iiinova — where your digital self keeps evolving

David Monchaud @dmonchaud.bsky.social · 14h

My first 1,000-citation paper 🥹 (and it's not a Nature or a Science but an @orgbiomolchem.rsc.org!).. Fun fact: this threshold was reached exactly on the 47th anniversary of the 1st publication of The Hitchhiker’s Guide to the Galaxy by Douglas Adams. 42th would have been far better, of course 😅

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David Monchaud @dmonchaud.bsky.social · 08/10/2026

Aging = stress. We have shown that DNA G-quadruplex #G4 landscape increases with age. We show here that the G4-helicase DHX36 expression increases also with age BUT as a stress-inducible helicase rather than a G4-driven responder. Now in JBC @asbmbjournals.bsky.social 👉 www.jbc.org/article/S002...

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David Monchaud @dmonchaud.bsky.social · 08/10/2026

Happy to be on this list for the 6th year in a row (actually a double list, since the c-score is calculated for both career-long achievements and 2025 alone). 👉 elsevier.digitalcommonsdata.com/datasets/btc... It doesn’t change much about our daily lab life, but it’s still a kind of recognition 🙂

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David Monchaud @dmonchaud.bsky.social · 05/10/2026

It was a real pleasure for me to have been invited to the Ludwig #A2Z meeting in Oxford, UK. Though I couldn’t attend all the talks, the diversity of topics was highly enriching. I was also glad to meet old firends and present our latest results on targeting three-way DNA junctions to fight cancer!

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David Monchaud @dmonchaud.bsky.social · 05/10/2026

𝙏𝙚𝙖𝙢𝙬𝙤𝙧𝙠 𝙢𝙖𝙠𝙚𝙨 𝙩𝙝𝙚 𝙙𝙧𝙚𝙖𝙢 𝙬𝙤𝙧𝙠! Proud to have been part of the ICMUB team that completed the 100 km #UTMA ultratrail (near Dijon) after over 14 hours of effort! 💪

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David Monchaud @dmonchaud.bsky.social · 04/09/2026

It was indeed a great pleasure and honor to have all of you in Reading, UK! This second meeting IMAJ#2 marks the second step of a three-step plan: "gather, expand, consolidate". I believe we’ve achieved that goal, and I can’t wait for IMAJ#3!

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David Monchaud @dmonchaud.bsky.social · 04/09/2026

It was a real pleasure for me to host a panel of researchers whose work I have long admired in Reading UK, for the second International Meeting on Nucleic Acid Junctions IMAJ#2. The idea was to meet, talk, and exchange ideas. The result even exceeded my highest expectations. Can’t wait for IMAJ#3!

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David Monchaud @dmonchaud.bsky.social · 03/08/2026

We keep on investigating the role(s) of G-quadruplex #G4 in aging and found a quite interesting correlation between age and the level of both G4s and related G4 helicase (particuarly here: DDX3X). With @mcgovernpeds.bsky.social In Cell Death Dis. @springernature.com 👉 doi.org/10.1038/s414...

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David Monchaud @dmonchaud.bsky.social · 03/08/2026

If you're working with guanine (G)-rich DNA/RNA sequences and want to know whether they fold into G-quadruplex (G4) structures—and which topology they adopt—it can now be done with the naked eye.. or almost! 🔬 Now in @sciencechinapress.bsky.social @springernature.com 👉 doi.org/10.1007/s114...

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David Monchaud @dmonchaud.bsky.social · 23/05/2026

And many thanks to Juan Carlos for the tour around Granada (and for the famous tapas!) 🇪🇸

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David Monchaud @dmonchaud.bsky.social · 19/05/2026

With the goal of further developing our #G4 molecular helicase 𝗣𝗵𝗽𝗖, we—in collaboration with Carla Cruz @ubeirainterior.bsky.social—have investigated the biodistribution of this molecule using gold nanocarriers for controlled release. Now in JDDST @elsevierlsj.bsky.social 👉 doi.org/10.1016/j.jd...

