iiinova — where your digital self keeps evolving

Reposted by Daniyal Jafree

JCI insight @insight.jci.org · 16/09/2026

Miller et al. developed a single-cell atlas of polycystic kidney disease that integrates multiple disease models: doi.org/10.1172/jci.... The atlas identified the involvement of osteopontin across models and in human patients. The atlas: bmblx.bmi.osumc.edu/scPKD/ @daniyaljafree.bsky.social

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Reposted by Daniyal Jafree

JCI insight @insight.jci.org · 03/09/2026

Welcome to the kidney! R Ariel Gomez & team examine the role of renin cells in renal neurovascular morphogenesis & remodeling. The video: mouse kidney cortex with renin cells (magenta), the renal arterial tree (green), nerve fibers (yellow): doi.org/10.1172/jci.... @the-asci.org

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Daniyal Jafree @daniyaljafree.bsky.social · 01/09/2026

Clinical-academic training is under strain. To understand why, we followed-up all UCL MBPhD graduates 131 graduates published >5,800 papers with citations 3x the field norm We identified barriers to training, relevant for all physician-scientists, to inform change www.medrxiv.org/content/10.6...

medrxiv.org

Integrated MB-PhD training is a long-term investment in the clinician-scientist workforce

Background: Clinician-scientists translate clinical observation into discovery, trials, and policy, yet this workforce is shrinking across health systems worldwide. Integrated MB-PhD training, pausing...

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Reposted by Daniyal Jafree

medRxivpreprint @medrxivpreprint.bsky.social · 31/08/2026

Integrated MB-PhD training is a long-term investment in the clinician-scientist workforce www.medrxiv.org/content/10.64898/20…

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Reposted by Daniyal Jafree

Waggoner Lab @labwaggoner.bsky.social · 13/08/2026

Angiopoietin-1 RNA therapy slows the progression of WT1 glomerular disease in a preclinical mouse model @ucl.ac.uk www.science.org/doi/10.1126/...

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Reposted by Daniyal Jafree

Meng Zhu @zhumeng123.bsky.social · 30/04/2026

Cambridge → Boston → Cambridge again: I’m thrilled to return to Cambridge(UK) to open my lab at the Gurdon Institute, University of Cambridge!🥳 (mzhulab.com) We study how dev timing shapes and being shaped by plasticity, evolution & ageing. 🚩Hiring at all levels: pls email me if interested!📩

mzhulab.com

Meng Zhu Lab

We study how development measures time and how timing matters in development, evolution and ageing.

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Reposted by Daniyal Jafree

Oliver Stone @oliverastone.bsky.social · 20/12/2025

Please check out our job post @biologists.bsky.social! We are recruiting a Postdoc Scientist to develop cutting-edge tools and techniques for bioengineering human lymphatic networks, as part of an interdisciplinary collaboration with the group of Prof Dame Molly Stevens! bit.ly/3La9idq

bit.ly

Postdoctoral position in vascular bioengineering in Oxford, UK - the Node

The Stone Group at the Institute of Developmental and Regenerative Medicine, University of Oxford, is looking for a motivated Postdoctoral Research Scientist to develop tools and techniques that enabl...

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Reposted by Daniyal Jafree

Lori O'Brien @llobrienlab.bsky.social · 26/09/2025

For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

Image of a fluorescently labeled adult mouse kidney showing AQP2 staining of collecting ducts and connecting segment in green and alpha SMA staining of the arterial tree in magenta. The collecting ducts look like squiggly branches.

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Reposted by Daniyal Jafree

UCL Great Ormond Street Institute of Child Health @uclchildhealth.bsky.social · 22/09/2025

Kidney transplant rejection linked to changes in lymphatic vessels Researchers found that when a kidney transplant is rejected, the lymphatic vessels around the transplanted kidney undergo changes, making it easier for the immune system to attack the new organ. www.ucl.ac.uk/news/2025/se...

ucl.ac.uk

Kidney transplant rejection linked to changes in lymphatic vessels

A link between kidney transplant rejection and changes in the body’s lymphatic vessels has been discovered in a UCL-led study.

