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Darshak Bhatt

@darshakbhatt.com
1.2K followers 2K following 19 posts

Postdoc @ UMCG.nl. Co-founder @ SynBioNL.com Interested in Synthetic Biology and Tumor Viro/Immunotherapy. DarshakBhatt.com

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Reposted by Darshak Bhatt
Tara C. Smith @aetiology.bsky.social · 23/09/2026
Tired: vaccination Wired: microdosing microbial peptides to boost immunity
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Nicola Rennie @nrennie.bsky.social · 14/08/2026
🎨New blog post 🎨 I've written down some of the things I talked about in my Ihaka Lecture last month ❓ what is creativity in #DataViz ❓ why does it matter ❓ how to create more creative charts Link: nrennie.rbind.io/blog/creativ... #RStats #ggplot2
nrennie.rbind.io
Why creativity matters in data visualisation – Nicola Rennie
Creativity is an important aspect of data visualisation, and it can affect engagement, recall, and trustworthiness. This blog post outlines what creativity means when it comes to data visualisation, w...
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Darshak Bhatt @darshakbhatt.com · 03/08/2026
Two weeks ago, I was invited to to present my work on studying virus-based cancer therapies in the Math/Oncology minisymposium at the #ECMTB2026 in Graz. Some photos of the talk and Graz👇
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Reposted by Darshak Bhatt
Nature Reviews Immunology @natrevimmunol.nature.com · 10/05/2026
ICYMI: Calibrating T cell responsiveness through interactions with self
dlvr.it
Calibrating T cell responsiveness through interactions with self
Nature Reviews Immunology, Published online: 08 May 2026; doi:10.1038/s41577-026-01305-2T cells integrate signals from self-ligands not only during thymic development but also as they circulate through secondary lymphoid organs. These encounters with self in the periphery shape their activation and function, thereby ‘training’ T cells to interpret and respond to foreign antigens.
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Arjun Raj @arjunraj.bsky.social · 14/11/2025
So awesome to have this great paper from Sam Reffsin and Sara Cherry out! In it, we use retrospective clone tracing to show that there are particular single cell states that are more susceptible to viral infection (both SARS-CoV-2 and flu)! www.cell.com/cell/fulltex...
cell.com
Single-cell susceptibility to viral infection is driven by variable cell states
Not all cells that can be infected by a virus become infected with that virus. Single-cell clone tracing reveals intrinsic cell states with variable expression patterns that increase susceptibility to...
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Darshak Bhatt @darshakbhatt.com · 12/09/2025
Very glad to share my first last-author paper, now published in iScience! 🎉In this study, we addressed a key challenge in virus-based cancer therapy: macrophage-mediated suppression, which limits viral infection and restricts T cell activation in tumors. Link: www.sciencedirect.com/science/arti...
sciencedirect.com
Alphavirus replicons encoding IFN-γ enhance cancer virotherapy by overcoming macrophage-mediated suppression
Interference by tumor-associated macrophages may significantly reduce the efficacy of therapeutic viruses designed to infect cancer cells and activate…
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Darshak Bhatt @darshakbhatt.com · 10/09/2025
This was a meaningful moment of introspection, looking back on 10 years of scientific mobility since I left India. Also fun to share my experience working across labs in France, Netherlands, and Brazil. Read here for the full story: www.sciencedirect.com/science/arti...
sciencedirect.com
Scientific mobility in microbiology – 10
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Hank Green @hankgreen.bsky.social · 07/04/2025
A tricky thing about modern society is that no one has any idea when they don’t die. Like, the number of lives saved by controlling air pollution in America is probably over 200,000 per year, but the number of people who think their life was saved by controlling air pollution is zero.
