Reposted by Saarikangas lab
New preprint! 🎉
We discovered an unexpected way that the postsynaptic scaffold protein Densin-180 binds SHANK proteins.
Instead of using a conventional C-terminal PDZ-binding motif, Densin-180 uses an internal PDZ-binding motif that engages the canonical SHANK3 PDZ domain. 🧵1/8
