro nutrient breakdown of various diets, and tumor burden based on diet post CART therapyShows keto enhanves CART19 proliferation via beta hydroxybutyrate
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Erica Saint Clair, PhD @esaintclair.bsky.social · 08/12/2024
#Rilzabrutinib Phase 3 LUNA 3 results in #thrombocytopenia at #ASH24 16/18 patients responded in two weeks 🧪
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Erica Saint Clair, PhD @esaintclair.bsky.social · 08/12/2024
Dr. Shan Liu just called out the Western diet as the "Fast Food" diet and she ain't wrong 😂 And look, the Western diet upped tumor volume... I have a good friend who came back from stage 4 lung cancer after a *massive* diet change, so I find this talk on #keto boosting #Car-T interesting #ASH24 🧪
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Erica Saint Clair, PhD @esaintclair.bsky.social · 08/12/2024
What am I missing? The #cemsidomide MonoDACTM degrader results showed a patient case study. It looks like it worked great during the first month, but after a few months disease came back with a bang...and close to 9 in 10 pts discont. (I recognize its a heavily pretreated pop. & oral) #ASH24 🧪
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Erica Saint Clair, PhD @esaintclair.bsky.social · 08/12/2024
Big congrats to Dr Rachel Rau looking at #blinatumomab in kids. Adding it into standard #chemo significantly cut relapses and increased disease free survival. She mentioned the data monitoring board suggested a stop to randomization for efficacy. #ASH24 #ASH2024 🧪
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Erica Saint Clair, PhD @esaintclair.bsky.social · 06/12/2024
Off to #ASH24!! Ready for some sun and lots of learning!
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Erica Saint Clair, PhD @esaintclair.bsky.social · 06/12/2024
The self-restraint it took not to eat all my end of the year thank yous to work colleagues... But seriously, #tonyschocoloney is my fave. And nothing beats the caramel sea salt.
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Erica Saint Clair, PhD @esaintclair.bsky.social · 06/12/2024
Hired out my first project on Fivver- turning my kids art into patches as a #stockingstuffer for my hubs. They need some work, and likely a different base material, but I am so excited!! #embroidery
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Erica Saint Clair, PhD @esaintclair.bsky.social · 05/12/2024
Saving to read later!
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Erica Saint Clair, PhD @esaintclair.bsky.social · 05/12/2024
Well, well, well. If it isn't my mom shaking her fingers at me saying "I told you so"
neurosciencenews.com
Cannabis Impacts Brain Plasticity via Astrocyte Receptors - Neuroscience News
Researchers discovered that cannabis affects brain development by interacting with CB1 receptors on astrocytes, not just neurons.
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Erica Saint Clair, PhD @esaintclair.bsky.social · 03/12/2024
Pretty excited about my #hiking club holiday patches this year!! #takeahike #embroidery
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Erica Saint Clair, PhD @esaintclair.bsky.social · 03/12/2024
This isn't at all surprising, but will be quite a hurdle for #US #chipmakers. A lot of electronics are about to get very expensive...
reuters.com
Explainer: How China could retaliate against new US chip curbs
Washington's new curbs on China's semiconductor industry are fanning fears that Beijing could strike back, as trade tensions between the two largest economies intensify.
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Erica Saint Clair, PhD @esaintclair.bsky.social · 03/12/2024
Has anyone else gotten completely addicted to #puzzmo? Found it during the #NYT tech worker strike and now I'm eyeing it as a stocking stuffer (for myself lol)
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Erica Saint Clair, PhD @esaintclair.bsky.social · 03/12/2024
I will always be so grateful for #AlphaFold collab. What an awesome tool! 🧪
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Reposted by Erica Saint Clair, PhD
Claudine Kraft's Lab @kraftlabfr.bsky.social · 28/11/2024
The link posted is not accessible, is this one the correct one? www.sciencedirect.com/science/arti...
sciencedirect.com
An engineered cereblon optimized for high throughput screening and molecular glue discovery
The majority of clinical degraders utilize an immunomodulatory imide drug (IMiD)-based derivative that directs their target to the E3 ligase receptor …
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Erica Saint Clair, PhD @esaintclair.bsky.social · 27/11/2024
I'm looking into radioisotopes at #ASH2024 and randomly came across this paper!! "A million times greater stability means that the compound lasts a million times longer. It is like comparing the length of one TV series episode with the length of a human life."
phys.org
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Erica Saint Clair, PhD @esaintclair.bsky.social · 25/11/2024
Anyone heading out to San Deigo for #ASH2024?
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Reposted by Erica Saint Clair, PhD
Scott McGrath @smcgrath.phd · 06/06/2024
🧪 Researchers created Cervix-on-a-Chip, a microfluidic model mimicking the human cervix, revealing tissue responses to infections. This innovation may lead to new treatments for female reproductive diseases 🩺🖥️🧬
genengnews.com
Cervix on a Chip Latest Advance for Women’s Health
Scientists developed a Cervix Chip to replicate tissue and microbiome interactions and offering a powerful new tool for studying women's health issues.