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Jake Wintermute @synbio1.bsky.social · 21/03/2025
When you grow yeast on yeast extract medium
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Darshak Bhatt @darshakbhatt.com · 21/03/2025
Presenting our poster on programming oncolytic alphavirus replicons with immunogenic signals at the Dutch Annual Virology symposium #DAVS2025 in #sunny Utrecht 🌞
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Oded Rechavi @odedrechavi.bsky.social · 01/03/2025
Friends! The science that we love is under threat. World-wide, there're forces seeking to make it corporate-like, focused on deliverables, or even the enemy of society. Take a stand & celebrate science & music! #theconferencetoendallconferences - Registration starts NOW! woodstock.img.cas.cz
woodstock.img.cas.cz
Woodstock.Bio2 + Night Science 2025 | Courses & Meetings
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John Wallingford @jbwallingford.bsky.social · 19/02/2025
The embryologist Ernst Haeckel is famous for his maxim that “ontogeny recapitulates phylogeny” and for sketchy imaging. While Haeckel figures prominently in #DevBiol, the Fifth Dalai Lama doesn’t. Perhaps he should, though. He scooped Haeckel by about 200 years. #LongBibliography 🧵 1/14
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bioRxiv Immunology @biorxiv-immuno.bsky.social · 17/02/2025
Programming alphavirus with IFN-γ overrides the adverse effects of macrophages on oncolytic virotherapy www.biorxiv.org/content/10.1101/202…
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Thijs Janzen @thijsjanzen.bsky.social · 17/02/2025
Another great preprint out together with @darshakbhatt.com using OVRI! www.biorxiv.org/content/10.1...
biorxiv.org
Programming alphavirus with IFN-γ overrides the adverse effects of macrophages on oncolytic virotherapy
Virus uptake by tumor-associated macrophages may significantly reduce the availability of oncolytic viruses for cancer cell infection and limit therapeutic efficacy. Through a computational model, we ...
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Darshak Bhatt @darshakbhatt.com · 16/02/2025
📣🎓Fun time talking to #C2PO about my PhD experience between @uspoficial.bsky.social & @umcgroningen.bsky.social. It was great reflecting on how working in different places shapes one's approach to research, collaboration, & problem-solving. Check the full interview here: c2po.usp.br/c2po-intervi...
c2po.usp.br
C2PO interviews Dr. Darshak Bhatt – C2PO – Comprehensive Center for Precision Oncology
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Darshak Bhatt @darshakbhatt.com · 06/01/2025
1/3 Happy to share one of the final chapters of my PhD on oncolytic virotherapy! This study explores how oncolytic virotherapy can impact the content and function of extracellular vesicles (EVs) from melanoma cells. www.nature.com/articles/s41...
nature.com
Oncolytic alphavirus-induced extracellular vesicles counteract the immunosuppressive effect of melanoma-derived extracellular vesicles - Scientific Reports
Scientific Reports - Oncolytic alphavirus-induced extracellular vesicles counteract the immunosuppressive effect of melanoma-derived extracellular vesicles
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Amii Illustrates @amiiillustrates.bsky.social · 19/12/2024
Funny cartoon of a person saying to the grim reaper “I’ve gotta check with work first”. Illustration drawn in simplistic line art style. By Amii Illustrates.
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Thiago Carvalho @cyrilpedia.bsky.social · 04/12/2024
"Researchers are rewarded if their papers are highly cited or published in prestigious journals (...) Conversely, developing and maintaining software, even if it supports a wide body of research or meets the needs of broad scientific communities, rarely results in similar opportunities."
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Anna Obenauf @obenaufa.bsky.social · 27/11/2024
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
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Darshak Bhatt @darshakbhatt.com · 25/11/2024
A dust bunny 👇 from Studio Ghibli
media.tenor.com
a black and white photo of a girl with the words dust bunny written on it
Alt: a black and white photo of a girl with the words dust bunny written on it with A studio ghibli dust bunny
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Darshak Bhatt @darshakbhatt.com · 23/11/2024
🥳Happy to share our article on oncolytic virotherapy and T-cell responses influencing outcomes. Key insights: timing of therapy, anticancer T-cell activity, and the diffusion of immune signals all play complex roles, sometimes reducing effectiveness. #Spatialmodel #oncolyticvirus #Stochasticity 💻🎉
nature.com
Effects of virus-induced immunogenic cues on oncolytic virotherapy - Scientific Reports
Scientific Reports - Effects of virus-induced immunogenic cues on oncolytic virotherapy
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Dialectical Systems @dialecticalsys.bsky.social · 31/10/2024
🚨 Paper Alert! "Six Personas to Adopt When Framing Theoretical Research Questions in Biology" guides research framing and debunks common misconceptions about theory. royalsocietypublishing.org/doi/10.1098/... #ProcB #Biology #Ecology #Evolution
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#BruceSterling @bruces.bsky.social · 22/11/2024
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Jonathan Eisen @phylogenomics.bsky.social · 22/11/2024
So. Incredibly. Cool.