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Reposted by Daniyal Jafree

Journal of Clinical Investigation @jci.org · 20/09/2025

Take a peek: This issue’s cover features 3D imaging and single-cell genomics by David A. Long @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az

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Reposted by Daniyal Jafree

Journal of Clinical Investigation @jci.org · 16/09/2025

An in-depth look at lymphatic reorganization! This issue’s cover features 3D imaging and single-cell genomics by David A. Long, @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az

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Daniyal Jafree @daniyaljafree.bsky.social · 17/09/2025

🚨 New paper in @jclinical-invest.bsky.social! Kidney lymphatics are a promising target in transplant rejection 🗺️ In rejection, lymphatics expand and adversely remodel ⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system www.jci.org/articles/vie... 1/4

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Reposted by Daniyal Jafree

UCL Great Ormond Street Institute of Child Health @uclchildhealth.bsky.social · 04/07/2025

First of its kind study for children with arthritis reveals possible new disease targets. Researchers have been able to see what happens in the inflamed joints of children with arthritis, giving insight into why treatments affect children differently. Read: www.ucl.ac.uk/news/2025/ju...

ucl.ac.uk

First of its kind study for children with arthritis reveals possible new disease targets

Researchers have been able to see what happens in the inflamed joints of children with arthritis, giving insight into why treatments affect children differently.

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Reposted by Daniyal Jafree

Elaine Emmerson @doctoremmerson.bsky.social · 26/07/2025

I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!

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Reposted by Daniyal Jafree

Filipa Simões @simoesfilipa.bsky.social · 07/07/2025

🧪 Job alert 🔊 we are hiring a Research Assistant - join the Simões Group at DPAG-IDRM @ox.ac.uk supporting #cardiovascular development and regeneration research, working with #zebrafish and #human stem cell systems: my.corehr.com/pls/uoxrecru... @oxforddpag.bsky.social @idrm.ox.ac.uk (1/4)

my.corehr.com

Job Details

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Reposted by Daniyal Jafree

Eirini Maniou @emaniou.bsky.social · 07/07/2025

PhD position available in our team @dublincityuni.bsky.social from September. Please share/ contact me for informal enquiries.

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Reposted by Daniyal Jafree

Lori O'Brien @llobrienlab.bsky.social · 20/06/2025

For #FluorescenceFriday I'm sharing the fantastic work of postdoc Sarah McLarnon! A follow up to our '23 Development paper where we asked: Does precise vascular patterning matter for function and what happens after ischemic injury? The results were surprising! journals.physiology.org/doi/full/10....

Image captured by a light-sheet microscope showing the arterial tree of an adult mouse kidney in magenta

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Reposted by Daniyal Jafree

Vishal Patel @vishal-d-patel.bsky.social · 28/05/2025

Thrilled to share our new work in Nature Communications! We discovered how methionine → SAM → METTL3 → RNA methylation axis guides kidney development, especially nephron progenitor differentiation. #Nephrology #Epitranscriptomics Here’s a quick breakdown www.nature.com/articles/s41...

nature.com

An RNA transmethylation pathway governs kidney nephrogenic potential - Nature Communications

The mechanisms governing kidney nephrogenic capacity are incompletely understood. Here, the authors reveal that METTL3-dependent RNA transmethylation is both necessary and sufficient to promote nephro...

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Daniyal Jafree @daniyaljafree.bsky.social · 27/03/2025

Thrilled to share a new paper from my PhD in David Long’s lab at UCL, published in the Disease Models & Mechanisms journal! doi.org/10.1242/dmm.... We studied kidney microvasculature in polycystic kidney disease (PKD), the most common genetic cause of kidney failure (1/5)

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