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David Monchaud @dmonchaud.bsky.social · 19/05/2026

In Genome Biol. @springernature.com we report on: 1/ the 𝗮𝗻𝘁𝗶𝗰𝗮𝗻𝗰𝗲𝗿 𝗮𝗰𝘁𝗶𝘃𝗶𝘁𝘆 of the G-quadruplex #G4 stabilizer 𝗤𝗡-𝟯𝟬𝟮 and a 𝘀𝘆𝗻𝘁𝗵𝗲𝘁𝗶𝗰 𝗹𝗲𝘁𝗵𝗮𝗹𝗶𝘁𝘆 𝘀𝘁𝗿𝗮𝘁𝗲𝗴𝘆 to improve it, and 2/ the genoprotective role of the G4 unwinder 𝗣𝗵𝗽𝗖 With @ucllifesciences.bsky.social & @westernu.ca 👉 doi.org/10.1186/s130...

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David Monchaud @dmonchaud.bsky.social · 29/04/2026

Happy to take you behind the scenes of the discovery of 7 alternative #DNA structures: 𝘁𝗿𝗶𝗽𝗹𝗲𝘅, G-quadruplex (𝗚𝟰), 𝗶-𝗺𝗼𝘁𝗶𝗳, both 3- and 4-way 𝗗𝗡𝗔 𝗷𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝘀, 𝗥-𝗹𝗼𝗼𝗽 and the left-handed duplex 𝗭-𝗗𝗡𝗔. Hope you'll enjoy this journey back in time! In @narjournal.bsky.social 👉 doi.org/10.1093/nar/...

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David Monchaud @dmonchaud.bsky.social · 11/04/2026

It is not. A comment from Crick:

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David Monchaud @dmonchaud.bsky.social · 19/03/2026

It was super great to welcome Chun Kit Kwok, from CityUHK, for a 2-day visit in our lab. A very enjoyable time discussing science in general, with of course a deep dive into RNA and G-quadruplex #G4 RNA. Thank you for coming!

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David Monchaud @dmonchaud.bsky.social · 02/02/2026

Biocatalysts made of DNA, and G-quadruplex #G4 DNA in particular, have found a myriad of applications. But is there a real-life application reported so far? Thrilled to report this long-awaited example with the remediation of industrial wastewater! In @academic.oup.com doi.org/10.1093/nsr/...

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David Monchaud @dmonchaud.bsky.social · 30/01/2026

FYI: the molecular helicase PhpC we developped to unfold G-quadruplex #G4 DNA and RNA both in vitro (see: shorturl.at/Ep8Il) and in human cells (e.g., shorturl.at/ue7rV, shorturl.at/zsheP & shorturl.at/MfUKW) is now commercially available at Idylle @idylle-labs.bsky.social 👉 shorturl.at/efE5l

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David Monchaud @dmonchaud.bsky.social · 16/12/2025

Happy to be one of these guys going down the White Dune before swimming 10k across the Dakhla bay. 4 days, 4 stages, 4 adventures. Thank you Morocco Swim Trek 🙏 👉 moroccoswimtrek.com

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David Monchaud @dmonchaud.bsky.social · 08/12/2025

How to recapitulate in vitro what happens in cells? Not easy! We investigated how guanine (G)-rich sequences interact with one another to decipher G4-associated gene expression regulation With Nanjing U & @polytechniqueparis.bsky.social @cnrs.fr In @narjournal.bsky.social: doi.org/10.1093/nar/...

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David Monchaud @dmonchaud.bsky.social · 29/11/2025

A huge thank you to Jean-Louis Mergny, Jérome and Pascale @polytechniqueparis.bsky.social for organizing the "G-quadruplex (G4) made in France": two days filled with diverse and fascinating exchanges on the many facets of #G4 research!