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Prakash Lab at Stanford @prakashlab.bsky.social · 21/11/2024
Our latest discovery of “lowest recorded temperature for eukaryotic cell motility” going all the way down to -15deg C. Come for the crazy cold Arctic & stay for diatoms. Will write longer thread - but enjoy video below of diatoms gliding on frozen ice surfaces. Congrats @zqing.bsky.social & team.
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Kelsey Jenkins, PhD @reptiliferous.bsky.social · 20/11/2024
This is actually the best way to look at fossils. Why would I zoom in on a pdf and protect my posture when I can just place my face mere inches from the computer screen???
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Itai Yanai @itaiyanai.bsky.social · 20/11/2024
In today's Nature: A ‘Wikipedia for cells’ www.nature.com/articles/d41... www.nature.com/immersive/d4...
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BioVoxxel (Jan Brocher) @biovoxxel.de · 20/11/2024
The #biovoxxel figure tools provide a convenient way in saving SVG vector graphic from Fiji and create publication figures in Inkscape. Thanks to Ved Sharma those SVGs can now also be opened in the browser and even in Adobe Illustrator, if you really have to use it (I won't blame you 😉)
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Elisabeth Bik @elisabethbik.bsky.social · 18/11/2024
Reading: Switzerland establishes center for scientific integrity From 2026, a new competence center will promote academic integrity at Swiss universities and serve as an advice center for misconduct. www.bluewin.ch/en/news/inte...
bluewin.ch
Switzerland establishes center for scientific integrity
From 2026, a new competence center will promote academic integrity at Swiss universities and serve as an advice center for misconduct.
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Kevin Collier @kevincollier.bsky.social · 11/11/2024
Bluesky these days
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Thiago Carvalho @cyrilpedia.bsky.social · 12/11/2024
'Structural engineering of F and HN glycoproteins has led to the identification of prefusion-stabilized F and chimeric immunogens that elicit high-titer neutralizing antibodies to diverse mumps viruses in mice compared to titers routinely observed following MMR vaccination in humans.' #Immunology
pnas.org
Structure-based design of glycoprotein subunit vaccines for mumps | PNAS
Mumps virus (MuV) is a highly contagious paramyxovirus that is endemic in most regions of the world and continues to cause outbreaks even in highly...
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Jesse Erasmus @jesseerasmus.bsky.social · 10/11/2024
Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list! go.bsky.app/SinqoJU
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Oded Rechavi @odedrechavi.bsky.social · 11/11/2024
The hero nodding in agreement during the entire presentation after the talk
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Melanie D. White @melaniedwhite.bsky.social · 08/11/2024
Happy #FluorescenceFriday! Here’s a transgenic quail embryo growing some beautiful blood vessels 😍
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Darshak Bhatt @darshakbhatt.com · 08/11/2024
Hello world! Thanks for the friendly connections so far! Looking forward to explore & share science updates/stories. I share my thesis & cover on Oncolytic virotherapy for those interested in #Synbio #oncolyticviruses, virus-tumor-immune interactions & more. Link: doi.org/10.33612/diss.859671389
The cover of the book "Oncolytic Virotherapy: Analysis, Design, Models" by Darshak Bhatt features an illustration of a stylized virus in the center, depicted with complex geometric details. It is set against a background of interconnected cell-like shapes representing tumor tissue, creating a visual of biological intricacy. The background is primarily in dark blue and the design in white, with a yellow accent highlighting the genetic engineering of the virus.
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