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Erica Saint Clair, PhD @esaintclair.bsky.social · 06/06/2024
🧪 Im not doing anything other than sitting on a couch late at night for this to ever be truly useful for me. But yet...I want a pair... Also - who is out running in the dead of night? Like maybe 0.0001% of the population?
scitechdaily.com
Revolutionary Night Vision: Ultra-Thin Filters Transform Everyday Eyewear
Researchers have developed a groundbreaking thin infrared filter for night vision that can be integrated into everyday eyewear, allowing simultaneous viewing of the infrared and visible light spectra....
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Erica Saint Clair, PhD @esaintclair.bsky.social · 05/06/2024
🧪I could not list off any other cancer drug that maintains a 100% complete response rate at the 2 year mark. Is this a total unicorn? What's the catch?!? Anyone know of other drugs that got 100% CRR?
clinicaltrialsarena.com
GSK’s Jemperli shows potential in Phase II trial for locally advanced rectal cancer
GSK has reported updated results from a Phase II study of Jemperli for locally advanced mismatch repair deficient (dMMR) rectal cancer.
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Erica Saint Clair, PhD @esaintclair.bsky.social · 05/06/2024
🧪A sodium bicarbonate transporter (think baking soda transporter) helps seal the blood brain barrier after stroke. A bit over a year ago we also discovered the same transporter prevents pancreatic cancer from resisting immunotherapies. Oh, and lack of it creates cystic fibrosis like breathing
cell.com
Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation
Ye et al. highlight astrocytic Slc4a4’s role in astrocyte and BBB function under both normal and stroke conditions. Their study further emphasizes the significance of the Slc4a4-CCL2-CCR2 axis in BBB ...
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Erica Saint Clair, PhD @esaintclair.bsky.social · 03/06/2024
Um yes. Ten thousand times yes! If AI can't clean house physically, maybe it can clean house emotionally. If it's trained right, I am all for this (that is, of course, a HUGE caveat)🧪
uwaterloo.ca
AI saving humans from the emotional toll of monitoring hate speech |
A team of researchers at the University of Waterloo have developed a new machine-learning method that detects hate speech on social media platforms with 88 per cent accuracy, saving employees from
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Erica Saint Clair, PhD @esaintclair.bsky.social · 31/05/2024
Wait, so there's still a faulty valve 👀👀...and they're confident 27 of 28 thrusters are working 👀👀. Seems like launching without fixing issues is a bad plan. If I were headed into *space* I would want everything to be up to snuff. 🧪
dailymail.co.uk
Boeing to launch rocket - despite warning from NASA contractor
The first manned mission of Boeing's Starliner spacecraft is set to launch Saturday, after an earlier attempt was scuttled over a leaking valve on one of its oxygen tanks
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Erica Saint Clair, PhD @esaintclair.bsky.social · 29/05/2024
🧪Really not sure what to think about this. On the one hand, its insanely cool. On the other, it gives off big "Terminator" vibes...
interestingengineering.com
16 lab-grown brains run world’s first 'living computer' in Switzerland
The bioprocessor platform consists of brain organoids instead of silicon chips and processes data while consuming a million times less power.
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Erica Saint Clair, PhD @esaintclair.bsky.social · 28/05/2024
🧪 Fentanyl is a one two punch-boosts positive feelings while on drug, and uses another circuit to make withdrawal particularly nasty - both rely on mu receptors. Makes me wonder about the dev of other opioid pain killers that target other paths, like kappa. Will the FDA still shy away?
nature.com
Fentanyl addiction: the brain pathways behind the opioid crisis
How two neural pathways contribute to the deadly opioid’s addictive nature, and why babies are suing the South Korean government. Hear the biggest stories from the world of science | 22 May 2024
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Erica Saint Clair, PhD @esaintclair.bsky.social · 27/05/2024
This is super cool. I'd also love to program if to be able to zone in on a specific voice. Like say...mine, when trying to get the hubs attention while listening to audiobooks and what not around the house... 🧪
washington.edu
AI headphones let wearer listen to a single person in a crowd, by looking at them just once
A University of Washington team has developed an artificial intelligence system that lets someone wearing headphones look at a person speaking for three to five seconds to “enroll” them. The...
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Erica Saint Clair, PhD @esaintclair.bsky.social · 23/05/2024
Everywhere we look in the body, we're finding microplastics. Microplastics: -in the prostate might be lowering sperm count -in arteries quadruples heart attack/stroke risk -can cross the BBB and change cognition (in mice) We're all just along for the ride at this point but... 👀👀👀 🧪
bmcurol.biomedcentral.com
The first reported values of microplastics in prostate - BMC Urology
Background Microplastics are ubiquitous, widespread environmental pollutants with unavoidable human exposure. Herein, it was aimed to investigate the presence of microplastics in prostate tissue. Meth...