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David Monchaud @dmonchaud.bsky.social · 24/11/2025

Super proud of my team! They have simplified the synthesis of TASQs, enabling easier & faster access to these biomimetic G-quadruplex (G4) ligands used to image and identify cellular G4s. The TASQs story: doi.org/10.1021/acs.... This new article @chemistryeurope.bsky.social: doi.org/10.1002/chem...

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David Monchaud @dmonchaud.bsky.social · 03/11/2025

A novel biotechnological application for G4s, used for controlling the activity of a CRISPR-Cas12a device used for diagnosing human viral infection (HPV) in a spatio-temporal manner Now in Anal. Chem. @pubs.acs.org With Nanjing U. & @polytechniqueparis.bsky.social @cnrs.fr doi.org/10.1021/acs....

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David Monchaud @dmonchaud.bsky.social · 03/11/2025

The photoMultiTASQ is a new molecular tool to investigate G-quadruplex #G4 biology, notably for identifying G4 binding proteins by Chem-CLIP (chemical cross-linking and isolation by pull-down) In ACS Bio & Med Chem Au: doi.org/10.1021/acsb... With @iphc-strasbourg.bsky.social (FR) & WIS Rehovot (IS)

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David Monchaud @dmonchaud.bsky.social · 09/10/2025

Stimulating scientific days #ChemBioParis2025. Super great to hear Shankar Balasubramanian speaking about G-quadruplex, Matthew Disney about ChemCLIP and Dan Nomura about MYC druggability, among many others Kudos to @borisvauzeilles.bsky.social & the team for the organization chembioparis2025.com

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David Monchaud @dmonchaud.bsky.social · 28/08/2025

Honored to have been interviewed by Pour La Science, a wide-audience scientific magazine, to discuss the results from @simonelsasser.bsky.social / @puckknipscheer.bsky.social published in @science.org about how DNA repair proteins mold G-quadruplex #G4 👉 tinyurl.com/3k6pxu6d (sorry, in French only)

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David Monchaud @dmonchaud.bsky.social · 27/08/2025

Happy to describe a novel strategy to detect pollutants in food with a super high sensitivity, using G-quadruplex #G4 based biosensing devices. A collaboration with the University of Nanjing (CN) and Polytechnique Palaiseau (FR) Now in Anal. Chem. (@pubs.acs.org): doi.org/10.1021/acs....

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David Monchaud @dmonchaud.bsky.social · 26/08/2025

Happy to describe a novel strategy to combat colorectal cancer by pharmacologically modulating G-quadruplex #G4 RNA found in dysregulated lncRNAs, using the molecular helicase PhpC. A collaboration with ITTGN (India) and supported by @embo.org fellowships Now in BMC Biol.: doi.org/10.1186/s129...

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David Monchaud @dmonchaud.bsky.social · 20/06/2025

A novel demonstration of the G-quadruplex #G4 unfolding properties of PhpC, a quite unique prototype of G4 unfolder (or molecular helicase) we developed in the lab In collaboration with C. Cruz @ubeirainterior.bsky.social and R.H.E. Huson @westernu.bsky.social ‬ 👉 doi.org/10.1016/j.ij...

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David Monchaud @dmonchaud.bsky.social · 20/05/2025

The best of the best! The core of our community on #DNA #RNA junctions during the first meeting #IMAJ1 including @biometalusc.bsky.social, @sebastien-britton.bsky.social, @christinecardin.bsky.social, @granzhan.bsky.social, Jean-Louis, Mark and many others Thank you again for your participation!

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David Monchaud @dmonchaud.bsky.social · 19/05/2025

It was an absolute thrill and a real pleasure to organize the first meeting on #DNA #RNA junctions in Paris. Fantastic talks, lively discussions—and some excellent wine too! 🍷😁 A very promising beginning for this new community Stay tuned—we’ll be back next year! #IMAJ1 #CNRSchimie @cnrs.fr

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David Monchaud @dmonchaud.bsky.social · 07/04/2025

We're thrilled to have contributed to this @naturecomms.bsky.social paper on the role of G-quadruplex #G4 in mitochondrial RNA G4s can be targeted with ligands to inhibit mitochondrial translation and eventually functions, which jeopardizes cancer cells fate This is huge! 👉 doi.org/10.1038/s414...