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Erica Saint Clair, PhD @esaintclair.bsky.social · 22/05/2024
Today I learned I can respond to outlook emails with emoji's. It's giving me life.
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Erica Saint Clair, PhD @esaintclair.bsky.social · 22/05/2024
🧪Guys, there's a bee vaccine, and its essentially given through a massive candy delivery. I want this vaccine tech - imagine getting to eat a lollipop for your next booster (yes I know human vaccines don't work like this, but a girl can dream) Also, love this for the bees.
sciencenews.org
A vaccine for bees has an unexpected effect
Honeybees vaccinated against a bacterial disease were also protected from a viral disease.
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Erica Saint Clair, PhD @esaintclair.bsky.social · 21/05/2024
This is a really cool way to try and vaccinate for HIV. I think older generations would have never imagined a vaccine that protects from multiple HPV induced cancers - but my kids can now get one. It's entirely possible their kids get an HIV vaccine. And that's just incredible. 🧪
corporate.dukehealth.org
A Trial HIV Vaccine Triggered Elusive and Essential Antibodies in Humans
DURHAM, N.C. – An HIV vaccine candidate developed at the Duke Human Vaccine Institute triggered low levels of an elusive type of broadly neutralizing HIV antibodies among a small group of people enrol...
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Erica Saint Clair, PhD @esaintclair.bsky.social · 20/05/2024
Once I was lazy and asked ChatGPT for decay charts for some element. Was mid mtg with my boss walking through it when I was like...wait...that's not what alpha decay looks like... Ever since I haven't trusted GPT. Now I see it's literally worse than a coin toss... 🧪 dl.acm.org/doi/pdf/10.1...
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Erica Saint Clair, PhD @esaintclair.bsky.social · 20/05/2024
🧪Cool idea, but there's no way this scales in a meaningful way to make any sort of dent in climate change... Plus we know there's no infinite energy machine. Using this to scrub power plant emissions and then using the carbon monoxide as fuel for the same power plants feels like snake oil.
pubs.acs.org
Highly Efficient Carbon Dioxide Electroreduction via DNA-Directed Catalyst Immobilization
Electrochemical reduction of carbon dioxide (CO2) is a promising route to up-convert this industrial byproduct. However, to perform this reaction with a small-molecule catalyst, the catalyst must be p...
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Erica Saint Clair, PhD @esaintclair.bsky.social · 16/05/2024
I searched, there's no data on adverse events or on the number of patients who stopped b/c of side effects. Just some hand waving "it's fine". Kinda makes me think it's not fine. Because if it really was, why wouldn't Roche release the numbers? The field is too crowded for these shenanigans. 🧪
endpts.com
Roche teases 'encouraging' Phase 1 data for weight loss drug from $2.7B Carmot buyout
Roche offered a glimpse at promising early efficacy data on Thursday morning from a GLP-1/GIP agonist it obtained as part of its $2.7 billion acquisition of Carmot Therapeutics. In a Phase 1 trial tes...
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Erica Saint Clair, PhD @esaintclair.bsky.social · 14/05/2024
🧪Big fan of sun storms paired with clear Earth skies! I'd love to see your pics if you got to see the aurora in action!
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Erica Saint Clair, PhD @esaintclair.bsky.social · 13/05/2024
🧪When science meets art, and art meets science. Looks like the Mona Lisa was painted in Lecco Italy, and the data is going to be presented at a geology conference in...Lecco Italy. Talk about a coincidence!
theguardian.com
Mystery of where Mona Lisa was painted has been solved, geologist claims
Ann Pizzorusso says she has tracked down the background landscape of the world’s most famous painting
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Erica Saint Clair, PhD @esaintclair.bsky.social · 10/05/2024
4,000 connections into a single neuron, imaged in breathtaking detail. 🤯 And that's just one tiny tidbit from the cubic millimeter sampled. The images are out of this world. Go check them out! 🧪For detailed shared images: h01-release.storage.googleapis.com/gallery.html
theguardian.com
Scientists find 57,000 cells and 150m neural connections in tiny sample of human brain
Harvard researchers teamed up with Google to analyse the makeup of the brain, much of which is not yet understood
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Erica Saint Clair, PhD @esaintclair.bsky.social · 09/05/2024
This is a really cute clip showing how your health improves as your daily step count goes up. I had no idea 10k started as a marketing gimmick. And I really appreciate that this doesn't set a number - just shows you benefits at various step counts. 🧪
medscape.com
Need Your Patients to Move More? Show Them This
Every step patients take is a step in the right direction for a longer, healthier life.
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