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David Monchaud @dmonchaud.bsky.social · 11/03/2025

Welcome to BlueSky @jamchemsoc.bsky.social ! Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner #chembio #AcademicSky #SciSky

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David Monchaud @dmonchaud.bsky.social · 22/01/2025

A fully detailed protocol to visualize G-quadruplex #G4 DNA/RNA in human cells using clickable G4 ligands (in situ click imaging) now in @bio-protocol.bsky.social Interested?? All you need is: - the clickable ligand: www.sigmaaldrich.com/FR/en/produc... - and the protocol: doi.org/10.21769/Bio...

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David Monchaud @dmonchaud.bsky.social · 15/01/2025

Quite happy to see this out in @chemistryeurope.bsky.social (with ENS Paris FR, Szeged University HU, UTC Prague CZ) We report here on molecular tools used to detect G-quadruplex #G4 DNA/RNA in vitro, and on the mechanism underlying their unique photophysical properties. 👉 doi.org/10.1002/cmdc...

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David Monchaud @dmonchaud.bsky.social · 11/12/2024

A fully detailed method (40+ steps) to isolate/identify RNA G-quadruplex #G4 in human cells using G4-RNA precipitation (G4RP) protocol G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41... & G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...

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David Monchaud @dmonchaud.bsky.social · 03/12/2024

One of the ones I am most proud of. In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells. 👉https://dx.doi.org/10.1016/j.jbc.2024.108040 @cnrs.bsky.social

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David Monchaud @dmonchaud.bsky.social · 27/11/2024

My (little) contribution to make the field of G-quadruplex #G4 ligands accessible to all.. .. and to show how pivotal ligands have been as #ChemBio tools to decipher G4 biology. A personal view on the contribution of Pr. Stephen Neidle in a Sp. Issue honoring S. Neidle 😉 👉 doi.org/10.1007/s000...

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David Monchaud @dmonchaud.bsky.social · 17/11/2024

Kane is an artist, his work deserves to be highlighted ;-) this one is also one of his masterpieces

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David Monchaud @dmonchaud.bsky.social · 14/11/2024

Hi DNA/RNA folks! With @granzhan.bsky.social @sebastien-britton.bsky.social @glowsticks.bsky.social and others we are launching an International Research Network (IRN) on nucleic acid junctions #3WJ - Thanks @cnrs.bsky.social Chimie! 1st meeting next year (May 25) in Paris Contact me if interested

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David Monchaud @dmonchaud.bsky.social · 13/11/2024

(4/4) With my buddies @sebastien-britton.bsky.social and @granzhan.bsky.social we are currently designing, synthesizing and using small molecules aimed at interacting with alternative DNA and RNA structures (mostly three-way junctions #3WJ and G-quadruplex #G4) to decipher their cellular biology

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David Monchaud @dmonchaud.bsky.social · 13/11/2024

(3/4) ..or the use of chemicals "to interrogate, modify, and manipulate biological systems at the cellular level in a highly controlled manner" (Karl-Heinz Altmann, ChemBioChem 2009, 10, 16)

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David Monchaud @dmonchaud.bsky.social · 13/11/2024

(2/4) Then, the definition has evolved towards a more general notion involving the use of chemicals "as reversible modulators of biological systems to gain a deep understanding of cell circuitry and diseases biology" (Stuart L. Schreiber, Nat. Chem. Biol. 2005, 1, 64)..

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David Monchaud @dmonchaud.bsky.social · 13/11/2024

So let's talk about chemical biology! But what is it all about exactly? A thread (1/4) The notion of chemical biology (and of chemical genetics) was initially discussed between Linus Pauling and George Beadle as of 1945 and published in 1954 (Eng. Sci. 1954, 17, 9)

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